Muhammad Irfan

Muhammad Irfan, Nasir Rahim, Khalid Mahmood Malik

Accurate extraction and segmentation of the cerebral arteries from digital subtraction angiography (DSA) sequences is essential for developing reliable clinical management models of complex cerebrovascular diseases. Conventional loss functions often rely solely on pixel-wise overlap, overlooking the geometric and physical consistency of vascular boundaries, which can lead to fragmented or unstable vessel predictions. To overcome this limitation, we propose a novel \textit{Physics-Informed Loss} (PIL) that models the interaction between the predicted and ground-truth boundaries as an elastic process inspired by dislocation theory in materials physics. This formulation introduces a physics-based regularization term that enforces smooth contour evolution and structural consistency, allowing the network to better capture fine vascular geometry. The proposed loss is integrated into several segmentation architectures, including U-Net, U-Net++, SegFormer, and MedFormer, and evaluated on two public benchmarks: DIAS and DSCA. Experimental results demonstrate that PIL consistently outperforms conventional loss functions such as Cross-Entropy, Dice, Active Contour, and Surface losses, achieving superior sensitivity, F1 score, and boundary coherence. These findings confirm that the incorporation of physics-based boundary interactions into deep neural networks improves both the precision and robustness of vascular segmentation in dynamic angiographic imaging. The implementation of the proposed method is publicly available at https://github.com/irfantahir301/Physicsis_loss.

Anum Nawaz, Muhammad Irfan, Xianjia Yu et al.

Federated learning (FL) has attracted increasing attention to mitigate security and privacy challenges in traditional cloud-centric machine learning models specifically in healthcare ecosystems. FL methodologies enable the training of global models through localized policies, allowing independent operations at the edge clients' level. Conventional first-order FL approaches face several challenges in personalized model training due to heterogeneous non-independent and identically distributed (non-iid) data of each edge client. Recently, second-order FL approaches maintain the stability and consistency of non-iid datasets while improving personalized model training. This study proposes and develops a verifiable and auditable optimized second-order FL framework BFEL (blockchain-enhanced federated edge learning) based on optimized FedCurv for personalized healthcare systems. FedCurv incorporates information about the importance of each parameter to each client's task (through Fisher Information Matrix) which helps to preserve client-specific knowledge and reduce model drift during aggregation. Moreover, it minimizes communication rounds required to achieve a target precision convergence for each edge client while effectively managing personalized training on non-iid and heterogeneous data. The incorporation of Ethereum-based model aggregation ensures trust, verifiability, and auditability while public key encryption enhances privacy and security. Experimental results of federated CNNs and MLPs utilizing Mnist, Cifar-10, and PathMnist demonstrate the high efficiency and scalability of the proposed framework.

Muhammad Irfan, Anum Nawaz, Riku Klen et al.

Early detection and accurate diagnosis are essential to improving patient outcomes. The use of convolutional neural networks (CNNs) for tumor detection has shown promise, but existing models often suffer from overparameterization, which limits their performance gains. In this study, fuzzy sigmoid convolution (FSC) is introduced along with two additional modules: top-of-the-funnel and middle-of-the-funnel. The proposed methodology significantly reduces the number of trainable parameters without compromising classification accuracy. A novel convolutional operator is central to this approach, effectively dilating the receptive field while preserving input data integrity. This enables efficient feature map reduction and enhances the model's tumor detection capability. In the FSC-based model, fuzzy sigmoid activation functions are incorporated within convolutional layers to improve feature extraction and classification. The inclusion of fuzzy logic into the architecture improves its adaptability and robustness. Extensive experiments on three benchmark datasets demonstrate the superior performance and efficiency of the proposed model. The FSC-based architecture achieved classification accuracies of 99.17%, 99.75%, and 99.89% on three different datasets. The model employs 100 times fewer parameters than large-scale transfer learning architectures, highlighting its computational efficiency and suitability for detecting brain tumors early. This research offers lightweight, high-performance deep-learning models for medical imaging applications.