Yixuan Yuan

Chunwei Tian, Yixuan Yuan, Shichao Zhang et al.

CNNs with strong learning abilities are widely chosen to resolve super-resolution problem. However, CNNs depend on deeper network architectures to improve performance of image super-resolution, which may increase computational cost in general. In this paper, we present an enhanced super-resolution group CNN (ESRGCNN) with a shallow architecture by fully fusing deep and wide channel features to extract more accurate low-frequency information in terms of correlations of different channels in single image super-resolution (SISR). Also, a signal enhancement operation in the ESRGCNN is useful to inherit more long-distance contextual information for resolving long-term dependency. An adaptive up-sampling operation is gathered into a CNN to obtain an image super-resolution model with low-resolution images of different sizes. Extensive experiments report that our ESRGCNN surpasses the state-of-the-arts in terms of SISR performance, complexity, execution speed, image quality evaluation and visual effect in SISR. Code is found at https://github.com/hellloxiaotian/ESRGCNN.

Chunwei Tian, Yanning Zhang, Wangmeng Zuo et al.

Convolutional neural networks (CNNs) have obtained remarkable performance via deep architectures. However, these CNNs often achieve poor robustness for image super-resolution (SR) under complex scenes. In this paper, we present a heterogeneous group SR CNN (HGSRCNN) via leveraging structure information of different types to obtain a high-quality image. Specifically, each heterogeneous group block (HGB) of HGSRCNN uses a heterogeneous architecture containing a symmetric group convolutional block and a complementary convolutional block in a parallel way to enhance internal and external relations of different channels for facilitating richer low-frequency structure information of different types. To prevent appearance of obtained redundant features, a refinement block with signal enhancements in a serial way is designed to filter useless information. To prevent loss of original information, a multi-level enhancement mechanism guides a CNN to achieve a symmetric architecture for promoting expressive ability of HGSRCNN. Besides, a parallel up-sampling mechanism is developed to train a blind SR model. Extensive experiments illustrate that the proposed HGSRCNN has obtained excellent SR performance in terms of both quantitative and qualitative analysis. Codes can be accessed at https://github.com/hellloxiaotian/HGSRCNN.

Wuyang Li, Xinyu Liu, Yixuan Yuan

Domain Adaptive Object Detection (DAOD) leverages a labeled domain to learn an object detector generalizing to a novel domain free of annotations. Recent advances align class-conditional distributions by narrowing down cross-domain prototypes (class centers). Though great success,they ignore the significant within-class variance and the domain-mismatched semantics within the training batch, leading to a sub-optimal adaptation. To overcome these challenges, we propose a novel SemantIc-complete Graph MAtching (SIGMA) framework for DAOD, which completes mismatched semantics and reformulates the adaptation with graph matching. Specifically, we design a Graph-embedded Semantic Completion module (GSC) that completes mismatched semantics through generating hallucination graph nodes in missing categories. Then, we establish cross-image graphs to model class-conditional distributions and learn a graph-guided memory bank for better semantic completion in turn. After representing the source and target data as graphs, we reformulate the adaptation as a graph matching problem, i.e., finding well-matched node pairs across graphs to reduce the domain gap, which is solved with a novel Bipartite Graph Matching adaptor (BGM). In a nutshell, we utilize graph nodes to establish semantic-aware node affinity and leverage graph edges as quadratic constraints in a structure-aware matching loss, achieving fine-grained adaptation with a node-to-node graph matching. Extensive experiments verify that SIGMA outperforms existing works significantly. Our code is available at https://github.com/CityU-AIM-Group/SIGMA.

Xiaoqing Guo, Jie Liu, Tongliang Liu et al.

This paper studies a practical domain adaptive (DA) semantic segmentation problem where only pseudo-labeled target data is accessible through a black-box model. Due to the domain gap and label shift between two domains, pseudo-labeled target data contains mixed closed-set and open-set label noises. In this paper, we propose a simplex noise transition matrix (SimT) to model the mixed noise distributions in DA semantic segmentation and formulate the problem as estimation of SimT. By exploiting computational geometry analysis and properties of segmentation, we design three complementary regularizers, i.e. volume regularization, anchor guidance, convex guarantee, to approximate the true SimT. Specifically, volume regularization minimizes the volume of simplex formed by rows of the non-square SimT, which ensures outputs of segmentation model to fit into the ground truth label distribution. To compensate for the lack of open-set knowledge, anchor guidance and convex guarantee are devised to facilitate the modeling of open-set noise distribution and enhance the discriminative feature learning among closed-set and open-set classes. The estimated SimT is further utilized to correct noise issues in pseudo labels and promote the generalization ability of segmentation model on target domain data. Extensive experimental results demonstrate that the proposed SimT can be flexibly plugged into existing DA methods to boost the performance. The source code is available at https://github.com/CityU-AIM-Group/SimT.

Yifan Zhang, Qijian Zhang, Zhiyu Zhu et al.

The inherent ambiguity in ground-truth annotations of 3D bounding boxes, caused by occlusions, signal missing, or manual annotation errors, can confuse deep 3D object detectors during training, thus deteriorating detection accuracy. However, existing methods overlook such issues to some extent and treat the labels as deterministic. In this paper, we formulate the label uncertainty problem as the diversity of potentially plausible bounding boxes of objects. Then, we propose GLENet, a generative framework adapted from conditional variational autoencoders, to model the one-to-many relationship between a typical 3D object and its potential ground-truth bounding boxes with latent variables. The label uncertainty generated by GLENet is a plug-and-play module and can be conveniently integrated into existing deep 3D detectors to build probabilistic detectors and supervise the learning of the localization uncertainty. Besides, we propose an uncertainty-aware quality estimator architecture in probabilistic detectors to guide the training of the IoU-branch with predicted localization uncertainty. We incorporate the proposed methods into various popular base 3D detectors and demonstrate significant and consistent performance gains on both KITTI and Waymo benchmark datasets. Especially, the proposed GLENet-VR outperforms all published LiDAR-based approaches by a large margin and achieves the top rank among single-modal methods on the challenging KITTI test set. The source code and pre-trained models are publicly available at \url{https://github.com/Eaphan/GLENet}.

Yifan Zhang, Qijian Zhang, Junhui Hou et al.

To achieve reliable and precise scene understanding, autonomous vehicles typically incorporate multiple sensing modalities to capitalize on their complementary attributes. However, existing cross-modal 3D detectors do not fully utilize the image domain information to address the bottleneck issues of the LiDAR-based detectors. This paper presents a new cross-modal 3D object detector, namely UPIDet, which aims to unleash the potential of the image branch from two aspects. First, UPIDet introduces a new 2D auxiliary task called normalized local coordinate map estimation. This approach enables the learning of local spatial-aware features from the image modality to supplement sparse point clouds. Second, we discover that the representational capability of the point cloud backbone can be enhanced through the gradients backpropagated from the training objectives of the image branch, utilizing a succinct and effective point-to-pixel module. Extensive experiments and ablation studies validate the effectiveness of our method. Notably, we achieved the top rank in the highly competitive cyclist class of the KITTI benchmark at the time of submission. The source code is available at https://github.com/Eaphan/UPIDet.

Yiming Zeng, Yue Qian, Qijian Zhang et al.

This paper investigates the problem of temporally interpolating dynamic 3D point clouds with large non-rigid deformation. We formulate the problem as estimation of point-wise trajectories (i.e., smooth curves) and further reason that temporal irregularity and under-sampling are two major challenges. To tackle the challenges, we propose IDEA-Net, an end-to-end deep learning framework, which disentangles the problem under the assistance of the explicitly learned temporal consistency. Specifically, we propose a temporal consistency learning module to align two consecutive point cloud frames point-wisely, based on which we can employ linear interpolation to obtain coarse trajectories/in-between frames. To compensate the high-order nonlinear components of trajectories, we apply aligned feature embeddings that encode local geometry properties to regress point-wise increments, which are combined with the coarse estimations. We demonstrate the effectiveness of our method on various point cloud sequences and observe large improvement over state-of-the-art methods both quantitatively and visually. Our framework can bring benefits to 3D motion data acquisition. The source code is publicly available at https://github.com/ZENGYIMING-EAMON/IDEA-Net.git.

Jie Liu, Yixiao Zhang, Jie-Neng Chen et al.

An increasing number of public datasets have shown a marked impact on automated organ segmentation and tumor detection. However, due to the small size and partially labeled problem of each dataset, as well as a limited investigation of diverse types of tumors, the resulting models are often limited to segmenting specific organs/tumors and ignore the semantics of anatomical structures, nor can they be extended to novel domains. To address these issues, we propose the CLIP-Driven Universal Model, which incorporates text embedding learned from Contrastive Language-Image Pre-training (CLIP) to segmentation models. This CLIP-based label encoding captures anatomical relationships, enabling the model to learn a structured feature embedding and segment 25 organs and 6 types of tumors. The proposed model is developed from an assembly of 14 datasets, using a total of 3,410 CT scans for training and then evaluated on 6,162 external CT scans from 3 additional datasets. We rank first on the Medical Segmentation Decathlon (MSD) public leaderboard and achieve state-of-the-art results on Beyond The Cranial Vault (BTCV). Additionally, the Universal Model is computationally more efficient (6x faster) compared with dataset-specific models, generalized better to CT scans from varying sites, and shows stronger transfer learning performance on novel tasks.

Matthias Eisenmann, Annika Reinke, Vivienn Weru et al. · utoronto

The number of international benchmarking competitions is steadily increasing in various fields of machine learning (ML) research and practice. So far, however, little is known about the common practice as well as bottlenecks faced by the community in tackling the research questions posed. To shed light on the status quo of algorithm development in the specific field of biomedical imaging analysis, we designed an international survey that was issued to all participants of challenges conducted in conjunction with the IEEE ISBI 2021 and MICCAI 2021 conferences (80 competitions in total). The survey covered participants' expertise and working environments, their chosen strategies, as well as algorithm characteristics. A median of 72% challenge participants took part in the survey. According to our results, knowledge exchange was the primary incentive (70%) for participation, while the reception of prize money played only a minor role (16%). While a median of 80 working hours was spent on method development, a large portion of participants stated that they did not have enough time for method development (32%). 25% perceived the infrastructure to be a bottleneck. Overall, 94% of all solutions were deep learning-based. Of these, 84% were based on standard architectures. 43% of the respondents reported that the data samples (e.g., images) were too large to be processed at once. This was most commonly addressed by patch-based training (69%), downsampling (37%), and solving 3D analysis tasks as a series of 2D tasks. K-fold cross-validation on the training set was performed by only 37% of the participants and only 50% of the participants performed ensembling based on multiple identical models (61%) or heterogeneous models (39%). 48% of the respondents applied postprocessing steps.

Xiaoqing Guo, Yixuan Yuan

Noisy labels collected with limited annotation cost prevent medical image segmentation algorithms from learning precise semantic correlations. Previous segmentation arts of learning with noisy labels merely perform a pixel-wise manner to preserve semantics, such as pixel-wise label correction, but neglect the pair-wise manner. In fact, we observe that the pair-wise manner capturing affinity relations between pixels can greatly reduce the label noise rate. Motivated by this observation, we present a novel perspective for noisy mitigation by incorporating both pixel-wise and pair-wise manners, where supervisions are derived from noisy class and affinity labels, respectively. Unifying the pixel-wise and pair-wise manners, we propose a robust Joint Class-Affinity Segmentation (JCAS) framework to combat label noise issues in medical image segmentation. Considering the affinity in pair-wise manner incorporates contextual dependencies, a differentiated affinity reasoning (DAR) module is devised to rectify the pixel-wise segmentation prediction by reasoning about intra-class and inter-class affinity relations. To further enhance the noise resistance, a class-affinity loss correction (CALC) strategy is designed to correct supervision signals via the modeled noise label distributions in class and affinity labels. Meanwhile, CALC strategy interacts the pixel-wise and pair-wise manners through the theoretically derived consistency regularization. Extensive experiments under both synthetic and real-world noisy labels corroborate the efficacy of the proposed JCAS framework with a minimum gap towards the upper bound performance. The source code is available at \url{https://github.com/CityU-AIM-Group/JCAS}.

Jiaqi Wang, Zhengliang Liu, Lin Zhao et al.

Visual prompt engineering is a fundamental technology in the field of visual and image Artificial General Intelligence, serving as a key component for achieving zero-shot capabilities. As the development of large vision models progresses, the importance of prompt engineering becomes increasingly evident. Designing suitable prompts for specific visual tasks has emerged as a meaningful research direction. This review aims to summarize the methods employed in the computer vision domain for large vision models and visual prompt engineering, exploring the latest advancements in visual prompt engineering. We present influential large models in the visual domain and a range of prompt engineering methods employed on these models. It is our hope that this review provides a comprehensive and systematic description of prompt engineering methods based on large visual models, offering valuable insights for future researchers in their exploration of this field.

Xiang Li, Lin Zhao, Lu Zhang et al.

Large-scale Artificial General Intelligence (AGI) models, including Large Language Models (LLMs) such as ChatGPT/GPT-4, have achieved unprecedented success in a variety of general domain tasks. Yet, when applied directly to specialized domains like medical imaging, which require in-depth expertise, these models face notable challenges arising from the medical field's inherent complexities and unique characteristics. In this review, we delve into the potential applications of AGI models in medical imaging and healthcare, with a primary focus on LLMs, Large Vision Models, and Large Multimodal Models. We provide a thorough overview of the key features and enabling techniques of LLMs and AGI, and further examine the roadmaps guiding the evolution and implementation of AGI models in the medical sector, summarizing their present applications, potentialities, and associated challenges. In addition, we highlight potential future research directions, offering a holistic view on upcoming ventures. This comprehensive review aims to offer insights into the future implications of AGI in medical imaging, healthcare, and beyond.

Xinyu Liu, Wuyang Li, Yixuan Yuan

Semi-supervised medical image segmentation aims to leverage limited annotated data and rich unlabeled data to perform accurate segmentation. However, existing semi-supervised methods are highly dependent on the quality of self-generated pseudo labels, which are prone to incorrect supervision and confirmation bias. Meanwhile, they are insufficient in capturing the label distributions in latent space and suffer from limited generalization to unlabeled data. To address these issues, we propose a Latent Diffusion Label Rectification Model (DiffRect) for semi-supervised medical image segmentation. DiffRect first utilizes a Label Context Calibration Module (LCC) to calibrate the biased relationship between classes by learning the category-wise correlation in pseudo labels, then apply Latent Feature Rectification Module (LFR) on the latent space to formulate and align the pseudo label distributions of different levels via latent diffusion. It utilizes a denoising network to learn the coarse to fine and fine to precise consecutive distribution transportations. We evaluate DiffRect on three public datasets: ACDC, MS-CMRSEG 2019, and Decathlon Prostate. Experimental results demonstrate the effectiveness of DiffRect, e.g. it achieves 82.40\% Dice score on ACDC with only 1\% labeled scan available, outperforms the previous state-of-the-art by 4.60\% in Dice, and even rivals fully supervised performance. Code is released at \url{https://github.com/CUHK-AIM-Group/DiffRect}.

Jiaqi Wang, Enze Shi, Sigang Yu et al.

Prompt engineering is a critical technique in the field of natural language processing that involves designing and optimizing the prompts used to input information into models, aiming to enhance their performance on specific tasks. With the recent advancements in large language models, prompt engineering has shown significant superiority across various domains and has become increasingly important in the healthcare domain. However, there is a lack of comprehensive reviews specifically focusing on prompt engineering in the medical field. This review will introduce the latest advances in prompt engineering in the field of natural language processing for the medical field. First, we will provide the development of prompt engineering and emphasize its significant contributions to healthcare natural language processing applications such as question-answering systems, text summarization, and machine translation. With the continuous improvement of general large language models, the importance of prompt engineering in the healthcare domain is becoming increasingly prominent. The aim of this article is to provide useful resources and bridges for healthcare natural language processing researchers to better explore the application of prompt engineering in this field. We hope that this review can provide new ideas and inspire for research and application in medical natural language processing.

Zhenxiang Xiao, Yuzhong Chen, Lu Zhang et al.

Prompts have been proven to play a crucial role in large language models, and in recent years, vision models have also been using prompts to improve scalability for multiple downstream tasks. In this paper, we focus on adapting prompt design based on instruction tuning into a visual transformer model for image classification which we called Instruction-ViT. The key idea is to implement multi-modal prompts (text or image prompt) related to category information to guide the fine-tuning of the model. Based on the experiments of several image captionining tasks, the performance and domain adaptability were improved. Our work provided an innovative strategy to fuse multi-modal prompts with better performance and faster adaptability for visual classification models.

Yifan Liu, Wuyang Li, Cheng Wang et al.

Tooth point cloud segmentation is a fundamental task in many orthodontic applications. Current research mainly focuses on fully supervised learning which demands expensive and tedious manual point-wise annotation. Although recent weakly-supervised alternatives are proposed to use weak labels for 3D segmentation and achieve promising results, they tend to fail when the labels are extremely sparse. Inspired by the powerful promptable segmentation capability of the Segment Anything Model (SAM), we propose a framework named SAMTooth that leverages such capacity to complement the extremely sparse supervision. To automatically generate appropriate point prompts for SAM, we propose a novel Confidence-aware Prompt Generation strategy, where coarse category predictions are aggregated with confidence-aware filtering. Furthermore, to fully exploit the structural and shape clues in SAM's outputs for assisting the 3D feature learning, we advance a Mask-guided Representation Learning that re-projects the generated tooth masks of SAM into 3D space and constrains these points of different teeth to possess distinguished representations. To demonstrate the effectiveness of the framework, we conduct experiments on the public dataset and surprisingly find with only 0.1\% annotations (one point per tooth), our method can surpass recent weakly supervised methods by a large margin, and the performance is even comparable to the recent fully-supervised methods, showcasing the significant potential of applying SAM to 3D perception tasks with sparse labels. Code is available at https://github.com/CUHK-AIM-Group/SAMTooth.

Yifan Zhang, Junhui Hou, Yixuan Yuan

Recent years have witnessed significant advancements in deep learning-based 3D object detection, leading to its widespread adoption in numerous applications. As 3D object detectors become increasingly crucial for security-critical tasks, it is imperative to understand their robustness against adversarial attacks. This paper presents the first comprehensive evaluation and analysis of the robustness of LiDAR-based 3D detectors under adversarial attacks. Specifically, we extend three distinct adversarial attacks to the 3D object detection task, benchmarking the robustness of state-of-the-art LiDAR-based 3D object detectors against attacks on the KITTI and Waymo datasets. We further analyze the relationship between robustness and detector properties. Additionally, we explore the transferability of cross-model, cross-task, and cross-data attacks. Thorough experiments on defensive strategies for 3D detectors are conducted, demonstrating that simple transformations like flipping provide little help in improving robustness when the applied transformation strategy is exposed to attackers. \revise{Finally, we propose balanced adversarial focal training, based on conventional adversarial training, to strike a balance between accuracy and robustness.} Our findings will facilitate investigations into understanding and defending against adversarial attacks on LiDAR-based 3D object detectors, thus advancing the field. The source code is publicly available at \url{https://github.com/Eaphan/Robust3DOD}.

Xinyu Liu, Wuyang Li, Qiushi Yang et al.

Domain Adaptive Object Detection (DAOD) models a joint distribution of images and labels from an annotated source domain and learns a domain-invariant transformation to estimate the target labels with the given target domain images. Existing methods assume that the source domain labels are completely clean, yet large-scale datasets often contain error-prone annotations due to instance ambiguity, which may lead to a biased source distribution and severely degrade the performance of the domain adaptive detector de facto. In this paper, we represent the first effort to formulate noisy DAOD and propose a Noise Latent Transferability Exploration (NLTE) framework to address this issue. It is featured with 1) Potential Instance Mining (PIM), which leverages eligible proposals to recapture the miss-annotated instances from the background; 2) Morphable Graph Relation Module (MGRM), which models the adaptation feasibility and transition probability of noisy samples with relation matrices; 3) Entropy-Aware Gradient Reconcilement (EAGR), which incorporates the semantic information into the discrimination process and enforces the gradients provided by noisy and clean samples to be consistent towards learning domain-invariant representations. A thorough evaluation on benchmark DAOD datasets with noisy source annotations validates the effectiveness of NLTE. In particular, NLTE improves the mAP by 8.4\% under 60\% corrupted annotations and even approaches the ideal upper bound of training on a clean source dataset.

Guiyao Tie, Jiawen Shi, Dingjie Song et al.

Scientific research is being reshaped by AI systems that move beyond isolated assistance toward longer-horizon workflows spanning literature grounding, hypothesis generation, experimentation, validation, reporting, and revision. This shift marks a transition from task-level AI for science to workflow-level research automation. Yet current systems remain fragmented, differing in autonomy, domain scope, execution environment, validation mechanism, and human oversight, while still struggling with evidence preservation, reproducibility, weak-direction rejection, provenance tracking, cross-domain robustness, and accountable scientific closure. This survey examines these developments through AutoResearch, defined as the developmental spectrum of AI-powered scientific workflow automation. Within it, Vibe Research denotes the human-steered region of prompt-based assistance and human-verified execution, whereas emerging AI-led systems coordinate larger portions of the discovery loop without achieving robust autonomy. We analyze how research systems redistribute control, evidence, execution, validation, and accountability across workflows and organize the field around five workflow conditions: literature and research grounding; hypothesis formation and planning; experimentation and tool use; feedback, validation, and review; and reporting and knowledge communication. We further synthesize AI scientist systems, mixed-initiative co-research frameworks, benchmarks, domain deployments, and open-source infrastructures. Finally, we propose five evaluation dimensions--novelty, validity, impact, reliability, and provenance--and show that AutoResearch autonomy is domain-conditioned, being more credible in structured, executable, and rapidly verifiable settings but limited in embodied, delayed, heterogeneous, ethical, or institutionally accountable contexts.

Zhengliang Liu, Hanqi Jiang, Tianyang Zhong et al.

In this paper, we present a large-scale evaluation probing GPT-4V's capabilities and limitations for biomedical image analysis. GPT-4V represents a breakthrough in artificial general intelligence (AGI) for computer vision, with applications in the biomedical domain. We assess GPT-4V's performance across 16 medical imaging categories, including radiology, oncology, ophthalmology, pathology, and more. Tasks include modality recognition, anatomy localization, disease diagnosis, report generation, and lesion detection. The extensive experiments provide insights into GPT-4V's strengths and weaknesses. Results show GPT-4V's proficiency in modality and anatomy recognition but difficulty with disease diagnosis and localization. GPT-4V excels at diagnostic report generation, indicating strong image captioning skills. While promising for biomedical imaging AI, GPT-4V requires further enhancement and validation before clinical deployment. We emphasize responsible development and testing for trustworthy integration of biomedical AGI. This rigorous evaluation of GPT-4V on diverse medical images advances understanding of multimodal large language models (LLMs) and guides future work toward impactful healthcare applications.

Xinyu Liu, Zhen Chen, Wuyang Li et al.

Transformers have shown remarkable performance in 3D medical image segmentation, but their high computational requirements and need for large amounts of labeled data limit their applicability. To address these challenges, we consider two crucial aspects: model efficiency and data efficiency. Specifically, we propose Light-UNETR, a lightweight transformer designed to achieve model efficiency. Light-UNETR features a Lightweight Dimension Reductive Attention (LIDR) module, which reduces spatial and channel dimensions while capturing both global and local features via multi-branch attention. Additionally, we introduce a Compact Gated Linear Unit (CGLU) to selectively control channel interaction with minimal parameters. Furthermore, we introduce a Contextual Synergic Enhancement (CSE) learning strategy, which aims to boost the data efficiency of Transformers. It first leverages the extrinsic contextual information to support the learning of unlabeled data with Attention-Guided Replacement, then applies Spatial Masking Consistency that utilizes intrinsic contextual information to enhance the spatial context reasoning for unlabeled data. Extensive experiments on various benchmarks demonstrate the superiority of our approach in both performance and efficiency. For example, with only 10% labeled data on the Left Atrial Segmentation dataset, our method surpasses BCP by 1.43% Jaccard while drastically reducing the FLOPs by 90.8% and parameters by 85.8%. Code is released at https://github.com/CUHK-AIM-Group/Light-UNETR.

Hongzhu Yi, Yujia Yang, Yuanxiang Wang et al.

In recent years, image editing models have made significant progress, enabling users to manipulate visual content in a flexible and interactive manner through natural language instructions. However, an important yet underexplored research direction remains dense visual document image editing, which involves modifying textual content within images while faithfully preserving the original text style and background context. Existing methods primarily focus on English scenarios and images with relatively sparse text, and thus cannot adequately address dense, structurally complex documents or non-Latin scripts such as Chinese. To bridge this gap, we propose VDE Bench (Visual Doc Edit Bench), a rigorously human annotated and evaluated benchmark specifically designed to assess the performance of image editing models on bilingual Chinese-English and complex visual document editing tasks. The benchmark comprises a high quality dataset of 942 instruction based image editing samples, whose seed images encompass dense Chinese and English text documents including academic papers, posters, presentation slides, examination materials, and newspapers. Furthermore, we introduce a novel evaluation framework that systematically quantifies editing performance at the OCR parsing level, thereby enabling fine grained assessment of text modification accuracy. Based on this benchmark, we conduct a comprehensive evaluation of representative image editing models. Human verification demonstrates a high degree of consistency between human judgments and automated evaluation metrics. VDE Bench constitutes the first systematic benchmark for evaluating the performance of image editing models on bilingual dense text visual documents.

Meilu Zhu, Zhiwei Wang, Axiu Mao et al.

Federated learning (FL) offers a privacy-preserving paradigm for collaborative medical image analysis without sharing raw data. However, the absence of standardized benchmarks for medical image segmentation hinders fair and comprehensive evaluation of FL methods. To address this gap, we introduce FL-MedSegBench, the first comprehensive benchmark for federated learning on medical image segmentation. Our benchmark encompasses nine segmentation tasks across ten imaging modalities, covering both 2D and 3D formats with realistic clinical heterogeneity. We systematically evaluate eight generic FL (gFL) and five personalized FL (pFL) methods across multiple dimensions: segmentation accuracy, fairness, communication efficiency, convergence behavior, and generalization to unseen domains. Extensive experiments reveal several key insights: (i) pFL methods, particularly those with client-specific batch normalization (\textit{e.g.}, FedBN), consistently outperform generic approaches; (ii) No single method universally dominates, with performance being dataset-dependent; (iii) Communication frequency analysis shows normalization-based personalization methods exhibit remarkable robustness to reduced communication frequency; (iv) Fairness evaluation identifies methods like Ditto and FedRDN that protect underperforming clients; (v) A method's generalization to unseen domains is strongly tied to its ability to perform well across participating clients. We will release an open-source toolkit to foster reproducible research and accelerate clinically applicable FL solutions, providing empirically grounded guidelines for real-world clinical deployment. The source code is available at https://github.com/meiluzhu/FL-MedSegBench.

Shengyuan Liu, Liuxin Bao, Qi Yang et al.

Medical image segmentation is evolving from task-specific models toward generalizable frameworks. Recent research leverages Multi-modal Large Language Models (MLLMs) as autonomous agents, employing reinforcement learning with verifiable reward (RLVR) to orchestrate specialized tools like the Segment Anything Model (SAM). However, these approaches often rely on single-turn, rigid interaction strategies and lack process-level supervision during training, which hinders their ability to fully exploit the dynamic potential of interactive tools and leads to redundant actions. To bridge this gap, we propose MedSAM-Agent, a framework that reformulates interactive segmentation as a multi-step autonomous decision-making process. First, we introduce a hybrid prompting strategy for expert-curated trajectory generation, enabling the model to internalize human-like decision heuristics and adaptive refinement strategies. Furthermore, we develop a two-stage training pipeline that integrates multi-turn, end-to-end outcome verification with a clinical-fidelity process reward design to promote interaction parsimony and decision efficiency. Extensive experiments across 6 medical modalities and 21 datasets demonstrate that MedSAM-Agent achieves state-of-the-art performance, effectively unifying autonomous medical reasoning with robust, iterative optimization. Code is available \href{https://github.com/CUHK-AIM-Group/MedSAM-Agent}{here}.

Zhen Zhao, Zicheng Wang, Longyue Wang et al.

Semi-supervised medical image segmentation studies have shown promise in training models with limited labeled data. However, current dominant teacher-student based approaches can suffer from the confirmation bias. To address this challenge, we propose AD-MT, an alternate diverse teaching approach in a teacher-student framework. It involves a single student model and two non-trainable teacher models that are momentum-updated periodically and randomly in an alternate fashion. To mitigate the confirmation bias from the diverse supervision, the core of AD-MT lies in two proposed modules: the Random Periodic Alternate (RPA) Updating Module and the Conflict-Combating Module (CCM). The RPA schedules the alternating diverse updating process with complementary data batches, distinct data augmentation, and random switching periods to encourage diverse reasoning from different teaching perspectives. The CCM employs an entropy-based ensembling strategy to encourage the model to learn from both the consistent and conflicting predictions between the teachers. Experimental results demonstrate the effectiveness and superiority of our AD-MT on the 2D and 3D medical segmentation benchmarks across various semi-supervised settings.

Zhen Zhao, Ye Liu, Meng Zhao et al.

Studies on semi-supervised medical image segmentation (SSMIS) have seen fast progress recently. Due to the limited labelled data, SSMIS methods mainly focus on effectively leveraging unlabeled data to enhance the segmentation performance. However, despite their promising performance, current state-of-the-art methods often prioritize integrating complex techniques and loss terms rather than addressing the core challenges of semi-supervised scenarios directly. We argue that the key to SSMIS lies in generating substantial and appropriate prediction disagreement on unlabeled data. To this end, we emphasize the crutiality of data perturbation and model stabilization in semi-supervised segmentation, and propose a simple yet effective approach to boost SSMIS performance significantly, dubbed DPMS. Specifically, we first revisit SSMIS from three distinct perspectives: the data, the model, and the loss, and conduct a comprehensive study of corresponding strategies to examine their effectiveness. Based on these examinations, we then propose DPMS, which adopts a plain teacher-student framework with a standard supervised loss and unsupervised consistency loss. To produce appropriate prediction disagreements, DPMS perturbs the unlabeled data via strong augmentations to enlarge prediction disagreements considerably. On the other hand, using EMA teacher when strong augmentation is applied does not necessarily improve performance. DPMS further utilizes a forwarding-twice and momentum updating strategies for normalization statistics to stabilize the training on unlabeled data effectively. Despite its simplicity, DPMS can obtain new state-of-the-art performance on the public 2D ACDC and 3D LA datasets across various semi-supervised settings, e.g. obtaining a remarkable 22.62% improvement against previous SOTA on ACDC with 5% labels.

Chenxin Li, Xinyu Liu, Cheng Wang et al.

Recent advances in learning multi-modal representation have witnessed the success in biomedical domains. While established techniques enable handling multi-modal information, the challenges are posed when extended to various clinical modalities and practical modalitymissing setting due to the inherent modality gaps. To tackle these, we propose an innovative Modality-prompted Heterogeneous Graph for Omnimodal Learning (GTP-4o), which embeds the numerous disparate clinical modalities into a unified representation, completes the deficient embedding of missing modality and reformulates the cross-modal learning with a graph-based aggregation. Specially, we establish a heterogeneous graph embedding to explicitly capture the diverse semantic properties on both the modality-specific features (nodes) and the cross-modal relations (edges). Then, we design a modality-prompted completion that enables completing the inadequate graph representation of missing modality through a graph prompting mechanism, which generates hallucination graphic topologies to steer the missing embedding towards the intact representation. Through the completed graph, we meticulously develop a knowledge-guided hierarchical cross-modal aggregation consisting of a global meta-path neighbouring to uncover the potential heterogeneous neighbors along the pathways driven by domain knowledge, and a local multi-relation aggregation module for the comprehensive cross-modal interaction across various heterogeneous relations. We assess the efficacy of our methodology on rigorous benchmarking experiments against prior state-of-the-arts. In a nutshell, GTP-4o presents an initial foray into the intriguing realm of embedding, relating and perceiving the heterogeneous patterns from various clinical modalities holistically via a graph theory. Project page: https://gtp-4-o.github.io/.

Chenxin Li, Hengyu Liu, Zhiwen Fan et al.

Recent advancements in large generative models and real-time neural rendering using point-based techniques pave the way for a future of widespread visual data distribution through sharing synthesized 3D assets. However, while standardized methods for embedding proprietary or copyright information, either overtly or subtly, exist for conventional visual content such as images and videos, this issue remains unexplored for emerging generative 3D formats like Gaussian Splatting. We present GaussianStego, a method for embedding steganographic information in the rendering of generated 3D assets. Our approach employs an optimization framework that enables the accurate extraction of hidden information from images rendered using Gaussian assets derived from large models, while maintaining their original visual quality. We conduct preliminary evaluations of our method across several potential deployment scenarios and discuss issues identified through analysis. GaussianStego represents an initial exploration into the novel challenge of embedding customizable, imperceptible, and recoverable information within the renders produced by current 3D generative models, while ensuring minimal impact on the rendered content's quality.

Chenxin Li, Brandon Y. Feng, Yifan Liu et al.

3D reconstruction of biological tissues from a collection of endoscopic images is a key to unlock various important downstream surgical applications with 3D capabilities. Existing methods employ various advanced neural rendering techniques for photorealistic view synthesis, but they often struggle to recover accurate 3D representations when only sparse observations are available, which is usually the case in real-world clinical scenarios. To tackle this {sparsity} challenge, we propose a framework leveraging the prior knowledge from multiple foundation models during the reconstruction process, dubbed as \textit{EndoSparse}. Experimental results indicate that our proposed strategy significantly improves the geometric and appearance quality under challenging sparse-view conditions, including using only three views. In rigorous benchmarking experiments against state-of-the-art methods, \textit{EndoSparse} achieves superior results in terms of accurate geometry, realistic appearance, and rendering efficiency, confirming the robustness to sparse-view limitations in endoscopic reconstruction. \textit{EndoSparse} signifies a steady step towards the practical deployment of neural 3D reconstruction in real-world clinical scenarios. Project page: https://endo-sparse.github.io/.

Zhihao Peng, Cheng Wang, Shengyuan Liu et al.

Brain imaging analysis is vital for diagnosing and treating brain disorders, and multimodal large language models (MLLMs) are increasingly assisting in that analysis. However, current brain-oriented visual question-answering (VQA) benchmarks either cover a few imaging modalities or are limited to coarse-grained pathological descriptions, hindering a comprehensive assessment of MLLMs throughout the full clinical continuum. To address these, we introduce OmniBrainBench, the first comprehensive multimodal VQA benchmark specifically designed to assess the multimodal comprehension capabilities of MLLMs in brain imaging analysis.OmniBrainBench consists of 15 distinct brain imaging modalities collected from 30 verified medical sources, yielding 9,527 validated VQA pairs and 31,706 images. It simulates clinical workflows and encompasses 15 multi-stage clinical tasks rigorously validated by a professional radiologist. Evaluation of 24 state-of-the-art models, including open-source, medical, and proprietary MLLMs, highlights the substantial challenges posed by OmniBrainBench. Our experiments reveal: (1) proprietary MLLMs (e.g., GPT-5) beat open-source and medical models but lag physicians; (2) medical MLLMs vary widely in performance; (3) open-source MLLMs trail overall but excel in specific tasks; (4) MLLMs underperform sharply in complex preoperative tasks, revealing a visual-to-clinical reasoning gap. OmniBrainBench sets a new standard for evaluating and advancing MLLMs in brain imaging analysis, highlighting gaps compared to expert clinical reasoning. We release it at benchmark \& code.

Wei Dai, Rui Liu, Zixuan Wu et al.

Early detection and accurate diagnosis can predict the risk of malignant disease transformation, thereby increasing the probability of effective treatment. Identifying mild syndrome with small pathological regions serves as an ominous warning and is fundamental in the early diagnosis of diseases. While deep learning algorithms, particularly convolutional neural networks (CNNs), have shown promise in segmenting medical objects, analyzing small areas in medical images remains challenging. This difficulty arises due to information losses and compression defects from convolution and pooling operations in CNNs, which become more pronounced as the network deepens, especially for small medical objects. To address these challenges, we propose a novel scale-variant attention-based network (SvANet) for accurately segmenting small-scale objects in medical images. The SvANet consists of scale-variant attention, cross-scale guidance, Monte Carlo attention, and vision transformer, which incorporates cross-scale features and alleviates compression artifacts for enhancing the discrimination of small medical objects. Quantitative experimental results demonstrate the superior performance of SvANet, achieving 96.12%, 96.11%, 89.79%, 84.15%, 80.25%, 73.05%, and 72.58% in mean Dice coefficient for segmenting kidney tumors, skin lesions, hepatic tumors, polyps, surgical excision cells, retinal vasculatures, and sperms, which occupy less than 1% of the image areas in KiTS23, ISIC 2018, ATLAS, PolypGen, TissueNet, FIVES, and SpermHealth datasets, respectively.

Zhen Chen, Qing Xu, Xinyu Liu et al.

In digital pathology, precise nuclei segmentation is pivotal yet challenged by the diversity of tissue types, staining protocols, and imaging conditions. Recently, the segment anything model (SAM) revealed overwhelming performance in natural scenarios and impressive adaptation to medical imaging. Despite these advantages, the reliance of labor-intensive manual annotation as segmentation prompts severely hinders their clinical applicability, especially for nuclei image analysis containing massive cells where dense manual prompts are impractical. To overcome the limitations of current SAM methods while retaining the advantages, we propose the Universal prompt-free SAM framework for Nuclei segmentation (UN-SAM), by providing a fully automated solution with remarkable generalization capabilities. Specifically, to eliminate the labor-intensive requirement of per-nuclei annotations for prompt, we devise a multi-scale Self-Prompt Generation (SPGen) module to revolutionize clinical workflow by automatically generating high-quality mask hints to guide the segmentation tasks. Moreover, to unleash the generalization capability of SAM across a variety of nuclei images, we devise a Domain-adaptive Tuning Encoder (DT-Encoder) to seamlessly harmonize visual features with domain-common and domain-specific knowledge, and further devise a Domain Query-enhanced Decoder (DQ-Decoder) by leveraging learnable domain queries for segmentation decoding in different nuclei domains. Extensive experiments prove that UN-SAM with exceptional performance surpasses state-of-the-arts in nuclei instance and semantic segmentation, especially the generalization capability in zero-shot scenarios. The source code is available at https://github.com/CUHK-AIM-Group/UN-SAM.

Lap Yan Lennon Chan, Chenxin Li, Yixuan Yuan

Accurate lesion segmentation in whole-body PET/CT scans is crucial for cancer diagnosis and treatment planning, but limited datasets often hinder the performance of automated segmentation models. In this paper, we explore the potential of leveraging the deep prior from a generative model to serve as a data augmenter for automated lesion segmentation in PET/CT scans. We adapt the DiffTumor method, originally designed for CT images, to generate synthetic PET-CT images with lesions. Our approach trains the generative model on the AutoPET dataset and uses it to expand the training data. We then compare the performance of segmentation models trained on the original and augmented datasets. Our findings show that the model trained on the augmented dataset achieves a higher Dice score, demonstrating the potential of our data augmentation approach. In a nutshell, this work presents a promising direction for improving lesion segmentation in whole-body PET/CT scans with limited datasets, potentially enhancing the accuracy and reliability of cancer diagnostics.

Jakob Dexl, Katharina Jeblick, Andreas Mittermeier et al.

We report the design and results of the third autoPET challenge (MICCAI 2024), which benchmarked automated lesion segmentation in whole-body PET/CT under a compositional generalization setting. Training data comprised 1,014 [18F]-FDG PET/CT studies from the University Hospital Tübingen and 597 [18F]/[68Ga]-PSMA PET/CT studies from the LMU University Hospital Munich, constituting the largest publicly available annotated PSMA PET/CT dataset to date. The held-out test set of 200 studies covered four tracer-center combinations, two of which represented unseen compositional pairings. A complementary data-centric award category isolated the contribution of data handling strategies by restricting participants to a fixed baseline model. Seventeen teams submitted 27 algorithms, predominantly nnU-Net-based 3D networks with PET/CT channel concatenation. The top-ranked algorithm achieved a mean DSC of 0.66, FNV of 3.18 mL, and FPV of 2.78 mL across all four test conditions, improving DSC by 8% and reducing the false-negative volume by 5 mL relative to the provided baseline. Ranking was stable across bootstrap resampling and alternative ranking schemes for the top tier. Beyond the benchmark, we provide an in-depth analysis of segmentation performance at the patient and lesion level. Three main conclusions can be drawn: (1) in-domain multitracer PET/CT segmentation is sufficient and probably approaching reader agreement; (2) compositional generalization to unseen tracer-center combinations remains an open problem mainly driven by systematic volume overestimation; (3) heterogeneity and case difficulty drive performance variation substantially more than the choice of algorithm among top-ranked teams.

Yifan Liu, Chenxin Li, Chen Yang et al.

Reconstructing deformable tissues from endoscopic videos is essential in many downstream surgical applications. However, existing methods suffer from slow rendering speed, greatly limiting their practical use. In this paper, we introduce EndoGaussian, a real-time endoscopic scene reconstruction framework built on 3D Gaussian Splatting (3DGS). By integrating the efficient Gaussian representation and highly-optimized rendering engine, our framework significantly boosts the rendering speed to a real-time level. To adapt 3DGS for endoscopic scenes, we propose two strategies, Holistic Gaussian Initialization (HGI) and Spatio-temporal Gaussian Tracking (SGT), to handle the non-trivial Gaussian initialization and tissue deformation problems, respectively. In HGI, we leverage recent depth estimation models to predict depth maps of input binocular/monocular image sequences, based on which pixels are re-projected and combined for holistic initialization. In SPT, we propose to model surface dynamics using a deformation field, which is composed of an efficient encoding voxel and a lightweight deformation decoder, allowing for Gaussian tracking with minor training and rendering burden. Experiments on public datasets demonstrate our efficacy against prior SOTAs in many aspects, including better rendering speed (195 FPS real-time, 100$\times$ gain), better rendering quality (37.848 PSNR), and less training overhead (within 2 min/scene), showing significant promise for intraoperative surgery applications. Code is available at: \url{https://yifliu3.github.io/EndoGaussian/}.

Cheng Wang, Yu Jiang, Zhihao Peng et al.

Functional Magnetic Resonance Imaging (fMRI) is essential for studying brain function and diagnosing neurological disorders, but current analysis methods face reproducibility and transferability issues due to complex pre-processing and task-specific models. We introduce NeuroSTORM (Neuroimaging Foundation Model with Spatial-Temporal Optimized Representation Modeling), a generalizable framework that directly learns from 4D fMRI volumes and enables efficient knowledge transfer across diverse applications. NeuroSTORM is pre-trained on 28.65 million fMRI frames (>9,000 hours) from over 50,000 subjects across multiple centers and ages 5 to 100. Using a Mamba backbone and a shifted scanning strategy, it efficiently processes full 4D volumes. We also propose a spatial-temporal optimized pre-training approach and task-specific prompt tuning to improve transferability. NeuroSTORM outperforms existing methods across five tasks: age/gender prediction, phenotype prediction, disease diagnosis, fMRI-to-image retrieval, and task-based fMRI classification. It demonstrates strong clinical utility on datasets from hospitals in the U.S., South Korea, and Australia, achieving top performance in disease diagnosis and cognitive phenotype prediction. NeuroSTORM provides a standardized, open-source foundation model to improve reproducibility and transferability in fMRI-based clinical research.

Yifan Zhang, Junhui Hou, Siyu Ren et al.

This paper introduces a novel self-supervised learning framework for enhancing 3D perception in autonomous driving scenes. Specifically, our approach, namely NCLR, focuses on 2D-3D neural calibration, a novel pretext task that estimates the rigid pose aligning camera and LiDAR coordinate systems. First, we propose the learnable transformation alignment to bridge the domain gap between image and point cloud data, converting features into a unified representation space for effective comparison and matching. Second, we identify the overlapping area between the image and point cloud with the fused features. Third, we establish dense 2D-3D correspondences to estimate the rigid pose. The framework not only learns fine-grained matching from points to pixels but also achieves alignment of the image and point cloud at a holistic level, understanding the LiDAR-to-camera extrinsic parameters. We demonstrate the efficacy of NCLR by applying the pre-trained backbone to downstream tasks, such as LiDAR-based 3D semantic segmentation, object detection, and panoptic segmentation. Comprehensive experiments on various datasets illustrate the superiority of NCLR over existing self-supervised methods. The results confirm that joint learning from different modalities significantly enhances the network's understanding abilities and effectiveness of learned representation. The code is publicly available at https://github.com/Eaphan/NCLR.

Shengyuan Liu, Boyun Zheng, Wenting Chen et al.

Endoscopic procedures are essential for diagnosing and treating internal diseases, and multi-modal large language models (MLLMs) are increasingly applied to assist in endoscopy analysis. However, current benchmarks are limited, as they typically cover specific endoscopic scenarios and a small set of clinical tasks, failing to capture the real-world diversity of endoscopic scenarios and the full range of skills needed in clinical workflows. To address these issues, we introduce EndoBench, the first comprehensive benchmark specifically designed to assess MLLMs across the full spectrum of endoscopic practice with multi-dimensional capacities. EndoBench encompasses 4 distinct endoscopic scenarios, 12 specialized clinical tasks with 12 secondary subtasks, and 5 levels of visual prompting granularities, resulting in 6,832 rigorously validated VQA pairs from 21 diverse datasets. Our multi-dimensional evaluation framework mirrors the clinical workflow--spanning anatomical recognition, lesion analysis, spatial localization, and surgical operations--to holistically gauge the perceptual and diagnostic abilities of MLLMs in realistic scenarios. We benchmark 23 state-of-the-art models, including general-purpose, medical-specialized, and proprietary MLLMs, and establish human clinician performance as a reference standard. Our extensive experiments reveal: (1) proprietary MLLMs outperform open-source and medical-specialized models overall, but still trail human experts; (2) medical-domain supervised fine-tuning substantially boosts task-specific accuracy; and (3) model performance remains sensitive to prompt format and clinical task complexity. EndoBench establishes a new standard for evaluating and advancing MLLMs in endoscopy, highlighting both progress and persistent gaps between current models and expert clinical reasoning. We publicly release our benchmark and code.

Hongtao Wu, Boyun Zheng, Dingjie Song et al.

Autonomous systems that generate scientific hypotheses, conduct experiments, and draft manuscripts have recently emerged as a promising paradigm for accelerating discovery. However, existing AI Scientists remain largely domain-agnostic, limiting their applicability to clinical medicine, where research is required to be grounded in medical evidence with specialized data modalities. In this work, we introduce Medical AI Scientist, the first autonomous research framework tailored to clinical autonomous research. It enables clinically grounded ideation by transforming extensively surveyed literature into actionable evidence through clinician-engineer co-reasoning mechanism, which improves the traceability of generated research ideas. It further facilitates evidence-grounded manuscript drafting guided by structured medical compositional conventions and ethical policies. The framework operates under 3 research modes, namely paper-based reproduction, literature-inspired innovation, and task-driven exploration, each corresponding to a distinct level of automated scientific inquiry with progressively increasing autonomy. Comprehensive evaluations by both large language models and human experts demonstrate that the ideas generated by the Medical AI Scientist are of substantially higher quality than those produced by commercial LLMs across 171 cases, 19 clinical tasks, and 6 data modalities. Meanwhile, our system achieves strong alignment between the proposed method and its implementation, while also demonstrating significantly higher success rates in executable experiments. Double-blind evaluations by human experts and the Stanford Agentic Reviewer suggest that the generated manuscripts approach MICCAI-level quality, while consistently surpassing those from ISBI and BIBM. The proposed Medical AI Scientist highlights the potential of leveraging AI for autonomous scientific discovery in healthcare.

Shengyuan Liu, Zhen Chen, Qiushi Yang et al.

Automated diagnostic systems (ADS) have shown significant potential in the early detection of polyps during endoscopic examinations, thereby reducing the incidence of colorectal cancer. However, due to high annotation costs and strict privacy concerns, acquiring high-quality endoscopic images poses a considerable challenge in the development of ADS. Despite recent advancements in generating synthetic images for dataset expansion, existing endoscopic image generation algorithms failed to accurately generate the details of polyp boundary regions and typically required medical priors to specify plausible locations and shapes of polyps, which limited the realism and diversity of the generated images. To address these limitations, we present Polyp-Gen, the first full-automatic diffusion-based endoscopic image generation framework. Specifically, we devise a spatial-aware diffusion training scheme with a lesion-guided loss to enhance the structural context of polyp boundary regions. Moreover, to capture medical priors for the localization of potential polyp areas, we introduce a hierarchical retrieval-based sampling strategy to match similar fine-grained spatial features. In this way, our Polyp-Gen can generate realistic and diverse endoscopic images for building reliable ADS. Extensive experiments demonstrate the state-of-the-art generation quality, and the synthetic images can improve the downstream polyp detection task. Additionally, our Polyp-Gen has shown remarkable zero-shot generalizability on other datasets. The source code is available at https://github.com/CUHK-AIM-Group/Polyp-Gen.

Meilu Zhu, Axiu Mao, Jun Liu et al.

Integrating low-rank adaptation (LoRA) with federated learning (FL) has received widespread attention recently, aiming to adapt pretrained foundation models (FMs) to downstream medical tasks via privacy-preserving decentralized training. However, owing to the direct combination of LoRA and FL, current methods generally undergo two problems, i.e., aggregation deviation, and differential privacy (DP) noise amplification effect. To address these problems, we propose a novel privacy-preserving federated finetuning framework called \underline{D}eviation \underline{E}liminating and Nois\underline{e} \underline{R}egulating (DEeR). Specifically, we firstly theoretically prove that the necessary condition to eliminate aggregation deviation is guaranteing the equivalence between LoRA parameters of clients. Based on the theoretical insight, a deviation eliminator is designed to utilize alternating minimization algorithm to iteratively optimize the zero-initialized and non-zero-initialized parameter matrices of LoRA, ensuring that aggregation deviation always be zeros during training. Furthermore, we also conduct an in-depth analysis of the noise amplification effect and find that this problem is mainly caused by the ``linear relationship'' between DP noise and LoRA parameters. To suppress the noise amplification effect, we propose a noise regulator that exploits two regulator factors to decouple relationship between DP and LoRA, thereby achieving robust privacy protection and excellent finetuning performance. Additionally, we perform comprehensive ablated experiments to verify the effectiveness of the deviation eliminator and noise regulator. DEeR shows better performance on public medical datasets in comparison with state-of-the-art approaches. The code is available at https://github.com/CUHK-AIM-Group/DEeR.

Yifan Liu, Keyu Fan, Weihao Yu et al.

Recent advances in generalizable 3D Gaussian Splatting have demonstrated promising results in real-time high-fidelity rendering without per-scene optimization, yet existing approaches still struggle to handle unfamiliar visual content during inference on novel scenes due to limited generalizability. To address this challenge, we introduce MonoSplat, a novel framework that leverages rich visual priors from pre-trained monocular depth foundation models for robust Gaussian reconstruction. Our approach consists of two key components: a Mono-Multi Feature Adapter that transforms monocular features into multi-view representations, coupled with an Integrated Gaussian Prediction module that effectively fuses both feature types for precise Gaussian generation. Through the Adapter's lightweight attention mechanism, features are seamlessly aligned and aggregated across views while preserving valuable monocular priors, enabling the Prediction module to generate Gaussian primitives with accurate geometry and appearance. Through extensive experiments on diverse real-world datasets, we convincingly demonstrate that MonoSplat achieves superior reconstruction quality and generalization capability compared to existing methods while maintaining computational efficiency with minimal trainable parameters. Codes are available at https://github.com/CUHK-AIM-Group/MonoSplat.

Panwang Pan, Chenguo Lin, Jingjing Zhao et al.

We introduce Diff4Splat, a feed-forward method that synthesizes controllable and explicit 4D scenes from a single image. Our approach unifies the generative priors of video diffusion models with geometry and motion constraints learned from large-scale 4D datasets. Given a single input image, a camera trajectory, and an optional text prompt, Diff4Splat directly predicts a deformable 3D Gaussian field that encodes appearance, geometry, and motion, all in a single forward pass, without test-time optimization or post-hoc refinement. At the core of our framework lies a video latent transformer, which augments video diffusion models to jointly capture spatio-temporal dependencies and predict time-varying 3D Gaussian primitives. Training is guided by objectives on appearance fidelity, geometric accuracy, and motion consistency, enabling Diff4Splat to synthesize high-quality 4D scenes in 30 seconds. We demonstrate the effectiveness of Diff4Splatacross video generation, novel view synthesis, and geometry extraction, where it matches or surpasses optimization-based methods for dynamic scene synthesis while being significantly more efficient.

Panwang Pan, Tingting Shen, Chenxin Li et al.

Recent advances in generative models have achieved high-fidelity in 3D human reconstruction, yet their utility for specific tasks (e.g., human 3D segmentation) remains constrained. We propose HumanCrafter, a unified framework that enables the joint modeling of appearance and human-part semantics from a single image in a feed-forward manner. Specifically, we integrate human geometric priors in the reconstruction stage and self-supervised semantic priors in the segmentation stage. To address labeled 3D human datasets scarcity, we further develop an interactive annotation procedure for generating high-quality data-label pairs. Our pixel-aligned aggregation enables cross-task synergy, while the multi-task objective simultaneously optimizes texture modeling fidelity and semantic consistency. Extensive experiments demonstrate that HumanCrafter surpasses existing state-of-the-art methods in both 3D human-part segmentation and 3D human reconstruction from a single image.

Shengyuan Liu, Zanting Ye, Yunrui Lin et al.

While specialized Medical Vision-Language Models (VLMs) have achieved remarkable success in interpreting 2D and 3D medical modalities, their deployment for 3D volumetric data remains constrained by significant computational inefficiencies. Current architectures typically suffer from massive anatomical redundancy due to the direct concatenation of consecutive 2D slices and lack the flexibility to handle heterogeneous information densities across different slices using fixed pruning ratios. To address these challenges, we propose MedPruner, a training-free and model-agnostic hierarchical token pruning framework specifically designed for efficient 3D medical image understanding. MedPruner introduces a two-stage mechanism: an Inter-slice Anchor-based Filtering module to eliminate slice-level temporal redundancy, followed by a Dynamic Information Nucleus Selection strategy that achieves adaptive token-level compression by quantifying cumulative attention weights. Extensive experiments on three 3D medical benchmarks and across three diverse medical VLMs reveal massive token redundancy in existing architectures. Notably, MedPruner enables models such as MedGemma to maintain or even exceed their original performance while retaining fewer than 5% of visual tokens, thereby drastically reducing computational overhead and validating the necessity of dynamic token selection for practical clinical deployment. Our code will be released.

Yifan Liu, Wuyang Li, Weihao Yu et al.

Computed Tomography serves as an indispensable tool in clinical workflows, providing non-invasive visualization of internal anatomical structures. Existing CT reconstruction works are limited to small-capacity model architecture and inflexible volume representation. In this work, we present X-GRM (X-ray Gaussian Reconstruction Model), a large feedforward model for reconstructing 3D CT volumes from sparse-view 2D X-ray projections. X-GRM employs a scalable transformer-based architecture to encode sparse-view X-ray inputs, where tokens from different views are integrated efficiently. Then, these tokens are decoded into a novel volume representation, named Voxel-based Gaussian Splatting (VoxGS), which enables efficient CT volume extraction and differentiable X-ray rendering. This combination of a high-capacity model and flexible volume representation, empowers our model to produce high-quality reconstructions from various testing inputs, including in-domain and out-domain X-ray projections. Our codes are available at: https://github.com/CUHK-AIM-Group/X-GRM.

Yiyang Lin, Chenhui Wang, Zhihao Peng et al.

Magnetic Resonance Imaging (MRI) field-strength enhancement holds immense value for both clinical diagnostics and advanced research. However, existing methods typically focus on isolated enhancement tasks, such as specific 64mT-to-3T or 3T-to-7T transitions using limited subject cohorts, thereby failing to exploit the shared degradation patterns inherent across different field strengths and severely restricting model generalization. To address this challenge, we propose \methodname, a unified framework integrating multiple modalities and enhancement tasks to mutually promote representation learning by exploiting these shared degradation characteristics. Specifically, our main contributions are threefold. Firstly, to overcome MRI data scarcity and capture continuous anatomical structures, \methodname departs from conventional methods that treat 3D MRI volumes as independent 2D slices. Instead, we directly exploit comprehensive 3D volumetric information by leveraging pre-trained 3D foundation models, thereby embedding generalized and robust structural representations to significantly boost enhancement performance. In addition, to mitigate the spectral bias of mainstream flow-matching models that often over-smooth high-frequency details, we explicitly incorporate the physical mechanisms of magnetic fields to introduce a Field-Aware Spectral Rectification Mechanism (FASRM), tailoring customized spectral corrections to distinct field strengths. Finally, to resolve the fundamental data bottleneck, we organize and publicly release a comprehensive paired multi-field MRI dataset, which is an order of magnitude larger than existing datasets. Extensive experiments demonstrate our method's superiority over state-of-the-art approaches, achieving an average improvement of approximately 1.81 dB in PSNR and 9.47\% in SSIM. Code will be released upon acceptance.

Chenhui Wang, Boyun Zheng, Liuxin Bao et al.

Precise prognostic modeling of glioblastoma (GBM) under varying treatment interventions is essential for optimizing clinical outcomes. While generative AI has shown promise in simulating GBM evolution, existing methods typically treat interventions as static conditional inputs rather than dynamic decision variables. Consequently, they fail to capture the complex, reciprocal interplay between tumor evolution and treatment response. To bridge this gap, we present Brain-WM, a pioneering brain GBM world model that unifies next-step treatment prediction and future MRI generation, thereby capturing the co-evolutionary dynamics between tumor and treatment. Specifically, Brain-WM encodes spatiotemporal dynamics into a shared latent space for joint autoregressive treatment prediction and flow-based future MRI generation. Then, instead of a conventional monolithic framework, Brain-WM adopts a novel Y-shaped Mixture-of-Transformers (MoT) architecture. This design structurally disentangles heterogeneous objectives, successfully leveraging cross-task synergies while preventing feature collapse. Finally, a synergistic multi-timepoint mask alignment objective explicitly anchors latent representations to anatomically grounded tumor structures and progression-aware semantics. Extensive validation on internal and external multi-institutional cohorts demonstrates the superiority of Brain-WM, achieving 91.5% accuracy in treatment planning and SSIMs of 0.8524, 0.8581, and 0.8404 for FLAIR, T1CE, and T2W sequences, respectively. Ultimately, Brain-WM offers a robust clinical sandbox for optimizing patient healthcare. The source code is made available at https://github.com/thibault-wch/Brain-GBM-world-model.

Zhiqin Yang, Yonggang Zhang, Chenxin Li et al.

Federated Learning (FL) confronts a significant challenge known as data heterogeneity, which impairs model performance and convergence. Existing methods have made notable progress in addressing this issue. However, improving performance in certain heterogeneity scenarios remains an overlooked question: \textit{How robust are these methods to deploy under diverse heterogeneity scenarios?} To answer this, we conduct comprehensive evaluations across varied heterogeneity scenarios, showing that most existing methods exhibit limited robustness. Meanwhile, insights from these experiments highlight that sharing statistical information can mitigate heterogeneity by enabling clients to update with a global perspective. Motivated by this, we propose \textbf{FedGPS} (\textbf{Fed}erated \textbf{G}oal-\textbf{P}ath \textbf{S}ynergy), a novel framework that seamlessly integrates statistical distribution and gradient information from others. Specifically, FedGPS statically modifies each client's learning objective to implicitly model the global data distribution using surrogate information, while dynamically adjusting local update directions with gradient information from other clients at each round. Extensive experiments show that FedGPS outperforms state-of-the-art methods across diverse heterogeneity scenarios, validating its effectiveness and robustness. The code is available at: https://github.com/CUHK-AIM-Group/FedGPS.

Xinyu Liu, Guolei Sun, Cheng Wang et al.

High-resolution (HR) medical videos are vital for accurate diagnosis, yet are hard to acquire due to hardware limitations and physiological constraints. Clinically, the collected low-resolution (LR) medical videos present unique challenges for video super-resolution (VSR) models, including camera shake, noise, and abrupt frame transitions, which result in significant optical flow errors and alignment difficulties. Additionally, tissues and organs exhibit continuous and nuanced structures, but current VSR models are prone to introducing artifacts and distorted features that can mislead doctors. To this end, we propose MedVSR, a tailored framework for medical VSR. It first employs Cross State-Space Propagation (CSSP) to address the imprecise alignment by projecting distant frames as control matrices within state-space models, enabling the selective propagation of consistent and informative features to neighboring frames for effective alignment. Moreover, we design an Inner State-Space Reconstruction (ISSR) module that enhances tissue structures and reduces artifacts with joint long-range spatial feature learning and large-kernel short-range information aggregation. Experiments across four datasets in diverse medical scenarios, including endoscopy and cataract surgeries, show that MedVSR significantly outperforms existing VSR models in reconstruction performance and efficiency. Code released at https://github.com/CUHK-AIM-Group/MedVSR.