Qingyuan Feng

Zihui Ma, Lingyao Li, Juan Li et al.

Rapid, fine-grained disaster damage assessment is essential for effective emergency response, yet remains challenging due to limited ground sensors and delays in official reporting. Social media provides a rich, real-time source of human-centric observations, but its multimodal and unstructured nature presents challenges for traditional analytical methods. In this study, we propose a structured Multimodal, Multilingual, and Multidimensional (3M) pipeline that leverages multimodal large language models (MLLMs) to assess disaster impacts. We evaluate three foundation models across two major earthquake events using both macro- and micro-level analyses. Results show that MLLMs effectively integrate image-text signals and demonstrate a strong correlation with ground-truth seismic data. However, performance varies with language, epicentral distance, and input modality. This work highlights the potential of MLLMs for disaster assessment and provides a foundation for future research in applying MLLMs to real-time crisis contexts. The code and data are released at: https://github.com/missa7481/EMNLP25_earthquake

Qingyuan Feng, Evgenia Dueva, Artem Cherkasov et al.

In silico drug-target interaction (DTI) prediction is an important and challenging problem in biomedical research with a huge potential benefit to the pharmaceutical industry and patients. Most existing methods for DTI prediction including deep learning models generally have binary endpoints, which could be an oversimplification of the problem, and those methods are typically unable to handle cold-target problems, i.e., problems involving target protein that never appeared in the training set. Towards this, we contrived PADME (Protein And Drug Molecule interaction prEdiction), a framework based on Deep Neural Networks, to predict real-valued interaction strength between compounds and proteins without requiring feature engineering. PADME takes both compound and protein information as inputs, so it is capable of solving cold-target (and cold-drug) problems. To our knowledge, we are the first to combine Molecular Graph Convolution (MGC) for compound featurization with protein descriptors for DTI prediction. We used multiple cross-validation split schemes and evaluation metrics to measure the performance of PADME on multiple datasets, including the ToxCast dataset, and PADME consistently dominates baseline methods. The results of a case study, which predicts the binding affinity between various compounds and androgen receptor (AR), suggest PADME's potential in drug development. The scalability of PADME is another advantage in the age of Big Data.