Claudio De Stefano

Nicole Dalia Cilia, Claudio De Stefano, Francesco Fontanella et al. · gatech

Using kinematic properties of handwriting to support the diagnosis of neurodegenerative disease is a real challenge: non-invasive detection techniques combined with machine learning approaches promise big steps forward in this research field. In literature, the tasks proposed focused on different cognitive skills to elicitate handwriting movements. In particular, the meaning and phonology of words to copy can compromise writing fluency. In this paper, we investigated how word semantics and phonology affect the handwriting of people affected by Alzheimer's disease. To this aim, we used the data from six handwriting tasks, each requiring copying a word belonging to one of the following categories: regular (have a predictable phoneme-grapheme correspondence, e.g., cat), non-regular (have atypical phoneme-grapheme correspondence, e.g., laugh), and non-word (non-meaningful pronounceable letter strings that conform to phoneme-grapheme conversion rules). We analyzed the data using a machine learning approach by implementing four well-known and widely-used classifiers and feature selection. The experimental results showed that the feature selection allowed us to derive a different set of highly distinctive features for each word type. Furthermore, non-regular words needed, on average, more features but achieved excellent classification performance: the best result was obtained on a non-regular, reaching an accuracy close to 90%.

Cesare Davide Pace, Alessandro Marco De Nunzio, Claudio De Stefano et al.

Markerless biomechanics increasingly relies on 3D skeletal keypoints extracted from video, yet downstream biomechanical mappings typically treat these estimates as deterministic, providing no principled mechanism for frame-wise quality control. In this work, we investigate predictive uncertainty as a quantitative measure of confidence for mapping 3D pose keypoints to 3D anatomical landmarks, a critical step preceding inverse kinematics and musculoskeletal analysis. Within a temporal learning framework, we model both uncertainty arising from observation noise and uncertainty related to model limitations. Using synchronized motion capture ground truth on AMASS, we evaluate uncertainty at frame and joint level through error--uncertainty rank correlation, risk--coverage analysis, and catastrophic outlier detection. Across experiments, uncertainty estimates, particularly those associated with model uncertainty, exhibit a strong monotonic association with landmark error (Spearman $ρ\approx 0.63$), enabling selective retention of reliable frames (error reduced to $\approx 16.8$ mm at 10% coverage) and accurate detection of severe failures (ROC-AUC $\approx 0.92$ for errors $>50$ mm). Reliability ranking remains stable under controlled input degradation, including Gaussian noise and simulated missing joints. In contrast, uncertainty attributable to observation noise provides limited additional benefit in this setting, suggesting that dominant failures in keypoint-to-landmark mapping are driven primarily by model uncertainty. Our results establish predictive uncertainty as a practical, frame-wise tool for automatic quality control in markerless biomechanical pipelines.

Gabriele Lozupone, Alessandro Bria, Francesco Fontanella et al.

This study presents Latent Diffusion Autoencoder (LDAE), a novel encoder-decoder diffusion-based framework for efficient and meaningful unsupervised learning in medical imaging, focusing on Alzheimer disease (AD) using brain MR from the ADNI database as a case study. Unlike conventional diffusion autoencoders operating in image space, LDAE applies the diffusion process in a compressed latent representation, improving computational efficiency and making 3D medical imaging representation learning tractable. To validate the proposed approach, we explore two key hypotheses: (i) LDAE effectively captures meaningful semantic representations on 3D brain MR associated with AD and ageing, and (ii) LDAE achieves high-quality image generation and reconstruction while being computationally efficient. Experimental results support both hypotheses: (i) linear-probe evaluations demonstrate promising diagnostic performance for AD (ROC-AUC: 90%, ACC: 84%) and age prediction (MAE: 4.1 years, RMSE: 5.2 years); (ii) the learned semantic representations enable attribute manipulation, yielding anatomically plausible modifications; (iii) semantic interpolation experiments show strong reconstruction of missing scans, with SSIM of 0.969 (MSE: 0.0019) for a 6-month gap. Even for longer gaps (24 months), the model maintains robust performance (SSIM > 0.93, MSE < 0.004), indicating an ability to capture temporal progression trends; (iv) compared to conventional diffusion autoencoders, LDAE significantly increases inference throughput (20x faster) while also enhancing reconstruction quality. These findings position LDAE as a promising framework for scalable medical imaging applications, with the potential to serve as a foundation model for medical image analysis. Code available at https://github.com/GabrieleLozupone/LDAE

Cesare Davide Pace, Alessandro Marco De Nunzio, Claudio De Stefano et al.

Human pose estimation, a vital task in computer vision, involves detecting and localising human joints in images and videos. While single-frame pose estimation has seen significant progress, it often fails to capture the temporal dynamics for understanding complex, continuous movements. We propose Poseidon, a novel multi-frame pose estimation architecture that extends the ViTPose model by integrating temporal information for enhanced accuracy and robustness to address these limitations. Poseidon introduces key innovations: (1) an Adaptive Frame Weighting (AFW) mechanism that dynamically prioritises frames based on their relevance, ensuring that the model focuses on the most informative data; (2) a Multi-Scale Feature Fusion (MSFF) module that aggregates features from different backbone layers to capture both fine-grained details and high-level semantics; and (3) a Cross-Attention module for effective information exchange between central and contextual frames, enhancing the model's temporal coherence. The proposed architecture improves performance in complex video scenarios and offers scalability and computational efficiency suitable for real-world applications. Our approach achieves state-of-the-art performance on the PoseTrack21 and PoseTrack18 datasets, achieving mAP scores of 88.3 and 87.8, respectively, outperforming existing methods.