Marta Cimitile

Susanna Cifani, Mario Luca Bernardi, Marta Cimitile

Modern information systems require autonomous agents capable of navigating complex workflows, yet current methodologies often struggle with the transition from structured metadata parsing to general environmental perception. While the integration of MLLMs has enabled agents to interact directly with GUIs, existing approaches typically treat task sequences as discrete, linear episodes. This fragmentation prevents agents from capturing the underlying transition topology, limiting their effectiveness in novel or non-stationary scenarios. To address this, we propose a novel multimodal multi-agent framework that achieves automatic workflow execution through a distinct two-phase pipeline. First, during an offline discovery phase, the architecture adaptively constructs a topological knowledge base from fragmented execution logs. During inference, agents leverage Adaptive Retrieval-Augmented Generation (RAG) over this fixed, pre-established graph, coupled with a closed-loop collaborative verification protocol to dynamically self-correct and navigate. This graph-based approach facilitates superior task decomposition and adaptive navigation performance. We validate our framework in a real-world context, demonstrating its ability to maintain high reliability and semantic awareness even with limited training data.

Pasquale Ardimento, Mario Luca Bernardi, Marta Cimitile et al.

This study analyzes COVID-19 care pathways using the COVID Data for Shared Learning dataset. We build a transparent, reproducible pipeline that transforms heterogeneous clinical tables into a process-mining-ready event log and applies discovery, declarative conformance checking, and outcome analysis. The reconstructed pathways highlight the monitoring backbone of inpatient care, variability at the Emergency department-admission interface, and outcome differences driven by age and exposure to intensive care units. These insights support triage standardization, capacity planning, and step-down coordination from intensive care units to lower-acuity wards, showing how process mining can inform evidence-based hospital governance.

Pasquale Ardimento, Mario Luca Bernardi, Marta Cimitile et al.

This paper presents a reproducible and process-aware pipeline for predictive monitoring of clinical pathways. The approach integrates data lifting, temporal reconstruction, event log construction, prefix-based representations, and predictive modeling to support continuous reasoning on partially observed patient trajectories, overcoming the limitations of traditional retrospective process mining. The framework is evaluated on COVID-19 clinical pathways using ICU admission as the prediction target, considering 4,479 patient cases and 46,804 prefixes. Predictive models are trained and evaluated using a case-level split, with 896 patients in the test set. Logistic Regression achieves the best performance (AUC 0.906, F1-score 0.835). A detailed prefix-based analysis shows that predictive performance improves progressively as new clinical events become available, with AUC increasing from 0.642 at early stages to 0.942 at later stages of the pathway. The results highlight two key findings: predictive signals emerge progressively along clinical pathways, and process-aware representations enable effective early risk estimation from evolving patient trajectories. Overall, the findings suggest that predictive monitoring in healthcare is best conceived as a continuous, dynamically aware process, in which risk estimates are progressively refined as the patient journey evolves.