Felipe Giuste

Felipe Giuste, Wenqi Shi, Yuanda Zhu et al.

Despite the myriad peer-reviewed papers demonstrating novel Artificial Intelligence (AI)-based solutions to COVID-19 challenges during the pandemic, few have made significant clinical impact. The impact of artificial intelligence during the COVID-19 pandemic was greatly limited by lack of model transparency. This systematic review examines the use of Explainable Artificial Intelligence (XAI) during the pandemic and how its use could overcome barriers to real-world success. We find that successful use of XAI can improve model performance, instill trust in the end-user, and provide the value needed to affect user decision-making. We introduce the reader to common XAI techniques, their utility, and specific examples of their application. Evaluation of XAI results is also discussed as an important step to maximize the value of AI-based clinical decision support systems. We illustrate the classical, modern, and potential future trends of XAI to elucidate the evolution of novel XAI techniques. Finally, we provide a checklist of suggestions during the experimental design process supported by recent publications. Common challenges during the implementation of AI solutions are also addressed with specific examples of potential solutions. We hope this review may serve as a guide to improve the clinical impact of future AI-based solutions.

Felipe O. Giuste, Juan C. Vizcarra

Image classification requires the generation of features capable of detecting image patterns informative of group identity. The objective of this study was to classify images from the public CIFAR-10 image dataset by leveraging combinations of disparate image feature sources from both manual and deep learning approaches. Histogram of oriented gradients (HOG) and pixel intensities successfully inform classification (53% and 59% classification accuracy, respectively), yet there is much room for improvement. VGG16 with ImageNet trained weights and a CIFAR-10 optimized model (CIFAR-VGG) further improve upon image classification (60% and 93.43% accuracy, respectively). We further improved classification by utilizing transfer learning to re-establish optimal network weights for VGG16 (TL-VGG) and Inception ResNet v2 (TL-Inception) resulting in significant performance increases (85% and 90.74%, respectively), yet fail to surpass CIFAR-VGG. We hypothesized that if each generated feature set obtained some unique insight into the classification problem, then combining these features would result in greater classification accuracy, surpassing that of CIFAR-VGG. Upon selection of the top 1000 principal components from TL-VGG, TL-Inception, HOG, pixel intensities, and CIFAR-VGG, we achieved testing accuracy of 94.6%, lending support to our hypothesis.