Tim Jahn

César Ojeda, Niklas Hartung, Wilhelm Huisinga et al.

We introduce Prior-Fitted Functional Flows, a generative foundation model for pharmacokinetics that enables zero-shot population synthesis and individual forecasting without manual parameter tuning. We learn functional vector fields, explicitly conditioned on the sparse, irregular data of an entire study population. This enables the generation of coherent virtual cohorts as well as forecasting of partially observed patient trajectories with calibrated uncertainty. We construct a new open-access literature corpus to inform our priors, and demonstrate state-of-the-art predictive accuracy on extensive real-world datasets.

Harshit Bajpai, Ankik Kumar Giri, Tim Jahn et al.

Solving inverse problems requires appropriate regularization techniques to ensure well-posedness and stability. In recent years, denoiser-driven methods have emerged as effective regularization strategies, achieving state-of-the-art performance in various imaging applications. However, their stability and convergence within iterative regularization frameworks remain largely unexplored. In this work, we extend the framework of Regularization by Denoising (RED) by introducing a novel denoiser-driven iterative regularization scheme, referred to as \texttt{DDIR}, that incorporates a new regularization functional based on averaged denoisers. The proposed approach employs an adaptive step-size strategy together with an \emph{a posteriori} stopping rule to ensure stability while alleviating oscillatory behavior and semi-convergence effects induced by noise. As our main theoretical contribution, we prove that the resulting reconstruction method constitutes a stable and convergent regularization scheme in the classical sense. To the best of our knowledge, this provides the first rigorous justification of \texttt{DDIR} within the framework of regularization theory. Finally, we demonstrate the performance of the proposed method through numerical experiments on image deblurring and phase retrieval Computed Tomography (CT) using three denoisers, namely median, TNRD, and TV proximal. The results highlight the effectiveness of the method in terms of reconstruction accuracy and computational efficiency.

Bulcsú Sándor, Tim Jahn, Laura Martin et al.

We investigate the sensorimotor loop of simple robots simulated within the LPZRobots environment from the point of view of dynamical systems theory. For a robot with a cylindrical shaped body and an actuator controlled by a single proprioceptual neuron we find various types of periodic motions in terms of stable limit cycles. These are self-organized in the sense, that the dynamics of the actuator kicks in only, for a certain range of parameters, when the barrel is already rolling, stopping otherwise. The stability of the resulting rolling motions terminates generally, as a function of the control parameters, at points where fold bifurcations of limit cycles occur. We find that several branches of motion types exist for the same parameters, in terms of the relative frequencies of the barrel and of the actuator, having each their respective basins of attractions in terms of initial conditions. For low drivings stable limit cycles describing periodic and drifting back-and-forth motions are found additionally. These modes allow to generate symmetry breaking explorative behavior purely by the timing of an otherwise neutral signal with respect to the cyclic back-and-forth motion of the robot.