Idris Kempf

Liam Perreault, Idris Kempf, Kirill Sechkar et al.

Cybergenetic gene expression control in bacteria enables applications in engineering biology, drug development, and biomanufacturing. AI-based controllers offer new possibilities for real-time, single-cell-level regulation but typically require large datasets and re-training for new systems. Data-enabled Predictive Control (DeePC) offers better sample efficiency without prior modelling. We apply DeePC to a system with two inputs (optogenetic control and media concentration) and two outputs (expression of gene of interest and host growth rate). Using basis functions to address nonlinearities, we demonstrate that DeePC remains robust to parameter variations and performs among the best control strategies while using the least data.

Idris Kempf, Paul J. Goulart, Stephen Duncan

This paper deals with model predictive control problems for large scale dynamical systems with cyclic symmetry. Based on the properties of block circulant matrices, we introduce a complex-valued coordinate transformation that block diagonalizes and truncates the original finite-horizon optimal control problem. Using this coordinate transformation, we develop a modified alternating direction method of multipliers (ADMM) algorithm for general constrained quadratic programs with block circulant blocks. We test our modified algorithm in two different simulated examples and show that our coordinate transformation significantly increases the computation speed.