Lingyao Li

Wenyue Hua, Lizhou Fan, Lingyao Li et al.

Can we avoid wars at the crossroads of history? This question has been pursued by individuals, scholars, policymakers, and organizations throughout human history. In this research, we attempt to answer the question based on the recent advances of Artificial Intelligence (AI) and Large Language Models (LLMs). We propose \textbf{WarAgent}, an LLM-powered multi-agent AI system, to simulate the participating countries, their decisions, and the consequences, in historical international conflicts, including the World War I (WWI), the World War II (WWII), and the Warring States Period (WSP) in Ancient China. By evaluating the simulation effectiveness, we examine the advancements and limitations of cutting-edge AI systems' abilities in studying complex collective human behaviors such as international conflicts under diverse settings. In these simulations, the emergent interactions among agents also offer a novel perspective for examining the triggers and conditions that lead to war. Our findings offer data-driven and AI-augmented insights that can redefine how we approach conflict resolution and peacekeeping strategies. The implications stretch beyond historical analysis, offering a blueprint for using AI to understand human history and possibly prevent future international conflicts. Code and data are available at \url{https://github.com/agiresearch/WarAgent}.

Chong Zhang, Xinyi Liu, Zhongmou Zhang et al.

Can AI Agents simulate real-world trading environments to investigate the impact of external factors on stock trading activities (e.g., macroeconomics, policy changes, company fundamentals, and global events)? These factors, which frequently influence trading behaviors, are critical elements in the quest for maximizing investors' profits. Our work attempts to solve this problem through large language model based agents. We have developed a multi-agent AI system called StockAgent, driven by LLMs, designed to simulate investors' trading behaviors in response to the real stock market. The StockAgent allows users to evaluate the impact of different external factors on investor trading and to analyze trading behavior and profitability effects. Additionally, StockAgent avoids the test set leakage issue present in existing trading simulation systems based on AI Agents. Specifically, it prevents the model from leveraging prior knowledge it may have acquired related to the test data. We evaluate different LLMs under the framework of StockAgent in a stock trading environment that closely resembles real-world conditions. The experimental results demonstrate the impact of key external factors on stock market trading, including trading behavior and stock price fluctuation rules. This research explores the study of agents' free trading gaps in the context of no prior knowledge related to market data. The patterns identified through StockAgent simulations provide valuable insights for LLM-based investment advice and stock recommendation. The code is available at https://github.com/MingyuJ666/Stockagent.

Huizi Yu, Jiayan Zhou, Lingyao Li et al. · harvard

Background: Simulated patient systems are important in medical education and research, providing safe, integrative training environments and supporting clinical decision making. Advances in artificial intelligence (AI), especially large language models (LLMs), can enhance simulated patients by replicating medical conditions and doctor patient interactions with high fidelity and at low cost, but effectiveness and trustworthiness remain open challenges. Methods: We developed AIPatient, a simulated patient system powered by LLM based AI agents. The system uses a retrieval augmented generation (RAG) framework with six task specific agents for complex reasoning. To improve realism, it is linked to the AIPatient knowledge graph built from de identified real patient data in the MIMIC III intensive care database. Results: We evaluated electronic health record (EHR) based medical question answering (QA), readability, robustness, stability, and user experience. AIPatient reached 94.15 percent QA accuracy when all six agents were enabled, outperforming versions with partial or no agent integration. The knowledge base achieved an F1 score of 0.89. Readability scores showed a median Flesch Reading Ease of 68.77 and a median Flesch Kincaid Grade of 6.4, indicating accessibility for most medical trainees and clinicians. Robustness and stability were supported by non significant variance in repeated trials (analysis of variance F value 0.61, p greater than 0.1; F value 0.78, p greater than 0.1). A user study with medical students showed that AIPatient provides high fidelity, usability, and educational value, comparable to or better than human simulated patients for history taking. Conclusions: LLM based simulated patient systems can deliver accurate, readable, and reliable medical encounters and show strong potential to transform medical education.

Lizhou Fan, Lingyao Li, Zihui Ma et al.

Large language models (LLMs) are a class of language models that have demonstrated outstanding performance across a range of natural language processing (NLP) tasks and have become a highly sought-after research area, because of their ability to generate human-like language and their potential to revolutionize science and technology. In this study, we conduct bibliometric and discourse analyses of scholarly literature on LLMs. Synthesizing over 5,000 publications, this paper serves as a roadmap for researchers, practitioners, and policymakers to navigate the current landscape of LLMs research. We present the research trends from 2017 to early 2023, identifying patterns in research paradigms and collaborations. We start with analyzing the core algorithm developments and NLP tasks that are fundamental in LLMs research. We then investigate the applications of LLMs in various fields and domains including medicine, engineering, social science, and humanities. Our review also reveals the dynamic, fast-paced evolution of LLMs research. Overall, this paper offers valuable insights into the current state, impact, and potential of LLMs research and its applications.

Lingyao Li, Lizhou Fan, Shubham Atreja et al.

Harmful content is pervasive on social media, poisoning online communities and negatively impacting participation. A common approach to address this issue is to develop detection models that rely on human annotations. However, the tasks required to build such models expose annotators to harmful and offensive content and may require significant time and cost to complete. Generative AI models have the potential to understand and detect harmful content. To investigate this potential, we used ChatGPT and compared its performance with MTurker annotations for three frequently discussed concepts related to harmful content: Hateful, Offensive, and Toxic (HOT). We designed five prompts to interact with ChatGPT and conducted four experiments eliciting HOT classifications. Our results show that ChatGPT can achieve an accuracy of approximately 80% when compared to MTurker annotations. Specifically, the model displays a more consistent classification for non-HOT comments than HOT comments compared to human annotations. Our findings also suggest that ChatGPT classifications align with provided HOT definitions, but ChatGPT classifies "hateful" and "offensive" as subsets of "toxic." Moreover, the choice of prompts used to interact with ChatGPT impacts its performance. Based on these in-sights, our study provides several meaningful implications for employing ChatGPT to detect HOT content, particularly regarding the reliability and consistency of its performance, its understand-ing and reasoning of the HOT concept, and the impact of prompts on its performance. Overall, our study provides guidance about the potential of using generative AI models to moderate large volumes of user-generated content on social media.

Shaoze Zhou, Diana Nelly Rivera Rodriguez, Pedro Remior et al.

In-person small-group conversations play a crucial role in everyday life; however, facilitating effective group interaction can be challenging, as the real-time nature demands full attention, offers no opportunity for revision, and requires interpreting non-verbal cues. Using Mixed Reality to provide proactive information support shows promise in helping individuals engage in and contribute to group conversations. We present a preliminary participatory design and qualitative study (N = 10) using focus groups and two technology probes to explore the opportunities of designing proactive information support in in-person small-group conversations. We reveal key design opportunities concerning how to maximize the benefits of proactive information support and how to effectively design such supporting information. Our study is crucial for paving the way toward designing future proactive AI agents to enable the paradigm of augmented in-person small-group conversation experience.

Lingyao Li, Junjie Xiong, Changjia Zhu et al.

Large language models (LLMs) are increasingly used in academic peer review, yet their reliability, alignment with human judgment, and robustness to adversarial attacks remain poorly understood. We present a systematic benchmark of LLM-as-a-Reviewer on 898 papers stratified from NeurIPS and ICLR, evaluating 12 LLMs along three axes: rating calibration, divergence from human reviewers, and resistance to prompt injection embedded via an invisible font-mapping attack. We find that LLMs systematically overrate weaker submissions and diverge from humans in topical emphasis, under-flagging Clarity and over-flagging Reproducibility, while producing reviews two to three times longer with lower lexical diversity and a more standardized vocabulary. Prompt injection remains highly effective. Simple hidden instructions can promote low-scoring papers to acceptance-level ratings in a substantial fraction of cases, with effectiveness varying sharply across model families. While LLMs offer utility in structuring evaluations, their integration into peer review requires safeguards against both intrinsic biases and adversarial risks.

Lingyao Li, Deyi Li, Chen Chen et al.

Large language models (LLMs) are increasingly deployed across healthcare applications, including clinical documentation, diagnostic reasoning, medicine recommendation, and medical education. Their outputs are largely unstructured clinical text, which is difficult to reliably evaluate at scale. LLM-as-a-Judge, in which an LLM evaluates another system's output against task-specific criteria, offers a scalable alternative and is increasingly used in clinical evaluation, yet its validity in healthcare remains underexamined. Existing reviews focus on general-purpose LLM evaluation or on risk framework, rather than systematically characterizing how LLM-as-a-Judge is applied in healthcare and how well their judgments align with human experts. We therefore conduct a PRISMA-guided comprehensive review of LLM-as-a-Judge applications in healthcare, searching five databases for studies published between January 2023 and February 2026. After screening 541 records, 134 studies meet the eligibility and are coded by health scenario, judge configuration, technical approach, and validation design. LLM-as-a-Judge is concentrated in clinical decision support, clinical natural language processing (NLP), medical knowledge and question answering (QA), and medical communication. OpenAI models are the most frequently used judges, and prompt engineering appears in nearly all studies, with ensemble, multi-agent, and retrieval-augmented designs as common extensions. Among studies reporting human validation, LLM judges often show moderate to strong alignment with expert judgments, although reliability varies substantially across tasks. Overall, this review positions LLM-as-a-Judge as a promising framework for scalable healthcare AI evaluation, while emphasizing that its clinical value depends on model design and rigorous validation.

Lizhou Fan, Wenyue Hua, Lingyao Li et al.

Complex reasoning ability is one of the most important features of current LLMs, which has also been leveraged to play an integral role in complex decision-making tasks. Therefore, the investigation into the reasoning capabilities of Large Language Models (LLMs) is critical: numerous benchmarks have been established to assess the reasoning abilities of LLMs. However, current benchmarks are inadequate in offering a rigorous evaluation of the full extent of reasoning abilities that LLMs are capable of achieving. They are also prone to the risk of overfitting, as these benchmarks, being publicly accessible and static, allow models to potentially tailor their responses to specific benchmark metrics, thereby inflating their performance. Addressing these limitations, our research introduces a new benchmark, named NPHardEval. This benchmark is designed to evaluate the reasoning abilities of LLMs across a broad spectrum of 900 algorithmic questions, extending up to the NP-Hard complexity class. These questions are meticulously chosen to represent a wide range of complexity class below the NP-hard complexity class, offering a rigorous measure of the reasoning ability of LLMs. Through this study, we shed light on the current state of reasoning in LLMs, providing an objective and rigorous perspective through the comparison of LLMs' performance across complex classes. Moreover, this benchmark is designed with a dynamic update mechanism, where the datapoints are refreshed on a monthly basis. Such regular updates play a crucial role in mitigating the risk of LLMs overfitting to the benchmark, promoting a more accurate and reliable assessment of their reasoning capabilities. The benchmark dataset and code of NPHardEval are available at https://github.com/casmlab/NPHardEval.

Junyu Wang, Changjia Zhu, Yuanbo Zhou et al.

This paper studies how multimodal large language models (MLLMs) undermine the security guarantees of visual CAPTCHA. We identify the attack surface where an adversary can cheaply automate CAPTCHA solving using off-the-shelf models. We evaluate 7 leading commercial and open-source MLLMs across 18 real-world CAPTCHA task types, measuring single-shot accuracy, success under limited retries, end-to-end latency, and per-solve cost. We further analyze the impact of task-specific prompt engineering and few-shot demonstrations on solver effectiveness. We reveal that MLLMs can reliably solve recognition-oriented and low-interaction CAPTCHA tasks at human-like cost and latency, whereas tasks requiring fine-grained localization, multi-step spatial reasoning, or cross-frame consistency remain significantly harder for current models. By examining the reasoning traces of such MLLMs, we investigate the underlying mechanisms of why models succeed/fail on specific CAPTCHA puzzles and use these insights to derive defense-oriented guidelines for selecting and strengthening CAPTCHA tasks. We conclude by discussing implications for platform operators deploying CAPTCHA as part of their abuse-mitigation pipeline.Code Availability (https://anonymous.4open.science/r/Captcha-465E/).

Lizhou Fan, Lingyao Li, Libby Hemphill

Background: Online toxicity, encompassing behaviors such as harassment, bullying, hate speech, and the dissemination of misinformation, has become a pressing social concern in the digital age. The 2022 Mpox outbreak, initially termed "Monkeypox" but subsequently renamed to mitigate associated stigmas and societal concerns, serves as a poignant backdrop to this issue. Objective: In this research, we undertake a comprehensive analysis of the toxic online discourse surrounding the 2022 Mpox outbreak. Our objective is to dissect its origins, characterize its nature and content, trace its dissemination patterns, and assess its broader societal implications, with the goal of providing insights that can inform strategies to mitigate such toxicity in future crises. Methods: We collected more than 1.6 million unique tweets and analyzed them from five dimensions, including context, extent, content, speaker, and intent. Utilizing BERT-based topic modeling and social network community clustering, we delineated the toxic dynamics on Twitter. Results: We identified five high-level topic categories in the toxic online discourse on Twitter, including disease (46.6%), health policy and healthcare (19.3%), homophobia (23.9%), politics (6.0%), and racism (4.1%). Through the toxicity diffusion networks of mentions, retweets, and the top users, we found that retweets of toxic content were widespread, while influential users rarely engaged with or countered this toxicity through retweets. Conclusions: By tracking topical dynamics, we can track the changing popularity of toxic content online, providing a better understanding of societal challenges. Network dynamics spotlight key social media influencers and their intents, indicating that addressing these central figures in toxic discourse can enhance crisis communication and inform policy-making.

Zihui Ma, Lingyao Li, Libby Hemphill et al.

Effective disaster response is critical for affected communities. Responders and decision-makers would benefit from reliable, timely measures of the issues impacting their communities during a disaster, and social media offers a potentially rich data source. Social media can reflect public concerns and demands during a disaster, offering valuable insights for decision-makers to understand evolving situations and optimize resource allocation. We used Bidirectional Encoder Representations from Transformers (BERT) topic modeling to cluster topics from Twitter data. Then, we conducted a temporal-spatial analysis to examine the distribution of these topics across different regions during the 2020 western U.S. wildfire season. Our results show that Twitter users mainly focused on three topics:"health impact," "damage," and "evacuation." We used the Susceptible-Infected-Recovered (SIR) theory to explore the magnitude and velocity of topic diffusion on Twitter. The results displayed a clear relationship between topic trends and wildfire propagation patterns. The estimated parameters obtained from the SIR model in selected cities revealed that residents exhibited a high level of several concerns during the wildfire. Our study details how the SIR model and topic modeling using social media data can provide decision-makers with a quantitative approach to measure disaster response and support their decision-making processes.

Wenyue Hua, Ollie Liu, Lingyao Li et al.

This paper investigates the rationality of large language models (LLMs) in strategic decision-making contexts, specifically within the framework of game theory. We evaluate several state-of-the-art LLMs across a spectrum of complete-information and incomplete-information games. Our findings reveal that LLMs frequently deviate from rational strategies, particularly as the complexity of the game increases with larger payoff matrices or deeper sequential trees. To address these limitations, we design multiple game-theoretic workflows that guide the reasoning and decision-making processes of LLMs. These workflows aim to enhance the models' ability to compute Nash Equilibria and make rational choices, even under conditions of uncertainty and incomplete information. Experimental results demonstrate that the adoption of these workflows significantly improves the rationality and robustness of LLMs in game-theoretic tasks. Specifically, with the workflow, LLMs exhibit marked improvements in identifying optimal strategies, achieving near-optimal allocations in negotiation scenarios, and reducing susceptibility to exploitation during negotiations. Furthermore, we explore the meta-strategic considerations of whether it is rational for agents to adopt such workflows, recognizing that the decision to use or forgo the workflow constitutes a game-theoretic issue in itself. Our research contributes to a deeper understanding of LLMs' decision-making capabilities in strategic contexts and provides insights into enhancing their rationality through structured workflows. The findings have implications for the development of more robust and strategically sound AI agents capable of navigating complex interactive environments. Code and data supporting this study are available at \url{https://github.com/Wenyueh/game_theory}.

Deyi Li, Zijun Yao, Qi Xu et al.

The growing adoption of electronic health record (EHR) systems has provided unprecedented opportunities for predictive modeling to guide clinical decision making. Structured EHRs contain longitudinal observations of patients across hospital visits, where each visit is represented by a set of medical codes. While sequence-based, graph-based, and graph-enhanced sequence approaches have been developed to capture rich code interactions over time or within the same visits, they often overlook the inherent heterogeneous roles of medical codes arising from distinct clinical characteristics and contexts. To this end, in this study we propose the Disease Trajectory-aware Transformer for EHR (DT-BEHRT), a graph-enhanced sequential architecture that disentangles disease trajectories by explicitly modeling diagnosis-centric interactions within organ systems and capturing asynchronous progression patterns. To further enhance the representation robustness, we design a tailored pre-training methodology that combines trajectory-level code masking with ontology-informed ancestor prediction, promoting semantic alignment across multiple modeling modules. Extensive experiments on multiple benchmark datasets demonstrate that DT-BEHRT achieves strong predictive performance and provides interpretable patient representations that align with clinicians' disease-centered reasoning. The source code is publicly accessible at https://github.com/GatorAIM/DT-BEHRT.git.

Yiheng Chen, Zihui Ma, Peishi Jiang et al.

Land surface temperature (LST) super-resolution is important for environmental monitoring. However, it remains challenging as coarse thermal observations severely underdetermine fine-scale structure. In this paper, we propose Earth Foundation Model-guided Diffusion (EFDiff), a novel framework for super-resolution under extreme spatial degradation. EFDiff uses the Prithvi-EO-2.0 Earth foundation model to encode high-resolution multispectral reflectance into geospatial embeddings, which are injected into the denoising network via cross-attention to guide fine-scale reconstruction from highly degraded observations. We study two variants, EFDiff-$ε$ and EFDiff-$x_0$, which offer complementary trade-offs between perceptual realism and pixel-level fidelity. We evaluate EFDiff under an extreme $32\times$ scale gap using a globally diverse benchmark comprising 242,416 co-registered Landsat thermal-reflectance patches. Results show that EFDiff consistently outperforms baseline methods and that cross-attention conditioning by EFM is more effective than HLS channel concatenation. Although we present EFDiff in the context of LST super-resolution, the framework is broadly applicable to remote sensing problems in which pretrained geospatial representations can guide generative reconstruction.

Binghao Yan, Yunbi Nam, Lingyao Li et al.

Recent advancements in deep learning, particularly large language models (LLMs), made a significant impact on how researchers study microbiome and metagenomics data. Microbial protein and genomic sequences, like natural languages, form a language of life, enabling the adoption of LLMs to extract useful insights from complex microbial ecologies. In this paper, we review applications of deep learning and language models in analyzing microbiome and metagenomics data. We focus on problem formulations, necessary datasets, and the integration of language modeling techniques. We provide an extensive overview of protein/genomic language modeling and their contributions to microbiome studies. We also discuss applications such as novel viromics language modeling, biosynthetic gene cluster prediction, and knowledge integration for metagenomics studies.

Yiheng Chen, Alina Hagen, Fan Yang et al.

Wildfires require governments to communicate under conditions of urgency, uncertainty, and intense public scrutiny, yet such communication now unfolds within a digitally mediated environment shaped by polarization and engagement-based amplification. We analyze over 1.3 million wildfire-related social media posts from California (2016-2025) to examine how institutional actors are evaluated within this landscape. Users' stance toward government is actor-specific: individual political officials are discussed more negatively than operational agencies across federal, state, and local levels, and this gap widens during extreme wildfire events. Moreover, interaction networks become increasingly modular over time, consolidating into polarized communities in which negativity concentrates within cohesive clusters. Engagement-weighted measures show that highly interactive negative content disproportionately shapes visible discourse, while crisis periods redirect attention from emergency agencies to high-profile political figures, reinforcing reputational divergence. These findings indicate that wildfire communication operates within a polarized, engagement-ranked ecosystem in which evaluative tone, network structure, and visibility dynamics jointly shape institutional perception. Effective disaster communication should therefore account for the structural conditions of contemporary digital public communities.

Renkai Ma, Ben Zefeng Zhang, Chen Chen et al.

Large Language Model (LLM) chatbots like ChatGPT have emerged as cognitive scaffolding for autistic users, yet the tension between their utility and risk remains under-articulated. Through an inductive thematic analysis of 3,984 social media posts by self-identified autistic users, we apply a technology affordance lens to examine this duality. We found that while users leveraged ChatGPT to offload executive dysfunction, regulate emotions, translate neurotypical communication, and validate their autistic identity, these affordances coexist with risks to their well-being: reinforcing delusional thinking, erasing authentic identity through automated masking, and triggering conflicts with the autistic sense of justice. As part of our preliminary work, this poster identifies trade-offs in autistic users' interactions with ChatGPT and concludes by outlining our future work on developing neuro-inclusive technologies that address these tensions through beneficial friction, bidirectional translation, and the delineation of emotional validation from reality.

Shuhang Lin, Zhencan Peng, Lingyao Li et al.

Recent advances in Large Language Model (LLM)-based agents have been propelled by Retrieval-Augmented Generation (RAG), which grants the models access to vast external knowledge bases. Despite RAG's success in improving agent performance, agent-level cache management, particularly constructing, maintaining, and updating a compact, relevant corpus dynamically tailored to each agent's need, remains underexplored. Therefore, we introduce ARC (Agent RAG Cache Mechanism), a novel, annotation-free caching framework that dynamically manages small, high-value corpora for each agent. By synthesizing historical query distribution patterns with the intrinsic geometry of cached items in the embedding space, ARC automatically maintains a high-relevance cache. With comprehensive experiments on three retrieval datasets, our experimental results demonstrate that ARC reduces storage requirements to 0.015% of the original corpus while offering up to 79.8% has-answer rate and reducing average retrieval latency by 80%. Our results demonstrate that ARC can drastically enhance efficiency and effectiveness in RAG-powered LLM agents.

Renkai Ma, Shuo Niu, Lingyao Li et al.

AI companions enable deep emotional relationships by engaging a user's sense of identity, but they also pose risks like unhealthy emotional dependence. Mitigating these risks requires first understanding the underlying process of identity construction and negotiation with AI companions. Focusing on Character.AI (C.AI), a popular AI companion, we conducted an LLM-assisted thematic analysis of 22,374 online discussions on its subreddit. Using Identity Negotiation Theory as an analytical lens, we identified a three-stage process: 1) five user motivations; 2) an identity negotiation process involving three communication expectations and four identity co-construction strategies; and 3) three emotional outcomes. Our findings surface the identity work users perform as both performers and directors to co-construct identities in negotiation with C.AI. This process takes place within a socio-emotional sandbox where users can experiment with social roles and express emotions without non-human partners. Finally, we offer design implications for emotionally supporting users while mitigating the risks.

Shiwei Hong, Lingyao Li, Ethan Z. Rong et al.

Prior work has explored multi-turn interaction and feedback for LLM writing, but evaluations still largely center on prompts and localized feedback, leaving persistent public reception in online communities underexamined. We test whether broadcast community discussion improves stand-up comedy writing in a controlled multi-agent sandbox: in the discussion condition, critic and audience threads are recorded, filtered, stored as social memory, and later retrieved to condition subsequent generations, whereas the baseline omits discussion. Across 50 rounds (250 paired monologues) judged by five expert annotators using A/B preference and a 15-item rubric, discussion wins 75.6% of instances and improves Craft/Clarity (Δ = 0.440) and Social Response (Δ = 0.422), with occasional increases in aggressive humor.

Weige Cai, Tong Zhu, Jinyi Niu et al.

With the rapid advancement of large language models (LLMs), Multi-agent Systems (MAS) have achieved significant progress in various application scenarios. However, substantial challenges remain in designing versatile, robust, and efficient platforms for agent deployment. To address these limitations, we propose \textbf{LightAgent}, a lightweight yet powerful agentic framework, effectively resolving the trade-off between flexibility and simplicity found in existing frameworks. LightAgent integrates core functionalities such as Memory (mem0), Tools, and Tree of Thought (ToT), while maintaining an extremely lightweight structure. As a fully open-source solution, it seamlessly integrates with mainstream chat platforms, enabling developers to easily build self-learning agents. We have released LightAgent at \href{https://github.com/wxai-space/LightAgent}{https://github.com/wxai-space/LightAgent}

Zihui Ma, Lingyao Li, Juan Li et al.

Rapid, fine-grained disaster damage assessment is essential for effective emergency response, yet remains challenging due to limited ground sensors and delays in official reporting. Social media provides a rich, real-time source of human-centric observations, but its multimodal and unstructured nature presents challenges for traditional analytical methods. In this study, we propose a structured Multimodal, Multilingual, and Multidimensional (3M) pipeline that leverages multimodal large language models (MLLMs) to assess disaster impacts. We evaluate three foundation models across two major earthquake events using both macro- and micro-level analyses. Results show that MLLMs effectively integrate image-text signals and demonstrate a strong correlation with ground-truth seismic data. However, performance varies with language, epicentral distance, and input modality. This work highlights the potential of MLLMs for disaster assessment and provides a foundation for future research in applying MLLMs to real-time crisis contexts. The code and data are released at: https://github.com/missa7481/EMNLP25_earthquake

Wenyue Hua, Kaijie Zhu, Lingyao Li et al.

This study intends to systematically disentangle pure logic reasoning and text understanding by investigating the contrast across abstract and contextualized logical problems from a comprehensive set of domains. We explore whether LLMs demonstrate genuine reasoning capabilities across various domains when the underlying logical structure remains constant. We focus on two main questions (1) Can abstract logical problems alone accurately benchmark an LLM's reasoning ability in real-world scenarios, disentangled from contextual support in practical settings? (2) Does fine-tuning LLMs on abstract logic problem generalize to contextualized logic problems and vice versa? To investigate these questions, we focus on standard propositional logic, specifically propositional deductive and abductive logic reasoning. In particular, we construct instantiated datasets for deductive and abductive reasoning with 4 levels of difficulty, encompassing 12 distinct categories or domains based on the categorization of Wikipedia. Our experiments aim to provide insights into disentangling context in logical reasoning and the true reasoning capabilities of LLMs and their generalization potential. The code and dataset are available at: https://github.com/agiresearch/ContextHub.

Sam Lin, Wenyue Hua, Lingyao Li et al.

This study explores a novel approach to enhance the performance of Large Language Models (LLMs) through the optimization of input data within prompts. While previous research has primarily focused on refining instruction components and augmenting input data with in-context examples, our work investigates the potential benefits of optimizing the input data itself. We introduce a two-pronged strategy for input data optimization: content engineering and structural reformulation. Content engineering involves imputing missing values, removing irrelevant attributes, and enriching profiles by generating additional information inferred from existing attributes. Subsequent to content engineering, structural reformulation is applied to optimize the presentation of the modified content to LLMs, given their sensitivity to input format. Our findings suggest that these optimizations can significantly improve the performance of LLMs in various tasks, offering a promising avenue for future research in prompt engineering. The source code is available at https://anonymous.4open.science/r/ADO-6BC5/

Xiang Li, Wenyue Hua, Kaijie Zhu et al.

Large Vision-Language Models (LVLMs) have demonstrated impressive capabilities in multimodal understanding, yet their reasoning abilities remain underexplored. Existing benchmarks tend to focus on perception or text-based comprehension, offering limited insight into how well these models perform on structured, logic-driven tasks that require both visual and linguistic reasoning. To address this gap, we introduce NPHardEval4V, a multimodal benchmark suite grounded in four classical NP-hard problems: Knapsack, Set Cover, Traveling Salesperson, and Vertex Cover. Each task is presented through a combination of structured visual layouts and textual prompts, designed to assess the ability of LVLMs to perform combinatorial reasoning under visual-linguistic constraints. We evaluate a set of advanced open-source and closed-source vision-language models under a unified prompting and problem representation framework. This enables fair comparison across models and task types, while isolating key variables affecting performance. Our results show that while these models perform reasonably well on perception-based inputs, they struggle with global optimization, abstraction, and constraint satisfaction. No single model demonstrates consistent reasoning capability across all problem types, and common failure patterns reveal fundamental limitations in current architectures. By leveraging the structure and complexity of NP-hard problems, NPHardEval4V provides a scalable, interpretable, and challenging testbed for diagnosing reasoning behaviors in LVLMs. We hope this benchmark can support the community in building more robust, inference-capable multimodal systems. The benchmark dataset and code are available at https://github.com/lizhouf/NPHardEval4.

Huizi Yu, Lizhou Fan, Lingyao Li et al.

Large Language Models (LLMs) have rapidly become important tools in Biomedical and Health Informatics (BHI), enabling new ways to analyze data, treat patients, and conduct research. This study aims to provide a comprehensive overview of LLM applications in BHI, highlighting their transformative potential and addressing the associated ethical and practical challenges. We reviewed 1,698 research articles from January 2022 to December 2023, categorizing them by research themes and diagnostic categories. Additionally, we conducted network analysis to map scholarly collaborations and research dynamics. Our findings reveal a substantial increase in the potential applications of LLMs to a variety of BHI tasks, including clinical decision support, patient interaction, and medical document analysis. Notably, LLMs are expected to be instrumental in enhancing the accuracy of diagnostic tools and patient care protocols. The network analysis highlights dense and dynamically evolving collaborations across institutions, underscoring the interdisciplinary nature of LLM research in BHI. A significant trend was the application of LLMs in managing specific disease categories such as mental health and neurological disorders, demonstrating their potential to influence personalized medicine and public health strategies. LLMs hold promising potential to further transform biomedical research and healthcare delivery. While promising, the ethical implications and challenges of model validation call for rigorous scrutiny to optimize their benefits in clinical settings. This survey serves as a resource for stakeholders in healthcare, including researchers, clinicians, and policymakers, to understand the current state and future potential of LLMs in BHI.

Dong Shu, Chong Zhang, Mingyu Jin et al.

Jailbreak attacks represent one of the most sophisticated threats to the security of large language models (LLMs). To deal with such risks, we introduce an innovative framework that can help evaluate the effectiveness of jailbreak attacks on LLMs. Unlike traditional binary evaluations focusing solely on the robustness of LLMs, our method assesses the attacking prompts' effectiveness. We present two distinct evaluation frameworks: a coarse-grained evaluation and a fine-grained evaluation. Each framework uses a scoring range from 0 to 1, offering unique perspectives and allowing for the assessment of attack effectiveness in different scenarios. Additionally, we develop a comprehensive ground truth dataset specifically tailored for jailbreak prompts. This dataset is a crucial benchmark for our current study and provides a foundational resource for future research. By comparing with traditional evaluation methods, our study shows that the current results align with baseline metrics while offering a more nuanced and fine-grained assessment. It also helps identify potentially harmful attack prompts that might appear harmless in traditional evaluations. Overall, our work establishes a solid foundation for assessing a broader range of attack prompts in prompt injection.

Shuhang Lin, Wenyue Hua, Lingyao Li et al.

This paper presents BattleAgent, an emulation system that combines the Large Vision-Language Model and Multi-agent System. This novel system aims to simulate complex dynamic interactions among multiple agents, as well as between agents and their environments, over a period of time. It emulates both the decision-making processes of leaders and the viewpoints of ordinary participants, such as soldiers. The emulation showcases the current capabilities of agents, featuring fine-grained multi-modal interactions between agents and landscapes. It develops customizable agent structures to meet specific situational requirements, for example, a variety of battle-related activities like scouting and trench digging. These components collaborate to recreate historical events in a lively and comprehensive manner while offering insights into the thoughts and feelings of individuals from diverse viewpoints. The technological foundations of BattleAgent establish detailed and immersive settings for historical battles, enabling individual agents to partake in, observe, and dynamically respond to evolving battle scenarios. This methodology holds the potential to substantially deepen our understanding of historical events, particularly through individual accounts. Such initiatives can also aid historical research, as conventional historical narratives often lack documentation and prioritize the perspectives of decision-makers, thereby overlooking the experiences of ordinary individuals. BattelAgent illustrates AI's potential to revitalize the human aspect in crucial social events, thereby fostering a more nuanced collective understanding and driving the progressive development of human society.

Zhenkun Li, Lingyao Li, Shuhang Lin et al.

Single-agent LLMs hit hard limits--finite context, role overload, and brittle domain transfer. Conventional multi-agent fixes soften those edges yet expose fresh pains: ill-posed decompositions, fuzzy contracts, and verification overhead that blunts the gains. We therefore present Know-The-Ropes (KtR), a framework that converts domain priors into an algorithmic blueprint hierarchy, in which tasks are recursively split into typed, controller-mediated subtasks, each solved zero-shot or with the lightest viable boost (e.g., chain-of-thought, micro-tune, self-check). Grounded in the No-Free-Lunch theorem, KtR trades the chase for a universal prompt for disciplined decomposition. On the Knapsack problem (3-8 items), three GPT-4o-mini agents raise accuracy from 3% zero-shot to 95% on size-5 instances after patching a single bottleneck agent. On the tougher Task-Assignment problem (6-15 jobs), a six-agent o3-mini blueprint hits 100% up to size 10 and 84% on sizes 13-15, versus 11% zero-shot. Algorithm-aware decomposition plus targeted augmentation thus turns modest models into reliable collaborators--no ever-larger monoliths required.

Junjie Xiong, Changjia Zhu, Shuhang Lin et al.

Large Language Models (LLMs) are increasingly equipped with capabilities of real-time web search and integrated with protocols like Model Context Protocol (MCP). This extension could introduce new security vulnerabilities. We present a systematic investigation of LLM vulnerabilities to hidden adversarial prompts through malicious font injection in external resources like webpages, where attackers manipulate code-to-glyph mapping to inject deceptive content which are invisible to users. We evaluate two critical attack scenarios: (1) "malicious content relay" and (2) "sensitive data leakage" through MCP-enabled tools. Our experiments reveal that indirect prompts with injected malicious font can bypass LLM safety mechanisms through external resources, achieving varying success rates based on data sensitivity and prompt design. Our research underscores the urgent need for enhanced security measures in LLM deployments when processing external content.

Chi Zhang, Changjia Zhu, Junjie Xiong et al.

Large Language Models (LLMs) have revolutionized content creation across digital platforms, offering unprecedented capabilities in natural language generation and understanding. These models enable beneficial applications such as content generation, question and answering (Q&A), programming, and code reasoning. Meanwhile, they also pose serious risks by inadvertently or intentionally producing toxic, offensive, or biased content. This dual role of LLMs, both as powerful tools for solving real-world problems and as potential sources of harmful language, presents a pressing sociotechnical challenge. In this survey, we systematically review recent studies spanning unintentional toxicity, adversarial jailbreaking attacks, and content moderation techniques. We propose a unified taxonomy of LLM-related harms and defenses, analyze emerging multimodal and LLM-assisted jailbreak strategies, and assess mitigation efforts, including reinforcement learning with human feedback (RLHF), prompt engineering, and safety alignment. Our synthesis highlights the evolving landscape of LLM safety, identifies limitations in current evaluation methodologies, and outlines future research directions to guide the development of robust and ethically aligned language technologies.

Lingyao Li, Dawei Li, Zhenhui Ou et al.

Efficient simulation is essential for enhancing proactive preparedness for sudden-onset disasters such as earthquakes. Recent advancements in large language models (LLMs) as world models show promise in simulating complex scenarios. This study examines multiple LLMs to proactively estimate perceived earthquake impacts. Leveraging multimodal datasets including geospatial, socioeconomic, building, and street-level imagery data, our framework generates Modified Mercalli Intensity (MMI) predictions at zip code and county scales. Evaluations on the 2014 Napa and 2019 Ridgecrest earthquakes using USGS ''Did You Feel It? (DYFI)'' reports demonstrate significant alignment, as evidenced by a high correlation of 0.88 and a low RMSE of 0.77 as compared to real reports at the zip code level. Techniques such as RAG and ICL can improve simulation performance, while visual inputs notably enhance accuracy compared to structured numerical data alone. These findings show the promise of LLMs in simulating disaster impacts that can help strengthen pre-event planning.

Lingyao Li, Runlong Yu, Qikai Hu et al.

Image geolocalization, the task of identifying the geographic location depicted in an image, is important for applications in crisis response, digital forensics, and location-based intelligence. While recent advances in large language models (LLMs) offer new opportunities for visual reasoning, their ability to perform image geolocalization remains underexplored. In this study, we introduce a benchmark called IMAGEO-Bench that systematically evaluates accuracy, distance error, geospatial bias, and reasoning process. Our benchmark includes three diverse datasets covering global street scenes, points of interest (POIs) in the United States, and a private collection of unseen images. Through experiments on 10 state-of-the-art LLMs, including both open- and closed-source models, we reveal clear performance disparities, with closed-source models generally showing stronger reasoning. Importantly, we uncover geospatial biases as LLMs tend to perform better in high-resource regions (e.g., North America, Western Europe, and California) while exhibiting degraded performance in underrepresented areas. Regression diagnostics demonstrate that successful geolocalization is primarily dependent on recognizing urban settings, outdoor environments, street-level imagery, and identifiable landmarks. Overall, IMAGEO-Bench provides a rigorous lens into the spatial reasoning capabilities of LLMs and offers implications for building geolocation-aware AI systems.

Tianqi Shang, Weiqing He, Charles Zheng et al.

The rise of Large Language Models (LLMs) has enabled the development of specialized AI agents with domain-specific reasoning and interaction capabilities, particularly in healthcare. While recent frameworks simulate medical decision-making, they largely focus on single-turn tasks where a doctor agent receives full case information upfront -- diverging from the real-world diagnostic process, which is inherently uncertain, interactive, and iterative. In this paper, we introduce MIMIC-Patient, a structured dataset built from the MIMIC-III electronic health records (EHRs), designed to support dynamic, patient-level simulations. Building on this, we propose DynamiCare, a novel dynamic multi-agent framework that models clinical diagnosis as a multi-round, interactive loop, where a team of specialist agents iteratively queries the patient system, integrates new information, and dynamically adapts its composition and strategy. We demonstrate the feasibility and effectiveness of DynamiCare through extensive experiments, establishing the first benchmark for dynamic clinical decision-making with LLM-powered agents.

Joseph Lee, Tianqi Shang, Jae Young Baik et al.

Large Language Models (LLMs) have shown promise in clinical decision support, yet their application to triage remains underexplored. We systematically investigate the capabilities of LLMs in emergency department triage through two key dimensions: (1) robustness to distribution shifts and missing data, and (2) counterfactual analysis of intersectional biases across sex and race. We assess multiple LLM-based approaches, ranging from continued pre-training to in-context learning, as well as machine learning approaches. Our results indicate that LLMs exhibit superior robustness, and we investigate the key factors contributing to the promising LLM-based approaches. Furthermore, in this setting, we identify gaps in LLM preferences that emerge in particular intersections of sex and race. LLMs generally exhibit sex-based differences, but they are most pronounced in certain racial groups. These findings suggest that LLMs encode demographic preferences that may emerge in specific clinical contexts or particular combinations of characteristics.

Lingyao Li

Social media and online review platforms have become valuable sources for studying how people express opinions, report experiences, and respond to events across space. This work presents a practical guide to using user-generated social data for geospatial research on public opinion, human behavior, and place-based experience. It shows the promise of using these data as a form of passive, distributed, and human-centered sensing that complements traditional surveys and sensor systems. Methodologically, the chapter outlines a general workflow that includes platform-aware data collection, information extraction, geospatial anchoring, and statistical modeling. It also discusses how advances in large language models (LLMs) strengthen the ability to extract structured information from noisy and unstructured content. Four case studies illustrate this framework: COVID-19 vaccine acceptance, earthquake damage assessment, airport service quality, and accessibility in urban environment. Across these cases, social media data are shown to support timely measurement of public attitudes, rapid approximation of geographically distributed impacts, and fine-grained understanding of place-based experiences.

Yuhang Wang, Yiyao Xu, Chaoyun Yang et al.

Existing driving automation (DA) systems on production vehicles rely on human drivers to decide when to engage DA while requiring them to remain continuously attentive and ready to intervene. This design demands substantial situational judgment and imposes significant cognitive load, leading to steep learning curves, suboptimal user experience, and safety risks from both over-reliance and delayed takeover. Predicting when drivers hand over control to DA and when they take it back is therefore critical for designing proactive, context-aware HMI, yet existing datasets rarely capture the multimodal context, including road scene, driver state, vehicle dynamics, and route environment. To fill this gap, we introduce BATON, a large-scale naturalistic dataset capturing real-world DA usage across 127 drivers, and 136.6 hours of driving. The dataset synchronizes front-view video, in-cabin video, decoded CAN bus signals, radar-based lead-vehicle interaction, and GPS-derived route context, forming a closed-loop multimodal record around each control transition. We define three benchmark tasks: driving action understanding, handover prediction, and takeover prediction, and evaluate baselines spanning sequence models, classical classifiers, and zero-shot VLMs. Results show that visual input alone is insufficient for reliable transition prediction: front-view video captures road context but not driver state, while in-cabin video reflects driver readiness but not the external scene. Incorporating CAN and route-context signals substantially improves performance over video-only settings, indicating strong complementarity across modalities. We further find takeover events develop more gradually and benefit from longer prediction horizons, whereas handover events depend more on immediate contextual cues, revealing an asymmetry with direct implications for HMI design in assisted driving systems.

Xiaoran Xu, Zhaoqian Xue, Chi Zhang et al.

Investigating the public experience of urgent care facilities is essential for promoting community healthcare development. Traditional survey methods often fall short due to limited scope, time, and spatial coverage. Crowdsourcing through online reviews or social media offers a valuable approach to gaining such insights. With recent advancements in large language models (LLMs), extracting nuanced perceptions from reviews has become feasible. This study collects Google Maps reviews across the DMV and Florida areas and conducts prompt engineering with the GPT model to analyze the aspect-based sentiment of urgent care. We first analyze the geospatial patterns of various aspects, including interpersonal factors, operational efficiency, technical quality, finances, and facilities. Next, we determine Census Block Group(CBG)-level characteristics underpinning differences in public perception, including population density, median income, GINI Index, rent-to-income ratio, household below poverty rate, no insurance rate, and unemployment rate. Our results show that interpersonal factors and operational efficiency emerge as the strongest determinants of patient satisfaction in urgent care, while technical quality, finances, and facilities show no significant independent effects when adjusted for in multivariate models. Among socioeconomic and demographic factors, only population density demonstrates a significant but modest association with patient ratings, while the remaining factors exhibit no significant correlations. Overall, this study highlights the potential of crowdsourcing to uncover the key factors that matter to residents and provide valuable insights for stakeholders to improve public satisfaction with urgent care.

Zhaoqian Xue, Guanhong Liu, Kai Wei et al.

Access to health resources is a critical determinant of public well-being and societal resilience, particularly during public health crises when demand for medical services and preventive care surges. However, disparities in accessibility persist across demographic and geographic groups, raising concerns about equity. Traditional survey methods often fall short due to limitations in coverage, cost, and timeliness. This study leverages crowdsourced data from Google Maps reviews, applying advanced natural language processing techniques, specifically ModernBERT, to extract insights on public perceptions of health resource accessibility in the United States during the COVID-19 pandemic. Additionally, we employ Partial Least Squares regression to examine the relationship between accessibility perceptions and key socioeconomic and demographic factors including political affiliation, racial composition, and educational attainment. Our findings reveal that public perceptions of health resource accessibility varied significantly across the U.S., with disparities peaking during the pandemic and slightly easing post-crisis. Political affiliation, racial demographics, and education levels emerged as key factors shaping these perceptions. These findings underscore the need for targeted interventions and policy measures to address inequities, fostering a more inclusive healthcare infrastructure that can better withstand future public health challenges.

Qingcheng Zeng, Guanhong Liu, Zhaoqian Xue et al.

On July 13, 2024, at the Trump rally in Pennsylvania, someone attempted to assassinate Republican Presidential Candidate Donald Trump. This attempt sparked a large-scale discussion on social media. We collected posts from X (formerly known as Twitter) one week before and after the assassination attempt and aimed to model the short-term effects of such a ``shock'' on public opinions and discussion topics. Specifically, our study addresses three key questions: first, we investigate how public sentiment toward Donald Trump shifts over time and across regions (RQ1) and examine whether the assassination attempt itself significantly affects public attitudes, independent of the existing political alignments (RQ2). Finally, we explore the major themes in online conversations before and after the crisis, illustrating how discussion topics evolved in response to this politically charged event (RQ3). By integrating large language model-based sentiment analysis, difference-in-differences modeling, and topic modeling techniques, we find that following the attempt the public response was broadly sympathetic to Trump rather than polarizing, despite baseline ideological and regional disparities.

Xiang Li, Huizi Yu, Wenkong Wang et al.

Objective: Emergency medical dispatch (EMD) is a high-stakes process challenged by caller distress, ambiguity, and cognitive load. Large Language Models (LLMs) and Multi-Agent Systems (MAS) offer opportunities to augment dispatchers. This study aimed to develop and evaluate a taxonomy-grounded, LLM-powered multi-agent system for simulating realistic EMD scenarios. Methods: We constructed a clinical taxonomy (32 chief complaints, 6 caller identities from MIMIC-III) and a six-phase call protocol. Using this framework, we developed an AutoGen-based MAS with Caller and Dispatcher Agents. The system grounds interactions in a fact commons to ensure clinical plausibility and mitigate misinformation. We used a hybrid evaluation framework: four physicians assessed 100 simulated cases for "Guidance Efficacy" and "Dispatch Effectiveness," supplemented by automated linguistic analysis (sentiment, readability, politeness). Results: Human evaluation, with substantial inter-rater agreement (Gwe's AC1 > 0.70), confirmed the system's high performance. It demonstrated excellent Dispatch Effectiveness (e.g., 94 % contacting the correct potential other agents) and Guidance Efficacy (advice provided in 91 % of cases), both rated highly by physicians. Algorithmic metrics corroborated these findings, indicating a predominantly neutral affective profile (73.7 % neutral sentiment; 90.4 % neutral emotion), high readability (Flesch 80.9), and a consistently polite style (60.0 % polite; 0 % impolite). Conclusion: Our taxonomy-grounded MAS simulates diverse, clinically plausible dispatch scenarios with high fidelity. Findings support its use for dispatcher training, protocol evaluation, and as a foundation for real-time decision support. This work outlines a pathway for safely integrating advanced AI agents into emergency response workflows.

Yiheng Chen, Lingyao Li, Zihui Ma et al.

Effective disaster response is essential for safeguarding lives and property. Existing statistical approaches often lack semantic context, generalize poorly across events, and offer limited interpretability. While Large language models (LLMs) provide few-shot generalization, they remain text-bound and blind to geography. To bridge this gap, we introduce a Geospatial Awareness Layer (GAL) that grounds LLM agents in structured earth data. Starting from raw wildfire detections, GAL automatically retrieves and integrates infrastructure, demographic, terrain, and weather information from external geodatabases, assembling them into a concise, unit-annotated perception script. This enriched context enables agents to produce evidence-based resource-allocation recommendations (e.g., personnel assignments, budget allocations), further reinforced by historical analogs and daily change signals for incremental updates. We evaluate the framework in real wildfire scenarios across multiple LLM models, showing that geospatially grounded agents can outperform baselines. The proposed framework can generalize to other hazards such as floods and hurricanes.

Lingyao Li, Haolun Wu, Zhenkun Li et al.

High-dimensional decision-making tasks, such as business partner selection, involve evaluating large candidate pools with heterogeneous numerical, categorical, and textual features. While large language models (LLMs) offer strong in-context reasoning capabilities, single-agent or debate-style systems often struggle with scalability and consistency in such settings. We propose PartnerMAS, a hierarchical multi-agent framework that decomposes evaluation into three layers: a Planner Agent that designs strategies, Specialized Agents that perform role-specific assessments, and a Supervisor Agent that integrates their outputs. To support systematic evaluation, we also introduce a curated benchmark dataset of venture capital co-investments, featuring diverse firm attributes and ground-truth syndicates. Across 140 cases, PartnerMAS consistently outperforms single-agent and debate-based multi-agent baselines, achieving up to 10--15\% higher match rates. Analysis of agent reasoning shows that planners are most responsive to domain-informed prompts, specialists produce complementary feature coverage, and supervisors play an important role in aggregation. Our findings demonstrate that structured collaboration among LLM agents can generate more robust outcomes than scaling individual models, highlighting PartnerMAS as a promising framework for high-dimensional decision-making in data-rich domains.

Naiyi Li, Zihui Ma, Runlong Yu et al.

Digital Twins (DTs) offer powerful tools for managing complex infrastructure systems, but their effectiveness is often limited by challenges in integrating unstructured knowledge. Recent advances in Large Language Models (LLMs) bring new potential to address this gap, with strong abilities in extracting and organizing diverse textual information. We therefore propose LSDTs (LLM-Augmented Semantic Digital Twins), a framework that helps LLMs extract planning knowledge from unstructured documents like environmental regulations and technical guidelines, and organize it into a formal ontology. This ontology forms a semantic layer that powers a digital twin-a virtual model of the physical system-allowing it to simulate realistic, regulation-aware planning scenarios. We evaluate LSDTs through a case study of offshore wind farm planning in Maryland, including its application during Hurricane Sandy. Results demonstrate that LSDTs support interpretable, regulation-aware layout optimization, enable high-fidelity simulation, and enhance adaptability in infrastructure planning. This work shows the potential of combining generative AI with digital twins to support complex, knowledge-driven planning tasks.

Zhijie Duan, Kai Wei, Zhaoqian Xue et al.

Social media is a rich source of real-world data that captures valuable patient experience information for pharmacovigilance. However, mining data from unstructured and noisy social media content remains a challenging task. We present a systematic framework that leverages large language models (LLMs) to extract medication side effects from social media and organize them into a knowledge graph (KG). We apply this framework to semaglutide for weight loss using data from Reddit. Using the constructed knowledge graph, we perform comprehensive analyses to investigate reported side effects across different semaglutide brands over time. These findings are further validated through comparison with adverse events reported in the FAERS database, providing important patient-centered insights into semaglutide's side effects that complement its safety profile and current knowledge base of semaglutide for both healthcare professionals and patients. Our work demonstrates the feasibility of using LLMs to transform social media data into structured KGs for pharmacovigilance.

Shubham Atreja, Joshua Ashkinaze, Lingyao Li et al.

Manually annotating data for computational social science tasks can be costly, time-consuming, and emotionally draining. While recent work suggests that LLMs can perform such annotation tasks in zero-shot settings, little is known about how prompt design impacts LLMs' compliance and accuracy. We conduct a large-scale multi-prompt experiment to test how model selection (ChatGPT, PaLM2, and Falcon7b) and prompt design features (definition inclusion, output type, explanation, and prompt length) impact the compliance and accuracy of LLM-generated annotations on four CSS tasks (toxicity, sentiment, rumor stance, and news frames). Our results show that LLM compliance and accuracy are highly prompt-dependent. For instance, prompting for numerical scores instead of labels reduces all LLMs' compliance and accuracy. The overall best prompting setup is task-dependent, and minor prompt changes can cause large changes in the distribution of generated labels. By showing that prompt design significantly impacts the quality and distribution of LLM-generated annotations, this work serves as both a warning and practical guide for researchers and practitioners.