Ugo Lomoio

Francesco Speziale, Ugo Lomoio, Fabiola Boccuto et al.

Cardiac amyloidosis (CA) is a rare and underdiagnosed infiltrative cardiomyopathy, and available datasets for machine-learning models are typically small, imbalanced and heterogeneous. This paper presents a Generative Adversarial Network (GAN) and a graphical command-line interface for generating realistic synthetic electrocardiogram (ECG) beats to support early diagnosis and patient stratification in CA. The tool is designed for usability, allowing clinical researchers to train class-specific generators once and then interactively produce large volumes of labelled synthetic beats that preserve the distribution of minority classes.

Ugo Lomoio, Pierangelo Veltri, Pietro Hiram Guzzi et al.

Electrocardiogram (ECG) signals play a pivotal role in cardiovascular diagnostics, providing essential information on the electrical activity of the heart. However, the inherent noise and limited resolution in ECG recordings can hinder accurate interpretation and diagnosis. In this paper, we propose a novel model for ECG super resolution (SR) that uses a DNAE to enhance temporal and frequency information inside ECG signals. Our approach addresses the limitations of traditional ECG signal processing techniques. Our model takes in input 5-second length ECG windows sampled at 50 Hz (very low resolution) and it is able to reconstruct a denoised super-resolution signal with an x10 upsampling rate (sampled at 500 Hz). We trained the proposed DCAE-SR on public available myocardial infraction ECG signals. Our method demonstrates superior performance in reconstructing high-resolution ECG signals from very low-resolution signals with a sampling rate of 50 Hz. We compared our results with the current deep-learning literature approaches for ECG super-resolution and some non-deep learning reproducible methods that can perform both super-resolution and denoising. We obtained current state-of-the-art performances in super-resolution of very low resolution ECG signals frequently corrupted by ECG artifacts. We were able to obtain a signal-to-noise ratio of 12.20 dB (outperforms previous 4.68 dB), mean squared error of 0.0044 (outperforms previous 0.0154) and root mean squared error of 4.86% (outperforms previous 12.40%). In conclusion, our DCAE-SR model offers a robust (to artefact presence), versatile and explainable solution to enhance the quality of ECG signals. This advancement holds promise in advancing the field of cardiovascular diagnostics, paving the way for improved patient care and high-quality clinical decisions

Ugo Lomoio, Tommaso Mazza, Pierangelo Veltri et al.

The increasing availability of large-scale omics data calls for robust analytical frameworks capable of handling complex gene expression datasets while offering interpretable results. Recent advances in artificial intelligence have enabled the identification of aberrant molecular patterns distinguishing disease states from healthy controls. Coupled with improvements in model interpretability, these tools now support the identification of genes potentially driving disease phenotypes. However, current approaches to gene anomaly detection often remain limited to single datasets and lack accessible graphical interfaces. Here, we introduce E-ABIN, a general-purpose, explainable framework for Anomaly detection in Biological Networks. E-ABIN combines classical machine learning and graph-based deep learning techniques within a unified, user-friendly platform, enabling the detection and interpretation of anomalies from gene expression or methylation-derived networks. By integrating algorithms such as Support Vector Machines, Random Forests, Graph Autoencoders (GAEs), and Graph Adversarial Attributed Networks (GAANs), E-ABIN ensures a high predictive accuracy while maintaining interpretability. We demonstrate the utility of E-ABIN through case studies of bladder cancer and coeliac disease, where it effectively uncovers biologically relevant anomalies and offers insights into disease mechanisms.