Pranav M Pawar

Ann Rachel, Pranav M Pawar, Mithun Mukharjee et al.

Lung cancer is a condition where there is abnormal growth of malignant cells that spread in an uncontrollable fashion in the lungs. Some common treatment strategies are surgery, chemotherapy, and radiation which aren't the best options due to the heterogeneous nature of cancer. In personalized medicine, treatments are tailored according to the individual's genetic information along with lifestyle aspects. In addition, AI-based deep learning methods can analyze large sets of data to find early signs of cancer, types of tumor, and prospects of treatment. The paper focuses on the development of personalized treatment plans using specific patient data focusing primarily on the genetic profile. Multi-Omics data from Genomics of Drug Sensitivity in Cancer have been used to build a predictive model along with machine learning techniques. The value of the target variable, LN-IC50, determines how sensitive or resistive a drug is. An XGBoost regressor is utilized to predict the drug response focusing on molecular and cellular features extracted from cancer datasets. Cross-validation and Randomized Search are performed for hyperparameter tuning to further optimize the model's predictive performance. For explanation purposes, SHAP (SHapley Additive exPlanations) was used. SHAP values measure each feature's impact on an individual prediction. Furthermore, interpreting feature relationships was performed using DeepSeek, a large language model trained to verify the biological validity of the features. Contextual explanations regarding the most important genes or pathways were provided by DeepSeek alongside the top SHAP value constituents, supporting the predictability of the model.

Isha Andrade, Shalaka S Mahadik, Mithun Mukherjee et al.

The proliferation of large-scale IoT networks has been both a blessing and a curse. Not only has it revolutionized the way organizations operate by increasing the efficiency of automated procedures, but it has also simplified our daily lives. However, while IoT networks have improved convenience and connectivity, they have also increased security risk due to unauthorized devices gaining access to these networks and exploiting existing weaknesses with specific attack types. The research proposes two lightweight deep learning (DL)-based intelligent intrusion detection systems (IDS). to enhance the security of IoT networks: the proposed convolutional neural network (CNN)-based IDS and the proposed long short-term memory (LSTM)-based IDS. The research evaluated the performance of both intelligent IDSs based on DL using the CICIoT2023 dataset. DL-based intelligent IDSs successfully identify and classify various cyber threats using binary, grouped, and multi-class classification. The proposed CNN-based IDS achieves an accuracy of 99.34%, 99.02% and 98.6%, while the proposed LSTM-based IDS achieves an accuracy of 99.42%, 99.13%, and 98.68% for binary, grouped, and multi-class classification, respectively.