J. S. Marron

Stephen M. Pizer, Zhiyuan Liu, Junjie Zhao et al.

We propose a means of computing fitted frames on the boundary and in the interior of objects and using them to provide the basis for producing geometric features from them that are not only alignment-free but most importantly can be made to correspond locally across a population of objects. We describe a representation targeted for anatomic objects which is designed to enable this strong locational correspondence within object populations and thus to provide powerful object statistics. It accomplishes this by understanding an object as the diffeomorphic deformation of the closure of the interior of an ellipsoid and by using a skeletal representation fitted throughout the deformation to produce a model of the target object, where the object is provided initially in the form of a boundary mesh. Via classification performance on hippocampi shape between individuals with a disorder vs. others, we compare our method to two state-of-theart methods for producing object representations that are intended to capture geometric correspondence across a population of objects and to yield geometric features useful for statistics, and we show notably improved classification performance by this new representation, which we call the evolutionary s-rep. The geometric features that are derived from each of the representations, especially via fitted frames, are discussed.

Andrew G. Allmon, J. S. Marron, Michael G. Hudgens

High-dimensional low sample size (HDLSS) data sets emerge frequently in many biomedical applications. A common task for analyzing HDLSS data is to assign data to the correct class using a classifier. Classifiers which use two labels and a linear combination of features are known as binary linear classifiers. The direction-projection-permutation (DiProPerm) test was developed for testing the difference of two high-dimensional distributions induced by a binary linear classifier. This paper discusses the key components of the DiProPerm test, introduces the diproperm R package, and demonstrates the package on a real-world data set.

Patrick K. Kimes, D. Neil Hayes, J. S. Marron et al.

Binary classification is a common statistical learning problem in which a model is estimated on a set of covariates for some outcome indicating the membership of one of two classes. In the literature, there exists a distinction between hard and soft classification. In soft classification, the conditional class probability is modeled as a function of the covariates. In contrast, hard classification methods only target the optimal prediction boundary. While hard and soft classification methods have been studied extensively, not much work has been done to compare the actual tasks of hard and soft classification. In this paper we propose a spectrum of statistical learning problems which span the hard and soft classification tasks based on fitting multiple decision rules to the data. By doing so, we reveal a novel collection of learning tasks of increasing complexity. We study the problems using the framework of large-margin classifiers and a class of piecewise linear convex surrogates, for which we derive statistical properties and a corresponding sub-gradient descent algorithm. We conclude by applying our approach to simulation settings and a magnetic resonance imaging (MRI) dataset from the Alzheimer's Disease Neuroimaging Initiative (ADNI) study.