Minghao Han

Zizhi Chen, Yizhen Gao, Minghao Han et al.

Multimodal biomedical Vision-Language Models (VLMs) exhibit immense potential in the field of Continual Learning (CL). However, they confront a core dilemma: how to preserve fine-grained intra-modality features while bridging the significant domain gap across different modalities. To address this challenge, we propose a comprehensive framework. Leveraging our 18-million multimodal and comprehensive medical retrieval database derived from PubMed scientific papers, we pioneer the integration of Retrieval-Augmented Generation (RAG) into CL. Specifically, we employ a multi-modal, multi-layer RAG system that provides real-time guidance for model fine-tuning through dynamic, on-demand knowledge retrieval. Building upon this, we introduce a dynamic knowledge distillation framework. This framework precisely resolves the aforementioned core dilemma by dynamically modulating the importance of the parameter space, the granularity of the distilled knowledge, and the data distribution of the reference dataset in accordance with the required level of detail. To thoroughly validate the clinical value of our strategy, we have designed a more rigorous \textbf{M}edical Generalist Task Incremental Learning (MGTIL) benchmark. This benchmark is engineered to simultaneously evaluate the model's capacity for adaptation to significant domain shifts, retention of subtle intra-domain features, and real-time learning of novel and complex medical tasks. Extensive experimental results demonstrate that our proposed method achieves state-of-the-art (SOTA) performance across all metrics. The code is provided in the supplementary materials.

Minghao Han, Dingkang Yang, Jiabei Cheng et al.

Recent advancements in multimodal pre-training models have significantly advanced computational pathology. However, current approaches predominantly rely on visual-language models, which may impose limitations from a molecular perspective and lead to performance bottlenecks. Here, we introduce a Unified Molecule-enhanced Pathology Image REpresentationn Learning framework (UMPIRE). UMPIRE aims to leverage complementary information from gene expression profiles to guide the multimodal pre-training, enhancing the molecular awareness of pathology image representation learning. We demonstrate that this molecular perspective provides a robust, task-agnostic training signal for learning pathology image embeddings. Due to the scarcity of paired data, approximately 4 million entries of spatial transcriptomics gene expression were collected to train the gene encoder. By leveraging powerful pre-trained encoders, UMPIRE aligns the encoders across over 697K pathology image-gene expression pairs. The performance of UMPIRE is demonstrated across various molecular-related downstream tasks, including gene expression prediction, spot classification, and mutation state prediction in whole slide images. Our findings highlight the effectiveness of multimodal data integration and open new avenues for exploring computational pathology enhanced by molecular perspectives. The code and pre-trained weights are available at https://github.com/Hanminghao/UMPIRE.

Minghao Han, Xukun Zhang, Dingkang Yang et al.

Survival prediction is a complex ordinal regression task that aims to predict the survival coefficient ranking among a cohort of patients, typically achieved by analyzing patients' whole slide images. Existing deep learning approaches mainly adopt multiple instance learning or graph neural networks under weak supervision. Most of them are unable to uncover the diverse interactions between different types of biological entities(\textit{e.g.}, cell cluster and tissue block) across multiple scales, while such interactions are crucial for patient survival prediction. In light of this, we propose a novel multi-scale heterogeneity-aware hypergraph representation framework. Specifically, our framework first constructs a multi-scale heterogeneity-aware hypergraph and assigns each node with its biological entity type. It then mines diverse interactions between nodes on the graph structure to obtain a global representation. Experimental results demonstrate that our method outperforms state-of-the-art approaches on three benchmark datasets. Code is publicly available at \href{https://github.com/Hanminghao/H2GT}{https://github.com/Hanminghao/H2GT}.

Minghao Han, Yuan Tian, Lixian Zhang et al.

Reinforcement learning is showing great potentials in robotics applications, including autonomous driving, robot manipulation and locomotion. However, with complex uncertainties in the real-world environment, it is difficult to guarantee the successful generalization and sim-to-real transfer of learned policies theoretically. In this paper, we introduce and extend the idea of robust stability and $H_\infty$ control to design policies with both stability and robustness guarantee. Specifically, a sample-based approach for analyzing the Lyapunov stability and performance robustness of a learning-based control system is proposed. Based on the theoretical results, a maximum entropy algorithm is developed for searching Lyapunov function and designing a policy with provable robust stability guarantee. Without any specific domain knowledge, our method can find a policy that is robust to various uncertainties and generalizes well to different test environments. In our experiments, we show that our method achieves better robustness to both large impulsive disturbances and parametric variations in the environment than the state-of-art results in both robust and generic RL, as well as classic control. Anonymous code is available to reproduce the experimental results at https://github.com/RobustStabilityGuaranteeRL/RobustStabilityGuaranteeRL.

Minghao Han, Xunyuan Yin

Shipboard carbon capture is a promising solution to help reduce carbon emissions in international shipping. In this work, we propose a data-driven dynamic modeling and economic predictive control approach within the Koopman framework. This integrated modeling and control approach is used to achieve safe and energy-efficient process operation of shipboard post-combustion carbon capture plants. Specifically, we propose a deep neural Koopman operator modeling approach, based on which a Koopman model with time-varying model parameters is established. This Koopman model predicts the overall economic operational cost and key system outputs, based on accessible partial state measurements. By leveraging this learned model, a constrained economic predictive control scheme is developed. Despite time-varying parameters involved in the formulated model, the formulated optimization problem associated with the economic predictive control design is convex, and it can be solved efficiently during online control implementations. Extensive tests are conducted on a high-fidelity simulation environment for shipboard post-combustion carbon capture processes. Four ship operational conditions are taken into account. The results show that the proposed method significantly improves the overall economic operational performance and carbon capture rate. Additionally, the proposed method guarantees safe operation by ensuring that hard constraints on the system outputs are satisfied.

Yizhou Liu, Jingwei Wei, Zizhi Chen et al.

Reinforcement learning (RL) with rule-based rewards has demonstrated strong potential in enhancing the reasoning and generalization capabilities of vision-language models (VLMs) and large language models (LLMs), while reducing computational overhead. However, its application in medical imaging remains underexplored. Existing reinforcement fine-tuning (RFT) approaches in this domain primarily target closed-ended visual question answering (VQA), limiting their applicability to real-world clinical reasoning. In contrast, open-ended medical VQA better reflects clinical practice but has received limited attention. While some efforts have sought to unify both formats via semantically guided RL, we observe that model-based semantic rewards often suffer from reward collapse, where responses with significant semantic differences receive similar scores. To address this, we propose ARMed (Adaptive Reinforcement for Medical Reasoning), a novel RL framework for open-ended medical VQA. ARMed first incorporates domain knowledge through supervised fine-tuning (SFT) on chain-of-thought data, then applies reinforcement learning with textual correctness and adaptive semantic rewards to enhance reasoning quality. We evaluate ARMed on six challenging medical VQA benchmarks. Results show that ARMed consistently boosts both accuracy and generalization, achieving a 32.64% improvement on in-domain tasks and an 11.65% gain on out-of-domain benchmarks. These results highlight the critical role of reward discriminability in medical RL and the promise of semantically guided rewards for enabling robust and clinically meaningful multimodal reasoning.

Minghao Han, Kiwan Wong, Adrian Wing-Keung Law et al.

In this work, we propose a meta-learning-based Koopman modeling and predictive control approach for nonlinear systems with parametric uncertainties. An adaptive deep meta-learning-based modeling approach, called Meta Adaptive Koopman Operator (MAKO), is proposed. Without knowledge of the parametric uncertainty, the proposed MAKO approach can learn a meta-model from a multi-modal dataset and efficiently adapt to new systems with previously unseen parameter settings by using online data. Based on the learned meta Koopman model, a predictive control scheme is developed, and the stability of the closed-loop system is ensured even in the presence of previously unseen parameter settings. Through extensive simulations, our proposed approach demonstrates superior performance in both modeling accuracy and control efficacy as compared to competitive baselines.

Yuan Tian, Minghao Han, Chetan Kulkarni et al.

Prescribing optimal operation based on the condition of the system and, thereby, potentially prolonging the remaining useful lifetime has a large potential for actively managing the availability, maintenance and costs of complex systems. Reinforcement learning (RL) algorithms are particularly suitable for this type of problems given their learning capabilities. A special case of a prescriptive operation is the power allocation task, which can be considered as a sequential allocation problem, where the action space is bounded by a simplex constraint. A general continuous action-space solution of such sequential allocation problems has still remained an open research question for RL algorithms. In continuous action-space, the standard Gaussian policy applied in reinforcement learning does not support simplex constraints, while the Gaussian-softmax policy introduces a bias during training. In this work, we propose the Dirichlet policy for continuous allocation tasks and analyze the bias and variance of its policy gradients. We demonstrate that the Dirichlet policy is bias-free and provides significantly faster convergence, better performance and better hyperparameters robustness over the Gaussian-softmax policy. Moreover, we demonstrate the applicability of the proposed algorithm on a prescriptive operation case, where we propose the Dirichlet power allocation policy and evaluate the performance on a case study of a set of multiple lithium-ion (Li-I) battery systems. The experimental results show the potential to prescribe optimal operation, improve the efficiency and sustainability of multi-power source systems.

Róbert Szász, Mike Allenspach, Minghao Han et al.

Flying manipulators are aerial drones with attached rigid-bodied robotic arms and belong to the latest and most actively developed research areas in robotics. The rigid nature of these arms often lack compliance, flexibility, and smoothness in movement. This work proposes to use a soft-bodied robotic arm attached to an omnidirectional micro aerial vehicle (OMAV) to leverage the compliant and flexible behavior of the arm, while remaining maneuverable and dynamic thanks to the omnidirectional drone as the floating base. The unification of the arm with the drone poses challenges in the modeling and control of such a combined platform; these challenges are addressed with this work. We propose a unified model for the flying manipulator based on three modeling principles: the Piecewise Constant Curvature (PCC) and Augmented Rigid Body Model (ARBM) hypotheses for modeling soft continuum robots and a floating-base approach borrowed from the traditional rigid-body robotics literature. To demonstrate the validity and usefulness of this parametrisation, a hierarchical model-based feedback controller is implemented. The controller is verified and evaluated in simulation on various dynamical tasks, where the nullspace motions, disturbance recovery, and trajectory tracking capabilities of the platform are examined and validated. The soft flying manipulator platform could open new application fields in aerial construction, goods delivery, human assistance, maintenance, and warehouse automation.

Minghao Han, Yuan Tian, Lixian Zhang et al.

Reinforcement learning (RL) is promising for complicated stochastic nonlinear control problems. Without using a mathematical model, an optimal controller can be learned from data evaluated by certain performance criteria through trial-and-error. However, the data-based learning approach is notorious for not guaranteeing stability, which is the most fundamental property for any control system. In this paper, the classic Lyapunov's method is explored to analyze the uniformly ultimate boundedness stability (UUB) solely based on data without using a mathematical model. It is further shown how RL with UUB guarantee can be applied to control dynamic systems with safety constraints. Based on the theoretical results, both off-policy and on-policy learning algorithms are proposed respectively. As a result, optimal controllers can be learned to guarantee UUB of the closed-loop system both at convergence and during learning. The proposed algorithms are evaluated on a series of robotic continuous control tasks with safety constraints. In comparison with the existing RL algorithms, the proposed method can achieve superior performance in terms of maintaining safety. As a qualitative evaluation of stability, our method shows impressive resilience even in the presence of external disturbances.

Minghao Han, Lixian Zhang, Jun Wang et al.

Reinforcement Learning (RL) and its integration with deep learning have achieved impressive performance in various robotic control tasks, ranging from motion planning and navigation to end-to-end visual manipulation. However, stability is not guaranteed in model-free RL by solely using data. From a control-theoretic perspective, stability is the most important property for any control system, since it is closely related to safety, robustness, and reliability of robotic systems. In this paper, we propose an actor-critic RL framework for control which can guarantee closed-loop stability by employing the classic Lyapunov's method in control theory. First of all, a data-based stability theorem is proposed for stochastic nonlinear systems modeled by Markov decision process. Then we show that the stability condition could be exploited as the critic in the actor-critic RL to learn a controller/policy. At last, the effectiveness of our approach is evaluated on several well-known 3-dimensional robot control tasks and a synthetic biology gene network tracking task in three different popular physics simulation platforms. As an empirical evaluation on the advantage of stability, we show that the learned policies can enable the systems to recover to the equilibrium or way-points when interfered by uncertainties such as system parametric variations and external disturbances to a certain extent.