Pratibha Kumari

Pratibha Kumari, Daniel Reisenbüchler, Lucas Luttner et al.

In recent years, there has been remarkable progress in the field of digital pathology, driven by the ability to model complex tissue patterns using advanced deep-learning algorithms. However, the robustness of these models is often severely compromised in the presence of data shifts (e.g., different stains, organs, centers, etc.). Alternatively, continual learning (CL) techniques aim to reduce the forgetting of past data when learning new data with distributional shift conditions. Specifically, rehearsal-based CL techniques, which store some past data in a buffer and then replay it with new data, have proven effective in medical image analysis tasks. However, privacy concerns arise as these approaches store past data, prompting the development of our novel Generative Latent Replay-based CL (GLRCL) approach. GLRCL captures the previous distribution through Gaussian Mixture Models instead of storing past samples, which are then utilized to generate features and perform latent replay with new data. We systematically evaluate our proposed framework under different shift conditions in histopathology data, including stain and organ shift. Our approach significantly outperforms popular buffer-free CL approaches and performs similarly to rehearsal-based CL approaches that require large buffers causing serious privacy violations.

Pratibha Kumari, Priyankar Choudhary, Pradeep K. Atrey et al.

Anomaly detection in multimedia datasets is a widely studied area. Yet, the concept drift challenge in data has been ignored or poorly handled by the majority of the anomaly detection frameworks. The state-of-the-art approaches assume that the data distribution at training and deployment time will be the same. However, due to various real-life environmental factors, the data may encounter drift in its distribution or can drift from one class to another in the late future. Thus, a one-time trained model might not perform adequately. In this paper, we systematically investigate the effect of concept drift on various detection models and propose a modified Adaptive Gaussian Mixture Model (AGMM) based framework for anomaly detection in multimedia data. In contrast to the baseline AGMM, the proposed extension of AGMM remembers the past for a longer period in order to handle the drift better. Extensive experimental analysis shows that the proposed model better handles the drift in data as compared with the baseline AGMM. Further, to facilitate research and comparison with the proposed framework, we contribute three multimedia datasets constituting faces as samples. The face samples of individuals correspond to the age difference of more than ten years to incorporate a longer temporal context.

Pedro R. A. S. Bassi, Wenxuan Li, Yucheng Tang et al.

How can we test AI performance? This question seems trivial, but it isn't. Standard benchmarks often have problems such as in-distribution and small-size test sets, oversimplified metrics, unfair comparisons, and short-term outcome pressure. As a consequence, good performance on standard benchmarks does not guarantee success in real-world scenarios. To address these problems, we present Touchstone, a large-scale collaborative segmentation benchmark of 9 types of abdominal organs. This benchmark is based on 5,195 training CT scans from 76 hospitals around the world and 5,903 testing CT scans from 11 additional hospitals. This diverse test set enhances the statistical significance of benchmark results and rigorously evaluates AI algorithms across various out-of-distribution scenarios. We invited 14 inventors of 19 AI algorithms to train their algorithms, while our team, as a third party, independently evaluated these algorithms on three test sets. In addition, we also evaluated pre-existing AI frameworks--which, differing from algorithms, are more flexible and can support different algorithms--including MONAI from NVIDIA, nnU-Net from DKFZ, and numerous other open-source frameworks. We are committed to expanding this benchmark to encourage more innovation of AI algorithms for the medical domain.

Yousef Sadegheih, Afshin Bozorgpour, Pratibha Kumari et al.

The rise of Transformer architectures has advanced medical image segmentation, leading to hybrid models that combine Convolutional Neural Networks (CNNs) and Transformers. However, these models often suffer from excessive complexity and fail to effectively integrate spatial and channel features, crucial for precise segmentation. To address this, we propose LHU-Net, a Lean Hybrid U-Net for volumetric medical image segmentation. LHU-Net prioritizes spatial feature extraction before refining channel features, optimizing both efficiency and accuracy. Evaluated on four benchmark datasets (Synapse, Left Atrial, BraTS-Decathlon, and Lung-Decathlon), LHU-Net consistently outperforms existing models across diverse modalities (CT/MRI) and output configurations. It achieves state-of-the-art Dice scores while using four times fewer parameters and 20% fewer FLOPs than competing models, without the need for pre-training, additional data, or model ensembles. With an average of 11 million parameters, LHU-Net sets a new benchmark for computational efficiency and segmentation accuracy. Our implementation is available on GitHub: https://github.com/xmindflow/LHUNet

Pratibha Kumari, Joohi Chauhan, Afshin Bozorgpour et al.

Medical imaging analysis has witnessed remarkable advancements even surpassing human-level performance in recent years, driven by the rapid development of advanced deep-learning algorithms. However, when the inference dataset slightly differs from what the model has seen during one-time training, the model performance is greatly compromised. The situation requires restarting the training process using both the old and the new data which is computationally costly, does not align with the human learning process, and imposes storage constraints and privacy concerns. Alternatively, continual learning has emerged as a crucial approach for developing unified and sustainable deep models to deal with new classes, tasks, and the drifting nature of data in non-stationary environments for various application areas. Continual learning techniques enable models to adapt and accumulate knowledge over time, which is essential for maintaining performance on evolving datasets and novel tasks. This systematic review paper provides a comprehensive overview of the state-of-the-art in continual learning techniques applied to medical imaging analysis. We present an extensive survey of existing research, covering topics including catastrophic forgetting, data drifts, stability, and plasticity requirements. Further, an in-depth discussion of key components of a continual learning framework such as continual learning scenarios, techniques, evaluation schemes, and metrics is provided. Continual learning techniques encompass various categories, including rehearsal, regularization, architectural, and hybrid strategies. We assess the popularity and applicability of continual learning categories in various medical sub-fields like radiology and histopathology...

Pratibha Kumari, Afshin Bozorgpour, Daniel Reisenbüchler et al.

White blood cell (WBC) classification plays a vital role in hematology for diagnosing various medical conditions. However, it faces significant challenges due to domain shifts caused by variations in sample sources (e.g., blood or bone marrow) and differing imaging conditions across hospitals. Traditional deep learning models often suffer from catastrophic forgetting in such dynamic environments, while foundation models, though generally robust, experience performance degradation when the distribution of inference data differs from that of the training data. To address these challenges, we propose a generative replay-based Continual Learning (CL) strategy designed to prevent forgetting in foundation models for WBC classification. Our method employs lightweight generators to mimic past data with a synthetic latent representation to enable privacy-preserving replay. To showcase the effectiveness, we carry out extensive experiments with a total of four datasets with different task ordering and four backbone models including ResNet50, RetCCL, CTransPath, and UNI. Experimental results demonstrate that conventional fine-tuning methods degrade performance on previously learned tasks and struggle with domain shifts. In contrast, our continual learning strategy effectively mitigates catastrophic forgetting, preserving model performance across varying domains. This work presents a practical solution for maintaining reliable WBC classification in real-world clinical settings, where data distributions frequently evolve.

Pratibha Kumari, Daniel Reisenbüchler, Afshin Bozorgpour et al.

Whole slide image (WSI) classification has emerged as a powerful tool in computational pathology, but remains constrained by domain shifts, e.g., due to different organs, diseases, or institution-specific variations. To address this challenge, we propose an Attention-based Generative Latent Replay Continual Learning framework (AGLR-CL), in a multiple instance learning (MIL) setup for domain incremental WSI classification. Our method employs Gaussian Mixture Models (GMMs) to synthesize WSI representations and patch count distributions, preserving knowledge of past domains without explicitly storing original data. A novel attention-based filtering step focuses on the most salient patch embeddings, ensuring high-quality synthetic samples. This privacy-aware strategy obviates the need for replay buffers and outperforms other buffer-free counterparts while matching the performance of buffer-based solutions. We validate AGLR-CL on clinically relevant biomarker detection and molecular status prediction across multiple public datasets with diverse centers, organs, and patient cohorts. Experimental results confirm its ability to retain prior knowledge and adapt to new domains, offering an effective, privacy-preserving avenue for domain incremental continual learning in WSI classification.

Ruchi Bhatt, Pratibha Kumari, Dwarikanath Mahapatra et al.

Audio analysis is useful in many application scenarios. The state-of-the-art audio analysis approaches assume the data distribution at training and deployment time will be the same. However, due to various real-life challenges, the data may encounter drift in its distribution or can encounter new classes in the late future. Thus, a one-time trained model might not perform adequately. Continual learning (CL) approaches are devised to handle such changes in data distribution. There have been a few attempts to use CL approaches for audio analysis. Yet, there is a lack of a systematic evaluation framework. In this paper, we create a comprehensive CL dataset and characterize CL approaches for audio-based monitoring tasks. We have investigated the following CL and non-CL approaches: EWC, LwF, SI, GEM, A-GEM, GDumb, Replay, Naive, Cumulative, and Joint training. The study is very beneficial for researchers and practitioners working in the area of audio analysis for developing adaptive models. We observed that Replay achieved better results than other methods in the DCASE challenge data. It achieved an accuracy of 70.12% for the domain incremental scenario and an accuracy of 96.98% for the class incremental scenario.

Pratibha Kumari, Anterpreet Kaur Bedi, Mukesh Saini

Multimedia anomaly datasets play a crucial role in automated surveillance. They have a wide range of applications expanding from outlier objects/ situation detection to the detection of life-threatening events. For more than 1.5 decades, this field has attracted a lot of research attention, and as a result, more and more datasets dedicated to anomalous actions and object detection have been developed. Tapping these public anomaly datasets enable researchers to generate and compare various anomaly detection frameworks with the same input data. This paper presents a comprehensive survey on a variety of video, audio, as well as audio-visual datasets based on the application of anomaly detection. This survey aims to address the lack of a comprehensive comparison and analysis of multimedia public datasets based on anomaly detection. Also, it can assist researchers in selecting the best available dataset for bench-marking frameworks. Additionally, we discuss gaps in the existing dataset and insights for future direction towards developing multimodal anomaly detection datasets.

Pratibha Kumari, Mukesh Saini

When detecting anomalies in audio, it can often be necessary to consider concept drift: the distribution of the data may drift over time because of dynamically changing environments, and anomalies may become normal as time elapses. We propose to use adaptive Huffman coding for anomaly detection in audio with concept drift. Compared with the existing method of adaptive Gaussian mixture modeling (AGMM), adaptive Huffman coding does not require a priori information about the clusters and can adjust the number of clusters dynamically depending on the amount of variation in the audio. To control the size of the Huffman tree, we propose to merge clusters that are close to each other instead of replacing rare clusters with new data. This reduces redundancy in the Huffman tree while ensuring that it never forgets past information. On a dataset of audio with concept drift which we have curated ourselves, our proposed method achieves higher area under the curve (AUC) compared with AGMM and fixed-length Huffman trees. The proposed approach is also time-efficient and can be easily extended to other types of time series data (e.g., video).