Sen Zhang

Sen Zhang, Xiaoxiao He, Di Liu et al.

We present Large Sign Language Models (LSLM), a novel framework for translating 3D American Sign Language (ASL) by leveraging Large Language Models (LLMs) as the backbone, which can benefit hearing-impaired individuals' virtual communication. Unlike existing sign language recognition methods that rely on 2D video, our approach directly utilizes 3D sign language data to capture rich spatial, gestural, and depth information in 3D scenes. This enables more accurate and resilient translation, enhancing digital communication accessibility for the hearing-impaired community. Beyond the task of ASL translation, our work explores the integration of complex, embodied multimodal languages into the processing capabilities of LLMs, moving beyond purely text-based inputs to broaden their understanding of human communication. We investigate both direct translation from 3D gesture features to text and an instruction-guided setting where translations can be modulated by external prompts, offering greater flexibility. This work provides a foundational step toward inclusive, multimodal intelligent systems capable of understanding diverse forms of language.

Yichao Zhang, Ningyuan Deng, Xinyuan Song et al.

After AlphaFold won the Nobel Prize, protein prediction with deep learning once again became a hot topic. We comprehensively explore advanced deep learning methods applied to protein structure prediction and design. It begins by examining recent innovations in prediction architectures, with detailed discussions on improvements such as diffusion based frameworks and novel pairwise attention modules. The text analyses key components including structure generation, evaluation metrics, multiple sequence alignment processing, and network architecture, thereby illustrating the current state of the art in computational protein modelling. Subsequent chapters focus on practical applications, presenting case studies that range from individual protein predictions to complex biomolecular interactions. Strategies for enhancing prediction accuracy and integrating deep learning techniques with experimental validation are thoroughly explored. The later sections review the industry landscape of protein design, highlighting the transformative role of artificial intelligence in biotechnology and discussing emerging market trends and future challenges. Supplementary appendices provide essential resources such as databases and open source tools, making this volume a valuable reference for researchers and students.

Zhuo Zhang, Xiong Xiong, Sen Zhang et al.

PDEs arise ubiquitously in science and engineering, where solutions depend on parameters (physical properties, boundary conditions, geometry). Traditional numerical methods require re-solving the PDE for each parameter, making parameter space exploration prohibitively expensive. Recent machine learning advances, particularly physics-informed neural networks (PINNs) and neural operators, have revolutionized parametric PDE solving by learning solution operators that generalize across parameter spaces. We critically analyze two main paradigms: (1) PINNs, which embed physical laws as soft constraints and excel at inverse problems with sparse data, and (2) neural operators (e.g., DeepONet, Fourier Neural Operator), which learn mappings between infinite-dimensional function spaces and achieve unprecedented generalization. Through comparisons across fluid dynamics, solid mechanics, heat transfer, and electromagnetics, we show neural operators can achieve computational speedups of $10^3$ to $10^5$ times faster than traditional solvers for multi-query scenarios, while maintaining comparable accuracy. We provide practical guidance for method selection, discuss theoretical foundations (universal approximation, convergence), and identify critical open challenges: high-dimensional parameters, complex geometries, and out-of-distribution generalization. This work establishes a unified framework for understanding parametric PDE solvers via operator learning, offering a comprehensive, incrementally updated resource for this rapidly evolving field