Jiaru Wang

Sirong Piao, Ying Ming, Ruijie Zhao et al.

To characterize lobar and segmental airway volume differences between systemic lupus erythematosus (SLE) patients with interstitial lung disease (ILD) and those without ILD (non-ILD) using a deep learning-based approach on non-contrast chest high-resolution CT (HRCT). Methods: A retrospective analysis was conducted on 106 SLE patients (27 SLE-ILD, 79 SLE-non-ILD) who underwent HRCT. A customized deep learning framework based on the U-Net architecture was developed to automatically segment airway structures at the lobar and segmental levels via HRCT. Volumetric measurements of lung lobes and segments derived from the segmentations were statistically compared between the two groups using two-sample t-tests (significance threshold: p < 0.05). Results: At lobar level, significant airway volume enlargement in SLE-ILD patients was observed in the right upper lobe (p=0.009) and left upper lobe (p=0.039) compared to SLE-non-ILD. At the segmental level, significant differences were found in segments including R1 (p=0.016), R3 (p<0.001), and L3 (p=0.038), with the most marked changes in the upper lung zones, while lower zones showed non-significant trends. Conclusion: Our study demonstrates that an automated deep learning-based approach can effectively quantify airway volumes on HRCT scans and reveal significant, region-specific airway dilation in patients with SLE-ILD compared to those without ILD. The pattern of involvement, predominantly affecting the upper lobes and specific segments, highlights a distinct topographic phenotype of SLE-ILD and implicates airway structural alterations as a potential biomarker for disease presence. This AI-powered quantitative imaging biomarker holds promise for enhancing the early detection and monitoring of ILD in the SLE population, ultimately contributing to more personalized patient management.

Shiruo Hu, Wenbo Shan, Yingjia Li et al.

Hydro-Science and Engineering (Hydro-SE) is a critical and irreplaceable domain that secures human water supply, generates clean hydropower energy, and mitigates flood and drought disasters. Featuring multiple engineering objectives, Hydro-SE is an inherently interdisciplinary domain that integrates scientific knowledge with engineering expertise. This integration necessitates extensive expert collaboration in decision-making, which poses difficulties for intelligence. With the rapid advancement of large language models (LLMs), their potential application in the Hydro-SE domain is being increasingly explored. However, the knowledge and application abilities of LLMs in Hydro-SE have not been sufficiently evaluated. To address this issue, we propose the Hydro-SE LLM evaluation benchmark (Hydro-SE Bench), which contains 4,000 multiple-choice questions. Hydro-SE Bench covers nine subfields and enables evaluation of LLMs in aspects of basic conceptual knowledge, engineering application ability, and reasoning and calculation ability. The evaluation results on Hydro-SE Bench show that the accuracy values vary among 0.74 to 0.80 for commercial LLMs, and among 0.41 to 0.68 for small-parameter LLMs. While LLMs perform well in subfields closely related to natural and physical sciences, they struggle with domain-specific knowledge such as industry standards and hydraulic structures. Model scaling mainly improves reasoning and calculation abilities, but there is still great potential for LLMs to better handle problems in practical engineering application. This study highlights the strengths and weaknesses of LLMs for Hydro-SE tasks, providing model developers with clear training targets and Hydro-SE researchers with practical guidance for applying LLMs.

Ruijie Zhao, Zuopeng Tan, Xiao Xue et al.

Pulmonary segment segmentation is crucial for cancer localization and surgical planning. However, the pixel-wise annotation of pulmonary segments is laborious, as the boundaries between segments are indistinguishable in medical images. To this end, we propose a weakly supervised learning (WSL) method, termed Anatomy-Hierarchy Supervised Learning (AHSL), which consults the precise clinical anatomical definition of pulmonary segments to perform pulmonary segment segmentation. Since pulmonary segments reside within the lobes and are determined by the bronchovascular tree, i.e., artery, airway and vein, the design of the loss function is founded on two principles. First, segment-level labels are utilized to directly supervise the output of the pulmonary segments, ensuring that they accurately encompass the appropriate bronchovascular tree. Second, lobe-level supervision indirectly oversees the pulmonary segment, ensuring their inclusion within the corresponding lobe. Besides, we introduce a two-stage segmentation strategy that incorporates bronchovascular priori information. Furthermore, a consistency loss is proposed to enhance the smoothness of segment boundaries, along with an evaluation metric designed to measure the smoothness of pulmonary segment boundaries. Visual inspection and evaluation metrics from experiments conducted on a private dataset demonstrate the effectiveness of our method.