Bahram Jalali

Yiming Zhou, Callen MacPhee, Madhuri Suthar et al.

PhyCV is the first computer vision library which utilizes algorithms directly derived from the equations of physics governing physical phenomena. The algorithms appearing in the current release emulate, in a metaphoric sense, the propagation of light through a physical medium with natural and engineered diffractive properties followed by coherent detection. Unlike traditional algorithms that are a sequence of hand-crafted empirical rules or deep learning algorithms that are usually data-driven and computationally heavy, physics-inspired algorithms leverage physical laws of nature as blueprints for inventing algorithms. PhyCV features low-dimensionality and high- efficiency, making it ideal for edge computing applications. We demonstrate real-time video processing on NVIDIA Jetson Nano using PhyCV. In addition, these algorithms have the potential to be implemented in real physical devices for fast and efficient computation in the form of analog computing. The open-sourced code is available at https://github.com/JalaliLabUCLA/phycv

Callen MacPhee, Yiming Zhou, Koichiro Kishima et al.

Deep learning has achieved remarkable success in medical image analysis, yet its performance remains highly sensitive to the heterogeneity of clinical data. Differences in imaging hardware, staining protocols, and acquisition conditions produce substantial domain shifts that degrade model generalization across institutions. Here we present a physics-based data preprocessing framework based on the PhyCV (Physics-Inspired Computer Vision) family of algorithms, which standardizes medical images through deterministic transformations derived from optical physics. The framework models images as spatially varying optical fields that undergo a virtual diffractive propagation followed by coherent phase detection. This process suppresses non-semantic variability such as color and illumination differences while preserving diagnostically relevant texture and structural features. When applied to histopathological images from the Camelyon17-WILDS benchmark, PhyCV preprocessing improves out-of-distribution breast-cancer classification accuracy from 70.8% (Empirical Risk Minimization baseline) to 90.9%, matching or exceeding data-augmentation and domain-generalization approaches at negligible computational cost. Because the transform is physically interpretable, parameterizable, and differentiable, it can be deployed as a fixed preprocessing stage or integrated into end-to-end learning. These results establish PhyCV as a generalizable data refinery for medical imaging-one that harmonizes heterogeneous datasets through first-principles physics, improving robustness, interpretability, and reproducibility in clinical AI systems.

Callen MacPhee, Madhuri Suthar, Bahram Jalali

Phase-Stretch Adaptive Gradient-Field Extractor (PAGE) is an edge detection algorithm that is inspired by physics of electromagnetic diffraction and dispersion. A computational imaging algorithm, it identifies edges, their orientations and sharpness in a digital image where the image brightness changes abruptly. Edge detection is a basic operation performed by the eye and is crucial to visual perception. PAGE embeds an original image into a set of feature maps that can be used for object representation and classification. The algorithm performs exceptionally well as an edge and texture extractor in low light level and low contrast images. This manuscript is prepared to support the open-source code which is being simultaneously made available within the GitHub repository https://github.com/JalaliLabUCLA/Phase-Stretch-Adaptive-Gradient-field-Extractor/.

Sifeng He, Bahram Jalali

A hallucination-free and computationally efficient algorithm for enhancing the resolution of brain MRI images is demonstrated.

Madhuri Suthar, Mohammad Asghari, Bahram Jalali

One of the major open problems in computer vision is detection of features in visually impaired images. In this paper, we describe a potential solution using Phase Stretch Transform, a new computational approach for image analysis, edge detection and resolution enhancement that is inspired by the physics of the photonic time stretch technique. We mathematically derive the intrinsic nonlinear transfer function and demonstrate how it leads to (1) superior performance at low contrast levels and (2) a reconfigurable operator for hyper-dimensional classification. We prove that the Phase Stretch Transform equalizes the input image brightness across the range of intensities resulting in a high dynamic range in visually impaired images. We also show further improvement in the dynamic range by combining our method with the conventional techniques. Finally, our results show a method for computation of mathematical derivatives via group delay dispersion operations.

Bahram Jalali, Madhuri Suthar, Mohamad Asghari et al.

We show that dispersive propagation of light followed by phase detection has properties that can be exploited for extracting features from the waveforms. This discovery is spearheading development of a new class of physics-inspired algorithms for feature extraction from digital images with unique properties and superior dynamic range compared to conventional algorithms. In certain cases, these algorithms have the potential to be an energy efficient and scalable substitute to synthetically fashioned computational techniques in practice today.