Kai Yang

Mohammad Hessam Olya, Dongxiao Zhu, Kai Yang

Developing reliable workload predictive models can affect many aspects of clinical decision making procedure. The primary challenge in healthcare systems is handling the demand uncertainty over the time. This issue becomes more critical for the healthcare facilities that provide service for chronic disease treatment because of the need for continuous treatments over the time. Although some researchers focused on exploring the methods for workload prediction recently, few types of research mainly focused on forecasting a quantitative measure for the workload of healthcare providers. Also, among the mentioned studies most of them just focused on workload prediction within one facility. The drawback of the previous studies is the problem is not investigated for multiple facilities where the quality of provided service, the equipment, and resources used for provided service as well as the diagnosis and treatment procedures may differ even for patients with similar conditions. To tackle the mentioned issue, this paper suggests a framework for patient workload prediction by using patients data from VA facilities across the US. To capture the information of patients with similar attributes and make the prediction more accurate, a heuristic cluster based algorithm for single task learning as well as a multi task learning approach are developed in this research.

Milad Zafar Nezhad, Najibesadat Sadati, Kai Yang et al.

Survival analysis has been developed and applied in the number of areas including manufacturing, finance, economics and healthcare. In healthcare domain, usually clinical data are high-dimensional, sparse and complex and sometimes there exists few amount of time-to-event (labeled) instances. Therefore building an accurate survival model from electronic health records is challenging. With this motivation, we address this issue and provide a new survival analysis framework using deep learning and active learning with a novel sampling strategy. First, our approach provides better representation with lower dimensions from clinical features using labeled (time-to-event) and unlabeled (censored) instances and then actively trains the survival model by labeling the censored data using an oracle. As a clinical assistive tool, we introduce a simple effective treatment recommendation approach based on our survival model. In the experimental study, we apply our approach on SEER-Medicare data related to prostate cancer among African-Americans and white patients. The results indicate that our approach outperforms significantly than baseline models.

Milad Zafar Nezhad, Dongxiao Zhu, Najibesadat Sadati et al.

Traditional medicine typically applies one-size-fits-all treatment for the entire patient population whereas precision medicine develops tailored treatment schemes for different patient subgroups. The fact that some factors may be more significant for a specific patient subgroup motivates clinicians and medical researchers to develop new approaches to subgroup detection and analysis, which is an effective strategy to personalize treatment. In this study, we propose a novel patient subgroup detection method, called Supervised Biclustring (SUBIC) using convex optimization and apply our approach to detect patient subgroups and prioritize risk factors for hypertension (HTN) in a vulnerable demographic subgroup (African-American). Our approach not only finds patient subgroups with guidance of a clinically relevant target variable but also identifies and prioritizes risk factors by pursuing sparsity of the input variables and encouraging similarity among the input variables and between the input and target variables

Issac Shams, Saeede Ajorlou, Kai Yang

Hospital readmission has become a critical metric of quality and cost of healthcare. Medicare anticipates that nearly $17 billion is paid out on the 20% of patients who are readmitted within 30 days of discharge. Although several interventions such as transition care management and discharge reengineering have been practiced in recent years, the effectiveness and sustainability depends on how well they can identify and target patients at high risk of rehospitalization. Based on the literature, most current risk prediction models fail to reach an acceptable accuracy level; none of them considers patient's history of readmission and impacts of patient attribute changes over time; and they often do not discriminate between planned and unnecessary readmissions. Tackling such drawbacks, we develop a new readmission metric based on administrative data that can identify potentially avoidable readmissions from all other types of readmission. We further propose a tree based classification method to estimate the predicted probability of readmission that can directly incorporate patient's history of readmission and risk factors changes over time. The proposed methods are validated with 2011-12 Veterans Health Administration data from inpatients hospitalized for heart failure, acute myocardial infarction, pneumonia, or chronic obstructive pulmonary disease in the State of Michigan. Results shows improved discrimination power compared to the literature (c-statistics>80%) and good calibration.