Alexander Wietfeld

Alexander Wietfeld, Wolfgang Kellerer

Multiple access (MA) schemes can enable cooperation between multiple nodes in future diffusion-based molecular communication (DBMC) networks. Non-orthogonal MA for DBMC networks (DBMC-NOMA) is a promising option for efficient simultaneous MA using a single molecule type. This paper studies parameter optimization and bit error probability (BEP) reduction for asynchronous DBMC-NOMA. First, we analytically derive the associated BEP and compare DBMCNOMA with time-division and molecule-division MA. We show that asynchronous offsets can improve performance, and the upper-bound performance can be approached under almost all considered conditions by avoiding a small set of worst-case offset configurations, for which we propose and characterize a dedicated avoidance mechanism. We then propose DBMCaNOMAly, a pilot-symbol-based optimization protocol for asynchronous DBMC-NOMA, and evaluate it using Monte Carlo simulations. DBMC-aNOMAly provides robust BEP reduction across different network sizes and noise levels, under sampling jitter, and under changing runtime conditions, outperforming protocols from previous work. An end-to-end efficiency analysis further shows that these gains translate into increased net throughput after compensating for the pilot overhead. DBMCaNOMAly uses simple operations such as comparisons and additions that are compatible with chemical reaction networks, motivating future realistic modeling of the protocol.

Alexander Wietfeld, Oguz Turgut, Eneritz Somoza Rodríguez et al.

MC networks are envisioned to enable synthetic information exchange between nanoscale biological entities. For many algorithm proposals in the MC research field, the question of implementation at nanoscales and in biological environments remains open. Chemical reaction networks (CRNs) provide a natural framework to model computing processes in biological systems, while detailed simulations capture realistic stochastic effects. In this work, we present ChemSICal-Net, a comprehensive CRN simulation model of a chemical receiver implementing successive interference cancellation (SIC) to differentiate messages from multiple transmitters. We present the structure of the SIC algorithm in the form of basic chemical building blocks and incorporate clocked timing control by a chemical oscillator. We propose an adaptive Bayesian optimization (BO) scheme with a Gaussian process surrogate to find appropriate values for the reaction rate constants and the initial concentrations and show that it outperforms baseline methods from related work based on a fair computational cost metric. Then, the performance of the ChemSICal-Net framework is evaluated stochastically across a range of clock speeds and in different configurations focusing on communication system metrics such as detection accuracy and decision time. Our results highlight that the timing via a chemical clock can improve the detection accuracy by a factor of 2 in scenarios with shorter decision times, which underlines how the trade-off between decision time and detection probability can shape CRN design choices. The BO scheme is shown to reliably optimize parameters for different configurations by approximately one order of magnitude compared to the non-optimized case. Our system reveals the need for a multi-scale approach with external BO and stochastic simulation of molecular reaction dynamics for communication-metric-focused system design.