BIO-PHOct 29, 2018
Space-time fractional diffusion in cell movement models with delayGissell Estrada-Rodriguez, Heiko Gimperlein, Kevin J. Painter et al.
The movement of organisms and cells can be governed by occasional long distance runs, according to an approximate Lévy walk. For T cells migrating through chronically-infected brain tissue, runs are further interrupted by long pauses, and the aim here is to clarify the form of continuous model equations which describe such movements. Starting from a microscopic velocity-jump model based on experimental observations, we include power-law distributions of run and waiting times and investigate the relevant parabolic limit from a kinetic equation for resting and moving individuals. In biologically relevant regimes we derive nonlocal diffusion equations, including fractional Laplacians in space and fractional time derivatives. Its analysis and numerical experiments shed light on how the searching strategy, and the impact from chemokinesis responses to chemokines, shorten the average time taken to find rare targets in the absence of direct guidance information such as chemotaxis.
ROFeb 14, 2022
Efficient quantitative assessment of robot swarms: coverage and targeting Lévy strategiesSiobhan Duncan, Gissell Estrada-Rodriguez, Jakub Stocek et al.
Biologically inspired strategies have long been adapted to swarm robotic systems, including biased random walks, reaction to chemotactic cues and long-range coordination. In this paper we apply analysis tools developed for modeling biological systems, such as continuum descriptions, to the efficient quantitative characterization of robot swarms. As an illustration, both Brownian and Lévy strategies with a characteristic long-range movement are discussed. As a result we obtain computationally fast methods for the optimization of robot movement laws to achieve a prescribed collective behavior. We show how to compute performance metrics like coverage and hitting times, and illustrate the accuracy and efficiency of our approach for area coverage and search problems. Comparisons between the continuum model and robotic simulations confirm the quantitative agreement and speed up of our approach. Results confirm and quantify the advantage of Lévy strategies over Brownian motion for search and area coverage problems in swarm robotics.
NAApr 16, 2019
Space-time adaptive finite elements for nonlocal parabolic variational inequalitiesHeiko Gimperlein, Jakub Stocek
This article considers the error analysis of finite element discretizations and adaptive mesh refinement procedures for nonlocal dynamic contact and friction, both in the domain and on the boundary. For a large class of parabolic variational inequalities associated to the fractional Laplacian we obtain a priori and a posteriori error estimates and study the resulting space-time adaptive mesh-refinement procedures. Particular emphasis is placed on mixed formulations, which include the contact forces as a Lagrange multiplier. Corresponding results are presented for elliptic problems. Our numerical experiments for $2$-dimensional model problems confirm the theoretical results: They indicate the efficiency of the a posteriori error estimates and illustrate the convergence properties of space-time adaptive, as well as uniform and graded discretizations.