Maximilian Schäfer

Bastian Heinlein, Nuria Zurita Jiménez, Kaikai Zhu et al.

In this paper, we introduce an autoencoder (AE)-based scheme for end-to-end optimization of a multi-user molecule mixture communication system. In the proposed scheme, each transmitter leverages an encoder network that maps the user symbol to a molecule mixture. The mixtures then propagate through the channel to the receiver, which samples the channel using a non-linear, cross-reactive sensor array. A decoder network then estimates the symbol transmitted by each user based on the sensor observations. The proposed scheme achieves, for a given signal-to-noise ratio, lower symbol error rates than a baseline scheme from the literature in a single-user setting with full channel state information. We additionally demonstrate that the proposed AE-based scheme allows reliable communication when the channel is unknown or changing. Finally, we show that for multiple access the system can account for different user priorities. In summary, the proposed AE-based scheme enables end-to-end system optimization in complex scenarios unsuitable for analytical treatment and thereby brings molecular communication systems closer to real-world deployment.

Timo Jakumeit, Bastian Heinlein, Vukašin Spasojević et al.

Synthetic molecular communication (MC) has emerged as a powerful framework for modeling, analyzing, and designing communication systems where information is encoded into properties of molecules. Among the envisioned applications of MC is the localization of molecule sources in pipe networks (PNs) like the human cardiovascular system (CVS), sewage networks (SNs), and industrial plants. While existing algorithms mostly focus on simplified scenarios, in this paper, we propose the first framework for source localization in complex PNs with known topology, by leveraging the mixture of inverse Gaussians for hemodynamic transport (MIGHT) model as a closed-form representation for advection-diffusion-driven MC in PNs. We propose a matched filter (MF)-based approach to identify molecule sources under realistic conditions such as unknown release times, random numbers of released molecules, sensor noise, and limited sensor sampling rate. We apply the algorithm to localize a source of viral markers in a real-world SN and show that the proposed scheme outperforms randomly guessing sources even at low signal-to-noise ratios (SNRs) at the sensor and achieves error-free localization under favorable conditions, i.e., high SNRs and sampling rates. Furthermore, by identifying clusters of frequently confused sources, reliable cluster-level localization is possible at substantially lower SNRs and sampling rates.

Timo Jakumeit, Lukas Brand, Josep M. Jornet et al.

Motivated by classical communications engineering, early works in molecular communication (MC) largely adopted established modeling and signal processing concepts from wireless electromagnetic communication systems. In the context of the human cardiovascular system (CVS), MC channel models evolved from simple unbounded and single-duct environments mimicking individual blood vessels to complex vessel network (VN) topologies, generally at the expense of analytical tractability. Up until now, this has largely prohibited rigorous communication-theoretic analysis of large-scale VNs. In this work, we leverage a recently established closed-form analytical channel model for VNs, named mixture of inverse Gaussians for hemodynamic transport (MIGHT), to conduct the first systematic communication-theoretic study of MC in complex, large-scale VNs. Based on MIGHT, we derive a Poisson channel noise model and unveil structural analogies between multipath wireless communications (MWC) and advective-diffusive MC in VNs. In particular, we establish classical MWC metrics, namely the root mean squared (RMS) delay spread, the mean excess delay, and the coherence bandwidth, for MC in VNs and derive closed-form expressions for the channel frequency response and power delay profile (PDP). Building on this characterization, we propose a VN-adapted, coherent decision-feedback (DF) detector and show how the derived multipath metrics can inform the choice of critical system parameters like the symbol duration, the sampling time, and the memory length. Additionally, we evaluate the detector's performance in different VNs exhibiting inter-symbol interference (ISI). Together, these contributions open the door to a systematic, MWC-inspired MC system design for large-scale VNs.

Theofilos Symeonidis, Fardad Vakilipoor, Robert Schober et al.

Molecular communication (MC) is a communication paradigm in which information is conveyed through the controlled release, propagation, and reception of molecules. Many envisioned healthcare applications of MC are expected to operate inside the human body. In this environment, the cardiovascular system ( CVS) acts as the physical channel, which forms a closed-loop network where particle transport is mainly governed by the combined effects of diffusion and flow. Despite the fact that physiological flows in many parts of the human body are inherently pulsatile due to the cardiac cycle, most existing models for dispersive closed-loop MC channels assume a constant flow velocity. In this paper, we present a time-variant one-dimensional (1D ) channel model for dispersive closed-loop MC systems with pulsatile flow. We derive an analytical expression for the channel impulse response (CIR ), which follows a wrapped Normal distribution with time-variant mean and variance. The obtained model reveals the cyclostationary nature of the channel and quantifies the influence of pulsation on the temporal concentration profile compared to steady-flow systems. Finally, the model is validated by three-dimensional ( 3D ) particle-based simulations (PBS s), showing excellent agreement and enabling an efficient analytical characterization of the channel.