Carmen Delgado

Filip Lemic, Andra Blaga, Francesco Devoti et al.

Integrated Sensing and Communication (ISAC) couples radio sensing, data transmission, and control actions within a single closed-loop system. When Artificial Intelligence (AI)-driven policies adapt sensing and communication online across a variety of sensing tasks and objectives, end-to-end performance is shaped not only by waveform and channel conditions but also by inference latency, uncertainty, environmental dynamics, and hardware non-idealities, leading to fundamental trade-offs between sensing accuracy, communication reliability, and resource overhead. This manuscript presents a unified system architecture and evaluation methodology for AI-native ISAC, defined as ISAC in which learning-based agents adapt sensing, communication, and actuation policies online under uncertainty. We formalize the design space of closed-loop ISAC, propose a three-stage validation pipeline from bounds and feasibility analysis, through high-fidelity digital-twin simulation, to preliminary over-the-air validation, and provide a minimal reporting checklist that links technical Key Performance Indicators (KPIs) (e.g., data rate, SINR, target detection, parameter estimation, track quality, localization error, outage, latency, overhead, and energy per decision) to application-level Key Value Indicators (KVIs) (e.g., availability and mission effectiveness). Two representative instantiations, specifically Unmanned Aerial Vehicle (UAV)-based outdoor and Reconfigurable Intelligent Surface (RIS)-enabled indoor coverage extensions, are used to illustrate how to structure reproducible baselines and comparable evidence across heterogeneous deployments, helping bridge the gap between theoretical ISAC gains and deployment-ready performance claims.

Guillem Pascual, Filip Lemic, Carmen Delgado et al.

Advancements in nanotechnology and material science are paving the way toward nanoscale devices that combine sensing, computing, data and energy storage, and wireless communication. In precision medicine, these nanodevices show promise for disease diagnostics, treatment, and monitoring from within the patients' bloodstreams. Assigning the location of a sensed biological event with the event itself, which is the main proposition of flow-guided in-body nanoscale localization, would be immensely beneficial from the perspective of precision medicine. The nanoscale nature of the nanodevices and the challenging environment that the bloodstream represents, result in current flow-guided localization approaches being constrained in their communication and energy-related capabilities. The communication and energy constraints of the nanodevices result in different features of raw data for flow-guided localization, in turn affecting its performance. An analytical modeling of the effects of imperfect communication and constrained energy causing intermittent operation of the nanodevices on the raw data produced by the nanodevices would be beneficial. Hence, we propose an analytical model of raw data for flow-guided localization, where the raw data is modeled as a function of communication and energy-related capabilities of the nanodevice. We evaluate the model by comparing its output with the one obtained through the utilization of a simulator for objective evaluation of flow-guided localization, featuring comparably higher level of realism. Our results across a number of scenarios and heterogeneous performance metrics indicate high similarity between the model and simulator-generated raw datasets.