André Freitas

Oskar Wysocki, Jessica Katharine Davies, Markel Vigo et al.

This paper contributes with a pragmatic evaluation framework for explainable Machine Learning (ML) models for clinical decision support. The study revealed a more nuanced role for ML explanation models, when these are pragmatically embedded in the clinical context. Despite the general positive attitude of healthcare professionals (HCPs) towards explanations as a safety and trust mechanism, for a significant set of participants there were negative effects associated with confirmation bias, accentuating model over-reliance and increased effort to interact with the model. Also, contradicting one of its main intended functions, standard explanatory models showed limited ability to support a critical understanding of the limitations of the model. However, we found new significant positive effects which repositions the role of explanations within a clinical context: these include reduction of automation bias, addressing ambiguous clinical cases (cases where HCPs were not certain about their decision) and support of less experienced HCPs in the acquisition of new domain knowledge.

Magdalena Wysocka, Oskar Wysocki, Marie Zufferey et al.

There is an increasing interest in the use of Deep Learning (DL) based methods as a supporting analytical framework in oncology. However, most direct applications of DL will deliver models with limited transparency and explainability, which constrain their deployment in biomedical settings. This systematic review discusses DL models used to support inference in cancer biology with a particular emphasis on multi-omics analysis. It focuses on how existing models address the need for better dialogue with prior knowledge, biological plausibility and interpretability, fundamental properties in the biomedical domain. For this, we retrieved and analyzed 42 studies focusing on emerging architectural and methodological advances, the encoding of biological domain knowledge and the integration of explainability methods. We discuss the recent evolutionary arch of DL models in the direction of integrating prior biological relational and network knowledge to support better generalisation (e.g. pathways or Protein-Protein-Interaction networks) and interpretability. This represents a fundamental functional shift towards models which can integrate mechanistic and statistical inference aspects. We introduce a concept of bio-centric interpretability and according to its taxonomy, we discuss representational methodologies for the integration of domain prior knowledge in such models. The paper provides a critical outlook into contemporary methods for explainability and interpretabiltiy used in DL for cancer. The analysis points in the direction of a convergence between encoding prior knowledge and improved interpretability. We introduce bio-centric interpretability which is an important step towards formalisation of biological interpretability of DL models and developing methods that are less problem- or application-specific.

Leonardo Ranaldi, Giulia Pucci, Andre Freitas

The language ability of Large Language Models (LLMs) is often unbalanced towards English because of the imbalance in the distribution of the pre-training data. This disparity is demanded in further fine-tuning and affecting the cross-lingual abilities of LLMs. In this paper, we propose to empower Instructiontuned LLMs (It-LLMs) in languages other than English by building semantic alignment between them. Hence, we propose CrossAlpaca, an It-LLM with cross-lingual instruction-following and Translation-following demonstrations to improve semantic alignment between languages. We validate our approach on the multilingual Question Answering (QA) benchmarks XQUAD and MLQA and adapted versions of MMLU and BBH. Our models, tested over six different languages, outperform the It-LLMs tuned on monolingual data. The final results show that instruction tuning on non-English data is not enough and that semantic alignment can be further improved by Translation-following demonstrations.

Christina Niklaus, Matthias Cetto, André Freitas et al.

Sentences that present a complex syntax act as a major stumbling block for downstream Natural Language Processing applications whose predictive quality deteriorates with sentence length and complexity. The task of Text Simplification (TS) may remedy this situation. It aims to modify sentences in order to make them easier to process, using a set of rewriting operations, such as reordering, deletion, or splitting. State-of-the-art syntactic TS approaches suffer from two major drawbacks: first, they follow a very conservative approach in that they tend to retain the input rather than transforming it, and second, they ignore the cohesive nature of texts, where context spread across clauses or sentences is needed to infer the true meaning of a statement. To address these problems, we present a discourse-aware TS approach that splits and rephrases complex English sentences within the semantic context in which they occur. Based on a linguistically grounded transformation stage that uses clausal and phrasal disembedding mechanisms, complex sentences are transformed into shorter utterances with a simple canonical structure that can be easily analyzed by downstream applications. With sentence splitting, we thus address a TS task that has hardly been explored so far. Moreover, we introduce the notion of minimality in this context, as we aim to decompose source sentences into a set of self-contained minimal semantic units. To avoid breaking down the input into a disjointed sequence of statements that is difficult to interpret because important contextual information is missing, we incorporate the semantic context between the split propositions in the form of hierarchical structures and semantic relationships. In that way, we generate a semantic hierarchy of minimal propositions that leads to a novel representation of complex assertions that puts a semantic layer on top of the simplified sentences.

Yingji Zhang, Marco Valentino, Danilo S. Carvalho et al.

The injection of syntactic information in Variational AutoEncoders (VAEs) has been shown to result in an overall improvement of performances and generalisation. An effective strategy to achieve such a goal is to separate the encoding of distributional semantic features and syntactic structures into heterogeneous latent spaces via multi-task learning or dual encoder architectures. However, existing works employing such techniques are limited to LSTM-based VAEs. In this paper, we investigate latent space separation methods for structural syntactic injection in Transformer-based VAE architectures (i.e., Optimus). Specifically, we explore how syntactic structures can be leveraged in the encoding stage through the integration of graph-based and sequential models, and how multiple, specialised latent representations can be injected into the decoder's attention mechanism via low-rank operators. Our empirical evaluation, carried out on natural language sentences and mathematical expressions, reveals that the proposed end-to-end VAE architecture can result in a better overall organisation of the latent space, alleviating the information loss occurring in standard VAE setups, resulting in enhanced performances on language modelling and downstream generation tasks.

Jordan Meadows, Andre Freitas

Informal mathematical text underpins real-world quantitative reasoning and communication. Developing sophisticated methods of retrieval and abstraction from this dual modality is crucial in the pursuit of the vision of automating discovery in quantitative science and mathematics. We track the development of informal mathematical language processing approaches across five strategic sub-areas in recent years, highlighting the prevailing successful methodological elements along with existing limitations.

Yingji Zhang, Danilo S. Carvalho, André Freitas

Formal/symbolic semantics can provide canonical, rigid controllability and interpretability to sentence representations due to their \textit{localisation} or \textit{composition} property. How can we deliver such property to the current distributional sentence representations to control and interpret the generation of language models (LMs)? In this work, we theoretically frame the sentence semantics as the composition of \textit{semantic role - word content} features and propose the formal semantic geometry. To inject such geometry into Transformer-based LMs (i.e. GPT2), we deploy Transformer-based Variational AutoEncoder with a supervision approach, where the sentence generation can be manipulated and explained over low-dimensional latent Gaussian space. In addition, we propose a new probing algorithm to guide the movement of sentence vectors over such geometry. Experimental results reveal that the formal semantic geometry can potentially deliver better control and interpretation to sentence generation.

Danilo S. Carvalho, Giangiacomo Mercatali, Yingji Zhang et al.

Disentangling the encodings of neural models is a fundamental aspect for improving interpretability, semantic control and downstream task performance in Natural Language Processing. Currently, most disentanglement methods are unsupervised or rely on synthetic datasets with known generative factors. We argue that recurrent syntactic and semantic regularities in textual data can be used to provide the models with both structural biases and generative factors. We leverage the semantic structures present in a representative and semantically dense category of sentence types, definitional sentences, for training a Variational Autoencoder to learn disentangled representations. Our experimental results show that the proposed model outperforms unsupervised baselines on several qualitative and quantitative benchmarks for disentanglement, and it also improves the results in the downstream task of definition modeling.

Edoardo Manino, Julia Rozanova, Danilo Carvalho et al.

Metamorphic testing has recently been used to check the safety of neural NLP models. Its main advantage is that it does not rely on a ground truth to generate test cases. However, existing studies are mostly concerned with robustness-like metamorphic relations, limiting the scope of linguistic properties they can test. We propose three new classes of metamorphic relations, which address the properties of systematicity, compositionality and transitivity. Unlike robustness, our relations are defined over multiple source inputs, thus increasing the number of test cases that we can produce by a polynomial factor. With them, we test the internal consistency of state-of-the-art NLP models, and show that they do not always behave according to their expected linguistic properties. Lastly, we introduce a novel graphical notation that efficiently summarises the inner structure of metamorphic relations.

Maxime Delmas, Magdalena Wysocka, André Freitas

The sparsity of labelled data is an obstacle to the development of Relation Extraction models and the completion of databases in various biomedical areas. While being of high interest in drug-discovery, the natural-products literature, reporting the identification of potential bioactive compounds from organisms, is a concrete example of such an overlooked topic. To mark the start of this new task, we created the first curated evaluation dataset and extracted literature items from the LOTUS database to build training sets. To this end, we developed a new sampler inspired by diversity metrics in ecology, named Greedy Maximum Entropy sampler, or GME-sampler (https://github.com/idiap/gme-sampler). The strategic optimization of both balance and diversity of the selected items in the evaluation set is important given the resource-intensive nature of manual curation. After quantifying the noise in the training set, in the form of discrepancies between the input abstracts text and the expected output labels, we explored different strategies accordingly. Framing the task as an end-to-end Relation Extraction, we evaluated the performance of standard fine-tuning as a generative task and few-shot learning with open Large Language Models (LLaMA 7B-65B). In addition to their evaluation in few-shot settings, we explore the potential of open Large Language Models (Vicuna-13B) as synthetic data generator and propose a new workflow for this purpose. All evaluated models exhibited substantial improvements when fine-tuned on synthetic abstracts rather than the original noisy data. We provide our best performing (f1-score=59.0) BioGPT-Large model for end-to-end RE of natural-products relationships along with all the generated synthetic data and the evaluation dataset. See more details at https://github.com/idiap/abroad-re.

Julia Rozanova, Marco Valentino, Lucas Cordeiro et al.

Probing strategies have been shown to detect the presence of various linguistic features in large language models; in particular, semantic features intermediate to the "natural logic" fragment of the Natural Language Inference task (NLI). In the case of natural logic, the relation between the intermediate features and the entailment label is explicitly known: as such, this provides a ripe setting for interventional studies on the NLI models' representations, allowing for stronger causal conjectures and a deeper critical analysis of interventional probing methods. In this work, we carry out new and existing representation-level interventions to investigate the effect of these semantic features on NLI classification: we perform amnesic probing (which removes features as directed by learned linear probes) and introduce the mnestic probing variation (which forgets all dimensions except the probe-selected ones). Furthermore, we delve into the limitations of these methods and outline some pitfalls have been obscuring the effectivity of interventional probing studies.

Geonhee Kim, Marco Valentino, André Freitas

Recent studies on reasoning in language models (LMs) have sparked a debate on whether they can learn systematic inferential principles or merely exploit superficial patterns in the training data. To understand and uncover the mechanisms adopted for formal reasoning in LMs, this paper presents a mechanistic interpretation of syllogistic inference. Specifically, we present a methodology for circuit discovery aimed at interpreting content-independent and formal reasoning mechanisms. Through two distinct intervention methods, we uncover a sufficient and necessary circuit involving middle-term suppression that elucidates how LMs transfer information to derive valid conclusions from premises. Furthermore, we investigate how belief biases manifest in syllogistic inference, finding evidence of partial contamination from additional attention heads responsible for encoding commonsense and contextualized knowledge. Finally, we explore the generalization of the discovered mechanisms across various syllogistic schemes, model sizes and architectures. The identified circuit is sufficient and necessary for syllogistic schemes on which the models achieve high accuracy (>60%), with compatible activation patterns across models of different families. Overall, our findings suggest that LMs learn transferable content-independent reasoning mechanisms, but that, at the same time, such mechanisms do not involve generalizable and abstract logical primitives, being susceptible to contamination by the same world knowledge acquired during pre-training.

Alex Bogatu, Magdalena Wysocka, Oskar Wysocki et al.

Cytokine release syndrome (CRS), also known as cytokine storm, is one of the most consequential adverse effects of chimeric antigen receptor therapies that have shown promising results in cancer treatment. When emerging, CRS could be identified by the analysis of specific cytokine and chemokine profiles that tend to exhibit similarities across patients. In this paper, we exploit these similarities using machine learning algorithms and set out to pioneer a meta--review informed method for the identification of CRS based on specific cytokine peak concentrations and evidence from previous clinical studies. We argue that such methods could support clinicians in analyzing suspect cytokine profiles by matching them against CRS knowledge from past clinical studies, with the ultimate aim of swift CRS diagnosis. During evaluation with real--world CRS clinical data, we emphasize the potential of our proposed method of producing interpretable results, in addition to being effective in identifying the onset of cytokine storm.

Marco Valentino, Jordan Meadows, Lan Zhang et al.

This paper investigates the possibility of approximating multiple mathematical operations in latent space for expression derivation. To this end, we introduce different multi-operational representation paradigms, modelling mathematical operations as explicit geometric transformations. By leveraging a symbolic engine, we construct a large-scale dataset comprising 1.7M derivation steps stemming from 61K premises and 6 operators, analysing the properties of each paradigm when instantiated with state-of-the-art neural encoders. Specifically, we investigate how different encoding mechanisms can approximate expression manipulation in latent space, exploring the trade-off between learning different operators and specialising within single operations, as well as the ability to support multi-step derivations and out-of-distribution generalisation. Our empirical analysis reveals that the multi-operational paradigm is crucial for disentangling different operators, while discriminating the conclusions for a single operation is achievable in the original expression encoder. Moreover, we show that architectural choices can heavily affect the training dynamics, structural organisation, and generalisation of the latent space, resulting in significant variations across paradigms and classes of encoders.

Marco Valentino, André Freitas

A fundamental research goal for Explainable AI (XAI) is to build models that are capable of reasoning through the generation of natural language explanations. However, the methodologies to design and evaluate explanation-based inference models are still poorly informed by theoretical accounts on the nature of explanation. As an attempt to provide an epistemologically grounded characterisation for XAI, this paper focuses on the scientific domain, aiming to bridge the gap between theory and practice on the notion of a scientific explanation. Specifically, the paper combines a detailed survey of the modern accounts of scientific explanation in Philosophy of Science with a systematic analysis of corpora of natural language explanations, clarifying the nature and function of explanatory arguments from both a top-down (categorical) and a bottom-up (corpus-based) perspective. Through a mixture of quantitative and qualitative methodologies, the presented study allows deriving the following main conclusions: (1) Explanations cannot be entirely characterised in terms of inductive or deductive arguments as their main function is to perform unification; (2) An explanation must cite causes and mechanisms that are responsible for the occurrence of the event to be explained; (3) While natural language explanations possess an intrinsic causal-mechanistic nature, they are not limited to causes and mechanisms, also accounting for pragmatic elements such as definitions, properties and taxonomic relations; (4) Patterns of unification naturally emerge in corpora of explanations even if not intentionally modelled; (5) Unification is realised through a process of abstraction, whose function is to provide the inference substrate for subsuming the event to be explained under recurring patterns and high-level regularities.

Yingji Zhang, Danilo S. Carvalho, Ian Pratt-Hartmann et al.

Explainable natural language inference aims to provide a mechanism to produce explanatory (abductive) inference chains which ground claims to their supporting premises. A recent corpus called EntailmentBank strives to advance this task by explaining the answer to a question using an entailment tree \cite{dalvi2021explaining}. They employ the T5 model to directly generate the tree, which can explain how the answer is inferred. However, it lacks the ability to explain and control the generation of intermediate steps, which is crucial for the multi-hop inference process. % One recent corpus, EntailmentBank, aims to push this task forward by explaining an answer to a question according to an entailment tree \cite{dalvi2021explaining}. They employ T5 to generate the tree directly, which can explain how the answer is inferred but cannot explain how the intermediate is generated, which is essential to the multi-hop inference process. In this work, we focus on proposing a controlled natural language inference architecture for multi-premise explanatory inference. To improve control and enable explanatory analysis over the generation, we define lexical inference types based on Abstract Meaning Representation (AMR) graph and modify the architecture of T5 to learn a latent sentence representation (T5 bottleneck) conditioned on said type information. We also deliver a dataset of approximately 5000 annotated explanatory inference steps, with well-grounded lexical-symbolic operations. Experimental results indicate that the inference typing induced at the T5 bottleneck can help T5 to generate a conclusion under explicit control.

Hanadi Mardah, Oskar Wysocki, Markel Vigo et al.

The recent evolution in Natural Language Processing (NLP) methods, in particular in the field of argumentation mining, has the potential to transform the way we interact with text, supporting the interpretation and analysis of complex discourse and debates. Can a graphic visualisation of complex argumentation enable a more critical interpretation of the arguments? This study focuses on analysing the impact of argumentation graphs (AGs) compared with regular texts for supporting argument interpretation. We found that AGs outperformed the extrinsic metrics throughout most UEQ scales as well as the NASA-TLX workload in all the terms but not in temporal or physical demand. The AG model was liked by a more significant number of participants, despite the fact that both the text-based and AG models yielded comparable outcomes in the critical interpretation in terms of working memory and altering participants decisions. The interpretation process involves reference to argumentation schemes (linked to critical questions (CQs)) in AGs. Interestingly, we found that the participants chose more CQs (using argument schemes in AGs) when they were less familiar with the argument topics, making AG schemes on some scales (relatively) supportive of the interpretation process. Therefore, AGs were considered to deliver a more critical approach to argument interpretation, especially with unfamiliar topics. Based on the 25 participants conducted in this study, it appears that AG has demonstrated an overall positive effect on the argument interpretation process.

Alex Bogatu, Zili Zhou, Dónal Landers et al.

Entailment trees have been proposed to simulate the human reasoning process of explanation generation in the context of open--domain textual question answering. However, in practice, manually constructing these explanation trees proves a laborious process that requires active human involvement. Given the complexity of capturing the line of reasoning from question to the answer or from claim to premises, the issue arises of how to assist the user in efficiently constructing multi--level entailment trees given a large set of available facts. In this paper, we frame the construction of entailment trees as a sequence of active premise selection steps, i.e., for each intermediate node in an explanation tree, the expert needs to annotate positive and negative examples of premise facts from a large candidate list. We then iteratively fine--tune pre--trained Transformer models with the resulting positive and tightly controlled negative samples and aim to balance the encoding of semantic relationships and explanatory entailment relationships. Experimental evaluation confirms the measurable efficiency gains of the proposed active fine--tuning method in facilitating entailment trees construction: up to 20\% improvement in explanatory premise selection when compared against several alternatives.

Danilo S. Carvalho, Edoardo Manino, Julia Rozanova et al.

This work proposes a novel methodology for measuring compositional behavior in contemporary language embedding models. Specifically, we focus on adjectival modifier phenomena in adjective-noun phrases. In recent years, distributional language representation models have demonstrated great practical success. At the same time, the need for interpretability has elicited questions on their intrinsic properties and capabilities. Crucially, distributional models are often inconsistent when dealing with compositional phenomena in natural language, which has significant implications for their safety and fairness. Despite this, most current research on compositionality is directed towards improving their performance on similarity tasks only. This work takes a different approach, introducing three novel tests of compositional behavior inspired by Montague semantics. Our experimental results indicate that current neural language models do not behave according to the expected linguistic theories. This indicates that current language models may lack the capability to capture the semantic properties we evaluated on limited context, or that linguistic theories from Montagovian tradition may not match the expected capabilities of distributional models.

Bohao Yang, Yingji Zhang, Dong Liu et al.

Recent large language models (LLMs) have advanced table understanding capabilities but rely on converting tables into text sequences. While multimodal large language models (MLLMs) enable direct visual processing, they face limitations in handling scientific tables due to fixed input image resolutions and insufficient numerical reasoning capabilities. We present a comprehensive framework for multimodal scientific table understanding and reasoning with dynamic input image resolutions. Our framework consists of three key components: (1) MMSci-Pre, a domain-specific table structure learning dataset of 52K scientific table structure recognition samples, (2) MMSci-Ins, an instruction tuning dataset with 12K samples across three table-based tasks, and (3) MMSci-Eval, a benchmark with 3,114 testing samples specifically designed to evaluate numerical reasoning capabilities. Extensive experiments demonstrate that our domain-specific approach with 52K scientific table images achieves superior performance compared to 150K general-domain tables, highlighting the importance of data quality over quantity. Our proposed table-based MLLMs with dynamic input resolutions show significant improvements in both general table understanding and numerical reasoning capabilities, with strong generalisation to held-out datasets. Our code and data are publicly available at https://github.com/Bernard-Yang/MMSci_Table.

Mael Jullien, Alex Bogatu, Harriet Unsworth et al.

Matching patients to clinical trials demands a systematic and reasoned interpretation of documents which require significant expert-level background knowledge, over a complex set of well-defined eligibility criteria. Moreover, this interpretation process needs to operate at scale, over vast knowledge bases of trials. In this paper, we propose a scalable method that extends the capabilities of LLMs in the direction of systematizing the reasoning over sets of medical eligibility criteria, evaluating it in the context of real-world cases. The proposed method overlays a Set-guided reasoning method for LLMs. The proposed framework is evaluated on TREC 2022 Clinical Trials, achieving results superior to the state-of-the-art: NDCG@10 of 0.693 and Precision@10 of 0.73.

Jordan Meadows, Marco Valentino, Andre Freitas

This paper investigates how hallucination rates in Large Language Models (LLMs) may be controlled via a symbolic data generation framework, exploring a fundamental relationship between the rate of certain mathematical errors and types of input intervention. Specifically, we systematically generate data for a derivation generation task using a symbolic engine, applying targeted interventions to prompts to perturb features of mathematical derivations such as the surface forms of symbols, equational tree structures, and mathematical context. We then evaluate the effect of prompt interventions across a range of LLMs including fine-tuned T5 models, GPT, and LLaMa-based models. Our experiments suggest that T5-Large can outperform the few-shot performance of GPT-4 on various evaluation sets generated via the framework. However, an extensive evaluation based on human analysis, template-based error detection, and text generation metrics reveals model weaknesses beyond what the reference-based metrics singularly describe. We use these results to tie characteristic distributional footprints of interventions to the human evaluation of LLM derivation quality, potentially leading to significant control over fine-grained mathematical capabilities of language models with respect to specific types of errors.

Mokanarangan Thayaparan, Marco Valentino, André Freitas

Integer Linear Programming (ILP) provides a viable mechanism to encode explicit and controllable assumptions about explainable multi-hop inference with natural language. However, an ILP formulation is non-differentiable and cannot be integrated into broader deep learning architectures. Recently, Thayaparan et al. (2021a) proposed a novel methodology to integrate ILP with Transformers to achieve end-to-end differentiability for complex multi-hop inference. While this hybrid framework has been demonstrated to deliver better answer and explanation selection than transformer-based and existing ILP solvers, the neuro-symbolic integration still relies on a convex relaxation of the ILP formulation, which can produce sub-optimal solutions. To improve these limitations, we propose Diff-Comb Explainer, a novel neuro-symbolic architecture based on Differentiable BlackBox Combinatorial solvers (DBCS) (Pogančić et al., 2019). Unlike existing differentiable solvers, the presented model does not require the transformation and relaxation of the explicit semantic constraints, allowing for direct and more efficient integration of ILP formulations. Diff-Comb Explainer demonstrates improved accuracy and explainability over non-differentiable solvers, Transformers and existing differentiable constraint-based multi-hop inference frameworks.

Mauricio Jacobo-Romero, Danilo S. Carvalho, Andre Freitas

In this work, we examined Business Process (BP) production as a signal; this novel approach explores a BP workflow as a linear time-invariant (LTI) system. We analysed BP productivity in the frequency domain; this standpoint examines how labour and capital act as BP input signals and how their fundamental frequencies affect BP production. Our research also proposes a simulation framework of a BP in the frequency domain for estimating productivity gains due to the introduction of automation steps. Our ultimate goal was to supply evidence to address Solow's Paradox.

Mauricio Jacobo-Romero, Danilo S. Carvalho, André Freitas

This paper proposes a novel productivity estimation model to evaluate the effects of adopting Artificial Intelligence (AI) components in a production chain. Our model provides evidence to address the "AI's" Solow's Paradox. We provide (i) theoretical and empirical evidence to explain Solow's dichotomy; (ii) a data-driven model to estimate and asses productivity variations; (iii) a methodology underpinned on process mining datasets to determine the business process, BP, and productivity; (iv) a set of computer simulation parameters; (v) and empirical analysis on labour-distribution. These provide data on why we consider AI Solow's paradox a consequence of metric mismeasurement.

Nura Aljaafari, Danilo S. Carvalho, André Freitas

Locating and editing knowledge in large language models (LLMs) is crucial for enhancing their accuracy, safety, and inference rationale. We introduce ``concept editing'', an innovative variation of knowledge editing that uncovers conceptualisation mechanisms within these models. Using the reverse dictionary task, inference tracing, and input abstraction, we analyse the Multi-Layer Perceptron (MLP), Multi-Head Attention (MHA), and hidden state components of transformer models. Our results reveal distinct patterns: MLP layers employ key-value retrieval mechanism and context-dependent processing, which are highly associated with relative input tokens. MHA layers demonstrate a distributed nature with significant higher-level activations, suggesting sophisticated semantic integration. Hidden states emphasise the importance of the last token and top layers in the inference process. We observe evidence of gradual information building and distributed representation. These observations elucidate how transformer models process semantic information, paving the way for targeted interventions and improved interpretability techniques. Our work highlights the complex, layered nature of semantic processing in LLMs and the challenges of isolating and modifying specific concepts within these models.

Jordan Meadows, Marco Valentino, Damien Teney et al.

This paper proposes a methodology for generating and perturbing detailed derivations of equations at scale, aided by a symbolic engine, to evaluate the generalisability of Transformers to out-of-distribution mathematical reasoning problems. Instantiating the framework in the context of sequence classification tasks, we compare the capabilities of GPT-4, GPT-3.5, and a canon of fine-tuned BERT models, exploring the relationship between specific operators and generalisation failure via the perturbation of reasoning aspects such as symmetry and variable surface forms. Surprisingly, our empirical evaluation reveals that the average in-distribution performance of fine-tuned models surpasses GPT-3.5, and rivals GPT-4. However, perturbations to input reasoning can reduce their performance by up to 80 F1 points. Overall, the results suggest that the in-distribution performance of smaller open-source models may potentially rival GPT by incorporating appropriately structured derivation dependencies during training, and highlight a shared weakness between BERT and GPT involving a relative inability to decode indirect references to mathematical entities. We release the full codebase, constructed datasets, and fine-tuned models to encourage future progress in the field.

Maël Jullien, Marco Valentino, Hannah Frost et al.

How can we interpret and retrieve medical evidence to support clinical decisions? Clinical trial reports (CTR) amassed over the years contain indispensable information for the development of personalized medicine. However, it is practically infeasible to manually inspect over 400,000+ clinical trial reports in order to find the best evidence for experimental treatments. Natural Language Inference (NLI) offers a potential solution to this problem, by allowing the scalable computation of textual entailment. However, existing NLI models perform poorly on biomedical corpora, and previously published datasets fail to capture the full complexity of inference over CTRs. In this work, we present a novel resource to advance research on NLI for reasoning on CTRs. The resource includes two main tasks. Firstly, to determine the inference relation between a natural language statement, and a CTR. Secondly, to retrieve supporting facts to justify the predicted relation. We provide NLI4CT, a corpus of 2400 statements and CTRs, annotated for these tasks. Baselines on this corpus expose the limitations of existing NLI models, with 6 state-of-the-art NLI models achieving a maximum F1 score of 0.627. To the best of our knowledge, we are the first to design a task that covers the interpretation of full CTRs. To encourage further work on this challenging dataset, we make the corpus, competition leaderboard, website and code to replicate the baseline experiments available at: https://github.com/ai-systems/nli4ct

João Pedro Gandarela, Danilo S. Carvalho, André Freitas

This work presents a novel systematic methodology to analyse the capabilities and limitations of Large Language Models (LLMs) with feedback from a formal inference engine, on logic theory induction. The analysis is complexity-graded w.r.t. rule dependency structure, allowing quantification of specific inference challenges on LLM performance. Integrating LLMs with formal methods is a promising frontier in the Natural Language Processing field, as an important avenue for improving model inference control and explainability. In particular, inductive learning over complex sets of facts and rules, poses unique challenges for current autoregressive models, as they lack explicit symbolic grounding. While they can be complemented by formal systems, the properties delivered by LLMs regarding inductive learning, are not well understood and quantified. Empirical results indicate that the largest LLMs can achieve competitive results against a SOTA Inductive Logic Programming (ILP) system baseline, but also that tracking long predicate relationship chains is a more difficult obstacle than theory complexity for LLMs.

Mael Jullien, Marco Valentino, André Freitas

Large Language Models (LLMs) are at the forefront of NLP achievements but fall short in dealing with shortcut learning, factual inconsistency, and vulnerability to adversarial inputs.These shortcomings are especially critical in medical contexts, where they can misrepresent actual model capabilities. Addressing this, we present SemEval-2024 Task 2: Safe Biomedical Natural Language Inference for ClinicalTrials. Our contributions include the refined NLI4CT-P dataset (i.e., Natural Language Inference for Clinical Trials - Perturbed), designed to challenge LLMs with interventional and causal reasoning tasks, along with a comprehensive evaluation of methods and results for participant submissions. A total of 106 participants registered for the task contributing to over 1200 individual submissions and 25 system overview papers. This initiative aims to advance the robustness and applicability of NLI models in healthcare, ensuring safer and more dependable AI assistance in clinical decision-making. We anticipate that the dataset, models, and outcomes of this task can support future research in the field of biomedical NLI. The dataset, competition leaderboard, and website are publicly available.

Xin Quan, Marco Valentino, Louise A. Dennis et al.

Natural language explanations represent a proxy for evaluating explanation-based and multi-step Natural Language Inference (NLI) models. However, assessing the validity of explanations for NLI is challenging as it typically involves the crowd-sourcing of apposite datasets, a process that is time-consuming and prone to logical errors. To address existing limitations, this paper investigates the verification and refinement of natural language explanations through the integration of Large Language Models (LLMs) and Theorem Provers (TPs). Specifically, we present a neuro-symbolic framework, named Explanation-Refiner, that integrates TPs with LLMs to generate and formalise explanatory sentences and suggest potential inference strategies for NLI. In turn, the TP is employed to provide formal guarantees on the logical validity of the explanations and to generate feedback for subsequent improvements. We demonstrate how Explanation-Refiner can be jointly used to evaluate explanatory reasoning, autoformalisation, and error correction mechanisms of state-of-the-art LLMs as well as to automatically enhance the quality of explanations of variable complexity in different domains.

Xin Quan, Marco Valentino, Louise A. Dennis et al.

An increasing amount of research in Natural Language Inference (NLI) focuses on the application and evaluation of Large Language Models (LLMs) and their reasoning capabilities. Despite their success, however, LLMs are still prone to factual errors and inconsistencies in their explanations, offering limited control and interpretability for inference in complex domains. In this paper, we focus on ethical NLI, investigating how hybrid neuro-symbolic techniques can enhance the logical validity and alignment of ethical explanations produced by LLMs. Specifically, we present an abductive-deductive framework named Logic-Explainer, which integrates LLMs with an external backward-chaining solver to refine step-wise natural language explanations and jointly verify their correctness, reduce incompleteness and minimise redundancy. An extensive empirical analysis demonstrates that Logic-Explainer can improve explanations generated via in-context learning methods and Chain-of-Thought (CoT) on challenging ethical NLI tasks, while, at the same time, producing formal proofs describing and supporting models' reasoning. As ethical NLI requires commonsense reasoning to identify underlying moral violations, our results suggest the effectiveness of neuro-symbolic methods for multi-step NLI more broadly, opening new opportunities to enhance the logical consistency, reliability, and alignment of LLMs.

Yingji Zhang, Danilo S. Carvalho, Marco Valentino et al.

Achieving precise semantic control over the latent spaces of Variational AutoEncoders (VAEs) holds significant value for downstream tasks in NLP as the underlying generative mechanisms could be better localised, explained and improved upon. Recent research, however, has struggled to achieve consistent results, primarily due to the inevitable loss of semantic information in the variational bottleneck and limited control over the decoding mechanism. To overcome these challenges, we investigate discrete latent spaces in Vector Quantized Variational AutoEncoders (VQVAEs) to improve semantic control and generation in Transformer-based VAEs. In particular, We propose T5VQVAE, a novel model that leverages the controllability of VQVAEs to guide the self-attention mechanism in T5 at the token-level, exploiting its full generalization capabilities. Experimental results indicate that T5VQVAE outperforms existing state-of-the-art VAE models, including Optimus, in terms of controllability and preservation of semantic information across different tasks such as auto-encoding of sentences and mathematical expressions, text transfer, and inference. Moreover, T5VQVAE exhibits improved inference capabilities, suggesting potential applications for downstream natural language and symbolic reasoning tasks.

Giangiacomo Mercatali, Andre Freitas, Jie Chen

Interacting systems are prevalent in nature. It is challenging to accurately predict the dynamics of the system if its constituent components are analyzed independently. We develop a graph-based model that unveils the systemic interactions of time series observed at irregular time points, by using a directed acyclic graph to model the conditional dependencies (a form of causal notation) of the system components and learning this graph in tandem with a continuous-time model that parameterizes the solution curves of ordinary differential equations (ODEs). Our technique, a graph neural flow, leads to substantial enhancements over non-graph-based methods, as well as graph-based methods without the modeling of conditional dependencies. We validate our approach on several tasks, including time series classification and forecasting, to demonstrate its efficacy.

Magdalena Wysocka, Danilo Carvalho, Oskar Wysocki et al.

Syllogistic reasoning is crucial for Natural Language Inference (NLI). This capability is particularly significant in specialized domains such as biomedicine, where it can support automatic evidence interpretation and scientific discovery. This paper presents SylloBio-NLI, a novel framework that leverages external ontologies to systematically instantiate diverse syllogistic arguments for biomedical NLI. We employ SylloBio-NLI to evaluate Large Language Models (LLMs) on identifying valid conclusions and extracting supporting evidence across 28 syllogistic schemes instantiated with human genome pathways. Extensive experiments reveal that biomedical syllogistic reasoning is particularly challenging for zero-shot LLMs, which achieve an average accuracy between 70% on generalized modus ponens and 23% on disjunctive syllogism. At the same time, we found that few-shot prompting can boost the performance of different LLMs, including Gemma (+14%) and LLama-3 (+43%). However, a deeper analysis shows that both techniques exhibit high sensitivity to superficial lexical variations, highlighting a dependency between reliability, models' architecture, and pre-training regime. Overall, our results indicate that, while in-context examples have the potential to elicit syllogistic reasoning in LLMs, existing models are still far from achieving the robustness and consistency required for safe biomedical NLI applications.

Giangiacomo Mercatali, Yogesh Verma, Andre Freitas et al.

We introduce a novel score-based diffusion framework named Twigs that incorporates multiple co-evolving flows for enriching conditional generation tasks. Specifically, a central or trunk diffusion process is associated with a primary variable (e.g., graph structure), and additional offshoot or stem processes are dedicated to dependent variables (e.g., graph properties or labels). A new strategy, which we call loop guidance, effectively orchestrates the flow of information between the trunk and the stem processes during sampling. This approach allows us to uncover intricate interactions and dependencies, and unlock new generative capabilities. We provide extensive experiments to demonstrate strong performance gains of the proposed method over contemporary baselines in the context of conditional graph generation, underscoring the potential of Twigs in challenging generative tasks such as inverse molecular design and molecular optimization.

Lan Zhang, Marco Valentino, Andre Freitas

Thanks to their linguistic capabilities, LLMs offer an opportunity to bridge the gap between informal mathematics and formal languages through autoformalization. However, it is still unclear how well LLMs generalize to sophisticated and naturally occurring mathematical statements. To address this gap, we investigate the task of autoformalizing real-world mathematical definitions: a critical component of mathematical discourse. Specifically, we introduce two novel resources for autoformalization, collecting definitions from Wikipedia (Def_Wiki) and arXiv papers (Def_ArXiv). We then systematically evaluate a range of LLMs, analyzing their ability to formalize definitions into Isabelle/HOL. Furthermore, we investigate strategies to enhance LLMs' performance including refinement through external feedback from Proof Assistants, and formal definition grounding, where we augment LLMs' formalizations through relevant contextual elements from formal mathematical libraries. Our findings reveal that definitions present a greater challenge compared to existing benchmarks, such as miniF2F. In particular, we found that LLMs still struggle with self-correction, and aligning with relevant mathematical libraries. At the same time, structured refinement methods and definition grounding strategies yield notable improvements of up to 16% on self-correction capabilities and 43% on the reduction of undefined errors, highlighting promising directions for enhancing LLM-based autoformalization in real-world scenarios.

Dhairya Dalal, Marco Valentino, André Freitas et al.

While Large Language Models (LLMs) have found success in real-world applications, their underlying explanatory process is still poorly understood. This paper proposes IBE-Eval, a framework inspired by philosophical accounts on Inference to the Best Explanation (IBE) to advance the interpretation and evaluation of LLMs' explanations. IBE-Eval estimates the plausibility of natural language explanations through a combination of explicit logical and linguistic features including: consistency, parsimony, coherence, and uncertainty. Extensive experiments are conducted on Causal Question Answering (CQA), where \textit{IBE-Eval} is tasked to select the most plausible causal explanation amongst competing ones generated by LLMs (i.e., GPT 3.5 and Llama 2). The experiments reveal that IBE-Eval can successfully identify the best explanation with up to 77\% accuracy ($\approx 27\%$ above random), improving upon a GPT 3.5-as-a-Judge baseline ($\approx+17\%$) while being intrinsically more efficient and interpretable. Additional analyses suggest that, despite model-specific variances, LLM-generated explanations tend to conform to IBE criteria and that IBE-Eval is significantly correlated with human judgment, opening up opportunities for future development of automated explanation verification tools.

Nura Aljaafari, Danilo S. Carvalho, André Freitas

Understanding the internal mechanisms of large language models (LLMs) is integral to enhancing their reliability, interpretability, and inference processes. We present Constituent-Aware Pooling (CAP), a methodology designed to analyse how LLMs process compositional linguistic structures. Grounded in principles of compositionality, mechanistic interpretability, and information theory, CAP systematically intervenes in model activations through constituent-based pooling at various model levels. Our experiments on inverse definition modelling, hypernym and synonym prediction reveal critical insights into transformers' limitations in handling compositional abstractions. No specific layer integrates tokens into unified semantic representations based on their constituent parts. We observe fragmented information processing, which intensifies with model size, suggesting that larger models struggle more with these interventions and exhibit greater information dispersion. This fragmentation likely stems from transformers' training objectives and architectural design, preventing systematic and cohesive representations. Our findings highlight fundamental limitations in current transformer architectures regarding compositional semantics processing and model interpretability, underscoring the critical need for novel approaches in LLM design to address these challenges.

Yingji Zhang, Danilo S. Carvalho, Ian Pratt-Hartmann et al.

Deep generative neural networks, such as Variational AutoEncoders (VAEs), offer an opportunity to better understand and control language models from the perspective of sentence-level latent spaces. To combine the controllability of VAE latent spaces with the state-of-the-art performance of recent large language models (LLMs), we present in this work LlaMaVAE, which combines expressive encoder and decoder models (sentenceT5 and LlaMA) with a VAE architecture, aiming to provide better text generation control to LLMs. In addition, to conditionally guide the VAE generation, we investigate a new approach based on flow-based invertible neural networks (INNs) named Invertible CVAE. Experimental results reveal that LlaMaVAE can outperform the previous state-of-the-art VAE language model, Optimus, across various tasks, including language modelling, semantic textual similarity and definition modelling. Qualitative analysis on interpolation and traversal experiments also indicates an increased degree of semantic clustering and geometric consistency, which enables better generation control.

Nura Aljaafari, Danilo S. Carvalho, André Freitas

Large language models (LLMs) struggle with compositional generalisation, limiting their ability to systematically combine learned components to interpret novel inputs. While architectural modifications, fine-tuning, and data augmentation improve compositionality, they often have limited adaptability, face scalability constraints, or yield diminishing returns on real data. To address this, we propose CARMA, an intervention that enhances the stability and robustness of compositional reasoning in LLMs while preserving fine-tuned performance. CARMA employs mutual information regularisation and layer-wise stability constraints to mitigate feature fragmentation, ensuring structured representations persist across and within layers. We evaluate CARMA on inverse dictionary modelling and sentiment classification, measuring its impact on semantic consistency, performance stability, and robustness to lexical perturbations. Results show that CARMA reduces the variability introduced by fine-tuning, stabilises token representations, and improves compositional reasoning. While its effectiveness varies across architectures, CARMA's key strength lies in reinforcing learned structures rather than introducing new capabilities, making it a scalable auxiliary method. These findings suggest that integrating CARMA with fine-tuning can improve compositional generalisation while maintaining task-specific performance in LLMs.

Jordan Meadows, Tamsin James, Andre Freitas

Language models (LMs) can hallucinate when performing complex mathematical reasoning. Physics provides a rich domain for assessing their mathematical capabilities, where physical context requires that any symbolic manipulation satisfies complex semantics (\textit{e.g.,} units, tensorial order). In this work, we systematically remove crucial context from prompts to force instances where model inference may be algebraically coherent, yet unphysical. We assess LM capabilities in this domain using a curated dataset encompassing multiple notations and Physics subdomains. Further, we improve zero-shot scores using synthetic in-context examples, and demonstrate non-linear degradation of derivation quality with perturbation strength via the progressive omission of supporting premises. We find that the models' mathematical reasoning is not physics-informed in this setting, where physical context is predominantly ignored in favour of reverse-engineering solutions.

Mokanarangan Thayaparan, Marco Valentino, André Freitas

Integer Linear Programming (ILP) has been proposed as a formalism for encoding precise structural and semantic constraints for Natural Language Inference (NLI). However, traditional ILP frameworks are non-differentiable, posing critical challenges for the integration of continuous language representations based on deep learning. In this paper, we introduce a novel approach, named Diff-Comb Explainer, a neuro-symbolic architecture for explanation-based NLI based on Differentiable BlackBox Combinatorial Solvers (DBCS). Differently from existing neuro-symbolic solvers, Diff-Comb Explainer does not necessitate a continuous relaxation of the semantic constraints, enabling a direct, more precise, and efficient incorporation of neural representations into the ILP formulation. Our experiments demonstrate that Diff-Comb Explainer achieves superior performance when compared to conventional ILP solvers, neuro-symbolic black-box solvers, and Transformer-based encoders. Moreover, a deeper analysis reveals that Diff-Comb Explainer can significantly improve the precision, consistency, and faithfulness of the constructed explanations, opening new opportunities for research on neuro-symbolic architectures for explainable and transparent NLI in complex domains.

Julia Rozanova, Marco Valentino, André Freitas

Rigorous evaluation of the causal effects of semantic features on language model predictions can be hard to achieve for natural language reasoning problems. However, this is such a desirable form of analysis from both an interpretability and model evaluation perspective, that it is valuable to investigate specific patterns of reasoning with enough structure and regularity to identify and quantify systematic reasoning failures in widely-used models. In this vein, we pick a portion of the NLI task for which an explicit causal diagram can be systematically constructed: the case where across two sentences (the premise and hypothesis), two related words/terms occur in a shared context. In this work, we apply causal effect estimation strategies to measure the effect of context interventions (whose effect on the entailment label is mediated by the semantic monotonicity characteristic) and interventions on the inserted word-pair (whose effect on the entailment label is mediated by the relation between these words). Extending related work on causal analysis of NLP models in different settings, we perform an extensive interventional study on the NLI task to investigate robustness to irrelevant changes and sensitivity to impactful changes of Transformers. The results strongly bolster the fact that similar benchmark accuracy scores may be observed for models that exhibit very different behaviour. Moreover, our methodology reinforces previously suspected biases from a causal perspective, including biases in favour of upward-monotone contexts and ignoring the effects of negation markers.

Oskar Wysocki, Magdalena Wysocka, Danilo Carvalho et al.

We present BioLunar, developed using the Lunar framework, as a tool for supporting biological analyses, with a particular emphasis on molecular-level evidence enrichment for biomarker discovery in oncology. The platform integrates Large Language Models (LLMs) to facilitate complex scientific reasoning across distributed evidence spaces, enhancing the capability for harmonizing and reasoning over heterogeneous data sources. Demonstrating its utility in cancer research, BioLunar leverages modular design, reusable data access and data analysis components, and a low-code user interface, enabling researchers of all programming levels to construct LLM-enabled scientific workflows. By facilitating automatic scientific discovery and inference from heterogeneous evidence, BioLunar exemplifies the potential of the integration between LLMs, specialised databases and biomedical tools to support expert-level knowledge synthesis and discovery.

Magdalena Wysocka, Oskar Wysocki, Maxime Delmas et al.

The paper introduces a framework for the evaluation of the encoding of factual scientific knowledge, designed to streamline the manual evaluation process typically conducted by domain experts. Inferring over and extracting information from Large Language Models (LLMs) trained on a large corpus of scientific literature can potentially define a step change in biomedical discovery, reducing the barriers for accessing and integrating existing medical evidence. This work explores the potential of LLMs for dialoguing with biomedical background knowledge, using the context of antibiotic discovery. The framework involves of three evaluation steps, each assessing different aspects sequentially: fluency, prompt alignment, semantic coherence, factual knowledge, and specificity of the generated responses. By splitting these tasks between non-experts and experts, the framework reduces the effort required from the latter. The work provides a systematic assessment on the ability of eleven state-of-the-art models LLMs, including ChatGPT, GPT-4 and Llama 2, in two prompting-based tasks: chemical compound definition generation and chemical compound-fungus relation determination. Although recent models have improved in fluency, factual accuracy is still low and models are biased towards over-represented entities. The ability of LLMs to serve as biomedical knowledge bases is questioned, and the need for additional systematic evaluation frameworks is highlighted. While LLMs are currently not fit for purpose to be used as biomedical factual knowledge bases in a zero-shot setting, there is a promising emerging property in the direction of factuality as the models become domain specialised, scale-up in size and level of human feedback.

Xiaowei Huang, Wenjie Ruan, Wei Huang et al.

Large Language Models (LLMs) have exploded a new heatwave of AI for their ability to engage end-users in human-level conversations with detailed and articulate answers across many knowledge domains. In response to their fast adoption in many industrial applications, this survey concerns their safety and trustworthiness. First, we review known vulnerabilities and limitations of the LLMs, categorising them into inherent issues, attacks, and unintended bugs. Then, we consider if and how the Verification and Validation (V&V) techniques, which have been widely developed for traditional software and deep learning models such as convolutional neural networks as independent processes to check the alignment of their implementations against the specifications, can be integrated and further extended throughout the lifecycle of the LLMs to provide rigorous analysis to the safety and trustworthiness of LLMs and their applications. Specifically, we consider four complementary techniques: falsification and evaluation, verification, runtime monitoring, and regulations and ethical use. In total, 370+ references are considered to support the quick understanding of the safety and trustworthiness issues from the perspective of V&V. While intensive research has been conducted to identify the safety and trustworthiness issues, rigorous yet practical methods are called for to ensure the alignment of LLMs with safety and trustworthiness requirements.

Julia Rozanova, Marco Valentino, Andre Freitas

Rigorous evaluation of the causal effects of semantic features on language model predictions can be hard to achieve for natural language reasoning problems. However, this is such a desirable form of analysis from both an interpretability and model evaluation perspective, that it is valuable to zone in on specific patterns of reasoning with enough structure and regularity to be able to identify and quantify systematic reasoning failures in widely-used models. In this vein, we pick a portion of the NLI task for which an explicit causal diagram can be systematically constructed: in particular, the case where across two sentences (the premise and hypothesis), two related words/terms occur in a shared context. In this work, we apply causal effect estimation strategies to measure the effect of context interventions (whose effect on the entailment label is mediated by the semantic monotonicity characteristic) and interventions on the inserted word-pair (whose effect on the entailment label is mediated by the relation between these words.). Following related work on causal analysis of NLP models in different settings, we adapt the methodology for the NLI task to construct comparative model profiles in terms of robustness to irrelevant changes and sensitivity to impactful changes.

Marco Valentino, Danilo S. Carvalho, André Freitas

Natural language definitions possess a recursive, self-explanatory semantic structure that can support representation learning methods able to preserve explicit conceptual relations and constraints in the latent space. This paper presents a multi-relational model that explicitly leverages such a structure to derive word embeddings from definitions. By automatically extracting the relations linking defined and defining terms from dictionaries, we demonstrate how the problem of learning word embeddings can be formalised via a translational framework in Hyperbolic space and used as a proxy to capture the global semantic structure of definitions. An extensive empirical analysis demonstrates that the framework can help imposing the desired structural constraints while preserving the semantic mapping required for controllable and interpretable traversal. Moreover, the experiments reveal the superiority of the Hyperbolic word embeddings over the Euclidean counterparts and demonstrate that the multi-relational approach can obtain competitive results when compared to state-of-the-art neural models, with the advantage of being intrinsically more efficient and interpretable.

Maël Jullien, Marco Valentino, Hannah Frost et al.

This paper describes the results of SemEval 2023 task 7 -- Multi-Evidence Natural Language Inference for Clinical Trial Data (NLI4CT) -- consisting of 2 tasks, a Natural Language Inference (NLI) task, and an evidence selection task on clinical trial data. The proposed challenges require multi-hop biomedical and numerical reasoning, which are of significant importance to the development of systems capable of large-scale interpretation and retrieval of medical evidence, to provide personalized evidence-based care. Task 1, the entailment task, received 643 submissions from 40 participants, and Task 2, the evidence selection task, received 364 submissions from 23 participants. The tasks are challenging, with the majority of submitted systems failing to significantly outperform the majority class baseline on the entailment task, and we observe significantly better performance on the evidence selection task than on the entailment task. Increasing the number of model parameters leads to a direct increase in performance, far more significant than the effect of biomedical pre-training. Future works could explore the limitations of large models for generalization and numerical inference, and investigate methods to augment clinical datasets to allow for more rigorous testing and to facilitate fine-tuning. We envisage that the dataset, models, and results of this task will be useful to the biomedical NLI and evidence retrieval communities. The dataset, competition leaderboard, and website are publicly available.