Hector Zenil

Hector Zenil, Jesper Tegnér, Felipe S. Abrahão et al. · cambridge

Recent advances in machine learning and AI, including Generative AI and LLMs, are disrupting technological innovation, product development, and society as a whole. AI's contribution to technology can come from multiple approaches that require access to large training data sets and clear performance evaluation criteria, ranging from pattern recognition and classification to generative models. Yet, AI has contributed less to fundamental science in part because large data sets of high-quality data for scientific practice and model discovery are more difficult to access. Generative AI, in general, and Large Language Models in particular, may represent an opportunity to augment and accelerate the scientific discovery of fundamental deep science with quantitative models. Here we explore and investigate aspects of an AI-driven, automated, closed-loop approach to scientific discovery, including self-driven hypothesis generation and open-ended autonomous exploration of the hypothesis space. Integrating AI-driven automation into the practice of science would mitigate current problems, including the replication of findings, systematic production of data, and ultimately democratisation of the scientific process. Realising these possibilities requires a vision for augmented AI coupled with a diversity of AI approaches able to deal with fundamental aspects of causality analysis and model discovery while enabling unbiased search across the space of putative explanations. These advances hold the promise to unleash AI's potential for searching and discovering the fundamental structure of our world beyond what human scientists have been able to achieve. Such a vision would push the boundaries of new fundamental science rather than automatize current workflows and instead open doors for technological innovation to tackle some of the greatest challenges facing humanity today.

Hector Zenil, Alyssa Adams, Felipe S. Abrahão et al.

We present an agnostic signal reconstruction method for zero-knowledge one-way communication channels in which a receiver aims to interpret a message sent by an unknown source about which no prior knowledge is available and to which no return message can be sent. Our reconstruction method is agnostic vis-à-vis the arbitrarily chosen encoding-decoding scheme and other observer-dependent characteristics, such as the arbitrarily chosen computational model, probability distributions, or underlying mathematical theory. We investigate how non-random messages encode information about their intended physical properties, such as dimension and length scales of the space in which a signal or message may have been originally encoded, embedded, or generated. We focus on image data as a first illustration of the capabilities of the new method. We argue that our results have applications to life and technosignature detection, and to coding theory in general.

Jun Qi, Chao-Han Huck Yang, Pin-Yu Chen et al.

Hybrid quantum-classical learning models increasingly integrate neural networks with variational quantum circuits (VQCs) to exploit complementary inductive biases. However, many existing approaches rely on tightly coupled architectures or task-specific encoders, limiting conceptual clarity, generality, and transferability across learning settings. In this work, we introduce Quantum LEGO Learning, a modular and architecture-agnostic learning framework that treats classical and quantum components as reusable, composable learning blocks with well-defined roles. Within this framework, a pre-trained classical neural network serves as a frozen feature block, while a VQC acts as a trainable adaptive module that operates on structured representations rather than raw inputs. This separation enables efficient learning under constrained quantum resources and provides a principled abstraction for analyzing hybrid models. We develop a block-wise generalization theory that decomposes learning error into approximation and estimation components, explicitly characterizing how the complexity and training status of each block influence overall performance. Our analysis generalizes prior tensor-network-specific results and identifies conditions under which quantum modules provide representational advantages over comparably sized classical heads. Empirically, we validate the framework through systematic block-swap experiments across frozen feature extractors and both quantum and classical adaptive heads. Experiments on quantum dot classification demonstrate stable optimization, reduced sensitivity to qubit count, and robustness to realistic noise.

Haoling Zhang, Chao-Han Huck Yang, Hector Zenil et al.

NeuroEvolution is one of the most competitive evolutionary learning frameworks for designing novel neural networks for use in specific tasks, such as logic circuit design and digital gaming. However, the application of benchmark methods such as the NeuroEvolution of Augmenting Topologies (NEAT) remains a challenge, in terms of their computational cost and search time inefficiency. This paper advances a method which incorporates a type of topological edge coding, named Reverse Encoding Tree (RET), for evolving scalable neural networks efficiently. Using RET, two types of approaches -- NEAT with Binary search encoding (Bi-NEAT) and NEAT with Golden-Section search encoding (GS-NEAT) -- have been designed to solve problems in benchmark continuous learning environments such as logic gates, Cartpole, and Lunar Lander, and tested against classical NEAT and FS-NEAT as baselines. Additionally, we conduct a robustness test to evaluate the resilience of the proposed NEAT algorithms. The results show that the two proposed strategies deliver improved performance, characterized by (1) a higher accumulated reward within a finite number of time steps; (2) using fewer episodes to solve problems in targeted environments, and (3) maintaining adaptive robustness under noisy perturbations, which outperform the baselines in all tested cases. Our analysis also demonstrates that RET expends potential future research directions in dynamic environments. Code is available from https://github.com/HaolingZHANG/ReverseEncodingTree.

Hector Zenil

We formalise recursive self-training in Large Language Models (LLMs) and Generative AI as a discrete-time dynamical system. We prove that if the proportion of exogenous, externally grounded signal $α_t$ vanishes asymptotically ($α_t \to 0$), the system undergoes degenerative dynamics. We derive two fundamental failure modes: (1) \textit{Entropy Decay}, where finite sampling effects induce monotonic loss of distributional diversity, and (2) \textit{Variance Amplification}, where the absence of persistent grounding causes distributional drift via a random-walk mechanism. These behaviours are architectural invariants of distributional learning on finite samples. We show that the collapse results apply specifically to closed-loop density matching without persistent external signal. Systems with non-vanishing exogenous grounding fall outside this regime. However, mainstream Singularity, AGI, and ASI narratives typically posit systems that become increasingly autonomous and require little to no human or external intervention for self-improvement. In that autonomy regime, the vanishing-signal condition is satisfied, and collapse follows under KL-based objectives. To overcome these limits, we propose neurosymbolic integration based on algorithmic probability and program synthesis. The Coding Theorem Method (CTM) enables identification of generative mechanisms rather than mere correlations, escaping the distribution-only constraints that bind standard statistical learning. We conclude that fully autonomous recursive density matching leads to degenerative fixed points, whereas externally anchored or mechanism-based approaches operate under fundamentally different asymptotic dynamics.

Abbi Abdel-Rehim, Hector Zenil, Oghenejokpeme Orhobor et al.

Large language models LLMs have transformed AI and achieved breakthrough performance on a wide range of tasks In science the most interesting application of LLMs is for hypothesis formation A feature of LLMs which results from their probabilistic structure is that the output text is not necessarily a valid inference from the training text These are termed hallucinations and are harmful in many applications In science some hallucinations may be useful novel hypotheses whose validity may be tested by laboratory experiments Here we experimentally test the application of LLMs as a source of scientific hypotheses using the domain of breast cancer treatment We applied the LLM GPT4 to hypothesize novel synergistic pairs of FDA-approved noncancer drugs that target the MCF7 breast cancer cell line relative to the nontumorigenic breast cell line MCF10A In the first round of laboratory experiments GPT4 succeeded in discovering three drug combinations out of twelve tested with synergy scores above the positive controls GPT4 then generated new combinations based on its initial results this generated three more combinations with positive synergy scores out of four tested We conclude that LLMs are a valuable source of scientific hypotheses.

Yanbo Zhang, Sumeer A. Khan, Adnan Mahmud et al.

With recent Nobel Prizes recognising AI contributions to science, Large Language Models (LLMs) are transforming scientific research by enhancing productivity and reshaping the scientific method. LLMs are now involved in experimental design, data analysis, and workflows, particularly in chemistry and biology. However, challenges such as hallucinations and reliability persist. In this contribution, we review how Large Language Models (LLMs) are redefining the scientific method and explore their potential applications across different stages of the scientific cycle, from hypothesis testing to discovery. We conclude that, for LLMs to serve as relevant and effective creative engines and productivity enhancers, their deep integration into all steps of the scientific process should be pursued in collaboration and alignment with human scientific goals, with clear evaluation metrics. The transition to AI-driven science raises ethical questions about creativity, oversight, and responsibility. With careful guidance, LLMs could evolve into creative engines, driving transformative breakthroughs across scientific disciplines responsibly and effectively. However, the scientific community must also decide how much it leaves to LLMs to drive science, even when associations with 'reasoning', mostly currently undeserved, are made in exchange for the potential to explore hypothesis and solution regions that might otherwise remain unexplored by human exploration alone.

Alberto Hernández-Espinosa, Luan Ozelim, Felipe S. Abrahão et al.

We introduce an open-ended test grounded in algorithmic probability that can avoid benchmark contamination in the quantitative evaluation of frontier models in the context of their Artificial General Intelligence (AGI) and Superintelligence (ASI) claims. Unlike other tests, this test does not rely on statistical compression methods (such as GZIP or LZW), which are more closely related to Shannon entropy than to Kolmogorov complexity and are not able to test beyond simple pattern matching. The test challenges aspects of AI, in particular LLMs, related to features of intelligence of fundamental nature such as synthesis and model creation in the context of inverse problems (generating new knowledge from observation). We argue that metrics based on model abstraction and abduction (optimal Bayesian `inference') for predictive `planning' can provide a robust framework for testing intelligence, including natural intelligence (human and animal), narrow AI, AGI, and ASI. We found that LLM model versions tend to be fragile and incremental as a result of memorisation only with progress likely driven by the size of training data. The results were compared with a hybrid neurosymbolic approach that theoretically guarantees universal intelligence based on the principles of algorithmic probability and Kolmogorov complexity. The method outperforms LLMs in a proof-of-concept on short binary sequences. We prove that compression is equivalent and directly proportional to a system's predictive power and vice versa. That is, if a system can better predict it can better compress, and if it can better compress, then it can better predict. Our findings strengthen the suspicion regarding the fundamental limitations of LLMs, exposing them as systems optimised for the perception of mastery over human language.

Jun Qi, Chao-Han Yang, Samuel Yen-Chi Chen et al.

Quantum Machine Learning (QML) offers tremendous potential but is currently limited by the availability of qubits. We introduce an innovative approach that utilizes pre-trained neural networks to enhance Variational Quantum Circuits (VQC). This technique effectively separates approximation error from qubit count and removes the need for restrictive conditions, making QML more viable for real-world applications. Our method significantly improves parameter optimization for VQC while delivering notable gains in representation and generalization capabilities, as evidenced by rigorous theoretical analysis and extensive empirical testing on quantum dot classification tasks. Moreover, our results extend to applications such as human genome analysis, demonstrating the broad applicability of our approach. By addressing the constraints of current quantum hardware, our work paves the way for a new era of advanced QML applications, unlocking the full potential of quantum computing in fields such as machine learning, materials science, medicine, mimetics, and various interdisciplinary areas.

Hector Zenil, Felipe S. Abrahão, Luan C. S. M. Ozelim

Based on the principles of information theory, measure theory, and theoretical computer science, we introduce a signal deconvolution method with a wide range of applications to coding theory, particularly in zero-knowledge one-way communication channels, such as in deciphering messages (i.e., objects embedded into multidimensional spaces) from unknown generating sources about which no prior knowledge is available and to which no return message can be sent. Our multidimensional space reconstruction method from an arbitrary received signal is proven to be agnostic vis-à-vis the encoding-decoding scheme, computation model, programming language, formal theory, the computable (or semi-computable) method of approximation to algorithmic complexity, and any arbitrarily chosen (computable) probability measure. The method derives from the principles of an approach to Artificial General Intelligence (AGI) capable of building a general-purpose model of models independent of any arbitrarily assumed prior probability distribution. We argue that this optimal and universal method of decoding non-random data has applications to signal processing, causal deconvolution, topological and geometric properties encoding, cryptography, and bio- and technosignature detection.

Eduardo Y. Sakabe, Felipe S. Abrahão, Alexandre Simões et al.

Understanding and controlling the informational complexity of neural networks is a central challenge in machine learning, with implications for generalization, optimization, and model capacity. While most approaches rely on entropy-based loss functions and statistical metrics, these measures often fail to capture deeper, causally relevant algorithmic regularities embedded in network structure. We propose a shift toward algorithmic information theory, using Binarized Neural Networks (BNNs) as a first proxy. Grounded in algorithmic probability (AP) and the universal distribution it defines, our approach characterizes learning dynamics through a formal, causally grounded lens. We apply the Block Decomposition Method (BDM) -- a scalable approximation of algorithmic complexity based on AP -- and demonstrate that it more closely tracks structural changes during training than entropy, consistently exhibiting stronger correlations with training loss across varying model sizes and randomized training runs. These results support the view of training as a process of algorithmic compression, where learning corresponds to the progressive internalization of structured regularities. In doing so, our work offers a principled estimate of learning progression and suggests a framework for complexity-aware learning and regularization, grounded in first principles from information theory, complexity, and computability.

Alberto Hernández-Espinosa, Felipe S. Abrahão, Olaf Witkowski et al.

The AI alignment problem, which focusses on ensuring that artificial intelligence (AI), including AGI and ASI, systems act according to human values, presents profound challenges. With the progression from narrow AI to Artificial General Intelligence (AGI) and Superintelligence, fears about control and existential risk have escalated. Here, we investigate whether embracing inevitable AI misalignment can be a contingent strategy to foster a dynamic ecosystem of competing agents as a viable path to steer them in more human-aligned trends and mitigate risks. We explore how misalignment may serve and should be promoted as a counterbalancing mechanism to team up with whichever agents are most aligned to human interests, ensuring that no single system dominates destructively. The main premise of our contribution is that misalignment is inevitable because full AI-human alignment is a mathematical impossibility from Turing-complete systems, which we also offer as a proof in this contribution, a feature then inherited to AGI and ASI systems. We introduce a change-of-opinion attack test based on perturbation and intervention analysis to study how humans and agents may change or neutralise friendly and unfriendly AIs through cooperation and competition. We show that open models are more diverse and that most likely guardrails implemented in proprietary models are successful at controlling some of the agents' range of behaviour with positive and negative consequences while closed systems are more steerable and can also be used against proprietary AI systems. We also show that human and AI intervention has different effects hence suggesting multiple strategies.

Felipe S. Abrahão, Hector Zenil, Fabio Porto et al.

When mining large datasets in order to predict new data, limitations of the principles behind statistical machine learning pose a serious challenge not only to the Big Data deluge, but also to the traditional assumptions that data generating processes are biased toward low algorithmic complexity. Even when one assumes an underlying algorithmic-informational bias toward simplicity in finite dataset generators, we show that current approaches to machine learning (including deep learning, or any formal-theoretic hybrid mix of top-down AI and statistical machine learning approaches), can always be deceived, naturally or artificially, by sufficiently large datasets. In particular, we demonstrate that, for every learning algorithm (with or without access to a formal theory), there is a sufficiently large dataset size above which the algorithmic probability of an unpredictable deceiver is an upper bound (up to a multiplicative constant that only depends on the learning algorithm) for the algorithmic probability of any other larger dataset. In other words, very large and complex datasets can deceive learning algorithms into a ``simplicity bubble'' as likely as any other particular non-deceiving dataset. These deceiving datasets guarantee that any prediction effected by the learning algorithm will unpredictably diverge from the high-algorithmic-complexity globally optimal solution while converging toward the low-algorithmic-complexity locally optimal solution, although the latter is deemed a global one by the learning algorithm. We discuss the framework and additional empirical conditions to be met in order to circumvent this deceptive phenomenon, moving away from statistical machine learning towards a stronger type of machine learning based on, and motivated by, the intrinsic power of algorithmic information theory and computability theory.

Alexander Lavin, David Krakauer, Hector Zenil et al.

The original "Seven Motifs" set forth a roadmap of essential methods for the field of scientific computing, where a motif is an algorithmic method that captures a pattern of computation and data movement. We present the "Nine Motifs of Simulation Intelligence", a roadmap for the development and integration of the essential algorithms necessary for a merger of scientific computing, scientific simulation, and artificial intelligence. We call this merger simulation intelligence (SI), for short. We argue the motifs of simulation intelligence are interconnected and interdependent, much like the components within the layers of an operating system. Using this metaphor, we explore the nature of each layer of the simulation intelligence operating system stack (SI-stack) and the motifs therein: (1) Multi-physics and multi-scale modeling; (2) Surrogate modeling and emulation; (3) Simulation-based inference; (4) Causal modeling and inference; (5) Agent-based modeling; (6) Probabilistic programming; (7) Differentiable programming; (8) Open-ended optimization; (9) Machine programming. We believe coordinated efforts between motifs offers immense opportunity to accelerate scientific discovery, from solving inverse problems in synthetic biology and climate science, to directing nuclear energy experiments and predicting emergent behavior in socioeconomic settings. We elaborate on each layer of the SI-stack, detailing the state-of-art methods, presenting examples to highlight challenges and opportunities, and advocating for specific ways to advance the motifs and the synergies from their combinations. Advancing and integrating these technologies can enable a robust and efficient hypothesis-simulation-analysis type of scientific method, which we introduce with several use-cases for human-machine teaming and automated science.

Hector Zenil

At the intersection of what I call uncomputable art and computational epistemology, a form of experimental philosophy, we find an exciting and promising area of science related to causation with an alternative, possibly best possible, solution to the challenge of the inverse problem. That is the problem of finding the possible causes, mechanistic origins, first principles, and generative models of a piece of data from a physical phenomenon. Here we explain how generating and exploring software space following the framework of Algorithmic Information Dynamics, it is possible to find small models and learn to navigate a sci-fi-looking space that can advance the field of scientific discovery with complementary tools to offer an opportunity to advance science itself.

Santiago Hernández-Orozco, Hector Zenil, Jürgen Riedel et al.

We show how complexity theory can be introduced in machine learning to help bring together apparently disparate areas of current research. We show that this new approach requires less training data and is more generalizable as it shows greater resilience to random attacks. We investigate the shape of the discrete algorithmic space when performing regression or classification using a loss function parametrized by algorithmic complexity, demonstrating that the property of differentiation is not necessary to achieve results similar to those obtained using differentiable programming approaches such as deep learning. In doing so we use examples which enable the two approaches to be compared (small, given the computational power required for estimations of algorithmic complexity). We find and report that (i) machine learning can successfully be performed on a non-smooth surface using algorithmic complexity; (ii) that parameter solutions can be found using an algorithmic-probability classifier, establishing a bridge between a fundamentally discrete theory of computability and a fundamentally continuous mathematical theory of optimization methods; (iii) a formulation of an algorithmically directed search technique in non-smooth manifolds can be defined and conducted; (iv) exploitation techniques and numerical methods for algorithmic search to navigate these discrete non-differentiable spaces can be performed; in application of the (a) identification of generative rules from data observations; (b) solutions to image classification problems more resilient against pixel attacks compared to neural networks; (c) identification of equation parameters from a small data-set in the presence of noise in continuous ODE system problem, (d) classification of Boolean NK networks by (1) network topology, (2) underlying Boolean function, and (3) number of incoming edges.

Rise Ooi, Chao-Han Huck Yang, Pin-Yu Chen et al.

Networks are fundamental building blocks for representing data, and computations. Remarkable progress in learning in structurally defined (shallow or deep) networks has recently been achieved. Here we introduce evolutionary exploratory search and learning method of topologically flexible networks under the constraint of producing elementary computational steady-state input-output operations. Our results include; (1) the identification of networks, over four orders of magnitude, implementing computation of steady-state input-output functions, such as a band-pass filter, a threshold function, and an inverse band-pass function. Next, (2) the learned networks are technically controllable as only a small number of driver nodes are required to move the system to a new state. Furthermore, we find that the fraction of required driver nodes is constant during evolutionary learning, suggesting a stable system design. (3), our framework allows multiplexing of different computations using the same network. For example, using a binary representation of the inputs, the network can readily compute three different input-output functions. Finally, (4) the proposed evolutionary learning demonstrates transfer learning. If the system learns one function A, then learning B requires on average less number of steps as compared to learning B from tabula rasa. We conclude that the constrained evolutionary learning produces large robust controllable circuits, capable of multiplexing and transfer learning. Our study suggests that network-based computations of steady-state functions, representing either cellular modules of cell-to-cell communication networks or internal molecular circuits communicating within a cell, could be a powerful model for biologically inspired computing. This complements conceptualizations such as attractor based models, or reservoir computing.

Hector Zenil, Narsis A. Kiani, Allan A. Zea et al.

Complex data usually results from the interaction of objects produced by different generating mechanisms. Here we introduce a universal, unsupervised and parameter-free model-oriented approach, based upon the seminal concept of algorithmic probability, that decomposes an observation into its most likely algorithmic generative sources. Our approach uses a causal calculus to infer model representations. We demonstrate its ability to deconvolve interacting mechanisms regardless of whether the resultant objects are strings, space-time evolution diagrams, images or networks. While this is mostly a conceptual contribution and a novel framework, we provide numerical evidence evaluating the ability of our methods to separate data from observations produced by discrete dynamical systems such as cellular automata and complex networks. We think that these separating techniques can contribute to tackling the challenge of causation, thus complementing other statistically oriented approaches.

Hector Zenil, Liliana Badillo, Santiago Hernández-Orozco et al.

Previously referred to as `miraculous' in the scientific literature because of its powerful properties and its wide application as optimal solution to the problem of induction/inference, (approximations to) Algorithmic Probability (AP) and the associated Universal Distribution are (or should be) of the greatest importance in science. Here we investigate the emergence, the rates of emergence and convergence, and the Coding-theorem like behaviour of AP in Turing-subuniversal models of computation. We investigate empirical distributions of computing models in the Chomsky hierarchy. We introduce measures of algorithmic probability and algorithmic complexity based upon resource-bounded computation, in contrast to previously thoroughly investigated distributions produced from the output distribution of Turing machines. This approach allows for numerical approximations to algorithmic (Kolmogorov-Chaitin) complexity-based estimations at each of the levels of a computational hierarchy. We demonstrate that all these estimations are correlated in rank and that they converge both in rank and values as a function of computational power, despite fundamental differences between computational models. In the context of natural processes that operate below the Turing universal level because of finite resources and physical degradation, the investigation of natural biases stemming from algorithmic rules may shed light on the distribution of outcomes. We show that up to 60\% of the simplicity/complexity bias in distributions produced even by the weakest of the computational models can be accounted for by Algorithmic Probability in its approximation to the Universal Distribution.

Santiago Hernández-Orozco, Narsis A. Kiani, Hector Zenil

Natural selection explains how life has evolved over millions of years from more primitive forms. The speed at which this happens, however, has sometimes defied formal explanations when based on random (uniformly distributed) mutations. Here we investigate the application of a simplicity bias based on a natural but algorithmic distribution of mutations (no recombination) in various examples, particularly binary matrices in order to compare evolutionary convergence rates. Results both on synthetic and on small biological examples indicate an accelerated rate when mutations are not statistical uniform but \textit{algorithmic uniform}. We show that algorithmic distributions can evolve modularity and genetic memory by preservation of structures when they first occur sometimes leading to an accelerated production of diversity but also population extinctions, possibly explaining naturally occurring phenomena such as diversity explosions (e.g. the Cambrian) and massive extinctions (e.g. the End Triassic) whose causes are currently a cause for debate. The natural approach introduced here appears to be a better approximation to biological evolution than models based exclusively upon random uniform mutations, and it also approaches a formal version of open-ended evolution based on previous formal results. These results validate some suggestions in the direction that computation may be an equally important driver of evolution. We also show that inducing the method on problems of optimization, such as genetic algorithms, has the potential to accelerate convergence of artificial evolutionary algorithms.

Hector Zenil

Reprogramming matter may sound far-fetched, but we have been doing it with increasing power and staggering efficiency for at least 60 years, and for centuries we have been paving the way toward the ultimate reprogrammed fate of the universe, the vessel of all programs. How will we be doing it in 60 years' time and how will it impact life and the purpose both of machines and of humans?

Alyssa M Adams, Hector Zenil, Paul CW Davies et al.

Open-ended evolution (OEE) is relevant to a variety of biological, artificial and technological systems, but has been challenging to reproduce in silico. Most theoretical efforts focus on key aspects of open-ended evolution as it appears in biology. We recast the problem as a more general one in dynamical systems theory, providing simple criteria for open-ended evolution based on two hallmark features: unbounded evolution and innovation. We define unbounded evolution as patterns that are non-repeating within the expected Poincare recurrence time of an equivalent isolated system, and innovation as trajectories not observed in isolated systems. As a case study, we implement novel variants of cellular automata (CA) in which the update rules are allowed to vary with time in three alternative ways. Each is capable of generating conditions for open-ended evolution, but vary in their ability to do so. We find that state-dependent dynamics, widely regarded as a hallmark of life, statistically out-performs other candidate mechanisms, and is the only mechanism to produce open-ended evolution in a scalable manner, essential to the notion of ongoing evolution. This analysis suggests a new framework for unifying mechanisms for generating OEE with features distinctive to life and its artifacts, with broad applicability to biological and artificial systems.

Alyssa Adams, Hector Zenil, Eduardo Hermo Reyes et al.

Can we quantify the change of complexity throughout evolutionary processes? We attempt to address this question through an empirical approach. In very general terms, we simulate two simple organisms on a computer that compete over limited available resources. We implement Global Rules that determine the interaction between two Elementary Cellular Automata on the same grid. Global Rules change the complexity of the state evolution output which suggests that some complexity is intrinsic to the interaction rules themselves. The largest increases in complexity occurred when the interacting elementary rules had very little complexity, suggesting that they are able to accept complexity through interaction only. We also found that some Class 3 or 4 CA rules are more fragile than others to Global Rules, while others are more robust, hence suggesting some intrinsic properties of the rules independent of the Global Rule choice. We provide statistical mappings of Elementary Cellular Automata exposed to Global Rules and different initial conditions onto different complexity classes.

Nicolas Gauvrit, Fernando Soler-Toscano, Hector Zenil

Humans are sensitive to complexity and regularity in patterns. The subjective perception of pattern complexity is correlated to algorithmic (Kolmogorov-Chaitin) complexity as defined in computer science, but also to the frequency of naturally occurring patterns. However, the possible mediational role of natural frequencies in the perception of algorithmic complexity remains unclear. Here we reanalyze Hsu et al. (2010) through a mediational analysis, and complement their results in a new experiment. We conclude that human perception of complexity seems partly shaped by natural scenes statistics, thereby establishing a link between the perception of complexity and the effect of natural scene statistics.

Hector Zenil, Angelika Schmidt, Jesper Tegnér

Biology has taken strong steps towards becoming a computer science aiming at reprogramming nature after the realisation that nature herself has reprogrammed organisms by harnessing the power of natural selection and the digital prescriptive nature of replicating DNA. Here we further unpack ideas related to computability, algorithmic information theory and software engineering, in the context of the extent to which biology can be (re)programmed, and with how we may go about doing so in a more systematic way with all the tools and concepts offered by theoretical computer science in a translation exercise from computing to molecular biology and back. These concepts provide a means to a hierarchical organization thereby blurring previously clear-cut lines between concepts like matter and life, or between tumour types that are otherwise taken as different and may not have however a different cause. This does not diminish the properties of life or make its components and functions less interesting. On the contrary, this approach makes for a more encompassing and integrated view of nature, one that subsumes observer and observed within the same system, and can generate new perspectives and tools with which to view complex diseases like cancer, approaching them afresh from a software-engineering viewpoint that casts evolution in the role of programmer, cells as computing machines, DNA and genes as instructions and computer programs, viruses as hacking devices, the immune system as a software debugging tool, and diseases as an information-theoretic battlefield where all these forces deploy. We show how information theory and algorithmic programming may explain fundamental mechanisms of life and death.

Santiago Hernández-Orozco, Francisco Hernández-Quiroz, Hector Zenil et al.

We show that strategies implemented in automatic theorem proving involve an interesting tradeoff between execution speed, proving speedup/computational time and usefulness of information. We advance formal definitions for these concepts by way of a notion of normality related to an expected (optimal) theoretical speedup when adding useful information (other theorems as axioms), as compared with actual strategies that can be effectively and efficiently implemented. We propose the existence of an ineluctable tradeoff between this normality and computational time complexity. The argument quantifies the usefulness of information in terms of (positive) speed-up. The results disclose a kind of no-free-lunch scenario and a tradeoff of a fundamental nature. The main theorem in this paper together with the numerical experiment---undertaken using two different automatic theorem provers AProS and Prover9 on random theorems of propositional logic---provide strong theoretical and empirical arguments for the fact that finding new useful information for solving a specific problem (theorem) is, in general, as hard as the problem (theorem) itself.

Nicolas Gauvrit, Hector Zenil, Jesper Tegnér

We survey concepts at the frontier of research connecting artificial, animal and human cognition to computation and information processing---from the Turing test to Searle's Chinese Room argument, from Integrated Information Theory to computational and algorithmic complexity. We start by arguing that passing the Turing test is a trivial computational problem and that its pragmatic difficulty sheds light on the computational nature of the human mind more than it does on the challenge of artificial intelligence. We then review our proposed algorithmic information-theoretic measures for quantifying and characterizing cognition in various forms. These are capable of accounting for known biases in human behavior, thus vindicating a computational algorithmic view of cognition as first suggested by Turing, but this time rooted in the concept of algorithmic probability, which in turn is based on computational universality while being independent of computational model, and which has the virtue of being predictive and testable as a model theory of cognitive behavior.

Hector Zenil

One of the most important aims of the fields of robotics, artificial intelligence and artificial life is the design and construction of systems and machines as versatile and as reliable as living organisms at performing high level human-like tasks. But how are we to evaluate artificial systems if we are not certain how to measure these capacities in living systems, let alone how to define life or intelligence? Here I survey a concrete metric towards measuring abstract properties of natural and artificial systems, such as the ability to react to the environment and to control one's own behaviour.

German Terrazas, Hector Zenil, Natalio Krasnogor

Self-assembly is a phenomenon observed in nature at all scales where autonomous entities build complex structures, without external influences nor centralised master plan. Modelling such entities and programming correct interactions among them is crucial for controlling the manufacture of desired complex structures at the molecular and supramolecular scale. This work focuses on a programmability model for non DNA-based molecules and complex behaviour analysis of their self-assembled conformations. In particular, we look into modelling, programming and simulation of porphyrin molecules self-assembly and apply Kolgomorov complexity-based techniques to classify and assess simulation results in terms of information content. The analysis focuses on phase transition, clustering, variability and parameter discovery which as a whole pave the way to the notion of complex systems programmability.

Hector Zenil

What does it mean to claim that a physical or natural system computes? One answer, endorsed here, is that computing is about programming a system to behave in different ways. This paper offers an account of what it means for a physical system to compute based on this notion. It proposes a behavioural characterisation of computing in terms of a measure of programmability, which reflects a system's ability to react to external stimuli. The proposed measure of programmability is useful for classifying computers in terms of the apparent algorithmic complexity of their evolution in time. I make some specific proposals in this connection and discuss this approach in the context of other behavioural approaches, notably Turing's test of machine intelligence. I also anticipate possible objections and consider the applicability of these proposals to the task of relating abstract computation to nature-like computation.