Song Wu

Pinjun Luo, Guoqiang Xiao, Xinbo Gao et al.

The deep convolutional neural networks (CNNs)-based single image dehazing methods have achieved significant success. The previous methods are devoted to improving the network's performance by increasing the network's depth and width. The current methods focus on increasing the convolutional kernel size to enhance its performance by benefiting from the larger receptive field. However, directly increasing the size of the convolutional kernel introduces a massive amount of computational overhead and parameters. Thus, a novel Large Kernel Convolution Dehaze Block (LKD Block) consisting of the Decomposition deep-wise Large Kernel Convolution Block (DLKCB) and the Channel Enhanced Feed-forward Network (CEFN) is devised in this paper. The designed DLKCB can split the deep-wise large kernel convolution into a smaller depth-wise convolution and a depth-wise dilated convolution without introducing massive parameters and computational overhead. Meanwhile, the designed CEFN incorporates a channel attention mechanism into Feed-forward Network to exploit significant channels and enhance robustness. By combining multiple LKD Blocks and Up-Down sampling modules, the Large Kernel Convolution Dehaze Network (LKD-Net) is conducted. The evaluation results demonstrate the effectiveness of the designed DLKCB and CEFN, and our LKD-Net outperforms the state-of-the-art. On the SOTS indoor dataset, our LKD-Net dramatically outperforms the Transformer-based method Dehamer with only 1.79% #Param and 48.9% FLOPs. The source code of our LKD-Net is available at https://github.com/SWU-CS-MediaLab/LKD-Net.

Song Wu, Kaichao You, Weihua He et al.

Video frame interpolation is a challenging task due to the ever-changing real-world scene. Previous methods often calculate the bi-directional optical flows and then predict the intermediate optical flows under the linear motion assumptions, leading to isotropic intermediate flow generation. Follow-up research obtained anisotropic adjustment through estimated higher-order motion information with extra frames. Based on the motion assumptions, their methods are hard to model the complicated motion in real scenes. In this paper, we propose an end-to-end training method A^2OF for video frame interpolation with event-driven Anisotropic Adjustment of Optical Flows. Specifically, we use events to generate optical flow distribution masks for the intermediate optical flow, which can model the complicated motion between two frames. Our proposed method outperforms the previous methods in video frame interpolation, taking supervised event-based video interpolation to a higher stage.

Wuyang Lan, Wenzheng Wang, Changwei Ji et al.

Recent advances in reasoning with large language models (LLMs)has shown remarkable reasoning capabilities in domains such as mathematics and coding, yet their application to clinical diagnosis remains underexplored. Here, we introduce ClinicalGPT-R1, a reasoning enhanced generalist large language model for disease diagnosis. Trained on a dataset of 20,000 real-world clinical records, ClinicalGPT-R1 leverages diverse training strategies to enhance diagnostic reasoning. To benchmark performance, we curated MedBench-Hard, a challenging dataset spanning seven major medical specialties and representative diseases. Experimental results demonstrate that ClinicalGPT-R1 outperforms GPT-4o in Chinese diagnostic tasks and achieves comparable performance to GPT-4 in English settings. This comparative study effectively validates the superior performance of ClinicalGPT-R1 in disease diagnosis tasks. Resources are available at https://github.com/medfound/medfound.

Ziyu Fan, Zhijian Huang, Yahan Li et al.

Property-constrained molecular generation and editing are crucial in AI-driven drug discovery but remain hindered by two factors: (i) capturing the complex relationships between molecular structures and multiple properties remains challenging, and (ii) the narrow coverage and incomplete annotations of molecular properties weaken the effectiveness of property-based models. To tackle these limitations, we propose HSPAG, a data-efficient framework featuring hierarchical structure-property alignment. By treating SMILES and molecular properties as complementary modalities, the model learns their relationships at atom, substructure, and whole-molecule levels. Moreover, we select representative samples through scaffold clustering and hard samples via an auxiliary variational auto-encoder (VAE), substantially reducing the required pre-training data. In addition, we incorporate a property relevance-aware masking mechanism and diversified perturbation strategies to enhance generation quality under sparse annotations. Experiments demonstrate that HSPAG captures fine-grained structure-property relationships and supports controllable generation under multiple property constraints. Two real-world case studies further validate the editing capabilities of HSPAG.

Jiajian Ma, Fangqi Lu, Silin Huang et al.

Inpainting lesions within different normal backgrounds is a potential method of addressing the generalization problem, which is crucial for polyp segmentation models. However, seamlessly introducing polyps into complex endoscopic environments while simultaneously generating accurate pseudo-masks remains a challenge for current inpainting methods. To address these issues, we first leverage the pre-trained Stable Diffusion Inpaint and ControlNet, to introduce a robust generative model capable of inpainting polyps across different backgrounds. Secondly, we utilize the prior that synthetic polyps are confined to the inpainted region, to establish an inpainted region-guided pseudo-mask refinement network. We also propose a sample selection strategy that prioritizes well-aligned and hard synthetic cases for further model fine-tuning. Experiments demonstrate that our inpainting model outperformed baseline methods both qualitatively and quantitatively in inpainting quality. Moreover, our data augmentation strategy significantly enhances the performance of polyp segmentation models on external datasets, achieving or surpassing the level of fully supervised training benchmarks in that domain. Our code is available at https://github.com/497662892/PolypInpainter.

Weibing Zhao, Xu Yan, Jiantao Gao et al.

Point Cloud Sampling and Recovery (PCSR) is critical for massive real-time point cloud collection and processing since raw data usually requires large storage and computation. In this paper, we address a fundamental problem in PCSR: How to downsample the dense point cloud with arbitrary scales while preserving the local topology of discarding points in a case-agnostic manner (i.e. without additional storage for point relationship)? We propose a novel Locally Invertible Embedding for point cloud adaptive sampling and recovery (PointLIE). Instead of learning to predict the underlying geometry details in a seemingly plausible manner, PointLIE unifies point cloud sampling and upsampling to one single framework through bi-directional learning. Specifically, PointLIE recursively samples and adjusts neighboring points on each scale. Then it encodes the neighboring offsets of sampled points to a latent space and thus decouples the sampled points and the corresponding local geometric relationship. Once the latent space is determined and that the deep model is optimized, the recovery process could be conducted by passing the recover-pleasing sampled points and a randomly-drawn embedding to the same network through an invertible operation. Such a scheme could guarantee the fidelity of dense point recovery from sampled points. Extensive experiments demonstrate that the proposed PointLIE outperforms state-of-the-arts both quantitatively and qualitatively. Our code is released through https://github.com/zwb0/PointLIE.

Yuncheng Jiang, Zixun Zhang, Yiwen Hu et al.

Accurate polyp detection is critical for early colorectal cancer diagnosis. Although remarkable progress has been achieved in recent years, the complex colon environment and concealed polyps with unclear boundaries still pose severe challenges in this area. Existing methods either involve computationally expensive context aggregation or lack prior modeling of polyps, resulting in poor performance in challenging cases. In this paper, we propose the Enhanced CenterNet with Contrastive Learning (ECC-PolypDet), a two-stage training \& end-to-end inference framework that leverages images and bounding box annotations to train a general model and fine-tune it based on the inference score to obtain a final robust model. Specifically, we conduct Box-assisted Contrastive Learning (BCL) during training to minimize the intra-class difference and maximize the inter-class difference between foreground polyps and backgrounds, enabling our model to capture concealed polyps. Moreover, to enhance the recognition of small polyps, we design the Semantic Flow-guided Feature Pyramid Network (SFFPN) to aggregate multi-scale features and the Heatmap Propagation (HP) module to boost the model's attention on polyp targets. In the fine-tuning stage, we introduce the IoU-guided Sample Re-weighting (ISR) mechanism to prioritize hard samples by adaptively adjusting the loss weight for each sample during fine-tuning. Extensive experiments on six large-scale colonoscopy datasets demonstrate the superiority of our model compared with previous state-of-the-art detectors.

Yuci Liang, Xinheng Lyu, Wenting Chen et al.

Recent advancements in computational pathology have produced patch-level Multi-modal Large Language Models (MLLMs), but these models are limited by their inability to analyze whole slide images (WSIs) comprehensively and their tendency to bypass crucial morphological features that pathologists rely on for diagnosis. To address these challenges, we first introduce WSI-Bench, a large-scale morphology-aware benchmark containing 180k VQA pairs from 9,850 WSIs across 30 cancer types, designed to evaluate MLLMs' understanding of morphological characteristics crucial for accurate diagnosis. Building upon this benchmark, we present WSI-LLaVA, a novel framework for gigapixel WSI understanding that employs a three-stage training approach: WSI-text alignment, feature space alignment, and task-specific instruction tuning. To better assess model performance in pathological contexts, we develop two specialized WSI metrics: WSI-Precision and WSI-Relevance. Experimental results demonstrate that WSI-LLaVA outperforms existing models across all capability dimensions, with a significant improvement in morphological analysis, establishing a clear correlation between morphological understanding and diagnostic accuracy.

Ante Wang, Yujie Lin, Jingyao Liu et al.

Critical thinking is essential for building robust AI systems, preventing them from blindly accepting flawed data or biased reasoning. However, prior work has primarily focused on passive critical thinking, where models simply reject problematic queries without taking constructive steps to address user requests. In this work, we introduce proactive critical thinking, a paradigm where models actively seek missing or clarifying information from users to resolve their queries better. To evaluate this capability, we present GSM-MC and GSM-MCE, two novel benchmarks based on GSM8K for assessing mathematical reasoning under incomplete or misleading conditions. GSM-MC contains 1,368 math problems with a key variable deliberately removed, requiring models to identify and request the missing information. GSM-MCE further increases the difficulty by introducing irrelevant details to test robustness against distractions. Experiments on Qwen3 and Llama series models show that, while these models excel in traditional reasoning tasks due to extensive post-training and inference-time scaling, they struggle with proactive critical thinking, especially smaller ones. However, we demonstrate that reinforcement learning (RL) can significantly improve this ability. Using our enhanced RL algorithm, we achieve substantial gains, boosting the Qwen3-1.7B's accuracy from 0.15% to 73.98% on GSM-MC. We hope this work advances models that collaborate more effectively with users in problem-solving through proactive critical thinking.

Yihan Pan, Zhenghang Xu, Jin Guang et al.

We collaborate with a large teaching hospital in Shenzhen, China and build a high-fidelity simulation model for its ultrasound center to predict key performance metrics, including the distributions of queue length, waiting time and sojourn time, with high accuracy. The key challenge to build an accurate simulation model is to understanding the complicated patient routing at the ultrasound center. To address the issue, we propose a novel two-level routing component to the queueing network model. We apply machine learning tools to calibrate the key components of the queueing model from data with enhanced accuracy.