Matthew P. Buman

Eun Som Jeon, Hongjun Choi, Ankita Shukla et al.

Deep learning methods have achieved a lot of success in various applications involving converting wearable sensor data to actionable health insights. A common application areas is activity recognition, where deep-learning methods still suffer from limitations such as sensitivity to signal quality, sensor characteristic variations, and variability between subjects. To mitigate these issues, robust features obtained by topological data analysis (TDA) have been suggested as a potential solution. However, there are two significant obstacles to using topological features in deep learning: (1) large computational load to extract topological features using TDA, and (2) different signal representations obtained from deep learning and TDA which makes fusion difficult. In this paper, to enable integration of the strengths of topological methods in deep-learning for time-series data, we propose to use two teacher networks, one trained on the raw time-series data, and another trained on persistence images generated by TDA methods. The distilled student model utilizes only the raw time-series data at test-time. This approach addresses both issues. The use of KD with multiple teachers utilizes complementary information, and results in a compact model with strong supervisory features and an integrated richer representation. To assimilate desirable information from different modalities, we design new constraints, including orthogonality imposed on feature correlation maps for improving feature expressiveness and allowing the student to easily learn from the teacher. Also, we apply an annealing strategy in KD for fast saturation and better accommodation from different features, while the knowledge gap between the teachers and student is reduced. Finally, a robust student model is distilled, which uses only the time-series data as an input, while implicitly preserving topological features.

Fengxu Li, Stephanie M. Carpenter, Matthew P. Buman et al.

A common challenge for decision makers is selecting actions whose rewards are unknown and evolve over time based on prior policies. For instance, repeated use may reduce an action's effectiveness (habituation), while inactivity may restore it (recovery). These nonstationarities are captured by the Reducing or Gaining Unknown Efficacy (ROGUE) bandit framework, which models real-world settings such as behavioral health interventions. While existing algorithms can compute sublinear regret policies to optimize these settings, they may not provide sufficient exploration due to overemphasis on exploitation, limiting the ability to estimate population-level effects. This is a challenge of particular interest in micro-randomized trials (MRTs) that aid researchers in developing just-in-time adaptive interventions that have population-level effects while still providing personalized recommendations to individuals. In this paper, we first develop ROGUE-TS, a Thompson Sampling algorithm tailored to the ROGUE framework, and provide theoretical guarantees of sublinear regret. We then introduce a probability clipping procedure to balance personalization and population-level learning, with quantified trade-off that balances regret and minimum exploration probability. Validation on two MRT datasets concerning physical activity promotion and bipolar disorder treatment shows that our methods both achieve lower regret than existing approaches and maintain high statistical power through the clipping procedure without significantly increasing regret. This enables reliable detection of treatment effects while accounting for individual behavioral dynamics. For researchers designing MRTs, our framework offers practical guidance on balancing personalization with statistical validity.

Abdullah Mamun, Asiful Arefeen, Susan B. Racette et al.

Postprandial hyperglycemia, marked by the blood glucose level exceeding the normal range after consuming a meal, is a critical indicator of progression toward type 2 diabetes in people with prediabetes and in healthy individuals. A key metric for understanding blood glucose dynamics after eating is the postprandial area under the curve (AUC). Predicting postprandial AUC in advance based on a person's lifestyle factors, such as diet and physical activity level, and explaining the factors that affect postprandial blood glucose could allow an individual to adjust their lifestyle accordingly to maintain normal glucose levels. In this study, we developed an explainable machine learning solution, GlucoLens, that takes sensor-driven inputs and uses advanced data processing, large language models, and trainable machine learning models to predict postprandial AUC and hyperglycemia from diet, physical activity, and recent glucose patterns. We used data obtained from wearables in a five-week clinical trial of 10 adults who worked full-time to develop and evaluate the proposed computational model that integrates wearable sensing, multimodal data, and machine learning. Our machine learning model takes multimodal data from wearable activity and glucose monitoring sensors, along with food and work logs, and provides an interpretable prediction of the postprandial glucose pattern. Our GlucoLens system achieves a normalized root mean squared error (NRMSE) of 0.123 in its best configuration. On average, the proposed technology provides a 16% better performance level compared to the comparison models. Additionally, our technique predicts hyperglycemia with an accuracy of 73.3% and an F1 score of 0.716 and recommends different treatment options to help avoid hyperglycemia through diverse counterfactual explanations. Code available: https://github.com/ab9mamun/GlucoLens.

Anirudh Som, Hongjun Choi, Karthikeyan Natesan Ramamurthy et al.

Topological features such as persistence diagrams and their functional approximations like persistence images (PIs) have been showing substantial promise for machine learning and computer vision applications. This is greatly attributed to the robustness topological representations provide against different types of physical nuisance variables seen in real-world data, such as view-point, illumination, and more. However, key bottlenecks to their large scale adoption are computational expenditure and difficulty incorporating them in a differentiable architecture. We take an important step in this paper to mitigate these bottlenecks by proposing a novel one-step approach to generate PIs directly from the input data. We design two separate convolutional neural network architectures, one designed to take in multi-variate time series signals as input and another that accepts multi-channel images as input. We call these networks Signal PI-Net and Image PI-Net respectively. To the best of our knowledge, we are the first to propose the use of deep learning for computing topological features directly from data. We explore the use of the proposed PI-Net architectures on two applications: human activity recognition using tri-axial accelerometer sensor data and image classification. We demonstrate the ease of fusion of PIs in supervised deep learning architectures and speed up of several orders of magnitude for extracting PIs from data. Our code is available at https://github.com/anirudhsom/PI-Net.

Abdullah Mamun, Krista S. Leonard, Megan E. Petrov et al.

Objective: This research aims to develop a lifestyle intervention system, called MoveSense, that forecasts a patient's activity behavior to allow for early and personalized interventions in real-world clinical environments. Methods: We conducted two clinical studies involving 58 prediabetic veterans and 60 patients with obstructive sleep apnea to gather multimodal behavioral data using wearable devices. We develop multimodal long short-term memory (LSTM) network models, which are capable of forecasting the number of step counts of a patient up to 24 hours in advance by examining data from activity and engagement modalities. Furthermore, we design goal-based forecasting models to predict whether a person's next-day steps will be over a certain threshold. Results: Multimodal LSTM with early fusion achieves 33% and 37% lower mean absolute errors than linear regression and ARIMA respectively on the prediabetes dataset. LSTM also outperforms linear regression and ARIMA with a margin of 13% and 32% on the sleep dataset. Multimodal forecasting models also perform with 72% and 79% accuracy on the prediabetes dataset and sleep dataset respectively on goal-based forecasting. Conclusion: Our experiments conclude that multimodal LSTM models with early fusion are better than multimodal LSTM with late fusion and unimodal LSTM models and also than ARIMA and linear regression models. Significance: We address an important and challenging task of time-series forecasting in uncontrolled environments. Effective forecasting of a person's physical activity can aid in designing adaptive behavioral interventions to keep the user engaged and adherent to a prescribed routine.

Eun Som Jeon, Hongjun Choi, Matthew P. Buman et al.

The analysis of wearable sensor data has enabled many successes in several applications. To represent the high-sampling rate time-series with sufficient detail, the use of topological data analysis (TDA) has been considered, and it is found that TDA can complement other time-series features. Nonetheless, due to the large time consumption and high computational resource requirements of extracting topological features through TDA, it is difficult to deploy topological knowledge in various applications. To tackle this problem, knowledge distillation (KD) can be adopted, which is a technique facilitating model compression and transfer learning to generate a smaller model by transferring knowledge from a larger network. By leveraging multiple teachers in KD, both time-series and topological features can be transferred, and finally, a superior student using only time-series data is distilled. On the other hand, mixup has been popularly used as a robust data augmentation technique to enhance model performance during training. Mixup and KD employ similar learning strategies. In KD, the student model learns from the smoothed distribution generated by the teacher model, while mixup creates smoothed labels by blending two labels. Hence, this common smoothness serves as the connecting link that establishes a connection between these two methods. In this paper, we analyze the role of mixup in KD with time-series as well as topological persistence, employing multiple teachers. We present a comprehensive analysis of various methods in KD and mixup on wearable sensor data.

Eun Som Jeon, Anirudh Som, Ankita Shukla et al.

Deep neural networks are parametrized by several thousands or millions of parameters, and have shown tremendous success in many classification problems. However, the large number of parameters makes it difficult to integrate these models into edge devices such as smartphones and wearable devices. To address this problem, knowledge distillation (KD) has been widely employed, that uses a pre-trained high capacity network to train a much smaller network, suitable for edge devices. In this paper, for the first time, we study the applicability and challenges of using KD for time-series data for wearable devices. Successful application of KD requires specific choices of data augmentation methods during training. However, it is not yet known if there exists a coherent strategy for choosing an augmentation approach during KD. In this paper, we report the results of a detailed study that compares and contrasts various common choices and some hybrid data augmentation strategies in KD based human activity analysis. Research in this area is often limited as there are not many comprehensive databases available in the public domain from wearable devices. Our study considers databases from small scale publicly available to one derived from a large scale interventional study into human activity and sedentary behavior. We find that the choice of data augmentation techniques during KD have a variable level of impact on end performance, and find that the optimal network choice as well as data augmentation strategies are specific to a dataset at hand. However, we also conclude with a general set of recommendations that can provide a strong baseline performance across databases.

Anirudh Som, Narayanan Krishnamurthi, Matthew Buman et al.

Application and use of deep learning algorithms for different healthcare applications is gaining interest at a steady pace. However, use of such algorithms can prove to be challenging as they require large amounts of training data that capture different possible variations. This makes it difficult to use them in a clinical setting since in most health applications researchers often have to work with limited data. Less data can cause the deep learning model to over-fit. In this paper, we ask how can we use data from a different environment, different use-case, with widely differing data distributions. We exemplify this use case by using single-sensor accelerometer data from healthy subjects performing activities of daily living - ADLs (source dataset), to extract features relevant to multi-sensor accelerometer gait data (target dataset) for Parkinson's disease classification. We train the pre-trained model using the source dataset and use it as a feature extractor. We show that the features extracted for the target dataset can be used to train an effective classification model. Our pre-trained source model consists of a convolutional autoencoder, and the target classification model is a simple multi-layer perceptron model. We explore two different pre-trained source models, trained using different activity groups, and analyze the influence the choice of pre-trained model has over the task of Parkinson's disease classification.