Lukas Ortmann

Lukas Ortmann, Dawei Shi, Eyal Dassau et al.

The insulin sensitivity (IS) of the human body changes with a circadian rhythm. This adds to the time-varying feature of the glucose metabolism process and places challenges on the blood glucose (BG) control of patients with Type 1 Diabetes Mellitus. This paper presents a Model Predictive Controller that takes the periodic IS into account, in order to enhance BG control. The future effect of the IS is predicted using a machine learning technique, namely, a customized Gaussian Process (GP), based on historical training data. The training data for the GP is continuously updated during closed-loop control, which enables the control scheme to learn and adapt to intra-individual and inter-individual changes of the circadian IS rhythm. The necessary state information is provided by an Unscented Kalman Filter. The closed-loop performance of the proposed control scheme is evaluated for different scenarios (including fasting, announced meals and skipped meals) through in silico studies on simulation models of Göttingen Minipigs.

Marta Zagorowska, Lukas Ortmann, Giuseppe Belgioioso et al.

Online Feedback Optimization leverages properties of optimization algorithms to develop controllers for systems with limited model availability, which is often the case in process control. The interplay between the parameters of the chosen optimization algorithm, as well as lack of direct connection to the characteristics of the underlying process make their tuning challenging. We propose a method for adaptive tuning of Online Feedback Optimization controllers based on scaled projected gradient descent by using sensitivity of the desired objective to the parameters of the algorithm. The proposed adaptive tuning method limits the operator-tunable parameters to scalar values that represent how much the control inputs and the objective can change between iterations without requiring either additional information about the controlled system or repeated experiments. Numerical studies on a gas lift and a continuously-stirred tank reactor processes confirm that our adaptive scheme improves closed-loop performance of Online Feedback optimization compared to standard manual tuning methods.