Zhenwei Zhang

Yu Lei, Haolun Luo, Lituan Wang et al.

In weakly supervised medical image segmentation, the absence of structural priors and the discreteness of class feature distribution present a challenge, i.e., how to accurately propagate supervision signals from local to global regions without excessively spreading them to other irrelevant regions? To address this, we propose a novel weakly supervised medical image segmentation framework named PCLMix, comprising dynamic mix augmentation, pixel-level contrastive learning, and consistency regularization strategies. Specifically, PCLMix is built upon a heterogeneous dual-decoder backbone, addressing the absence of structural priors through a strategy of dynamic mix augmentation during training. To handle the discrete distribution of class features, PCLMix incorporates pixel-level contrastive learning based on prediction uncertainty, effectively enhancing the model's ability to differentiate inter-class pixel differences and intra-class consistency. Furthermore, to reinforce segmentation consistency and robustness, PCLMix employs an auxiliary decoder for dual consistency regularization. In the inference phase, the auxiliary decoder will be dropped and no computation complexity is increased. Extensive experiments on the ACDC dataset demonstrate that PCLMix appropriately propagates local supervision signals to the global scale, further narrowing the gap between weakly supervised and fully supervised segmentation methods. Our code is available at https://github.com/Torpedo2648/PCLMix.

Zhenbin Wang, Lei Zhang, Lituan Wang et al.

Magnetic Resonance Imaging (MRI) and Computed Tomography (CT) are the predominant modalities utilized in the field of medical imaging. Although MRI capture the complexity of anatomical structures with greater detail than CT, it entails a higher financial costs and requires longer image acquisition times. In this study, we aim to train latent diffusion model for CT to MRI conversion, replacing the commonly-used U-Net or Transformer backbone with a State-Space Model (SSM) called Mamba that operates on latent patches. First, we noted critical oversights in the scan scheme of most Mamba-based vision methods, including inadequate attention to the spatial continuity of patch tokens and the lack of consideration for their varying importance to the target task. Secondly, extending from this insight, we introduce Diffusion Mamba (DiffMa), employing soft masked to integrate Cross-Sequence Attention into Mamba and conducting selective scan in a spiral manner. Lastly, extensive experiments demonstrate impressive performance by DiffMa in medical image generation tasks, with notable advantages in input scaling efficiency over existing benchmark models. The code and models are available at https://github.com/wongzbb/DiffMa-Diffusion-Mamba

Zhenbin Wang, Lei Zhang, Lituan Wang et al.

Medical video generation models are expected to have a profound impact on the healthcare industry, including but not limited to medical education and training, surgical planning, and simulation. Current video diffusion models typically build on image diffusion architecture by incorporating temporal operations (such as 3D convolution and temporal attention). Although this approach is effective, its oversimplification limits spatio-temporal performance and consumes substantial computational resources. To counter this, we propose Medical Simulation Video Generator (MedSora), which incorporates three key elements: i) a video diffusion framework integrates the advantages of attention and Mamba, balancing low computational load with high-quality video generation, ii) an optical flow representation alignment method that implicitly enhances attention to inter-frame pixels, and iii) a video variational autoencoder (VAE) with frequency compensation addresses the information loss of medical features that occurs when transforming pixel space into latent features and then back to pixel frames. Extensive experiments and applications demonstrate that MedSora exhibits superior visual quality in generating medical videos, outperforming the most advanced baseline methods. Further results and code are available at https://wongzbb.github.io/MedSora

Bin Li, Li Li, Zhenwei Zhang et al.

Underwater optical images inevitably suffer from various degradation factors such as blurring, low contrast, and color distortion, which hinder the accuracy of object detection tasks. Due to the lack of paired underwater/clean images, most research methods adopt a strategy of first enhancing and then detecting, resulting in a lack of feature communication between the two learning tasks. On the other hand, due to the contradiction between the diverse degradation factors of underwater images and the limited number of samples, existing underwater enhancement methods are difficult to effectively enhance degraded images of unknown water bodies, thereby limiting the improvement of object detection accuracy. Therefore, most underwater target detection results are still displayed on degraded images, making it difficult to visually judge the correctness of the detection results. To address the above issues, this paper proposes a multi-task learning method that simultaneously enhances underwater images and improves detection accuracy. Compared with single-task learning, the integrated model allows for the dynamic adjustment of information communication and sharing between different tasks. Due to the fact that real underwater images can only provide annotated object labels, this paper introduces physical constraints to ensure that object detection tasks do not interfere with image enhancement tasks. Therefore, this article introduces a physical module to decompose underwater images into clean images, background light, and transmission images and uses a physical model to calculate underwater images for self-supervision. Numerical experiments demonstrate that the proposed model achieves satisfactory results in visual performance, object detection accuracy, and detection efficiency compared to state-of-the-art comparative methods.