Md. Rashadul Islam

Md. Rashadul Islam

NASA's Transiting Exoplanet Survey Satellite (TESS) has identified thousands of exoplanet candidates, yet many remain unconfirmed due to the limitations of manual vetting processes. This paper presents ExoNet, a multimodal deep learning framework that integrates phase-folded global and local light curve representations with stellar parameters using a late-fusion architecture combining 1D Convolutional Neural Networks and Multi-Head Attention. Trained on labeled Kepler data, ExoNet achieves strong classification performance and demonstrates effective generalization to TESS data. Applied to 200 unconfirmed TESS planet candidates, the model identifies multiple high-confidence candidates, including several within the habitable zone. The results highlight the effectiveness of multimodal fusion and attention mechanisms in automated exoplanet candidate validation.

Md. Rashadul Islam

Microgravity induces profound metabolic adaptations in mammalian physiology, yet the molecular mechanisms governing thermogenesis in female white adipose tissue (WAT) remain poorly characterized. This paper presents the first machine learning (ML) analysis of NASA Open Science Data Repository (OSDR) dataset OSD-970, derived from the Rodent Research-1 (RR-1) mission. Using RT-qPCR data from 89 adipogenesis and thermogenesis pathway genes in gonadal WAT of 16 female C57BL/6J mice (8 flight, 8 ground control) following 37 days aboard the International Space Station (ISS), we applied differential expression analysis, multiple ML classifiers with Leave-One-Out Cross-Validation (LOO-CV), and Explainable AI via SHapley Additive exPlanations (SHAP). The most striking finding is a dramatic 12.21-fold upregulation of Ucp1 (Delta-Delta-Ct = -3.61, p = 0.0167) in microgravity-exposed WAT, accompanied by significant activation of the thermogenesis pathway (mean pathway fold-change = 3.24). The best-performing model (Random Forest with top-20 features) achieved AUC = 0.922, Accuracy = 0.812, and F1 = 0.824 via LOO-CV. SHAP analysis consistently ranked Ucp1 among the top predictive features, while Angpt2, Irs2, Jun, and Klf-family transcription factors emerged as dominant consensus classifiers. Principal component analysis (PCA) revealed clear separation between flight and ground samples, with PC1 explaining 69.1% of variance. These results suggest rapid thermogenic reprogramming in female WAT as a compensatory response to microgravity. This study demonstrates the power of explainable AI for re-analysis of newly released NASA space biology datasets, with direct implications for female astronaut health on long-duration missions and for Earth-based obesity and metabolic disease research.