Bob Junyi Zou

Bob Junyi Zou, Sai Li, Tianyun Sun et al.

A fundamental challenge in recommender systems is balancing reliability for Low-Active Users (LAUs) with diversity for High-Active Users (HAUs). The key to this balance lies in quantifying model uncertainty, which approximates the risk of prediction errors and reveals the limits of the model's current knowledge. On large-scale short-video and livestream platforms, model uncertainty can warn of low-quality recommendations that may lead to disengagement of LAUs and at the same time identify opportunities to diversify content recommendation for HAUs. To leverage this dichotomy, we introduce a unified, production-ready framework that calibrates uncertainty to drive differentiated strategies. Specifically, we implement a model-uncertainty-based risk-averse deboosting policy for LAUs to suppress unreliable recommendations, while employing a risk-seeking Upper Confidence Bound (UCB) strategy for HAUs to encourage exploration. Validated on a major livestream platform, our framework demonstrates significant improvements in retention (active hours) and satisfaction (quality watch time ratio) for LAUs as well as remarkable increases in interest diversity and category coverage for HAUs, proving the value of uncertainty-aware recommendation in industrial settings.

Bob Junyi Zou, Lu Tian

Identifying truly predictive covariates while strictly controlling false discoveries remains a fundamental challenge in nonlinear, highly correlated, and low signal-to-noise regimes, where deep learning based feature selection methods are most attractive. We propose Group Regularization Importance Persistence in 2 Dimensions (GRIP2), a deep knockoff feature importance statistic that integrates first-layer feature activity over a two-dimensional regularization surface controlling both sparsity strength and sparsification geometry. To approximate this surface integral in a single training run, we introduce efficient block-stochastic sampling, which aggregates feature activity magnitudes across diverse regularization regimes along the optimization trajectory. The resulting statistics are antisymmetric by construction, ensuring finite-sample FDR control. In extensive experiments on synthetic and semi-real data, GRIP2 demonstrates improved robustness to feature correlation and noise level: in high correlation and low signal-to-noise ratio regimes where standard deep learning based feature selectors may struggle, our method retains high power and stability. Finally, on real-world HIV drug resistance data, GRIP2 recovers known resistance-associated mutations with power better than established linear baselines, confirming its reliability in practice.

Bob Junyi Zou, Matthew E. Levine, Dessi P. Zaharieva et al.

Hybrid models composing mechanistic ODE-based dynamics with flexible and expressive neural network components have grown rapidly in popularity, especially in scientific domains where such ODE-based modeling offers important interpretability and validated causal grounding (e.g., for counterfactual reasoning). The incorporation of mechanistic models also provides inductive bias in standard blackbox modeling approaches, critical when learning from small datasets or partially observed, complex systems. Unfortunately, as the hybrid models become more flexible, the causal grounding provided by the mechanistic model can quickly be lost. We address this problem by leveraging another common source of domain knowledge: \emph{ranking} of treatment effects for a set of interventions, even if the precise treatment effect is unknown. We encode this information in a \emph{causal loss} that we combine with the standard predictive loss to arrive at a \emph{hybrid loss} that biases our learning towards causally valid hybrid models. We demonstrate our ability to achieve a win-win, state-of-the-art predictive performance \emph{and} causal validity, in the challenging task of modeling glucose dynamics post-exercise in individuals with type 1 diabetes.

Bob Junyi Zou, Lu Tian

Hybrid neural ordinary differential equations (neural ODEs) integrate mechanistic models with neural ODEs, offering strong inductive bias and flexibility, and are particularly advantageous in data-scarce healthcare settings. However, excessive latent states and interactions from mechanistic models can lead to training inefficiency and over-fitting, limiting practical effectiveness of hybrid neural ODEs. In response, we propose a new hybrid pipeline for automatic state selection and structure optimization in mechanistic neural ODEs, combining domain-informed graph modifications with data-driven regularization to sparsify the model for improving predictive performance and stability while retaining mechanistic plausibility. Experiments on synthetic and real-world data show improved predictive performance and robustness with desired sparsity, establishing an effective solution for hybrid model reduction in healthcare applications.