Stewart A. Factor

Timothy Odonga, Jeanne M. Powell, Mark Saad et al.

Tremor is a common movement disorder associated with conditions like Parkinson's disease and Essential tremor, traditionally diagnosed through expert clinician assessment. Current automated detection methods rely on frequency-domain features informed by clinical expertise. In this work, we present an explainable, two-stage hierarchical framework for tremor detection in the time domain that learns tremor patterns directly from 3D kinematic marker time-series data across entire tremor-provoking trials. Our framework combined a deep convolutional and long short-term memory network to learn tremor representations from short, discrete, non-overlapping time segments of kinematic time series data from trials, which are then processed by a vision transformer that models their long-term temporal dynamics of time segment features for trial (session) level classification. Evaluated across nine body parts, the framework achieved F1-scores of 0.594 - 0.947 depending on body parts (average: 0.765), falling short of the frequency-domain state-of-the-art performance (0.909) while requiring minimal preprocessing. Attention weights and gradient-based class activation maps (Grad-CAM) identified time-domain features of tremor across body parts. This proof of concept demonstrated the feasibility of data-driven time-domain modeling for tremor detection across anatomically diverse body parts, while reducing reliance on expert-engineered spectral features and providing posthoc interpretability of temporal and anatomical patterns of tremor.

Timothy Odonga, Christine D. Esper, Stewart A. Factor et al.

Freezing of gait (FOG) is a debilitating feature of Parkinson's disease (PD), which is a cause of injurious falls among PD patients. Recent advances in wearable-based human activity recognition (HAR) technology have enabled the detection of FOG subtypes across benchmark datasets. Since FOG manifestation is heterogeneous, developing models that quantify FOG consistently across patients with varying demographics, FOG types, and PD conditions is important. Bias and fairness in FOG models remain understudied in HAR, with research focused mainly on FOG detection using single benchmark datasets. We evaluated the bias and fairness of HAR models for wearable-based FOG detection across demographics and PD conditions using multiple datasets and the effectiveness of transfer learning as a potential bias mitigation approach. Our evaluation using demographic parity ratio (DPR) and equalized odds ratio (EOR) showed model bias (DPR & EOR < 0.8) for all stratified demographic variables, including age, sex, and disease duration. Our experiments demonstrated that transfer learning from multi-site datasets and generic human activity representations significantly improved fairness (average change in DPR +0.027, +0.039, respectively) and performance (average change in F1-score +0.026, +0.018, respectively) across attributes, supporting the hypothesis that generic human activity representations learn fairer representations applicable to health analytics.

Vida Adeli, Ivan Klabucar, Javad Rajabi et al.

Objective gait assessment in Parkinson's Disease (PD) is limited by the absence of large, diverse, and clinically annotated motion datasets. We introduce CARE-PD, the largest publicly available archive of 3D mesh gait data for PD, and the first multi-site collection spanning 9 cohorts from 8 clinical centers. All recordings (RGB video or motion capture) are converted into anonymized SMPL meshes via a harmonized preprocessing pipeline. CARE-PD supports two key benchmarks: supervised clinical score prediction (estimating Unified Parkinson's Disease Rating Scale, UPDRS, gait scores) and unsupervised motion pretext tasks (2D-to-3D keypoint lifting and full-body 3D reconstruction). Clinical prediction is evaluated under four generalization protocols: within-dataset, cross-dataset, leave-one-dataset-out, and multi-dataset in-domain adaptation. To assess clinical relevance, we compare state-of-the-art motion encoders with a traditional gait-feature baseline, finding that encoders consistently outperform handcrafted features. Pretraining on CARE-PD reduces MPJPE (from 60.8mm to 7.5mm) and boosts PD severity macro-F1 by 17 percentage points, underscoring the value of clinically curated, diverse training data. CARE-PD and all benchmark code are released for non-commercial research at https://neurips2025.care-pd.ca/.