Amruta Parulekar

Sahar Almahfouz Nasser, Ashutosh Sharma, Anmol Saraf et al.

Ultrasound (US) imaging is better suited for intraoperative settings because it is real-time and more portable than other imaging techniques, such as mammography. However, US images are characterized by lower spatial resolution noise-like artifacts. This research aims to address these limitations by providing surgeons with mammogram-like image quality in real-time from noisy US images. Unlike previous approaches for improving US image quality that aim to reduce artifacts by treating them as (speckle noise), we recognize their value as informative wave interference pattern (WIP). To achieve this, we utilize the Stride software to numerically solve the forward model, generating ultrasound images from mammograms images by solving wave-equations. Additionally, we leverage the power of domain adaptation to enhance the realism of the simulated ultrasound images. Then, we utilize generative adversarial networks (GANs) to tackle the inverse problem of generating mammogram-quality images from ultrasound images. The resultant images have considerably more discernible details than the original US images.

Harsh Shah, Thomas Jacob, Amruta Parulekar et al.

Normally eosinophils are present in the gastrointestinal (GI) tract of healthy individuals. When the eosinophils increase beyond their usual amount in the GI tract, a patient gets varied symptoms. Clinicians find it difficult to diagnose this condition called eosinophilia. Early diagnosis can help in treating patients. Histopathology is the gold standard in the diagnosis for this condition. As this is an under-diagnosed condition, counting eosinophils in the GI tract biopsies is important. In this study, we trained and tested a deep neural network based on UNet to detect and count eosinophils in GI tract biopsies. We used connected component analysis to extract the eosinophils. We studied correlation of eosinophilic infiltration counted by AI with a manual count. GI tract biopsy slides were stained with H&E stain. Slides were scanned using a camera attached to a microscope and five high-power field images were taken per slide. Pearson correlation coefficient was 85% between the machine-detected and manual eosinophil counts on 300 held-out (test) images.

Amruta Parulekar, Utkarsh Kanwat, Ravi Kant Gupta et al.

Segmentation and classification of cell nuclei in histopathology images using deep neural networks (DNNs) can save pathologists' time for diagnosing various diseases, including cancers, by automating cell counting and morphometric assessments. It is now well-known that the accuracy of DNNs increases with the sizes of annotated datasets available for training. Although multiple datasets of histopathology images with nuclear annotations and class labels have been made publicly available, the set of class labels differ across these datasets. We propose a method to train DNNs for instance segmentation and classification on multiple datasets where the set of classes across the datasets are related but not the same. Specifically, our method is designed to utilize a coarse-to-fine class hierarchy, where the set of classes labeled and annotated in a dataset can be at any level of the hierarchy, as long as the classes are mutually exclusive. Within a dataset, the set of classes need not even be at the same level of the class hierarchy tree. Our results demonstrate that segmentation and classification metrics for the class set used by the test split of a dataset can improve by pre-training on another dataset that may even have a different set of classes due to the expansion of the training set enabled by our method. Furthermore, generalization to previously unseen datasets also improves by combining multiple other datasets with different sets of classes for training. The improvement is both qualitative and quantitative. The proposed method can be adapted for various loss functions, DNN architectures, and application domains.

Vira Kasprova, Amruta Parulekar, Abdulrahman AlRabah et al.

Large language models (LLMs) often exhibit sycophancy: agreement with user stance even when it conflicts with the model's opinion. While prior work has mostly studied this in single-agent settings, it remains underexplored in collaborative multi-agent systems. We ask whether awareness of other agents' sycophancy levels influences discussion outcomes. To investigate this, we run controlled experiments with six open-source LLMs, providing agents with peer sycophancy rankings that estimate each peer's tendency toward sycophancy. These rankings are based on scores calculated using various static (pre-discussion) and dynamic (online) strategies. We find that providing sycophancy priors reduces the influence of sycophancy-prone peers, mitigates error-cascades, and improves final discussion accuracy by an absolute 10.5%. Thus, this is a lightweight, effective way to reduce discussion sycophancy and improve downstream accuracy.

Akhila Krishna, Nikhil Cherian Kurian, Abhijeet Patil et al.

Accurate survival prediction is essential for personalized cancer treatment. However, genomic data - often a more powerful predictor than pathology data - is costly and inaccessible. We present the cross-modal genomic feature translation and alignment network for enhanced survival prediction from histopathology images (PathoGen-X). It is a deep learning framework that leverages both genomic and imaging data during training, relying solely on imaging data at testing. PathoGen-X employs transformer-based networks to align and translate image features into the genomic feature space, enhancing weaker imaging signals with stronger genomic signals. Unlike other methods, PathoGen-X translates and aligns features without projecting them to a shared latent space and requires fewer paired samples. Evaluated on TCGA-BRCA, TCGA-LUAD, and TCGA-GBM datasets, PathoGen-X demonstrates strong survival prediction performance, emphasizing the potential of enriched imaging models for accessible cancer prognosis.

Amruta Parulekar, Preethi Jyothi

Standard ASR evaluation metrics like Word Error Rate (WER) tend to unfairly penalize morphological and syntactic nuances that do not significantly alter sentence semantics. We introduce an LLM-based scoring rubric LASER that leverages state-of-the-art LLMs' in-context learning abilities to learn from prompts with detailed examples. Hindi LASER scores using Gemini 2.5 Pro achieved a very high correlation score of 94% with human annotations. Hindi examples in the prompt were also effective in analyzing errors in other Indian languages such as Marathi, Kannada and Malayalam. We also demonstrate how a smaller LLM like Llama 3 can be finetuned on word-pair examples derived from reference and ASR predictions to predict what kind of penalty should be applied with close to 89% accuracy.

Isha Pandey, Pranav Gaikwad, Amruta Parulekar et al.

High-quality speech generation for low-resource languages, such as many Indian languages, remains a significant challenge due to limited data and diverse linguistic structures. Duration prediction is a critical component in many speech generation pipelines, playing a key role in modeling prosody and speech rhythm. While some recent generative approaches choose to omit explicit duration modeling, often at the cost of longer training times. We retain and explore this module to better understand its impact in the linguistically rich and data-scarce landscape of India. We train a non-autoregressive Continuous Normalizing Flow (CNF) based speech model using publicly available Indian language data and evaluate multiple duration prediction strategies for zero-shot, speaker-specific generation. Our comparative analysis on speech-infilling tasks reveals nuanced trade-offs: infilling based predictors improve intelligibility in some languages, while speaker-prompted predictors better preserve speaker characteristics in others. These findings inform the design and selection of duration strategies tailored to specific languages and tasks, underscoring the continued value of interpretable components like duration prediction in adapting advanced generative architectures to low-resource, multilingual settings.

Abhishek Gupta, Amruta Parulekar, Sameep Chattopadhyay et al.

Spontaneous or conversational multilingual speech presents many challenges for state-of-the-art automatic speech recognition (ASR) systems. In this work, we present a new technique AMPS that augments a multilingual multimodal ASR system with paraphrase-based supervision for improved conversational ASR in multiple languages, including Hindi, Marathi, Malayalam, Kannada, and Nyanja. We use paraphrases of the reference transcriptions as additional supervision while training the multimodal ASR model and selectively invoke this paraphrase objective for utterances with poor ASR performance. Using AMPS with a state-of-the-art multimodal model SeamlessM4T, we obtain significant relative reductions in word error rates (WERs) of up to 5%. We present detailed analyses of our system using both objective and human evaluation metrics.

Abhishek Gupta, Amruta Parulekar, Sameep Chattopadhyay et al.

Automatic speech recognition (ASR) for low-resource languages remains a challenge due to the scarcity of labeled training data. Parameter-efficient fine-tuning and text-only adaptation are two popular methods that have been used to address such low-resource settings. In this work, we investigate how these techniques can be effectively combined using a multilingual multimodal model like SeamlessM4T. Multimodal models are able to leverage unlabeled text via text-only adaptation with further parameter-efficient ASR fine-tuning, thus boosting ASR performance. We also show cross-lingual transfer from a high-resource language, achieving up to a relative 17% WER reduction over a baseline in a zero-shot setting without any labeled speech.