Zero-Shot Contrastive Loss for Text-Guided Diffusion Image Style TransferSerin Yang, Hyunmin Hwang, Jong Chul Ye
Diffusion models have shown great promise in text-guided image style transfer, but there is a trade-off between style transformation and content preservation due to their stochastic nature. Existing methods require computationally expensive fine-tuning of diffusion models or additional neural network. To address this, here we propose a zero-shot contrastive loss for diffusion models that doesn't require additional fine-tuning or auxiliary networks. By leveraging patch-wise contrastive loss between generated samples and original image embeddings in the pre-trained diffusion model, our method can generate images with the same semantic content as the source image in a zero-shot manner. Our approach outperforms existing methods while preserving content and requiring no additional training, not only for image style transfer but also for image-to-image translation and manipulation. Our experimental results validate the effectiveness of our proposed method.
5.9CLMar 20Code
Dementia-R1: Reinforced Pretraining and Reasoning from Unstructured Clinical Notes for Real-World Dementia PrognosisChoonghan Kim, Hyunmin Hwang, Hangeol Chang et al.
While Large Language Models (LLMs) have shown strong performance on clinical text understanding, they struggle with longitudinal prediction tasks such as dementia prognosis, which require reasoning over complex, non-monotonic symptom trajectories across multiple visits. Standard supervised training lacks explicit annotations for symptom evolution, while direct Reinforcement Learning (RL) is hindered by sparse binary rewards. To address this challenge, we introduce Dementia-R1, an RL-based framework for longitudinal dementia prognosis from unstructured clinical notes. Our approach adopts a Cold-Start RL strategy that pre-trains the model to predict verifiable clinical indices extracted from patient histories, enhancing the capability to reason about disease progression before determining the final clinical status. Extensive experiments show that Dementia-R1 achieves the best overall performance on the AMC real-world unstructured cohort, reaching an AUROC of 84.02% and outperforming models up to 10x larger. The framework also generalizes to Parkinson's disease dementia prediction in an independent hospital cohort, achieving an AUROC of 78.37%. On the ADNI benchmark, our 7B model attains the highest AUROC among all LLM baselines at 83.17%, demonstrating strong longitudinal reasoning over fluctuating cognitive trajectories. Code is available at https://anonymous.4open.science/r/dementiar1-CDB5.
AgentPSO: Evolving Agent Reasoning Skill via Multi-agent Particle Swarm OptimizationHyunmin Hwang, Jaemin Kim, Choonghan Kim et al.
Multi-agent reasoning has shown promise for improving the problem-solving ability of large language models by allowing multiple agents to explore diverse reasoning paths. However, most existing multi-agent methods rely on inference-time debate or aggregation, which can be vulnerable to incorrect peer influence and biased consensus. Moreover, the agents themselves remain static, as their underlying reasoning skills do not evolve across tasks. In this paper, we introduce AgentPSO, a particle-swarm-inspired framework for evolving multi-agent reasoning skills. AgentPSO treats each agent as a particle-like reasoner whose state is a natural-language skill and whose velocity is a semantic update direction, iteratively moving agents toward stronger skill states to improve both individual and collective reasoning performance. Across training iterations, each agent updates its skill by combining its previous velocity, personal-best skill, global-best skill, and a self-reflective direction derived from peer reasoning trajectories. This enables agents to learn reusable reasoning behaviors from both their own experiences and the strongest skills discovered by the population, without updating the parameters of the backbone language model. Experiments on mathematical and general reasoning benchmarks show that AgentPSO improves over static single-agent skills and test-time-only multi-agent reasoning baselines. The evolved skills further transfer across benchmarks and to another backbone model, suggesting that AgentPSO captures reusable reasoning procedures rather than merely optimizing benchmark-specific prompts. Code is open-sourced at https://github.com/HYUNMIN-HWANG/AgentPSO/.
PACE-RAG: Patient-Aware Contextual and Evidence-based Policy RAG for Clinical Drug RecommendationChaeyoung Huh, Hyunmin Hwang, Jung Hwan Shin et al.
Drug recommendation requires a deep understanding of individual patient context, especially for complex conditions like Parkinson's disease. While LLMs possess broad medical knowledge, they fail to capture the subtle nuances of actual prescribing patterns. Existing RAG methods also struggle with these complexities because guideline-based retrieval remains too generic and similar-patient retrieval often replicates majority patterns without accounting for the unique clinical nuances of individual patients. To bridge this gap, we propose PACE-RAG (Patient-Aware Contextual and Evidence-based Policy RAG), a novel framework designed to synthesize individual patient context with the prescribing tendencies of similar cases. By analyzing treatment patterns tailored to specific clinical signals, PACE-RAG identifies optimal prescriptions and generates an explainable clinical summary. Evaluated on a Parkinson's cohort and the MIMIC-IV benchmark using Llama-3.1-8B and Qwen3-8B, PACE-RAG achieved state-of-the-art performance, reaching F1 scores of 80.84% and 47.22%, respectively. These results validate PACE-RAG as a robust, clinically grounded solution for personalized decision support. Our code is available at: https://github.com/ChaeYoungHuh/PACE-RAG.