Jun Yan

Wenjie Mo, Jiashu Xu, Qin Liu et al. · harvard

Existing studies in backdoor defense have predominantly focused on the training phase, overlooking the critical aspect of testing time defense. This gap becomes pronounced in the context of LLMs deployed as Web Services, which typically offer only black-box access, rendering training-time defenses impractical. To bridge this gap, this study critically examines the use of demonstrations as a defense mechanism against backdoor attacks in black-box LLMs. We retrieve task-relevant demonstrations from a clean data pool and integrate them with user queries during testing. This approach does not necessitate modifications or tuning of the model, nor does it require insight into the model's internal architecture. The alignment properties inherent in in-context learning play a pivotal role in mitigating the impact of backdoor triggers, effectively recalibrating the behavior of compromised models. Our experimental analysis demonstrates that this method robustly defends against both instance-level and instruction-level backdoor attacks, outperforming existing defense baselines across most evaluation scenarios.

Kai Sun, Siyan Xue, Fuchun Sun et al.

Recent advancements in deep learning have significantly revolutionized the field of clinical diagnosis and treatment, offering novel approaches to improve diagnostic precision and treatment efficacy across diverse clinical domains, thus driving the pursuit of precision medicine. The growing availability of multi-organ and multimodal datasets has accelerated the development of large-scale Medical Multimodal Foundation Models (MMFMs). These models, known for their strong generalization capabilities and rich representational power, are increasingly being adapted to address a wide range of clinical tasks, from early diagnosis to personalized treatment strategies. This review offers a comprehensive analysis of recent developments in MMFMs, focusing on three key aspects: datasets, model architectures, and clinical applications. We also explore the challenges and opportunities in optimizing multimodal representations and discuss how these advancements are shaping the future of healthcare by enabling improved patient outcomes and more efficient clinical workflows.