Chunming Li

Chu Han, Xipeng Pan, Lixu Yan et al.

Lung cancer is the leading cause of cancer death worldwide, and adenocarcinoma (LUAD) is the most common subtype. Exploiting the potential value of the histopathology images can promote precision medicine in oncology. Tissue segmentation is the basic upstream task of histopathology image analysis. Existing deep learning models have achieved superior segmentation performance but require sufficient pixel-level annotations, which is time-consuming and expensive. To enrich the label resources of LUAD and to alleviate the annotation efforts, we organize this challenge WSSS4LUAD to call for the outstanding weakly-supervised semantic segmentation (WSSS) techniques for histopathology images of LUAD. Participants have to design the algorithm to segment tumor epithelial, tumor-associated stroma and normal tissue with only patch-level labels. This challenge includes 10,091 patch-level annotations (the training set) and over 130 million labeled pixels (the validation and test sets), from 87 WSIs (67 from GDPH, 20 from TCGA). All the labels were generated by a pathologist-in-the-loop pipeline with the help of AI models and checked by the label review board. Among 532 registrations, 28 teams submitted the results in the test phase with over 1,000 submissions. Finally, the first place team achieved mIoU of 0.8413 (tumor: 0.8389, stroma: 0.7931, normal: 0.8919). According to the technical reports of the top-tier teams, CAM is still the most popular approach in WSSS. Cutmix data augmentation has been widely adopted to generate more reliable samples. With the success of this challenge, we believe that WSSS approaches with patch-level annotations can be a complement to the traditional pixel annotations while reducing the annotation efforts. The entire dataset has been released to encourage more researches on computational pathology in LUAD and more novel WSSS techniques.

Chunming Li, Shidong Wang, Tong Xin et al.

This paper presents a novel approach, Spectral-Interpretable and -Enhanced Transformer (SIEFormer), which leverages spectral analysis to reinterpret the attention mechanism within Vision Transformer (ViT) and enhance feature adaptability, with particular emphasis on challenging Generalized Category Discovery (GCD) tasks. The proposed SIEFormer is composed of two main branches, each corresponding to an implicit and explicit spectral perspective of the ViT, enabling joint optimization. The implicit branch realizes the use of different types of graph Laplacians to model the local structure correlations of tokens, along with a novel Band-adaptive Filter (BaF) layer that can flexibly perform both band-pass and band-reject filtering. The explicit branch, on the other hand, introduces a Maneuverable Filtering Layer (MFL) that learns global dependencies among tokens by applying the Fourier transform to the input ``value" features, modulating the transformed signal with a set of learnable parameters in the frequency domain, and then performing an inverse Fourier transform to obtain the enhanced features. Extensive experiments reveal state-of-the-art performance on multiple image recognition datasets, reaffirming the superiority of our approach through ablation studies and visualizations.

Chunming Li, Shidong Wang, Haofeng Zhang

The recently proposed Novel Category Discovery (NCD) adapt paradigm of transductive learning hinders its application in more real-world scenarios. In fact, few labeled data in part of new categories can well alleviate this burden, which coincides with the ease that people can label few of new category data. Therefore, this paper presents a new setting in which a trained agent is able to flexibly switch between the tasks of identifying examples of known (labelled) classes and clustering novel (completely unlabeled) classes as the number of query examples increases by leveraging knowledge learned from only a few (handful) support examples. Drawing inspiration from the discovery of novel categories using prior-based clustering algorithms, we introduce a novel framework that further relaxes its assumptions to the real-world open set level by unifying the concept of model adaptability in few-shot learning. We refer to this setting as Few-Shot Novel Category Discovery (FSNCD) and propose Semi-supervised Hierarchical Clustering (SHC) and Uncertainty-aware K-means Clustering (UKC) to examine the model's reasoning capabilities. Extensive experiments and detailed analysis on five commonly used datasets demonstrate that our methods can achieve leading performance levels across different task settings and scenarios.

Jin Qi, Miao Le, Chunming Li et al.

With a large influx of dermoscopy images and a growing shortage of dermatologists, automatic dermoscopic image analysis plays an essential role in skin cancer diagnosis. In this paper, a new deep fully convolutional neural network (FCNN) is proposed to automatically segment melanoma out of skin images by end-to-end learning with only pixels and labels as inputs. Our proposed FCNN is capable of using both local and global information to segment melanoma by adopting skipping layers. The public benchmark database consisting of 150 validation images, 600 test images and 2000 training images in the melanoma detection challenge 2017 at International Symposium Biomedical Imaging 2017 is used to test the performance of our algorithm. All large size images (for example, $4000\times 6000$ pixels) are reduced to much smaller images with $384\times 384$ pixels (more than 10 times smaller). We got and submitted preliminary results to the challenge without any pre or post processing. The performance of our proposed method could be further improved by data augmentation and by avoiding image size reduction.