Hua Guo

Tongxi Song, Ziyu Li, Zihan Li et al.

Self-supervised deep learning-based methods have shown great promise for accelerated magnetic resonance imaging (MRI) reconstruction, achieving high image quality without requiring fully sampled data for training. These methods typically partition the acquired data into two disjoint subsets to construct input-target pairs for optimizing the reconstruction network. However, existing approaches perform this partition exclusively within the spatial frequency (k-space) domain, leaving the coil dimension unexplored. To enforce full exploitation of signal correlation across receiver coils, we propose CoilDrop-MRI, which applies coil-wise dropout to the input and uses the dropped data as training targets in a self-supervised framework. This method is integrated into unrolled architectures in both image-domain (SENSE) and k-space (SPIRiT) formulations. We further demonstrate its versatility by extending CoilDrop-MRI to multi-shot, phase-corrected diffusion MRI (dMRI) reconstruction. CoilDrop-MRI is extensively validated on multi-site, multi-field-strength (0.3T, 0.55T, and 3T), and multi-modality (T1-weighted, T2-weighted, T2-FLAIR, and dMRI) datasets and consistently outperforms state-of-the-art self-supervised methods, achieving quality comparable to supervised reconstruction methods without requiring fully sampled reference training data. Moreover, CoilDrop-MRI exhibits strong data efficiency and robust generalization across imaging conditions, establishing it as a practical and versatile framework for self-supervised parallel MRI reconstruction.

Shoujin Huang, Guanxiong Luo, Yunlin Zhao et al.

Simultaneous multislice (SMS) imaging is a powerful technique for accelerating magnetic resonance imaging (MRI) acquisitions. However, SMS reconstruction remains challenging due to complex signal interactions between and within the excited slices. In this study, we introduce ROGER, a robust SMS MRI reconstruction method based on deep generative priors. Utilizing denoising diffusion probabilistic models (DDPM), ROGER begins with Gaussian noise and gradually recovers individual slices through reverse diffusion iterations while enforcing data consistency from measured k-space data within the readout concatenation framework. The posterior sampling procedure is designed such that the DDPM training can be performed on single-slice images without requiring modifications for SMS tasks. Additionally, our method incorporates a low-frequency enhancement (LFE) module to address the practical issue that SMS-accelerated fast spin echo (FSE) and echo planar imaging (EPI) sequences cannot easily embed fully-sampled autocalibration signals. Extensive experiments on both retrospectively and prospectively accelerated datasets demonstrate that ROGER consistently outperforms existing methods, enhancing both anatomical and functional imaging with strong out-of-distribution generalization. The source code and sample data for ROGER are available at https://github.com/Solor-pikachu/ROGER.

Yuanchao Ding, Hua Guo, Yewei Guan et al.

Transformer has been successfully used in practical applications, such as ChatGPT, due to its powerful advantages. However, users' input is leaked to the model provider during the service. With people's attention to privacy, privacy-preserving Transformer inference is on the demand of such services. Secure protocols for non-linear functions are crucial in privacy-preserving Transformer inference, which are not well studied. Thus, designing practical secure protocols for non-linear functions is hard but significant to model performance. In this work, we propose a framework \emph{East} to enable efficient and accurate secure Transformer inference. Firstly, we propose a new oblivious piecewise polynomial evaluation algorithm and apply it to the activation functions, which reduces the runtime and communication of GELU by over 1.5$\times$ and 2.5$\times$, compared to prior arts. Secondly, the secure protocols for softmax and layer normalization are carefully designed to faithfully maintain the desired functionality. Thirdly, several optimizations are conducted in detail to enhance the overall efficiency. We applied \emph{East} to BERT and the results show that the inference accuracy remains consistent with the plaintext inference without fine-tuning. Compared to Iron, we achieve about 1.8$\times$ lower communication within 1.2$\times$ lower runtime.

Yuxuan Zhang, Hua Guo, Chen Chen et al.

Montgomery modular multiplication is widely-used in public key cryptosystems (PKC) and affects the efficiency of upper systems directly. However, modulus is getting larger due to the increasing demand of security, which results in a heavy computing cost. High-performance implementation of Montgomery modular multiplication is urgently required to ensure the highly-efficient operations in PKC. However, existing high-speed implementations still need a large amount redundant computing to simplify the intermediate result. Supports to the redundant representation is extremely limited on Montgomery modular multiplication. In this paper, we propose an efficient parallel variant of iterative Montgomery modular multiplication, called DRMMM, that allows the quotient can be computed in multiple iterations. In this variant, terms in intermediate result and the quotient in each iteration are computed in different radix such that computation of the quotient can be pipelined. Based on proposed variant, we also design high-performance hardware implementation architecture for faster operation. In the architecture, intermediate result in every iteration is denoted as three parts to free from redundant computations. Finally, to support FPGA-based systems, we design operators based on FPGA underlying architecture for better area-time performance. The result of implementation and experiment shows that our method reduces the output latency by 38.3\% than the fastest design on FPGA.

Shanshan Wang, Shoujun Yu, Jian Cheng et al.

Diffusion magnetic resonance imaging (dMRI) provides critical insights into the microstructural and connectional organization of the human brain. However, the availability of high-field, open-access datasets that include raw k-space data for advanced research remains limited. To address this gap, we introduce Diff5T, a first comprehensive 5.0 Tesla diffusion MRI dataset focusing on the human brain. This dataset includes raw k-space data and reconstructed diffusion images, acquired using a variety of imaging protocols. Diff5T is designed to support the development and benchmarking of innovative methods in artifact correction, image reconstruction, image preprocessing, diffusion modelling and tractography. The dataset features a wide range of diffusion parameters, including multiple b-values and gradient directions, allowing extensive research applications in studying human brain microstructure and connectivity. With its emphasis on open accessibility and detailed benchmarks, Diff5T serves as a valuable resource for advancing human brain mapping research using diffusion MRI, fostering reproducibility, and enabling collaboration across the neuroscience and medical imaging communities.

Hikmat Khan, Ziyu Su, Huina Zhang et al.

Triple-negative breast cancer (TNBC) remains a major clinical challenge due to its aggressive behavior and lack of targeted therapies. Accurate early prediction of response to neoadjuvant chemotherapy (NACT) is essential for guiding personalized treatment strategies and improving patient outcomes. In this study, we present an attention-based multiple instance learning (MIL) framework designed to predict pathologic complete response (pCR) directly from pre-treatment hematoxylin and eosin (H&E)-stained biopsy slides. The model was trained on a retrospective in-house cohort of 174 TNBC patients and externally validated on an independent cohort (n = 30). It achieved a mean area under the curve (AUC) of 0.85 during five-fold cross-validation and 0.78 on external testing, demonstrating robust predictive performance and generalizability. To enhance model interpretability, attention maps were spatially co-registered with multiplex immuno-histochemistry (mIHC) data stained for PD-L1, CD8+ T cells, and CD163+ macrophages. The attention regions exhibited moderate spatial overlap with immune-enriched areas, with mean Intersection over Union (IoU) scores of 0.47 for PD-L1, 0.45 for CD8+ T cells, and 0.46 for CD163+ macrophages. The presence of these biomarkers in high-attention regions supports their biological relevance to NACT response in TNBC. This not only improves model interpretability but may also inform future efforts to identify clinically actionable histological biomarkers directly from H&E-stained biopsy slides, further supporting the utility of this approach for accurate NACT response prediction and advancing precision oncology in TNBC.