Jo Woon Chong

Yifan Li, Peter Ho, Jo Woon Chong

Keratoconus (KC) is a corneal disorder that results in blurry and distorted vision. Traditional diagnostic tools, while effective, are often bulky, costly, and require professional operation. In this paper, we present a portable and innovative methodology for diagnosing. Our proposed approach first captures the image reflected on the eye's cornea when a smartphone screen-generated Placido disc sheds its light on an eye, then utilizes a two-stage diagnosis for identifying the KC cornea and pinpointing the location of the KC on the cornea. The first stage estimates the height and width of the Placido disc extracted from the captured image to identify whether it has KC. In this KC identification, k-means clustering is implemented to discern statistical characteristics, such as height and width values of extracted Placido discs, from non-KC (control) and KC-affected groups. The second stage involves the creation of a distance matrix, providing a precise localization of KC on the cornea, which is critical for efficient treatment planning. The analysis of these distance matrices, paired with a logistic regression model and robust statistical analysis, reveals a clear distinction between control and KC groups. The logistic regression model, which classifies small areas on the cornea as either control or KC-affected based on the corresponding inter-disc distances in the distance matrix, reported a classification accuracy of 96.94%, which indicates that we can effectively pinpoint the protrusion caused by KC. This comprehensive, smartphone-based method is expected to detect KC and streamline timely treatment.

Yifan Li, Alan W Pang, Jo Woon Chong

Inhalation injuries present a challenge in clinical diagnosis and grading due to Conventional grading methods such as the Abbreviated Injury Score (AIS) being subjective and lacking robust correlation with clinical parameters like mechanical ventilation duration and patient mortality. This study introduces a novel deep learning-based diagnosis assistant tool for grading inhalation injuries using bronchoscopy images to overcome subjective variability and enhance consistency in severity assessment. Our approach leverages data augmentation techniques, including graphic transformations, Contrastive Unpaired Translation (CUT), and CycleGAN, to address the scarcity of medical imaging data. We evaluate the classification performance of two deep learning models, GoogLeNet and Vision Transformer (ViT), across a dataset significantly expanded through these augmentation methods. The results demonstrate GoogLeNet combined with CUT as the most effective configuration for grading inhalation injuries through bronchoscopy images and achieves a classification accuracy of 97.8%. The histograms and frequency analysis evaluations reveal variations caused by the augmentation CUT with distribution changes in the histogram and texture details of the frequency spectrum. PCA visualizations underscore the CUT substantially enhances class separability in the feature space. Moreover, Grad-CAM analyses provide insight into the decision-making process; mean intensity for CUT heatmaps is 119.6, which significantly exceeds 98.8 of the original datasets. Our proposed tool leverages mechanical ventilation periods as a novel grading standard, providing comprehensive diagnostic support.

Chae Ho Cho, Fatemehsadat Tabei, Tra Nguyen Phan et al.

The rapid enhancement of central power unit CPU performance enables the development of computationally-intensive healthcare mobile applications for smartphones and wearable devices. However, computationally intensive mobile applications require significant application development time during the application porting procedure when the number of considering target devices operating systems OSs is large. In this paper, we propose a novel retargetable application development platform for healthcare mobile applications, which reduces application development time with maintaining the performance of the algorithm. Although the number of applications target OSs increases, the amount of time required for the code conversion step in the application porting procedure remains constant in the proposed retargetable platform. Experimental results show that our proposed retargetable platform gives reduced application development time compared to the conventional platform with maintaining the performance of the mobile application.