Xudong Ye

Junhao Wei, Baili Lu, Zhenhong Peng et al.

Sequence-based deep learning offers a scalable alternative to structure-based scoring for protein-ligand binding affinity prediction. However, progress is hard to interpret when architectural priors are evaluated on canonical PDBbind-style splits that leak similarity classes across folds. We present HonestAffinity, a compact 1D-input predictor to isolate two priors under a leak-aware protocol: frozen ESM-2 (650M) protein embeddings and a learned binary pocket-position marker. We evaluate a multi-scale convolutional/Transformer template in three variants: HonestAffinity-Pocket, HonestAffinity-NoPocket, and HonestAffinity-Pocket-NoESM. All three train on 11,513 LP-PDBBind complexes in ~3 GPU-hours. We benchmark against five baselines on the LP-PDBBind 3-tier no-leak hold-out, CASF-2016, and a CASF-2016 non-train subset. Our central finding is a split-conditioned reversal rather than a uniformly best prior: HonestAffinity-Pocket achieves the best mean Pearson R on validation and CASF-2016 splits, whereas HonestAffinity-Pocket-NoESM achieves the best mean Pearson R on every strict LP no-leak tier (test_cl1-cl3). Both the pocket marker and ESM-2 input improve performance on familiar splits but reduce Pearson R on strict no-leak tiers. We argue models should report paired canonical and leak-proof ablations, and that deployment-regime-matched variants better describe these reversals than a single default. Code and scripts are linked in the footnote; checkpoints will be released upon acceptance.

Junhao Wei, Yanxiao Li, Seyedali Mirjalili et al.

The Whale Optimization Algorithm (WOA) has shown strong optimization ability but still suffers from premature convergence and weak search diversity. To address these issues, this paper proposes an enhanced WOA variant called CICDWOA. The proposed algorithm introduces a Good Nodes Set (GNS) method for uniform population initialization, a Collective Cognitive Sharing (CCS) mechanism to enhance group collaboration, and an Enhanced Spiral Updating strategy based on the Cauchy Inverse Cumulative Distribution (CICD) to strengthen global exploration and local exploitation balance. In addition, a nonlinear convergence factor and a Hybrid Gaussian-Cauchy mutation based on Differential Evolution (DE) further improve convergence efficiency and population diversity. CICDWOA was evaluated on 23 benchmark functions, 2D robot path planning problems, 3D UAV path planning tasks and 10 engineering design problems. Statistical experiment results show that CICDWOA achieves faster convergence, higher accuracy, and better robustness than classical WOA and other advanced metaheuristic algorithms. CICDWOA gained average Friedman value of 1.6790, ranking first among the SOTA algorithms. And the results of engineering simulations confirm that CICDWOA provides an effective and general framework for solving complex optimization and engineering problems. The code of CICDWOA are available on \href{URL}{https://github.com/JunhaoWei-mpu/ROBIS-Lab/tree/CICDWOA}.

Junhao Wei, Yanxiao Li, Bidong Chen et al.

We present a unified experiment, analysis, and benchmark study of multivariate time-series (MTS) anomaly detection. Ten family-representative detectors -- spanning statistical, reconstruction, association, frequency, and generic-transformer families -- are evaluated on five datasets (SMD, MSL, SMAP, PSM, and MSDS) under effectiveness, efficiency, robustness, and cross-dataset generalisation. All methods share the same windowing, scoring, hardware, and metric protocols. Effectiveness, ablation, and robustness use three random seeds; cross-dataset transfer uses seed~0 because each extra seed requires $250$ source-target evaluations. The benchmark yields three method-independent findings: no single-bias baseline dominates; absolute perturbation VUS-ROC is more informative than retention ratios; and MSDS behaves as an event-dense deployment workload rather than a sparse point-anomaly benchmark. Under this protocol we also introduce \ours{}, an adaptive detector family combining a NOTEARS-constrained directed channel-graph view with optional patch-attention and temporal-association views. \ours{} achieves the best macro-average VUS-ROC ($0.675$, $+5.1$~pt over the second-best LSTM-AE), ranks first overall, and reaches the top-3 on all five datasets. Its wins on MSL and MSDS are narrow, while its average and robustness gains are larger: under the same three-seed robustness protocol for every method, it obtains the strongest absolute VUS-ROC across noise, channel dropout, and time-shift perturbations. We release the MSDS preprocessing protocol, configurations, scripts, and seed-level metric dumps.

Junhao Wei, Haochen Li, Yanxiao Li et al.

Mining anomalies from unmanned aerial vehicle (UAV) state-estimation logs is challenging because failures are sparse, temporally structured, and distributed across heterogeneous PX4 telemetry streams with variable sensor availability and missing values. We present AeroTSBoost, a temporal-statistical boosting framework for real-world UAV telemetry anomaly mining. AeroTSBoost aligns multivariate flight logs, converts each window into deterministic descriptors that capture distributional shifts, quantile structure, endpoint drift, local dynamics, and lag correlation, and trains a class-balanced LightGBM detector. On UAV-SEAD, AeroTSBoost achieves the strongest AUPRC among evaluated classical, supervised tabular, neural reconstruction, recurrent, Granger-causality-based, and frequency-domain baselines. Across five seeds, it reaches $0.7516\pm0.0043$ AUPRC and $0.5342\pm0.0108$ threshold-swept event F1, improving AUPRC by 5.79 absolute points over the strongest non-AeroTSBoost baseline. Under purged chronological and leave-log-out protocols, it remains the best AUPRC method, reaching $0.6066\pm0.0193$ and $0.6388\pm0.0315$, respectively. On related ALFA fixed-wing UAV fault logs, AeroTSBoost reaches $0.9259\pm0.0076$ leave-sequence-out AUPRC, ahead of RandomForest ($0.8835\pm0.0797$) and moments-only ($0.8700\pm0.0481$). These results show that deterministic temporal-statistical representations remain highly competitive for sparse anomaly mining in operational cyber-physical telemetry.