H. Hannah Inbarani

A. Nisthana Parveen, H. Hannah Inbarani, E. N. Sathishkumar

Feature selection (FS) is a process which attempts to select more informative features. In some cases, too many redundant or irrelevant features may overpower main features for classification. Feature selection can remedy this problem and therefore improve the prediction accuracy and reduce the computational overhead of classification algorithms. The main aim of feature selection is to determine a minimal feature subset from a problem domain while retaining a suitably high accuracy in representing the original features. In this paper, Principal Component Analysis (PCA), Rough PCA, Unsupervised Quick Reduct (USQR) algorithm and Empirical Distribution Ranking (EDR) approaches are applied to discover discriminative features that will be the most adequate ones for classification. Efficiency of the approaches is evaluated using standard classification metrics.

P. K. Nizar Banu, H. Hannah Inbarani

With the rapid advances of microarray technologies, large amounts of high-dimensional gene expression data are being generated, which poses significant computational challenges. A first step towards addressing this challenge is the use of clustering techniques, which is essential in the data mining process to reveal natural structures and identify interesting patterns in the underlying data. A robust gene expression clustering approach to minimize undesirable clustering is proposed. In this paper, Penalized Fuzzy C-Means (PFCM) Clustering algorithm is described and compared with the most representative off-line clustering techniques: K-Means Clustering, Rough K-Means Clustering and Fuzzy C-Means clustering. These techniques are implemented and tested for a Brain Tumor gene expression Dataset. Analysis of the performance of the proposed approach is presented through qualitative validation experiments. From experimental results, it can be observed that Penalized Fuzzy C-Means algorithm shows a much higher usability than the other projected clustering algorithms used in our comparison study. Significant and promising clustering results are presented using Brain Tumor Gene expression dataset. Thus patterns seen in genome-wide expression experiments can be interpreted as indications of the status of cellular processes. In these clustering results, we find that Penalized Fuzzy C-Means algorithm provides useful information as an aid to diagnosis in oncology.

N. Kalaiselvi, H. Hannah Inbarani

Classification is one of the major issues in Data Mining Research fields. The classification problems in medical area often classify medical dataset based on the result of medical diagnosis or description of medical treatment by the medical practitioner. This research work discusses the classification process of Gene Expression data for three different cancers which are breast cancer, lung cancer and leukemia cancer with two classes which are cancerous stage and non cancerous stage. We have applied a fuzzy soft set similarity based classifier to enhance the accuracy to predict the stages among cancer genes and the informative genes are selected by using Entopy filtering.