Li Tian

Yu Shang, Yuming Lin, Yu Zheng et al.

Cities, as the essential environment of human life, encompass diverse physical elements such as buildings, roads and vegetation, which continuously interact with dynamic entities like people and vehicles. Crafting realistic, interactive 3D urban environments is essential for nurturing AGI systems and constructing AI agents capable of perceiving, decision-making, and acting like humans in real-world environments. However, creating high-fidelity 3D urban environments usually entails extensive manual labor from designers, involving intricate detailing and representation of complex urban elements. Therefore, accomplishing this automatically remains a longstanding challenge. Toward this problem, we propose UrbanWorld, the first generative urban world model that can automatically create a customized, realistic and interactive 3D urban world with flexible control conditions. UrbanWorld incorporates four key stages in the generation pipeline: flexible 3D layout generation from OSM data or urban layout with semantic and height maps, urban scene design with Urban MLLM, controllable urban asset rendering via progressive 3D diffusion, and MLLM-assisted scene refinement. We conduct extensive quantitative analysis on five visual metrics, demonstrating that UrbanWorld achieves SOTA generation realism. Next, we provide qualitative results about the controllable generation capabilities of UrbanWorld using both textual and image-based prompts. Lastly, we verify the interactive nature of these environments by showcasing the agent perception and navigation within the created environments. We contribute UrbanWorld as an open-source tool available at https://github.com/Urban-World/UrbanWorld.

Ni Yao, Hang Hu, Kaicong Chen et al.

Objectives To develop and validate a deep learning-based diagnostic model incorporating uncertainty estimation so as to facilitate radiologists in the preoperative differentiation of the pathological subtypes of renal cell carcinoma (RCC) based on CT images. Methods Data from 668 consecutive patients, pathologically proven RCC, were retrospectively collected from Center 1. By using five-fold cross-validation, a deep learning model incorporating uncertainty estimation was developed to classify RCC subtypes into clear cell RCC (ccRCC), papillary RCC (pRCC), and chromophobe RCC (chRCC). An external validation set of 78 patients from Center 2 further evaluated the model's performance. Results In the five-fold cross-validation, the model's area under the receiver operating characteristic curve (AUC) for the classification of ccRCC, pRCC, and chRCC was 0.868 (95% CI: 0.826-0.923), 0.846 (95% CI: 0.812-0.886), and 0.839 (95% CI: 0.802-0.88), respectively. In the external validation set, the AUCs were 0.856 (95% CI: 0.838-0.882), 0.787 (95% CI: 0.757-0.818), and 0.793 (95% CI: 0.758-0.831) for ccRCC, pRCC, and chRCC, respectively. Conclusions The developed deep learning model demonstrated robust performance in predicting the pathological subtypes of RCC, while the incorporated uncertainty emphasized the importance of understanding model confidence, which is crucial for assisting clinical decision-making for patients with renal tumors. Clinical relevance statement Our deep learning approach, integrated with uncertainty estimation, offers clinicians a dual advantage: accurate RCC subtype predictions complemented by diagnostic confidence references, promoting informed decision-making for patients with RCC.

Jiaqing Wang, Zhongfang Yang, Xingyuan Zhu et al.

Background: LLMs enable patient-facing conversational agents, creating a pathway toward digital twins that capture older adults' lived experiences and behavioral responses across time. A central barrier is personality drift -- inconsistent trait expression across repeated interactions -- which undermines reliability of generated trajectories and intervention-response simulation in geriatric care. Objective: To develop ELDER-SIM, a multi-role elderly-care conversational platform for building personality-stable digital twin agents, and to propose a psychometric validation framework for quantifying personality consistency in LLM-based agents. Methods: ELDER-SIM was implemented via n8n workflow orchestration with local LLM inference (Ollama/vLLM), integrating (1) Big Five (OCEAN) trait specifications, (2) a Cognitive Conceptualization Diagram (CCD) grounded in Beck's CBT framework, and (3) a MySQL-based long-term memory module. Ablation studies across four conditions -- Baseline, +Memory, +CCD, and +LoRA (fine-tuned on 19,717 instruction pairs from CHARLS) -- were evaluated via Cronbach's $α$, ICC, and role discrimination accuracy. Results: Reliability was acceptable to excellent across conditions (Cronbach's $α$: 0.70--0.94; ICC: 0.85--0.96). Role discrimination improved from 83.3% (Baseline) to 88.9% (+Memory), 94.4% (+CCD), and 97.2% (+LoRA). CCD produced the largest consistency gain (mean $α$ 0.702$\to$0.892), while LoRA achieved the highest overall consistency ($α$ 0.940; ICC 0.958). Conclusions: ELDER-SIM provides a psychometrically validated approach for constructing personality-consistent elderly digital twin agents. Structured cognitive modeling and domain adaptation reduce personality drift, supporting reliable longitudinal simulation for elderly mental health care and reproducible in silico evaluation before clinical deployment.

Mingyi He, Yuebing Liang, Shenhao Wang et al.

Urban design is a multifaceted process that demands careful consideration of site-specific constraints and collaboration among diverse professionals and stakeholders. The advent of generative artificial intelligence (GenAI) offers transformative potential by improving the efficiency of design generation and facilitating the communication of design ideas. However, most existing approaches are not well integrated with human design workflows. They often follow end-to-end pipelines with limited control, overlooking the iterative nature of real-world design. This study proposes a stepwise generative urban design framework that integrates multimodal diffusion models with human expertise to enable more adaptive and controllable design processes. Instead of generating design outcomes in a single end-to-end process, the framework divides the process into three key stages aligned with established urban design workflows: (1) road network and land use planning, (2) building layout planning, and (3) detailed planning and rendering. At each stage, multimodal diffusion models generate preliminary designs based on textual prompts and image-based constraints, which can then be reviewed and refined by human designers. We design an evaluation framework to assess the fidelity, compliance, and diversity of the generated designs. Experiments using data from Chicago and New York City demonstrate that our framework outperforms baseline models and end-to-end approaches across all three dimensions. This study underscores the benefits of multimodal diffusion models and stepwise generation in preserving human control and facilitating iterative refinements, laying the groundwork for human-AI interaction in urban design solutions.

Li Tian, Hanhui Li, Qifa Wang et al.

Most current anthropomorphic robotic hands can realize part of the human hand functions, particularly for object grasping. However, due to the complexity of the human hand, few current designs target at daily object manipulations, even for simple actions like rotating a pen. To tackle this problem, we introduce a gesture based framework, which adopts the widely-used 33 grasping gestures of Feix as the bases for hand design and implementation of manipulation. In the proposed framework, we first measure the motion ranges of human fingers for each gesture, and based on the results, we propose a simple yet dexterous robotic hand design with 13 degrees of actuation. Furthermore, we adopt a frame interpolation based method, in which we consider the base gestures as the key frames to represent a manipulation task, and use the simple linear interpolation strategy to accomplish the manipulation. To demonstrate the effectiveness of our framework, we define a three-level benchmark, which includes not only 62 test gestures from previous research, but also multiple complex and continuous actions. Experimental results on this benchmark validate the dexterity of the proposed design and our video is available in \url{https://drive.google.com/file/d/1wPtkd2P0zolYSBW7_3tVMUHrZEeXLXgD/view?usp=sharing}.

Li Tian, Hanhui Li, Muhammad Faaiz Khan Bin Abdul Halil et al.

Current anthropomorphic robotic hands mainly focus on improving their dexterity by devising new mechanical structures and actuation systems. However, most of them rely on a single structure/system (e.g., bone-only) and ignore the fact that the human hand is composed of multiple functional structures (e.g., skin, bones, muscles, and tendons). This not only increases the difficulty of the design process but also lowers the robustness and flexibility of the fabricated hand. Besides, other factors like customization, the time and cost for production, and the degree of resemblance between human hands and robotic hands, remain omitted. To tackle these problems, this study proposes a 3D printable multi-layer design that models the hand with the layers of skin, tissues, and bones. The proposed design first obtains the 3D surface model of a target hand via 3D scanning, and then generates the 3D bone models from the surface model based on a fast template matching method. To overcome the disadvantage of the rigid bone layer in deformation, the tissue layer is introduced and represented by a concentric tube based structure, of which the deformability can be explicitly controlled by a parameter. Besides, a low-cost yet effective underactuated system is adopted to drive the fabricated hand. The proposed design is tested with 33 widely used object grasping types, as well as special objects like fragile silken tofu, and outperforms previous designs remarkably. With the proposed design, anthropomorphic robotic hands can be produced fast with low cost, and be customizable and deformable.

Li Tian, Liyan Ma, Zhijie Wen et al.

Diabetic retinopathy (DR) is one of the leading causes of blindness. However, no specific symptoms of early DR lead to a delayed diagnosis, which results in disease progression in patients. To determine the disease severity levels, ophthalmologists need to focus on the discriminative parts of the fundus images. In recent years, deep learning has achieved great success in medical image analysis. However, most works directly employ algorithms based on convolutional neural networks (CNNs), which ignore the fact that the difference among classes is subtle and gradual. Hence, we consider automatic image grading of DR as a fine-grained classification task, and construct a bilinear model to identify the pathologically discriminative areas. In order to leverage the ordinal information among classes, we use an ordinal regression method to obtain the soft labels. In addition, other than only using a categorical loss to train our network, we also introduce the metric loss to learn a more discriminative feature space. Experimental results demonstrate the superior performance of the proposed method on two public IDRiD and DeepDR datasets.

Huaxiu Yao, Longkai Huang, Linjun Zhang et al.

Meta-learning has proven to be a powerful paradigm for transferring the knowledge from previous tasks to facilitate the learning of a novel task. Current dominant algorithms train a well-generalized model initialization which is adapted to each task via the support set. The crux lies in optimizing the generalization capability of the initialization, which is measured by the performance of the adapted model on the query set of each task. Unfortunately, this generalization measure, evidenced by empirical results, pushes the initialization to overfit the meta-training tasks, which significantly impairs the generalization and adaptation to novel tasks. To address this issue, we actively augment a meta-training task with "more data" when evaluating the generalization. Concretely, we propose two task augmentation methods, including MetaMix and Channel Shuffle. MetaMix linearly combines features and labels of samples from both the support and query sets. For each class of samples, Channel Shuffle randomly replaces a subset of their channels with the corresponding ones from a different class. Theoretical studies show how task augmentation improves the generalization of meta-learning. Moreover, both MetaMix and Channel Shuffle outperform state-of-the-art results by a large margin across many datasets and are compatible with existing meta-learning algorithms.

Xiao-Hui Yang, Li Tian, Yun-Mei Chen et al.

Sparse representation based classification (SRC) methods have achieved remarkable results. SRC, however, still suffer from requiring enough training samples, insufficient use of test samples and instability of representation. In this paper, a stable inverse projection representation based classification (IPRC) is presented to tackle these problems by effectively using test samples. An IPR is firstly proposed and its feasibility and stability are analyzed. A classification criterion named category contribution rate is constructed to match the IPR and complete classification. Moreover, a statistical measure is introduced to quantify the stability of representation-based classification methods. Based on the IPRC technique, a robust tumor recognition framework is presented by interpreting microarray gene expression data, where a two-stage hybrid gene selection method is introduced to select informative genes. Finally, the functional analysis of candidate's pathogenicity-related genes is given. Extensive experiments on six public tumor microarray gene expression datasets demonstrate the proposed technique is competitive with state-of-the-art methods.