Viviana Siless

Paula Feldman, Miguel Fainstein, Viviana Siless et al.

We present a data-driven generative framework for synthesizing blood vessel 3D geometry. This is a challenging task due to the complexity of vascular systems, which are highly variating in shape, size, and structure. Existing model-based methods provide some degree of control and variation in the structures produced, but fail to capture the diversity of actual anatomical data. We developed VesselVAE, a recursive variational Neural Network that fully exploits the hierarchical organization of the vessel and learns a low-dimensional manifold encoding branch connectivity along with geometry features describing the target surface. After training, the VesselVAE latent space can be sampled to generate new vessel geometries. To the best of our knowledge, this work is the first to utilize this technique for synthesizing blood vessels. We achieve similarities of synthetic and real data for radius (.97), length (.95), and tortuosity (.96). By leveraging the power of deep neural networks, we generate 3D models of blood vessels that are both accurate and diverse, which is crucial for medical and surgical training, hemodynamic simulations, and many other purposes.

Hugo Massaroli, Leonardo Iara, Emmanuel Iarussi et al.

Large language models (LLMs) are increasingly deployed in realworld applications, yet concerns about their fairness persist especially in highstakes domains like criminal justice, education, healthcare, and finance. This paper introduces transparent evaluation protocol for benchmarking the fairness of opensource LLMs using smart contracts on the Internet Computer Protocol (ICP) blockchain (Foundation, 2023). Our method ensures verifiable, immutable, and reproducible evaluations by executing onchain HTTP requests to hosted Hugging Face endpoints and storing datasets, prompts, and metrics directly onchain. We benchmark the Llama, DeepSeek, and Mistral models on the PISA dataset for academic performance prediction (OECD, 2018), a dataset suitable for fairness evaluation using statistical parity and equal opportunity metrics (Hardt et al., 2016). We also evaluate structured Context Association Metrics derived from the StereoSet dataset (Nadeem et al., 2020) to measure social bias in contextual associations. We further extend our analysis with a multilingual evaluation across English, Spanish, and Portuguese using the Kaleidoscope benchmark (Salazar et al., 2025), revealing cross-linguistic disparities. All code and results are open source, enabling community audits and longitudinal fairness tracking across model versions.

Paula Feldman, Martin Sinnona, Claudio Delrieux et al.

Anatomical trees are critical for clinical diagnosis and treatment planning, yet their complex and diverse geometry make accurate representation a significant challenge. Motivated by the latest advances in large language models, we introduce an autoregressive method for synthesizing anatomical trees. Our approach first embeds vessel structures into a learned discrete vocabulary using a VQ-VAE architecture, then models their generation autoregressively with a GPT-2 model. This method effectively captures intricate geometries and branching patterns, enabling realistic vascular tree synthesis. Comprehensive qualitative and quantitative evaluations reveal that our technique achieves high-fidelity tree reconstruction with compact discrete representations. Moreover, our B-spline representation of vessel cross-sections preserves critical morphological details that are often overlooked in previous' methods parameterizations. To the best of our knowledge, this work is the first to generate blood vessels in an autoregressive manner. Code is available at https://github.com/LIA-DiTella/VesselGPT-MICCAI.

Miguel Fainstein, Viviana Siless, Emmanuel Iarussi

In recent years, there has been a growing interest in training Neural Networks to approximate Unsigned Distance Fields (UDFs) for representing open surfaces in the context of 3D reconstruction. However, UDFs are non-differentiable at the zero level set which leads to significant errors in distances and gradients, generally resulting in fragmented and discontinuous surfaces. In this paper, we propose to learn a hyperbolic scaling of the unsigned distance field, which defines a new Eikonal problem with distinct boundary conditions. This allows our formulation to integrate seamlessly with state-of-the-art continuously differentiable implicit neural representation networks, largely applied in the literature to represent signed distance fields. Our approach not only addresses the challenge of open surface representation but also demonstrates significant improvement in reconstruction quality and training performance. Moreover, the unlocked field's differentiability allows the accurate computation of essential topological properties such as normal directions and curvatures, pervasive in downstream tasks such as rendering. Through extensive experiments, we validate our approach across various data sets and against competitive baselines. The results demonstrate enhanced accuracy and up to an order of magnitude increase in speed compared to previous methods.

Valentin Bonas, Martin Sinnona, Viviana Siless et al.

Data visualizations are central to scientific communication, journalism, and everyday decision-making, yet they are frequently prone to errors that can distort interpretation or mislead audiences. Rule-based visualization linters can flag violations, but they miss context and do not suggest meaningful design changes. Directly querying general-purpose LLMs about visualization quality is unreliable: lacking training to follow visualization design principles, they often produce inconsistent or incorrect feedback. In this work, we introduce a framework that combines chart de-rendering, automated analysis, and iterative improvement to deliver actionable, interpretable feedback on visualization design. Our system reconstructs the structure of a chart from an image, identifies design flaws using vision-language reasoning, and proposes concrete modifications supported by established principles in visualization research. Users can selectively apply these improvements and re-render updated figures, creating a feedback loop that promotes both higher-quality visualizations and the development of visualization literacy. In our evaluation on 1,000 charts from the Chart2Code benchmark, the system generated 10,452 design recommendations, which clustered into 10 coherent categories (e.g., axis formatting, color accessibility, legend consistency). These results highlight the promise of LLM-driven recommendation systems for delivering structured, principle-based feedback on visualization design, opening the door to more intelligent and accessible authoring tools.

Martin Sinnona, Valentin Bonas, Emmanuel Iarussi et al.

Data visualization rules-derived from decades of research in design and perception-ensure trustworthy chart communication. While prior work has shown that large language models (LLMs) can generate charts or flag misleading figures, it remains unclear whether they can reason about and enforce visualization rules directly. Constraint-based systems such as Draco encode these rules as logical constraints for precise automated checks, but maintaining symbolic encodings requires expert effort, motivating the use of LLMs as flexible rule validators. In this paper, we present the first systematic evaluation of LLMs against visualization rules using hard-verification ground truth derived from Answer Set Programming (ASP). We translated a subset of Draco's constraints into natural-language statements and generated a controlled dataset of 2,000 Vega-Lite specifications annotated with explicit rule violations. LLMs were evaluated on both accuracy in detecting violations and prompt adherence, which measures whether outputs follow the required structured format. Results show that frontier models achieve high adherence (Gemma 3 4B / 27B: 100%, GPT-oss 20B: 98%) and reliably detect common violations (F1 up to 0.82),yet performance drops for subtler perceptual rules (F1 < 0.15 for some categories) and for outputs generated from technical ASP formulations.Translating constraints into natural language improved performance by up to 150% for smaller models. These findings demonstrate the potential of LLMs as flexible, language-driven validators while highlighting their current limitations compared to symbolic solvers.

Martin Sinnona, Valentin Bonas, Viviana Siless et al.

Data visualization principles, derived from decades of research in design and perception, ensure proper visual communication. While prior work has shown that large language models (LLMs) can generate charts or flag misleading figures, it remains unclear whether they and their vision-language counterparts (VLMs) can reason about and enforce visualization principles directly. Constraint based systems encode these principles as logical rules for precise automated checks, but translating them into formal specifications demands expert knowledge. This motivates leveraging LLMs and VLMs as principle checkers that can reason about visual design directly, bypassing the need for symbolic rule specification. In this paper, we present the first systematic evaluation of both LLMs and VLMs on their ability to reason about visualization principles, using hard verification ground truth derived from Answer Set Programming (ASP). We compiled a set of visualization principles expressed as natural-language statements and generated a controlled dataset of approximately 2,000 Vega-Lite specifications annotated with explicit principle violations, complemented by over 300 real-world Vega-Lite charts. We evaluated both checking and fixing tasks, assessing how well models detect principle violations and correct flawed chart specifications. Our work highlights both the promise of large (vision-)language models as flexible validators and editors of visualization designs and the persistent gap with symbolic solvers on more nuanced aspects of visual perception. They also reveal an interesting asymmetry: frontier models tend to be more effective at correcting violations than at detecting them reliably.

Hugo Massaroli, Hernan Chaves, Pilar Anania et al.

Deep learning models have shown strong performance in diagnosing Alzheimer's disease (AD) using neuroimaging data, particularly 18F-FDG PET scans, with training datasets largely composed of North American cohorts such as those in the Alzheimer's Disease Neuroimaging Initiative (ADNI). However, their generalization to underrepresented populations remains underexplored. In this study, we benchmark convolutional and Transformer-based models on the ADNI dataset and assess their generalization performance on a novel Latin American clinical cohort from the FLENI Institute in Buenos Aires, Argentina. We show that while all models achieve high AUCs on ADNI (up to .96, .97), their performance drops substantially on FLENI (down to .82, .80, respectively), revealing a significant domain shift. The tested architectures demonstrated similar performance, calling into question the supposed advantages of transformers for this specific task. Through ablation studies, we identify per-image normalization and a correct sampling selection as key factors for generalization. Occlusion sensitivity analysis further reveals that models trained on ADNI, generally attend to canonical hypometabolic regions for the AD class, but focus becomes unclear for the other classes and for FLENI scans. These findings highlight the need for population-aware validation of diagnostic AI models and motivate future work on domain adaptation and cohort diversification.

Paula Feldman, Miguel Fainstein, Viviana Siless et al.

Anatomical trees play an important role in clinical diagnosis and treatment planning. Yet, accurately representing these structures poses significant challenges owing to their intricate and varied topology and geometry. Most existing methods to synthesize vasculature are rule based, and despite providing some degree of control and variation in the structures produced, they fail to capture the diversity and complexity of actual anatomical data. We developed a Recursive variational Neural Network (RvNN) that fully exploits the hierarchical organization of the vessel and learns a low-dimensional manifold encoding branch connectivity along with geometry features describing the target surface. After training, the RvNN latent space can be sampled to generate new vessel geometries. By leveraging the power of generative neural networks, we generate 3D models of blood vessels that are both accurate and diverse, which is crucial for medical and surgical training, hemodynamic simulations, and many other purposes. These results closely resemble real data, achieving high similarity in vessel radii, length, and tortuosity across various datasets, including those with aneurysms. To the best of our knowledge, this work is the first to utilize this technique for synthesizing blood vessels.