Brandon Helfield

Sepideh K. Gharamaleki, Brandon Helfield, Hassan Rivaz

Ultrasound Localization Microscopy (ULM) is an emerging technique that employs the localization of echogenic microbubbles (MBs) to finely sample and image the microcirculation beyond the diffraction limit of ultrasound imaging. Conventional MB localization methods are mainly based on considering a specific Point Spread Function (PSF) for MBs, which leads to loss of information caused by overlapping MBs, non-stationary PSFs, and harmonic MB echoes. Therefore, it is imperative to devise methods that can accurately localize MBs while being resilient to MB nonlinearities and variations of MB concentrations that distort MB PSFs. This paper proposes a transformer-based MB localization approach to address this issue. We adopted DEtection TRansformer (DETR) arXiv:2005.12872 , which is an end-to-end object recognition method that detects a unique bounding box for each of the detected objects using set-based Hungarian loss and bipartite matching. To the authors' knowledge, this is the first time transformers have been used for MB localization. To appraise the proposed strategy, the pre-trained DETR network's performance has been tested for detecting MBs using transfer learning principles. We have fine-tuned the network on a subset of randomly selected frames of the dataset provided by the IEEE IUS Ultra-SR challenge organizers and then tested on the rest using cross-validation. For the simulation dataset, the paper supports the deployment of transformer-based solutions for MB localization at high accuracy.

Sepideh KhakzadGharamaleki, Hassan Rivaz, Brandon Helfield

Conventional pulse-echo ultrasound suffers when low-cost probes deliver only narrow fractional bandwidths, elongating pulses and erasing high-frequency detail. We address this limitation by learning a data-driven mapping from band-limited to broadband spectrogram of radio-frequency (RF) lines. To this end, a variation of Tiny Vision Transform (ViT) auto-encoder is trained on simulation data using a curriculum-weighted loss. On heterogeneous speckle-cyst phantoms, the network reduces image-domain MSE by 90 percent, boosts PSNR by 6.7 dB, and raises SSIM to 0.965 compared with the narrow-band input. It also sharpens point-target rows in a completely unseen resolution phantom, demonstrating strong out-of-distribution generalisation without sacrificing frame rate or phase information. These results indicate that a purely software upgrade can endow installed narrow-band probes with broadband-like performance, potentially widening access to high-resolution ultrasound in resource-constrained settings.

Sepideh K. Gharamaleki, Brandon Helfield, Hassan Rivaz

Super-resolution ultrasound imaging with ultrasound localization microscopy (ULM) offers a high-resolution view of microvascular structures. Yet, ULM image quality heavily relies on precise microbubble (MB) detection. Despite the crucial role of localization algorithms, there has been limited focus on the practical pitfalls in MB detection tasks such as setting the detection threshold. This study examines how False Positives (FPs) and False Negatives (FNs) affect ULM image quality by systematically adding controlled detection errors to simulated data. Results indicate that while both FP and FN rates impact Peak Signal-to-Noise Ratio (PSNR) similarly, increasing FP rates from 0\% to 20\% decreases Structural Similarity Index (SSIM) by 7\%, whereas same FN rates cause a greater drop of around 45\%. Moreover, dense MB regions are more resilient to detection errors, while sparse regions show high sensitivity, showcasing the need for robust MB detection frameworks to enhance super-resolution imaging.

Sepideh K. Gharamaleki, Brandon Helfield, Hassan Rivaz

Super-resolution ultrasound (SR-US) is a powerful imaging technique for capturing microvasculature and blood flow at high spatial resolution. However, accurate microbubble (MB) localization remains a key challenge, as errors in localization can propagate through subsequent stages of the super-resolution process, affecting overall performance. In this paper, we explore the potential of ensemble learning techniques to enhance MB localization by increasing detection sensitivity and reducing false positives. Our study evaluates the effectiveness of ensemble methods on both in vivo and simulated outputs of a Deformable DEtection TRansformer (Deformable DETR) network. As a result of our study, we are able to demonstrate the advantages of these ensemble approaches by showing improved precision and recall in MB detection and offering insights into their application in SR-US.