Haijiang Hu

Xinmeng Hou, Ziting Chang, Zhouquan Lu et al.

Large language models (LLMs) fail on over one-third of multi-hop questions with counterfactual premises and remain vulnerable to adversarial prompts that trigger biased or factually incorrect responses, which exposes a fundamental deficit in self-regulated reasoning. We propose \textbf{MetaCrit}, a multi-agent framework grounded in Nelson and Narens' metacognitive regulation theory. MetaCrit decomposes reasoning regulation into four agents: object-level generation, a \emph{monitoring} agent that assesses response validity, a \emph{control} agent that critiques logical soundness, and a meta-level synthesizer that integrates all signals into a final response. Evaluation across eight benchmarks, four model backbones, and a college-level analytical writing study shows that MetaCrit significantly improves content truthfulness and logical soundness while eliminating toxic outputs. Its modular design allows individual agents to be integrated into existing frameworks as drop-in components without architectural modifications.

Chunlei Li, Yilei Shi, Haoxi Hu et al.

High-resolution computed tomography (CT) imaging is essential for medical diagnosis but requires increased radiation exposure, creating a critical trade-off between image quality and patient safety. While deep learning methods have shown promise in CT super-resolution, they face challenges with complex degradations and limited medical training data. Meanwhile, large-scale pre-trained diffusion models, particularly Stable Diffusion, have demonstrated remarkable capabilities in synthesizing fine details across various vision tasks. Motivated by this, we propose a novel framework that adapts Stable Diffusion for CT blind super-resolution. We employ a practical degradation model to synthesize realistic low-quality images and leverage a pre-trained vision-language model to generate corresponding descriptions. Subsequently, we perform super-resolution using Stable Diffusion with a specialized controlling strategy, conditioned on both low-resolution inputs and the generated text descriptions. Extensive experiments show that our method outperforms existing approaches, demonstrating its potential for achieving high-quality CT imaging at reduced radiation doses. Our code will be made publicly available.

Hui Xie, Haiqin Hu, Lijuan Ding et al.

Radiotherapy treatment planning often relies on time-consuming, trial-and-error adjustments that heavily depend on the expertise of specialists, while existing deep learning methods face limitations in generalization, prediction accuracy, and clinical applicability. To tackle these challenges, we propose ADDiff-Dose, an Anatomical-Dose Dual Constraints Conditional Diffusion Model for end-to-end multi-tumor dose prediction. The model employs LightweightVAE3D to compress high-dimensional CT data and integrates multimodal inputs, including target and organ-at-risk (OAR) masks and beam parameters, within a progressive noise addition and denoising framework. It incorporates conditional features via a multi-head attention mechanism and utilizes a composite loss function combining MSE, conditional terms, and KL divergence to ensure both dosimetric accuracy and compliance with clinical constraints. Evaluation on a large-scale public dataset (2,877 cases) and three external institutional cohorts (450 cases in total) demonstrates that ADDiff-Dose significantly outperforms traditional baselines, achieving an MAE of 0.101-0.154 (compared to 0.316 for UNet and 0.169 for GAN models), a DICE coefficient of 0.927 (a 6.8% improvement), and limiting spinal cord maximum dose error to within 0.1 Gy. The average plan generation time per case is reduced to 22 seconds. Ablation studies confirm that the structural encoder enhances compliance with clinical dose constraints by 28.5%. To our knowledge, this is the first study to introduce a conditional diffusion model framework for radiotherapy dose prediction, offering a generalizable and efficient solution for automated treatment planning across diverse tumor sites, with the potential to substantially reduce planning time and improve clinical workflow efficiency.