Jana Hutter

Daiqi Liu, Tomás Arias-Vergara, Jana Hutter et al.

Accurate classification of articulatory-phonological features plays a vital role in understanding human speech production and developing robust speech technologies, particularly in clinical contexts where targeted phonemic analysis and therapy can improve disease diagnosis accuracy and personalized rehabilitation. In this work, we propose a multimodal deep learning framework that combines real-time magnetic resonance imaging (rtMRI) and speech signals to classify three key articulatory dimensions: manner of articulation, place of articulation, and voicing. We perform classification on 15 phonological classes derived from the aforementioned articulatory dimensions and evaluate the system with four audio/vision configurations: unimodal rtMRI, unimodal audio signals, multimodal middle fusion, and contrastive learning-based audio-vision fusion. Experimental results on the USC-TIMIT dataset show that our contrastive learning-based approach achieves state-of-the-art performance, with an average F1-score of 0.81, representing an absolute increase of 0.23 over the unimodal baseline. The results confirm the effectiveness of contrastive representation learning for multimodal articulatory analysis. Our code and processed dataset will be made publicly available at https://github.com/DaE-plz/AC_Contrastive_Phonology to support future research.

Vladyslav Zalevskyi, Thomas Sanchez, Margaux Roulet et al.

Segmentation of fetal brain tissue from magnetic resonance imaging (MRI) plays a crucial role in the study of in utero neurodevelopment. However, automated tools face substantial domain shift challenges as they must be robust to highly heterogeneous clinical data, often limited in numbers and lacking annotations. Indeed, high variability of the fetal brain morphology, MRI acquisition parameters, and superresolution reconstruction (SR) algorithms adversely affect the model's performance when evaluated out-of-domain. In this work, we introduce FetalSynthSeg, a domain randomization method to segment fetal brain MRI, inspired by SynthSeg. Our results show that models trained solely on synthetic data outperform models trained on real data in out-ofdomain settings, validated on a 120-subject cross-domain dataset. Furthermore, we extend our evaluation to 40 subjects acquired using lowfield (0.55T) MRI and reconstructed with novel SR models, showcasing robustness across different magnetic field strengths and SR algorithms. Leveraging a generative synthetic approach, we tackle the domain shift problem in fetal brain MRI and offer compelling prospects for applications in fields with limited and highly heterogeneous data.

Vladyslav Zalevskyi, Thomas Sanchez, Misha Kaandorp et al.

Accurate fetal brain tissue segmentation and biometric analysis are essential for studying brain development in utero. The FeTA Challenge 2024 advanced automated fetal brain MRI analysis by introducing biometry prediction as a new task alongside tissue segmentation. For the first time, our diverse multi-centric test set included data from a new low-field (0.55T) MRI dataset. Evaluation metrics were also expanded to include the topology-specific Euler characteristic difference (ED). Sixteen teams submitted segmentation methods, most of which performed consistently across both high- and low-field scans. However, longitudinal trends indicate that segmentation accuracy may be reaching a plateau, with results now approaching inter-rater variability. The ED metric uncovered topological differences that were missed by conventional metrics, while the low-field dataset achieved the highest segmentation scores, highlighting the potential of affordable imaging systems when paired with high-quality reconstruction. Seven teams participated in the biometry task, but most methods failed to outperform a simple baseline that predicted measurements based solely on gestational age, underscoring the challenge of extracting reliable biometric estimates from image data alone. Domain shift analysis identified image quality as the most significant factor affecting model generalization, with super-resolution pipelines also playing a substantial role. Other factors, such as gestational age, pathology, and acquisition site, had smaller, though still measurable, effects. Overall, FeTA 2024 offers a comprehensive benchmark for multi-class segmentation and biometry estimation in fetal brain MRI, underscoring the need for data-centric approaches, improved topological evaluation, and greater dataset diversity to enable clinically robust and generalizable AI tools.

Ziyao Shang, Misha Kaandorp, Kelly Payette et al.

Magnetic resonance imaging (MRI) has played a crucial role in fetal neurodevelopmental research. Structural annotations of MR images are an important step for quantitative analysis of the developing human brain, with Deep learning providing an automated alternative for this otherwise tedious manual process. However, segmentation performances of Convolutional Neural Networks often suffer from domain shift, where the network fails when applied to subjects that deviate from the distribution with which it is trained on. In this work, we aim to train networks capable of automatically segmenting fetal brain MRIs with a wide range of domain shifts pertaining to differences in subject physiology and acquisition environments, in particular shape-based differences commonly observed in pathological cases. We introduce a novel data-driven train-time sampling strategy that seeks to fully exploit the diversity of a given training dataset to enhance the domain generalizability of the trained networks. We adapted our sampler, together with other existing data augmentation techniques, to the SynthSeg framework, a generator that utilizes domain randomization to generate diverse training data, and ran thorough experimentations and ablation studies on a wide range of training/testing data to test the validity of the approaches. Our networks achieved notable improvements in the segmentation quality on testing subjects with intense anatomical abnormalities (p < 1e-4), though at the cost of a slighter decrease in performance in cases with fewer abnormalities. Our work also lays the foundation for future works on creating and adapting data-driven sampling strategies for other training pipelines.

Daiqi Liu, Tomás Arias-Vergara, Johannes Enk et al.

Accurately segmenting articulatory structures in real-time magnetic resonance imaging (rtMRI) remains challenging, as most existing methods rely almost entirely on visual cues. Yet synchronized acoustic and phonological signals provide complementary context that can enrich visual information and improve precision. In this paper, we introduce VocSegMRI, a multimodal framework that integrates video, audio, and phonological inputs through cross-attention fusion for dynamic feature alignment. To further enhance cross-modal representation, we incorporate a contrastive learning objective that improves segmentation performance even when the audio modality is unavailable at inference. Evaluated on a sub-set of USC-75 rtMRI dataset, our approach achieves state-of-the-art performance, with a Dice score of 0.95 and a 95th percentile Hausdorff Distance (HD_95) of 4.20 mm, outperforming both unimodal and multimodal baselines. Ablation studies confirm the contributions of cross-attention and contrastive learning to segmentation precision and robustness. These results highlight the value of integrative multimodal modeling for accurate vocal tract analysis.

Diego Fajardo-Rojas, Levente Baljer, Jordina Aviles Verdera et al.

Preterm birth is a major cause of mortality and lifelong morbidity in childhood. Its complex and multifactorial origins limit the effectiveness of current clinical predictors and impede optimal care. In this study, a dual-branch deep learning architecture (PUUMA) was developed to predict gestational age (GA) at birth using T2* fetal MRI data from 295 pregnancies, encompassing a heterogeneous and imbalanced population. The model integrates both global whole-uterus and local placental features. Its performance was benchmarked against linear regression using cervical length measurements obtained by experienced clinicians from anatomical MRI and other Deep Learning architectures. The GA at birth predictions were assessed using mean absolute error. Accuracy, sensitivity, and specificity were used to assess preterm classification. Both the fully automated MRI-based pipeline and the cervical length regression achieved comparable mean absolute errors (3 weeks) and good sensitivity (0.67) for detecting preterm birth, despite pronounced class imbalance in the dataset. These results provide a proof of concept for automated prediction of GA at birth from functional MRI, and underscore the value of whole-uterus functional imaging in identifying at-risk pregnancies. Additionally, we demonstrate that manual, high-definition cervical length measurements derived from MRI, not currently routine in clinical practice, offer valuable predictive information. Future work will focus on expanding the cohort size and incorporating additional organ-specific imaging to improve generalisability and predictive performance.