Erin Wolf Chambers

Guangyu Meng, Pengfei Gu, Peixian Liang et al.

Contrastive learning (CL) has become a powerful approach for learning representations from unlabeled images. However, existing CL methods focus predominantly on visual appearance features while neglecting topological characteristics (e.g., connectivity patterns, boundary configurations, cavity formations) that provide valuable cues for medical image analysis. To address this limitation, we propose a new topological CL framework (TopoCL) that explicitly exploits topological structures during contrastive learning for medical imaging. Specifically, we first introduce topology-aware augmentations that control topological perturbations using a relative bottleneck distance between persistence diagrams, preserving medically relevant topological properties while enabling controlled structural variations. We then design a Hierarchical Topology Encoder that captures topological features through self-attention and cross-attention mechanisms. Finally, we develop an adaptive mixture-of-experts (MoE) module to dynamically integrate visual and topological representations. TopoCL can be seamlessly integrated with existing CL methods. We evaluate TopoCL on five representative CL methods (SimCLR, MoCo-v3, BYOL, DINO, and Barlow Twins) and five diverse medical image classification datasets. The experimental results show that TopoCL achieves consistent improvements: an average gain of +3.26% in linear probe classification accuracy with strong statistical significance, verifying its effectiveness.

Erin Wolf Chambers, Ishika Ghosh, Elizabeth Munch et al.

Mapper graphs are widely used tools in topological data analysis and visualization. They can be understood as discrete approximations of Reeb graphs, providing insight into the shape and connectivity of complex data. Given a high-dimensional point cloud together with a real-valued function defined on it, a mapper graph summarizes the induced topological structure: each node represents a local neighborhood, and edges connect nodes whose corresponding neighborhoods overlap. Our focus is the interleaving distance for mapper graphs, arising as a discretized analogue of the interleaving distance for Reeb graphs-a quantity known to be NP-hard to compute. This distance measures how similar two mapper graphs are by quantifying how much they must be ``stretched'' to be made comparable. Recent work introduced a loss function that gives an upper bound on this distance. The loss evaluates how far a given collection of maps, called an assignment, is from being a true interleaving. Importantly, it is computationally tractable, offering a practical way to bound the distance, however the quality of the bound is dependent on the choice of assignment. In this paper, we develop the first framework for bounding the interleaving distance on mapper graphs. We present the bound in two ways: first, by formulating an integer linear program (ILP) that determines whether an $n$-interleaving exists for a given $n$; and second, by constructing an ILP that identifies an assignment with minimal loss for that $n$. We also evaluate the method on small examples where the interleaving distance is known, and on benchmark and simulated datasets, demonstrating the utility of the approach for classification tasks based on mapper graphs.