Jeffrey G. Ojemann

Jing Wu, Kaitlyn Casimo, David J. Caldwell et al.

Identification of intended movement type and movement phase of hand grasp shaping are critical features for the control of volitional neuroprosthetics. We demonstrate that neural dynamics during visually-guided imagined grasp shaping can encode intended movement. We apply Procrustes analysis and LASSO regression to achieve 72% accuracy (chance = 25%) in distinguishing between visually-guided imagined grasp trajectories. Further, we can predict the stage of grasp shaping in the form of elapsed time from start of trial (R2=0.4). Our approach contributes to more accurate single-trial decoding of higher-level movement goals and the phase of grasping movements in individuals not trained with brain-computer interfaces. We also find that the overall time-varying trajectory structure of imagined movements tend to be consistent within individuals, and that transient trajectory deviations within trials return to the task-dependent trajectory mean. These overall findings may contribute to the further understanding of the cortical dynamics of human motor imagery.

Jing Wu, Benjamin R. Shuman, Bingni W. Brunton et al.

Neural correlates of movement planning onset and direction may be present in human electrocorticography in the signal dynamics of both motor and non-motor cortical regions. We use a three-stage model of jPCA reduced-rank hidden Markov model (jPCA-RR-HMM), regularized shrunken-centroid discriminant analysis (RDA), and LASSO regression to extract direction-sensitive planning information and movement onset in an upper-limb 3D isometric force task in a human subject. This mode achieves a relatively high true positive force-onset prediction rate of 60% within 250ms, and an above-chance 36% accuracy (17% chance) in predicting one of six planned 3D directions of isometric force using pre-movement signals. We also find direction-distinguishing information up to 400ms before force onset in the pre-movement signals, captured by electrodes placed over the limb-ipsilateral dorsal premotor regions. This approach can contribute to more accurate decoding of higher-level movement goals, at earlier timescales, and inform sensor placement. Our results also contribute to further understanding of the spatiotemporal features of human motor planning.