Afshan Hashmi

Afshan Hashmi

Diabetic retinopathy (DR) is a leading cause of vision impairment worldwide, and automated grading systems play a crucial role in large-scale screening programs. However, deep learning models often exhibit degraded performance when deployed across datasets acquired under different imaging conditions. This study presents a robust dual-resolution deep learning framework for DR grading that integrates attention-based feature fusion with ordinal regression to improve cross-dataset generalization. The proposed method employs two parallel EfficientNet backbones operating at different spatial resolutions to capture complementary retinal features. A learnable attention mechanism adaptively fuses multi-resolution representations, while an ordinal regression formulation based on the cumulative link model (CORAL) explicitly accounts for the ordered nature of DR severity levels. To mitigate domain discrepancies between datasets, a preprocessing strategy combining circular cropping, contrast enhancement, and histogram matching is applied. The model was trained on the APTOS 2019 dataset and evaluated on both an internal validation split and an external Messidor-2 test set. Experimental results demonstrate strong grading performance, achieving a quadratic weighted kappa (QWK) of 0.88 on the APTOS validation set and 0.68 on the unseen Messidor-2 dataset, indicating improved robustness for cross-dataset DR grading applications.

Afshan Hashmi

Retrieval-Augmented Generation (RAG) has become the standard paradigm for grounding Large Language Model outputs in external knowledge. Lumer et al. [1] presented the first systematic evaluation comparing vector-based agentic RAG against hierarchical node-based reasoning systems for financial document QA across 1,200 SEC filings, finding vector-based systems achieved a 68% win rate. Concurrently, the PageIndex framework [2] demonstrated 98.7% accuracy on FinanceBench through purely reasoning-based retrieval. This paper extends their work by: (i) implementing and evaluating three retrieval architectures: Vector RAG, Tree Reasoning, and the proposed Adaptive Hybrid Retrieval (AHR) across financial, legal, and medical domains; (ii) introducing a four-tier query complexity benchmark; and (iii) employing GPT-4-powered LLM-as-judge evaluation. Experiments reveal that Tree Reasoning achieves the highest overall score (0.900), but no single paradigm dominates across all tiers: Vector RAG wins on multi-document synthesis (Tier 4, score 0.900), while the Hybrid AHR achieves the best performance on cross-reference (0.850) and multi-section queries (0.929). Cross-reference recall reaches 100% for tree-based and hybrid approaches versus 91.7% for vector search, quantifying a critical capability gap. Validation on FinanceBench (150 expert-annotated questions on real SEC 10-K and 10-Q filings) confirms and strengthens these findings: Tree Reasoning scores 0.938, Hybrid AHR 0.901, and Vector RAG 0.821, with the Tree--Vector quality gap widening to 11.7 percentage points on real-world documents. These findings support the development of adaptive retrieval systems that dynamically select strategies based on query complexity and document structure. All code and data are publicly available.

Afshan Hashmi

Background: Alzheimer's disease (AD) affects over 55 million people worldwide. Accurate, interpretable detection of normal cognition (NC), mild cognitive impairment (MCI), and AD from routine clinical assessments remains a critical unmet need. Methods: An XGBoost classifier was developed for three-class detection using eight clinical features from the Alzheimer's Disease Neuroimaging Initiative (ADNI): MMSE, CDR Global, CDR Sum of Boxes (CDR-SB), MoCA, FAQ, age, sex, and education. Hyperparameters were optimised using Optuna (50 trials); class imbalance was addressed with SMOTE. Performance was evaluated by macro AUC-ROC with 1,000-iteration bootstrap 95% confidence intervals, macro F1, balanced accuracy, and Cohen's kappa. SHAP values provided feature-level explainability. Results: The dataset comprised 1,641 baseline subjects (608 NC, 767 MCI, 266 AD). On five-fold cross-validation, mean macro AUC was 0.983 (SD 0.007), accuracy 0.944 (SD 0.006), and macro F1 0.929 (SD 0.008). On the held-out test set (n = 247), macro AUC was 0.982 (95% CI: 0.965--0.995), accuracy 0.943, balanced accuracy 0.932, macro F1 0.927, and Cohen's kappa 0.909. SHAP analysis identified CDR Global as the dominant predictor for NC and MCI, while CDR-SB and MMSE together drove AD classification. Conclusion: An explainable machine learning model trained on routine clinical assessments achieves near-perfect three-class Alzheimer's detection. SHAP analysis reveals clinically plausible, class-specific feature importance patterns supporting clinical validity. Future work will extend this framework with speech biomarkers for multimodal detection.