Xiaoyan Cai

Chong Ma, Zihao Wu, Jiaqi Wang et al.

The 'Impression' section of a radiology report is a critical basis for communication between radiologists and other physicians, and it is typically written by radiologists based on the 'Findings' section. However, writing numerous impressions can be laborious and error-prone for radiologists. Although recent studies have achieved promising results in automatic impression generation using large-scale medical text data for pre-training and fine-tuning pre-trained language models, such models often require substantial amounts of medical text data and have poor generalization performance. While large language models (LLMs) like ChatGPT have shown strong generalization capabilities and performance, their performance in specific domains, such as radiology, remains under-investigated and potentially limited. To address this limitation, we propose ImpressionGPT, which leverages the in-context learning capability of LLMs by constructing dynamic contexts using domain-specific, individualized data. This dynamic prompt approach enables the model to learn contextual knowledge from semantically similar examples from existing data. Additionally, we design an iterative optimization algorithm that performs automatic evaluation on the generated impression results and composes the corresponding instruction prompts to further optimize the model. The proposed ImpressionGPT model achieves state-of-the-art performance on both MIMIC-CXR and OpenI datasets without requiring additional training data or fine-tuning the LLMs. This work presents a paradigm for localizing LLMs that can be applied in a wide range of similar application scenarios, bridging the gap between general-purpose LLMs and the specific language processing needs of various domains.

Zhengliang Liu, Tianyang Zhong, Yiwei Li et al.

The rise of large language models (LLMs) has marked a pivotal shift in the field of natural language processing (NLP). LLMs have revolutionized a multitude of domains, and they have made a significant impact in the medical field. Large language models are now more abundant than ever, and many of these models exhibit bilingual capabilities, proficient in both English and Chinese. However, a comprehensive evaluation of these models remains to be conducted. This lack of assessment is especially apparent within the context of radiology NLP. This study seeks to bridge this gap by critically evaluating thirty two LLMs in interpreting radiology reports, a crucial component of radiology NLP. Specifically, the ability to derive impressions from radiologic findings is assessed. The outcomes of this evaluation provide key insights into the performance, strengths, and weaknesses of these LLMs, informing their practical applications within the medical domain.

Tianyang Zhong, Wei Zhao, Yutong Zhang et al.

Radiology report generation, as a key step in medical image analysis, is critical to the quantitative analysis of clinically informed decision-making levels. However, complex and diverse radiology reports with cross-source heterogeneity pose a huge generalizability challenge to the current methods under massive data volume, mainly because the style and normativity of radiology reports are obviously distinctive among institutions, body regions inspected and radiologists. Recently, the advent of large language models (LLM) offers great potential for recognizing signs of health conditions. To resolve the above problem, we collaborate with the Second Xiangya Hospital in China and propose ChatRadio-Valuer based on the LLM, a tailored model for automatic radiology report generation that learns generalizable representations and provides a basis pattern for model adaptation in sophisticated analysts' cases. Specifically, ChatRadio-Valuer is trained based on the radiology reports from a single institution by means of supervised fine-tuning, and then adapted to disease diagnosis tasks for human multi-system evaluation (i.e., chest, abdomen, muscle-skeleton, head, and maxillofacial $\&$ neck) from six different institutions in clinical-level events. The clinical dataset utilized in this study encompasses a remarkable total of \textbf{332,673} observations. From the comprehensive results on engineering indicators, clinical efficacy and deployment cost metrics, it can be shown that ChatRadio-Valuer consistently outperforms state-of-the-art models, especially ChatGPT (GPT-3.5-Turbo) and GPT-4 et al., in terms of the diseases diagnosis from radiology reports. ChatRadio-Valuer provides an effective avenue to boost model generalization performance and alleviate the annotation workload of experts to enable the promotion of clinical AI applications in radiology reports.

Zhengliang Liu, Hanqi Jiang, Tianyang Zhong et al.

In this paper, we present a large-scale evaluation probing GPT-4V's capabilities and limitations for biomedical image analysis. GPT-4V represents a breakthrough in artificial general intelligence (AGI) for computer vision, with applications in the biomedical domain. We assess GPT-4V's performance across 16 medical imaging categories, including radiology, oncology, ophthalmology, pathology, and more. Tasks include modality recognition, anatomy localization, disease diagnosis, report generation, and lesion detection. The extensive experiments provide insights into GPT-4V's strengths and weaknesses. Results show GPT-4V's proficiency in modality and anatomy recognition but difficulty with disease diagnosis and localization. GPT-4V excels at diagnostic report generation, indicating strong image captioning skills. While promising for biomedical imaging AI, GPT-4V requires further enhancement and validation before clinical deployment. We emphasize responsible development and testing for trustworthy integration of biomedical AGI. This rigorous evaluation of GPT-4V on diverse medical images advances understanding of multimodal large language models (LLMs) and guides future work toward impactful healthcare applications.

Yeyuan Wang, Dehong Gao, Bin Li et al.

The impressive performance of Large Language Model (LLM) has prompted researchers to develop Multi-modal LLM (MLLM), which has shown great potential for various multi-modal tasks. However, current MLLM often struggles to effectively address fine-grained multi-modal challenges. We argue that this limitation is closely linked to the models' visual grounding capabilities. The restricted spatial awareness and perceptual acuity of visual encoders frequently lead to interference from irrelevant background information in images, causing the models to overlook subtle but crucial details. As a result, achieving fine-grained regional visual comprehension becomes difficult. In this paper, we break down multi-modal understanding into two stages, from Coarse to Fine (CoF). In the first stage, we prompt the MLLM to locate the approximate area of the answer. In the second stage, we further enhance the model's focus on relevant areas within the image through visual prompt engineering, adjusting attention weights of pertinent regions. This, in turn, improves both visual grounding and overall performance in downstream tasks. Our experiments show that this approach significantly boosts the performance of baseline models, demonstrating notable generalization and effectiveness. Our CoF approach is available online at https://github.com/Gavin001201/CoF.

Bin Li, Dehong Gao, Yeyuan Wang et al.

Despite the significant success of Large Vision-Language models(LVLMs), these models still suffer hallucinations when describing images, generating answers that include non-existent objects. It is reported that these models tend to over-focus on certain irrelevant image tokens that do not contain critical information for answering the question and distort the output. To address this, we propose an Instruction-Aligned Visual Attention(IAVA) approach, which identifies irrelevant tokens by comparing changes in attention weights under two different instructions. By applying contrastive decoding, we dynamically adjust the logits generated from original image tokens and irrelevant image tokens, reducing the model's over-attention to irrelevant information. The experimental results demonstrate that IAVA consistently outperforms existing decoding techniques on benchmarks such as MME, POPE, and TextVQA in mitigating object hallucinations. Our IAVA approach is available online at https://github.com/Lee-lab558/IAVA.

Jingjing Xu, Xuancheng Ren, Yi Zhang et al.

Narrative story generation is a challenging problem because it demands the generated sentences with tight semantic connections, which has not been well studied by most existing generative models. To address this problem, we propose a skeleton-based model to promote the coherence of generated stories. Different from traditional models that generate a complete sentence at a stroke, the proposed model first generates the most critical phrases, called skeleton, and then expands the skeleton to a complete and fluent sentence. The skeleton is not manually defined, but learned by a reinforcement learning method. Compared to the state-of-the-art models, our skeleton-based model can generate significantly more coherent text according to human evaluation and automatic evaluation. The G-score is improved by 20.1% in the human evaluation. The code is available at https://github.com/lancopku/Skeleton-Based-Generation-Model

Kaidi Chen, Ben Chen, Dehong Gao et al.

Existing Neural Machine Translation (NMT) models mainly handle translation in the general domain, while overlooking domains with special writing formulas, such as e-commerce and legal documents. Taking e-commerce as an example, the texts usually include amounts of domain-related words and have more grammar problems, which leads to inferior performances of current NMT methods. To address these problems, we collect two domain-related resources, including a set of term pairs (aligned Chinese-English bilingual terms) and a parallel corpus annotated for the e-commerce domain. Furthermore, we propose a two-step fine-tuning paradigm (named G2ST) with self-contrastive semantic enhancement to transfer one general NMT model to the specialized NMT model for e-commerce. The paradigm can be used for the NMT models based on Large language models (LLMs). Extensive evaluations on real e-commerce titles demonstrate the superior translation quality and robustness of our G2ST approach, as compared with state-of-the-art NMT models such as LLaMA, Qwen, GPT-3.5, and even GPT-4.

Yeyuan Wang, Dehong Gao, Lei Yi et al.

Existing Vision-Language Pretraining (VLP) methods have achieved remarkable improvements across a variety of vision-language tasks, confirming their effectiveness in capturing coarse-grained semantic correlations. However, their capability for fine-grained understanding, which is critical for many nuanced vision-language applications, remains limited. Prevailing VLP models often overlook the intricate distinctions in expressing different modal features and typically depend on the similarity of holistic features for cross-modal interactions. Moreover, these models directly align and integrate features from different modalities, focusing more on coarse-grained general representations, thus failing to capture the nuanced differences necessary for tasks demanding a more detailed perception. In response to these limitations, we introduce Negative Augmented Samples(NAS), a refined vision-language pretraining model that innovatively incorporates NAS to specifically address the challenge of fine-grained understanding. NAS utilizes a Visual Dictionary(VD) as a semantic bridge between visual and linguistic domains. Additionally, it employs a Negative Visual Augmentation(NVA) method based on the VD to generate challenging negative image samples. These samples deviate from positive samples exclusively at the token level, thereby necessitating that the model discerns the subtle disparities between positive and negative samples with greater precision. Comprehensive experiments validate the efficacy of NAS components and underscore its potential to enhance fine-grained vision-language comprehension.

Yufei Ma, Zihan Liang, Huangyu Dai et al.

The growing demand for larger-scale models in the development of \textbf{L}arge \textbf{L}anguage \textbf{M}odels (LLMs) poses challenges for efficient training within limited computational resources. Traditional fine-tuning methods often exhibit instability in multi-task learning and rely heavily on extensive training resources. Here, we propose MoDULA (\textbf{M}ixture \textbf{o}f \textbf{D}omain-Specific and \textbf{U}niversal \textbf{L}oR\textbf{A}), a novel \textbf{P}arameter \textbf{E}fficient \textbf{F}ine-\textbf{T}uning (PEFT) \textbf{M}ixture-\textbf{o}f-\textbf{E}xpert (MoE) paradigm for improved fine-tuning and parameter efficiency in multi-task learning. The paradigm effectively improves the multi-task capability of the model by training universal experts, domain-specific experts, and routers separately. MoDULA-Res is a new method within the MoDULA paradigm, which maintains the model's general capability by connecting universal and task-specific experts through residual connections. The experimental results demonstrate that the overall performance of the MoDULA-Flan and MoDULA-Res methods surpasses that of existing fine-tuning methods on various LLMs. Notably, MoDULA-Res achieves more significant performance improvements in multiple tasks while reducing training costs by over 80\% without losing general capability. Moreover, MoDULA displays flexible pluggability, allowing for the efficient addition of new tasks without retraining existing experts from scratch. This progressive training paradigm circumvents data balancing issues, enhancing training efficiency and model stability. Overall, MoDULA provides a scalable, cost-effective solution for fine-tuning LLMs with enhanced parameter efficiency and generalization capability.

Yeyuan Wang, Dehong Gao, Rujiao Long et al.

Direct Preference Optimization (DPO) has gained significant attention for its simplicity and computational efficiency in aligning large language models (LLMs). Recent advancements have extended DPO to multimodal scenarios, achieving strong performance. However, traditional DPO relies on binary preference optimization, rewarding or penalizing entire responses without considering fine-grained segment correctness, leading to suboptimal solutions. The root of this issue lies in the absence of fine-grained supervision during the optimization process. To address this, we propose Adaptive Sentence-level Preference Optimization (ASPO), which evaluates individual sentences for more precise preference optimization. By dynamically calculating adaptive rewards at the sentence level based on model predictions, ASPO enhances response content assessment without additional models or parameters. This significantly improves the alignment of multimodal features. Extensive experiments show that ASPO substantially enhances the overall performance of multimodal models.

Bingzhen Wei, Xuancheng Ren, Xu Sun et al.

Abstractive text summarization is a highly difficult problem, and the sequence-to-sequence model has shown success in improving the performance on the task. However, the generated summaries are often inconsistent with the source content in semantics. In such cases, when generating summaries, the model selects semantically unrelated words with respect to the source content as the most probable output. The problem can be attributed to heuristically constructed training data, where summaries can be unrelated to the source content, thus containing semantically unrelated words and spurious word correspondence. In this paper, we propose a regularization approach for the sequence-to-sequence model and make use of what the model has learned to regularize the learning objective to alleviate the effect of the problem. In addition, we propose a practical human evaluation method to address the problem that the existing automatic evaluation method does not evaluate the semantic consistency with the source content properly. Experimental results demonstrate the effectiveness of the proposed approach, which outperforms almost all the existing models. Especially, the proposed approach improves the semantic consistency by 4\% in terms of human evaluation.

Jingjing Xu, Xu Sun, Sujian Li et al.

In recent years, neural networks have proven to be effective in Chinese word segmentation. However, this promising performance relies on large-scale training data. Neural networks with conventional architectures cannot achieve the desired results in low-resource datasets due to the lack of labelled training data. In this paper, we propose a deep stacking framework to improve the performance on word segmentation tasks with insufficient data by integrating datasets from diverse domains. Our framework consists of two parts, domain-based models and deep stacking networks. The domain-based models are used to learn knowledge from different datasets. The deep stacking networks are designed to integrate domain-based models. To reduce model conflicts, we innovatively add communication paths among models and design various structures of deep stacking networks, including Gaussian-based Stacking Networks, Concatenate-based Stacking Networks, Sequence-based Stacking Networks and Tree-based Stacking Networks. We conduct experiments on six low-resource datasets from various domains. Our proposed framework shows significant performance improvements on all datasets compared with several strong baselines.