Amanda Whitbrook

Grazziela P. Figueredo, Peer-Olaf Siebers, Uwe Aickelin et al.

Advances in healthcare and in the quality of life significantly increase human life expectancy. With the ageing of populations, new un-faced challenges are brought to science. The human body is naturally selected to be well-functioning until the age of reproduction to keep the species alive. However, as the lifespan extends, unseen problems due to the body deterioration emerge. There are several age-related diseases with no appropriate treatment; therefore, the complex ageing phenomena needs further understanding. Immunosenescence, the ageing of the immune system, is highly correlated to the negative effects of ageing, such as the increase of auto-inflammatory diseases and decrease in responsiveness to new diseases. Besides clinical and mathematical tools, we believe there is opportunity to further exploit simulation tools to understand immunosenescence. Compared to real-world experimentation, benefits include time and cost effectiveness due to the laborious, resource-intensiveness of the biological environment and the possibility of conducting experiments without ethic restrictions. Contrasted with mathematical models, simulation modelling is more suitable for representing complex systems and emergence. In addition, there is the belief that simulation models are easier to communicate in interdisciplinary contexts. Our work investigates the usefulness of simulations to understand immunosenescence by employing two different simulation methods, agent-based and system dynamics simulation, to a case study of immune cells depletion with age.

Qi Chen, Amanda Whitbrook, Uwe Aickelin et al.

In this paper, the Dempster-Shafer method is employed as the theoretical basis for creating data classification systems. Testing is carried out using three popular (multiple attribute) benchmark datasets that have two, three and four classes. In each case, a subset of the available data is used for training to establish thresholds, limits or likelihoods of class membership for each attribute, and hence create mass functions that establish probability of class membership for each attribute of the test data. Classification of each data item is achieved by combination of these probabilities via Dempster's Rule of Combination. Results for the first two datasets show extremely high classification accuracy that is competitive with other popular methods. The third dataset is non-numerical and difficult to classify, but good results can be achieved provided the system and mass functions are designed carefully and the right attributes are chosen for combination. In all cases the Dempster-Shafer method provides comparable performance to other more popular algorithms, but the overhead of generating accurate mass functions increases the complexity with the addition of new attributes. Overall, the results suggest that the D-S approach provides a suitable framework for the design of classification systems and that automating the mass function design and calculation would increase the viability of the algorithm for complex classification problems.

Amanda Whitbrook, Uwe Aickelin, Jonathan M. Garibaldi

In mobile robotics, a solid test for adaptation is the ability of a control system to function not only in a diverse number of physical environments, but also on a number of different robotic platforms. This paper demonstrates that a set of behaviours evolved in simulation on a miniature robot (epuck) can be transferred to a much larger-scale platform (Pioneer), both in simulation and in the real world. The chosen architecture uses artificial evolution of epuck behaviours to obtain a genetic sequence, which is then employed to seed an idiotypic, artificial immune system (AIS) on the Pioneers. Despite numerous hardware and software differences between the platforms, navigation and target-finding experiments show that the evolved behaviours transfer very well to the larger robot when the idiotypic AIS technique is used. In contrast, transferability is poor when reinforcement learning alone is used, which validates the adaptability of the chosen architecture.