Lubin Gan

Lubin Gan, Jing Zhang, Heng Zhang et al.

Whole slide image (WSI) analysis heavily relies on multiple instance learning (MIL). While recent methods benefit from large-scale foundation models and advanced sequence modeling to capture long-range dependencies, they still struggle with two critical issues. First, directly applying frozen, task-agnostic features often leads to suboptimal separability due to the domain gap with specific histological tasks. Second, relying solely on global aggregators can cause over-smoothing, where sparse but critical diagnostic signals are overshadowed by the dominant background context. In this paper, we present ReconMIL, a novel framework designed to bridge this domain gap and balance global-local feature aggregation. Our approach introduces a Latent Space Reconstruction module that adaptively projects generic features into a compact, task-specific manifold, improving boundary delineation. To prevent information dilution, we develop a bi-stream architecture combining a Mamba-based global stream for contextual priors and a CNN-based local stream to preserve subtle morphological anomalies. A scale-adaptive selection mechanism dynamically fuses these two streams, determining when to rely on overall architecture versus local saliency. Evaluations across multiple diagnostic and survival prediction benchmarks show that ReconMIL consistently outperforms current state-of-the-art methods, effectively localizing fine-grained diagnostic regions while suppressing background noise. Visualization results confirm the models superior ability to localize diagnostic regions by effectively balancing global structure and local granularity.

Heng Zheng, Yuling Shi, Xiaodong Gu et al.

Visual geo-localization requires extensive geographic knowledge and sophisticated reasoning to determine image locations without GPS metadata. Traditional retrieval methods are constrained by database coverage and quality. Recent Large Vision-Language Models (LVLMs) enable direct location reasoning from image content, yet individual models struggle with diverse geographic regions and complex scenes. Existing multi-agent systems improve performance through model collaboration but treat all agent interactions uniformly. They lack mechanisms to handle conflicting predictions effectively. We propose \textbf{GraphGeo}, a multi-agent debate framework using heterogeneous graph neural networks for visual geo-localization. Our approach models diverse debate relationships through typed edges, distinguishing supportive collaboration, competitive argumentation, and knowledge transfer. We introduce a dual-level debate mechanism combining node-level refinement and edge-level argumentation modeling. A cross-level topology refinement strategy enables co-evolution between graph structure and agent representations. Experiments on multiple benchmarks demonstrate GraphGeo significantly outperforms state-of-the-art methods. Our framework transforms cognitive conflicts between agents into enhanced geo-localization accuracy through structured debate.

Lubin Gan, Jing Zhang, Linhao Qu et al.

The fine-grained classification of brain tumor subtypes from histopathological whole slide images is highly challenging due to subtle morphological variations and the scarcity of annotated data. Although vision-language models have enabled promising zero-shot classification, their ability to capture fine-grained pathological features remains limited, resulting in suboptimal subtype discrimination. To address these challenges, we propose the Fine-Grained Patch Alignment Network (FG-PAN), a novel zero-shot framework tailored for digital pathology. FG-PAN consists of two key modules: (1) a local feature refinement module that enhances patch-level visual features by modeling spatial relationships among representative patches, and (2) a fine-grained text description generation module that leverages large language models to produce pathology-aware, class-specific semantic prototypes. By aligning refined visual features with LLM-generated fine-grained descriptions, FG-PAN effectively increases class separability in both visual and semantic spaces. Extensive experiments on multiple public pathology datasets, including EBRAINS and TCGA, demonstrate that FG-PAN achieves state-of-the-art performance and robust generalization in zero-shot brain tumor subtype classification.

Xiaoman Wu, Lubin Gan, Siying Wu et al.

Multi-contrast Magnetic Resonance Imaging super-resolution (MC-MRI SR) aims to enhance low-resolution (LR) contrasts leveraging high-resolution (HR) references, shortening acquisition time and improving imaging efficiency while preserving anatomical details. The main challenge lies in maintaining spatial-semantic consistency, ensuring anatomical structures remain well-aligned and coherent despite structural discrepancies and motion between the target and reference images. Conventional methods insufficiently model spatial-semantic consistency and underuse frequency-domain information, which leads to poor fine-grained alignment and inadequate recovery of high-frequency details. In this paper, we propose the Spatial-Semantic Consistent Model (SSCM), which integrates a Dynamic Spatial Warping Module for inter-contrast spatial alignment, a Semantic-Aware Token Aggregation Block for long-range semantic consistency, and a Spatial-Frequency Fusion Block for fine structure restoration. Experiments on public and private datasets show that SSCM achieves state-of-the-art performance with fewer parameters while ensuring spatially and semantically consistent reconstructions.

Lubin Gan, Xiaoman Wu, Jing Zhang et al.

Multiple instance learning (MIL) has become the leading approach for extracting discriminative features from whole slide images (WSIs) in computational pathology. Attention-based MIL methods can identify key patches but tend to overlook contextual relationships. Transformer models are able to model interactions but require quadratic computational cost and are prone to overfitting. State space models (SSMs) offer linear complexity, yet shuffling patch order disrupts histological meaning and reduces interpretability. In this work, we introduce SemaMIL, which integrates Semantic Reordering (SR), an adaptive method that clusters and arranges semantically similar patches in sequence through a reversible permutation, with a Semantic-guided Retrieval State Space Module (SRSM) that chooses a representative subset of queries to adjust state space parameters for improved global modeling. Evaluation on four WSI subtype datasets shows that, compared to strong baselines, SemaMIL achieves state-of-the-art accuracy with fewer FLOPs and parameters.

Heng Zhang, Tianyi Zhang, Zijun Liu et al.

Text-attributed graphs are widely used across domains, offering rich opportunities for zero-shot learning via graph-text alignment. However, existing methods struggle with tasks requiring fine-grained pattern recognition, particularly on heterophilic graphs. Through empirical and theoretical analysis, we identify an \textbf{over-abstraction problem}: current approaches operate at excessively large hyperbolic radii, compressing multi-scale structural information into uniform high-level abstractions. This abstraction-induced information loss obscures critical local patterns essential for accurate predictions. By analyzing embeddings in hyperbolic space, we demonstrate that optimal graph learning requires \textbf{faithful preservation} of fine-grained structural details, better retained by representations positioned closer to the origin. To address this, we propose \textbf{H4G}, a framework that systematically reduces embedding radii using learnable block-diagonal scaling matrices and Möbius matrix multiplication. This approach restores access to fine-grained patterns while maintaining global receptive ability with minimal computational overhead. Experiments show H4G achieves state-of-the-art zero-shot performance with \textbf{12.8\%} improvement on heterophilic graphs and \textbf{8.4\%} on homophilic graphs, confirming that radius reduction enables faithful multi-scale representation for advancing zero-shot graph learning.

Heng Zhang, Haichuan Hu, Yaomin Shen et al.

Large Vision-Language Models (LVLMs) have demonstrated impressive performance on multimodal tasks through scaled architectures and extensive training. However, existing Mixture of Experts (MoE) approaches face challenges due to the asymmetry between visual and linguistic processing. Visual information is spatially complete, while language requires maintaining sequential context. As a result, MoE models struggle to balance modality-specific features and cross-modal interactions. Through systematic analysis, we observe that language experts in deeper layers progressively lose contextual grounding and rely more on parametric knowledge rather than utilizing the provided visual and linguistic information. To address this, we propose AsyMoE, a novel architecture that models this asymmetry using three specialized expert groups. We design intra-modality experts for modality-specific processing, hyperbolic inter-modality experts for hierarchical cross-modal interactions, and evidence-priority language experts to suppress parametric biases and maintain contextual grounding. Extensive experiments demonstrate that AsyMoE achieves 26.58% and 15.45% accuracy improvements over vanilla MoE and modality-specific MoE respectively, with 25.45% fewer activated parameters than dense models.